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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
ULS00063 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate None - {{∅}} True - {{t}} Unconfirmed presence
UCR05552 NH(3) + chorismate = 4-amino-4-deoxychorismate + H(2)O True - {{t}} None - {{∅}} Missing
UCR04621 7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H(2)O None - {{∅}} None - {{∅}} Unexplained
UER00149 4-aminobenzoate from chorismate: step 1/2~1 L-glutamine + 1 NH(3) + 1 chorismate => 1 4-amino-4-deoxychorismate + 1 L-glutamate. True - {{t}} True - {{t}} Confirmed presence
UCR03067 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate True - {{t}} True - {{t}} Confirmed presence
UCR02237 7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + phosphate True - {{t}} True - {{t}} Confirmed presence
UER00153 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 2/4~1 7,8-dihydroneopterin 3'-phosphate + 1 H(2)O => 1 7,8-dihydroneopterin + 1 phosphate. None - {{∅}} None - {{∅}} Unexplained
UER00818 7,8-dihydrofolate from folate: step 1/1~1 H(+) + 1 NADPH + 1 folate => 1 7,8-dihydrofolate + 1 NADP(+). None - {{∅}} None - {{∅}} Unexplained
UER00155 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4~1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 ATP => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 AMP. True - {{t}} True - {{t}} Confirmed presence
UER00152 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 1/4~1 7,8-dihydroneopterin triphosphate + 1 H(2)O => 1 7,8-dihydroneopterin 3'-phosphate + 1 diphosphate. None - {{∅}} None - {{∅}} Unexplained
ULS00411 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate None - {{∅}} True - {{t}} Unconfirmed presence
UER00156 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2~1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 1 4-aminobenzoate => 1 7,8-dihydropteroate + 1 diphosphate. True - {{t}} True - {{t}} Confirmed presence
UCR02236 7,8-dihydrofolate + NADP(+) = H(+) + NADPH + folate None - {{∅}} None - {{∅}} Unexplained
UER00150 4-aminobenzoate from chorismate: step 2/2~1 4-amino-4-deoxychorismate => 1 4-aminobenzoate + 1 pyruvate. True - {{t}} True - {{t}} Confirmed presence
ULS00062 4-aminobenzoate from chorismate None - {{∅}} True - {{t}} Unconfirmed presence
UER00157 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2~1 7,8-dihydropteroate + 1 ATP + 1 L-glutamate => 1 7,8-dihydrofolate + 1 ADP + 1 phosphate. None - {{∅}} True - {{t}} Unconfirmed presence
UCR00939 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH True - {{t}} True - {{t}} Confirmed presence
VariantPath-2-UPA00077 None - {{∅}} True - {{t}} Unconfirmed presence
VariantPath-1-UPA00077 None - {{∅}} None - {{∅},{t}} Unexplained
UCR04638 7,8-dihydroneopterin triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate None - {{∅}} None - {{∅}} Unexplained
ULS00412 7,8-dihydrofolate from folate None - {{∅}} None - {{∅}} Unexplained
UCR03503 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + AMP True - {{t}} True - {{t}} Confirmed presence
UER00154 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4~1 7,8-dihydroneopterin => 1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 1 glycolaldehyde. True - {{t}} True - {{t}} Confirmed presence
UCR03504 7,8-dihydroneopterin = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde True - {{t}} True - {{t}} Confirmed presence
UPA00077 tetrahydrofolate biosynthesis~Biosynthesis of tetrahydrofolic acid (tetrahydrofolate, THF), the active form of folic acid (vitamin B9). Folic acid is an essential vitamin (B9), which plays a key role in the methylation cycle and in DNA biosynthesis. The folic acid derivatives are made up of a pterdine ring attached to a p-aminobenzoate and a polyglutamyl chain. Tetrahydrofolic acid have C1 units enzymically attached. These C1 units (as a formyl group) are passed on to enzymes in the purine pathway that insert the C-2 and C-8 into the purine ring. A methylene group (-CH2-) attached to tetrahydrofolate is used to convert the uracil-type pyrimidine base found in RNA into the thymine base found in DNA. A further folate cofactor, i.e. 5-methyltetrahydrofolate, is involved in the remethylation of the homocysteine produced in the methylation cycle back to methionine. After activation to S-adenosylmethionine this acts as a methyl donor for the dozens of different methyltransferases present in all cells. Folate deficiency results in reduction of purine and pyrimidine biosynthesis and consequently DNA biosynthesis and cell division. Folate deficiency receives increasing attention due to its relation to cardiovascular disease and different forms of dementia. The folate pathway represents a powerful target for combating rapidly dividing systems such as cancer cells, bacteria and malaria parasites. None - {{∅}} True - {{t}} Unconfirmed presence
UCR05553 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate True - {{t}} True - {{t}} Confirmed presence
ULS00064 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate None - {{∅}} True - {{t}} Unconfirmed presence
UER00158 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1~1 7,8-dihydrofolate + 1 H(+) + 1 NADPH => 1 5,6,7,8-tetrahydrofolate + 1 NADP(+). True - {{t}} True - {{t}} Confirmed presence
UCR00256 H(2)O + L-glutamine = L-glutamate + NH(3) True - {{t}} True - {{t}} Confirmed presence
VariantPath-3-UPA00077 None - {{∅}} True - {{t}} Unconfirmed presence