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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
UCR00271 2-oxoglutarate + H(2)O + acetyl-CoA = (R)-homocitrate + CoA None - {{∅}} None - {{∅}} Unexplained
UER00035 L-lysine from L-alpha-aminoadipate (Thermus route): step 1/5~1 ATP + 1 L-alpha-aminoadipate + 1 [LysW] => 1 ADP + 1 [LysW]-L-2-aminoadipate + 1 phosphate. None - {{∅}} None - {{∅}} Unexplained
UER01027 L-alpha-aminoadipate from 2-oxoglutarate: step 3/5~1 H(2)O + 1 homo-cis-aconitate => 1 homoisocitrate. None - {{∅}} None - {{∅}} Unexplained
UCR09777 H(+) + NADPH + [LysW]-L-2-aminoadipyl 6-phosphate = NADP(+) + [LysW]-L-2-aminoadipate 6-semialdehyde + phosphate None - {{∅}} None - {{∅}} Unexplained
UCR09779 H(2)O + [LysW]-L-lysine = L-lysine + [LysW] None - {{∅}} None - {{∅}} Unexplained
UCR04863 alpha-aminoadipoyl-C6-AMP + holo-Lys2 = AMP + alpha-aminoadipoyl-S-acyl enzyme None - {{∅}} None - {{∅}} Unexplained
UER00029 L-alpha-aminoadipate from 2-oxoglutarate: step 2/5~1 (R)-homocitrate => 1 H(2)O + 1 homo-cis-aconitate. None - {{∅}} None - {{∅}} Unexplained
UCR04390 H(+) + NADPH + alpha-aminoadipoyl-S-acyl enzyme = L-2-aminoadipate 6-semialdahyde + NADP(+) + holo-Lys2 None - {{∅}} None - {{∅}} Unexplained
UER00032 L-lysine from L-alpha-aminoadipate (fungal route): step 1/3~1 ATP + 1 H(+) + 1 L-alpha-aminoadipate + 1 NADPH => 1 AMP + 1 L-2-aminoadipate 6-semialdahyde + 1 NADP(+) + 1 diphosphate + 1 holo-Lys2. None - {{∅}} None - {{∅}} Unexplained
UCR04371 homoisocitrate = H(2)O + homo-cis-aconitate None - {{∅}} None - {{∅}} Unexplained
UCR04862 NAD(+) + homoisocitrate = 2-oxaloglutaric acid + H(+) + NADH None - {{∅}} None - {{∅}} Unexplained
UER00033 L-lysine from L-alpha-aminoadipate (fungal route): step 2/3~1 H(+) + 1 L-2-aminoadipate 6-semialdahyde + 1 L-glutamate + 1 NADPH => 1 H(2)O + 1 NADP(+) + 1 saccharopine. None - {{∅}} None - {{∅}} Unexplained
UCR00715 H(2)O + NAD(+) + saccharopine = 2-oxoglutarate + H(+) + L-lysine + NADH None - {{∅}} None - {{∅}} Unexplained
UER00028 L-alpha-aminoadipate from 2-oxoglutarate: step 1/5~1 2-oxoglutarate + 1 H(2)O + 1 acetyl-CoA => 1 (R)-homocitrate + 1 CoA. None - {{∅}} None - {{∅}} Unexplained
ULS00013 L-lysine from L-alpha-aminoadipate (fungal route) None - {{∅}} None - {{∅}} Unexplained
UCR09775 ATP + L-alpha-aminoadipate + [LysW] = ADP + [LysW]-L-2-aminoadipate + phosphate None - {{∅}} None - {{∅}} Unexplained
UER00031 L-alpha-aminoadipate from 2-oxoglutarate: step 5/5~1 2-oxoadipate + 1 L-glutamate => 1 2-oxoglutarate + 1 L-alpha-aminoadipate. None - {{∅}} None - {{∅}} Unexplained
UER00036 L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5~1 ATP + 1 [LysW]-L-2-aminoadipate => 1 ADP + 1 [LysW]-L-2-aminoadipyl 6-phosphate. None - {{∅}} None - {{∅}} Unexplained
UER00038 L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5~1 L-glutamate + 1 [LysW]-L-2-aminoadipate 6-semialdehyde => 1 2-oxoglutarate + 1 [LysW]-L-lysine. None - {{∅}} None - {{∅}} Unexplained
UCR01939 2-oxoglutarate + L-alpha-aminoadipate = 2-oxoadipate + L-glutamate False - {{∅},{f}} None - {{∅}} Absent
UER00039 L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5~1 H(2)O + 1 [LysW]-L-lysine => 1 L-lysine + 1 [LysW]. None - {{∅}} None - {{∅}} Unexplained
UER00030 L-alpha-aminoadipate from 2-oxoglutarate: step 4/5~1 NAD(+) + 1 homoisocitrate => 1 2-oxoadipate + 1 CO(2) + 1 H(+) + 1 NADH. None - {{∅}} None - {{∅}} Unexplained
UCR09778 L-glutamate + [LysW]-L-2-aminoadipate 6-semialdehyde = 2-oxoglutarate + [LysW]-L-lysine None - {{∅}} None - {{∅}} Unexplained
VariantPath-2-UPA00033 None - {{∅}} None - {{∅}} Unexplained
ULS00012 L-alpha-aminoadipate from 2-oxoglutarate None - {{∅}} None - {{∅}} Unexplained
VariantPath-1-UPA00033 None - {{∅}} None - {{∅}} Unexplained
ULS00014 L-lysine from L-alpha-aminoadipate (Thermus route) None - {{∅}} None - {{∅}} Unexplained
UCR03444 (R)-homocitrate = H(2)O + homo-cis-aconitate None - {{∅}} None - {{∅}} Unexplained
UCR02315 H(2)O + NADP(+) + saccharopine = H(+) + L-2-aminoadipate 6-semialdahyde + L-glutamate + NADPH None - {{∅}} None - {{∅}} Unexplained
UCR03098 ATP + L-alpha-aminoadipate = alpha-aminoadipoyl-C6-AMP + diphosphate None - {{∅}} None - {{∅}} Unexplained
UCR01936 2-oxaloglutaric acid = 2-oxoadipate + CO(2) None - {{∅}} None - {{∅}} Unexplained
UER00034 L-lysine from L-alpha-aminoadipate (fungal route): step 3/3~1 H(2)O + 1 NAD(+) + 1 saccharopine => 1 2-oxoglutarate + 1 H(+) + 1 L-lysine + 1 NADH. None - {{∅}} None - {{∅}} Unexplained
UCR09776 ATP + [LysW]-L-2-aminoadipate = ADP + [LysW]-L-2-aminoadipyl 6-phosphate None - {{∅}} None - {{∅}} Unexplained
UPA00033 L-lysine biosynthesis via AAA pathway~Biosynthesis of L-lysine through the alpha-amino adipic acid (AAA) pathway. It was first believed that this pathway was a specific character of fungi. In 1998, a gene cluster of a thermophilic bacterium (Thermus thermophilus) was shown to synthesize L-lysine through the AAA pathway. This pathway is present in hyperthermophilic archaea too (P. horikoshii and P. abyssi). Hence, this pathway is distributed among the three super-kingdoms as proposed by Woese and Fox in 1997 [PMID:270744]. None - {{∅}} None - {{∅}} Unexplained
UER00037 L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5~1 H(+) + 1 NADPH + 1 [LysW]-L-2-aminoadipyl 6-phosphate => 1 NADP(+) + 1 [LysW]-L-2-aminoadipate 6-semialdehyde + 1 phosphate. None - {{∅}} None - {{∅}} Unexplained