ULS00026 |
O-acetyl-L-homoserine from L-homoserine |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00214 |
L-homocysteine from O-succinyl-L-homoserine |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
MUER16 |
Meta-UER 16~H(+) + L-aspartate 4-semialdehyde + [NADH or NADPH] => L-homoserine + [NAD(+) or NADP(+)]. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UPA00051 |
L-methionine biosynthesis via de novo pathway~Sulfur-containing amino-acid L-methionine (2-amino-4-(methylthio)butanoic acid) is synthesized de novo by most microorganisms and plants after the initial steps of inorganic sulfate assimilation and synthesis of cysteine or homocysteine. There are two alternative pathways of methionine synthesis in microorganisms. The enterobacterial type trans-sulfuration pathway involves cystathionine as an intermediate and utilizes cysteine as the sulfur source. In contrast, the direct sulfhydrylation pathway found in yeast (Saccharomyces cerevisiae), spirochete (Leptospira meyeri) and actinomycetes (Corynebacterium glutamicum) bypasses cystathionine and uses inorganic sulfur instead. Although yeast, fungi and higher plants have both transsulfuration and direct sulfhydrylation pathways, only the bacteria C. glutamicum, B. subtilis, P. aeruginosa, P. putida and L. meyeri have been shown to have both pathways. Methionine biosynthesis is a central pathway, as it controls a large number of cellular processes such as translation of mRNA into proteins (not only as a substrate for protein elongation but also as the initiator of protein synthesis) and transmethylation reactions via the formation of S-adenosylmethionine (SAM) (cf activated methyl cycle pathway). |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00025 |
L-homoserine from L-aspartate |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
UCR01776 |
L-homoserine + acetyl-CoA = CoA + O-acetyl-L-homoserine |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00029 |
L-cystathionine from O-succinyl-L-homoserine |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
ULS00213 |
L-cystathionine from O-acetyl-L-homoserine |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
UCR01286 |
H(2)O + L-cystathionine = L-homocysteine + NH(3) + pyruvate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR01773 |
L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
MUER12 |
Meta-UER 12~1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR01775 |
L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR01777 |
L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-9-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UER00449 |
L-homocysteine from O-succinyl-L-homoserine: step 1/1~1 O-succinyl-L-homoserine + 1 hydrogen sulfide => 1 L-homocysteine + 1 succinate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00030 |
L-homocysteine from L-cystathionine |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
UCR03217 |
L-cysteine + O-acetyl-L-homoserine = L-cystathionine + acetate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
VariantPath-6-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
ULS00035 |
L-methionine from L-homocysteine (BhmT route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-7-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
VariantPath-8-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UCR01288 |
O-succinyl-L-homoserine + hydrogen sulfide = L-homocysteine + succinate |
True - {{t}} |
None - {{∅}} |
Missing |
|
ULS00031 |
L-homocysteine from O-acetyl-L-homoserine |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
MUER7 |
Meta-UER 7~1 L-homocysteine + 1 betaine => 1 L-methionine + 1 N,N-dimethylglycine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-2-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
VariantPath-11-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
VariantPath-10-UPA00051 |
|
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
VariantPath-1-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
VariantPath-3-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UER00950 |
None~1 H(+) + 1 L-aspartate 4-semialdehyde + 1 NADPH => 1 L-homoserine + 1 NADP(+). |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
VariantPath-12-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
VariantPath-5-UPA00051 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
UCR02291 |
L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR04405 |
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
VariantPath-4-UPA00051 |
|
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00949 |
None~1 H(+) + 1 L-aspartate 4-semialdehyde + 1 NADH => 1 L-homoserine + 1 NAD(+). |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR00480 |
ATP + L-aspartate = 4-phospho-L-aspartate + ADP |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00027 |
O-succinyl-L-homoserine from L-homoserine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00079 |
L-homocysteine from O-acetyl-L-homoserine: step 1/1~1 O-acetyl-L-homoserine + 1 hydrogen sulfide => 1 L-homocysteine + 1 acetate. |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00033 |
L-methionine from L-homocysteine (MetH route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UCR03260 |
L-cysteine + O-succinyl-L-homoserine = L-cystathionine + succinate |
True - {{t}} |
None - {{∅}} |
Missing |
|
UER00075 |
O-succinyl-L-homoserine from L-homoserine: step 1/1~1 L-homoserine + 1 succinyl-CoA => 1 CoA + 1 O-succinyl-L-homoserine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00078 |
L-homocysteine from L-cystathionine: step 1/1~1 H(2)O + 1 L-cystathionine => 1 L-homocysteine + 1 NH(3) + 1 pyruvate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR02821 |
L-homocysteine + betaine = L-methionine + N,N-dimethylglycine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00082 |
L-methionine from L-homocysteine (MetE route): step 1/1~1 5-methyltetrahydropteroyltri-L-glutamate + 1 L-homocysteine => 1 L-methionine + 1 tetrahydropteroyltri-L-glutamate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR00946 |
5-methyl-THF + L-homocysteine = 5,6,7,8-tetrahydrofolate + L-methionine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
UER00081 |
L-methionine from L-homocysteine (MetH route): step 1/1~1 5-methyl-THF + 1 L-homocysteine => 1 5,6,7,8-tetrahydrofolate + 1 L-methionine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
VariantPath-1-MUER16 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
MUER21 |
Meta-UER 21~1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00074 |
O-acetyl-L-homoserine from L-homoserine: step 1/1~1 L-homoserine + 1 acetyl-CoA => 1 CoA + 1 O-acetyl-L-homoserine. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00077 |
L-cystathionine from O-succinyl-L-homoserine: step 1/1~1 L-cysteine + 1 O-succinyl-L-homoserine => 1 L-cystathionine + 1 succinate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
ULS00034 |
L-methionine from L-homocysteine (MetE route) |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|
VariantPath-2-MUER16 |
|
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UCR01287 |
O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
UER00448 |
L-cystathionine from O-acetyl-L-homoserine: step 1/1~1 L-cysteine + 1 O-acetyl-L-homoserine => 1 L-cystathionine + 1 acetate. |
True - {{∅},{t}} |
True - {{t}} |
Confirmed presence |
|