UER00818 |
7,8-dihydrofolate from folate: step 1/1~1 H(+) + 1 NADPH + 1 folate => 1 7,8-dihydrofolate + 1 NADP(+). |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR02237 |
7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + phosphate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00152 |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4~1 7,8-dihydroneopterin triphosphate + 1 H(2)O => 1 7,8-dihydroneopterin 3'-phosphate + 1 diphosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR05552 |
NH(3) + chorismate = 4-amino-4-deoxychorismate + H(2)O |
True - {{t}} |
None - {{∅}} |
Missing |
|
ULS00063 |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate |
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UCR02236 |
7,8-dihydrofolate + NADP(+) = H(+) + NADPH + folate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UPA00077 |
tetrahydrofolate biosynthesis~Biosynthesis of tetrahydrofolic acid (tetrahydrofolate, THF), the active form of folic acid (vitamin B9). Folic acid is an essential vitamin (B9), which plays a key role in the methylation cycle and in DNA biosynthesis. The folic acid derivatives are made up of a pterdine ring attached to a p-aminobenzoate and a polyglutamyl chain. Tetrahydrofolic acid have C1 units enzymically attached. These C1 units (as a formyl group) are passed on to enzymes in the purine pathway that insert the C-2 and C-8 into the purine ring. A methylene group (-CH2-) attached to tetrahydrofolate is used to convert the uracil-type pyrimidine base found in RNA into the thymine base found in DNA. A further folate cofactor, i.e. 5-methyltetrahydrofolate, is involved in the remethylation of the homocysteine produced in the methylation cycle back to methionine. After activation to S-adenosylmethionine this acts as a methyl donor for the dozens of different methyltransferases present in all cells. Folate deficiency results in reduction of purine and pyrimidine biosynthesis and consequently DNA biosynthesis and cell division. Folate deficiency receives increasing attention due to its relation to cardiovascular disease and different forms of dementia. The folate pathway represents a powerful target for combating rapidly dividing systems such as cancer cells, bacteria and malaria parasites. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
UER00150 |
4-aminobenzoate from chorismate: step 2/2~1 4-amino-4-deoxychorismate => 1 4-aminobenzoate + 1 pyruvate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00149 |
4-aminobenzoate from chorismate: step 1/2~1 L-glutamine + 1 NH(3) + 1 chorismate => 1 4-amino-4-deoxychorismate + 1 L-glutamate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00064 |
7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
UER00155 |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4~1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 ATP => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 AMP. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00157 |
7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2~1 7,8-dihydropteroate + 1 ATP + 1 L-glutamate => 1 7,8-dihydrofolate + 1 ADP + 1 phosphate. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
ULS00062 |
4-aminobenzoate from chorismate |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
UCR03504 |
7,8-dihydroneopterin = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00411 |
5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
UCR03503 |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + AMP |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR04638 |
7,8-dihydroneopterin triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-1-UPA00077 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
VariantPath-3-UPA00077 |
|
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
VariantPath-2-UPA00077 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UER00158 |
5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1~1 7,8-dihydrofolate + 1 H(+) + 1 NADPH => 1 5,6,7,8-tetrahydrofolate + 1 NADP(+). |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR05553 |
4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00156 |
7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2~1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 4-aminobenzoate => 1 7,8-dihydropteroate + 1 diphosphate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00154 |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4~1 7,8-dihydroneopterin => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 glycolaldehyde. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR00256 |
H(2)O + L-glutamine = L-glutamate + NH(3) |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR04621 |
7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H(2)O |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR00939 |
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00153 |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4~1 7,8-dihydroneopterin 3'-phosphate + 1 H(2)O => 1 7,8-dihydroneopterin + 1 phosphate. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
ULS00412 |
7,8-dihydrofolate from folate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR03067 |
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|