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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
Evidence_74958 TIGR02962 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Component_54162 cupin domain protein, unknown function None - {{∅}} None - {{∅}} Unexplained
Evidence_75007 TIGR03178 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75006 TIGR03178 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75082 TIGR02961 HMM None - {{∅}} None - {{∅}} Unexplained
GenProp0687 allantoin catabolism to oxamate and carbamoyl-phosphate~Allantoin ([(4S)-2,5-dioxoimidazolidin-4-yl]urea) is a breakdown product of urate and may be obtained by an endogenous urate catabolism pathway or by transport from the environment. This catabolism pathway avoids the production of urea (as in the pathway to glyoxalate -- GenProp0686) and instead produces ammonia by the action of allantoate amidohydrolase (3.5.3.9) and the breakdown of carbamoyl-phosphate by carbamate kinase (2.7.2.2). A by-product of this pathway is oxamate (oxalic monoamide) which is presumably excreted. None - {{∅}} None - {{∅},{t}} Unexplained
Component_54063 OHCU decarboxylase None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75018 GenProp0687 GENPROP None - {{∅}} None - {{∅},{t}} Unexplained
Evidence_72653 TIGR02965 HMM None - {{∅}} None - {{∅}} Unexplained
Component_51807 xanthine dehydrogenase, molybdopterin subunit None - {{∅}} None - {{∅}} Unexplained
Evidence_72651 TIGR02964 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_75000 TIGR00746 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_74955 TIGR03164 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_74948 PF01014 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Component_54134 cupin domain protein, unknown function None - {{∅}} None - {{∅}} Unexplained
GenProp0700 purine catabolism via urate, xanthine and allantoin~This property is an overview of the complete catabolic pathways leading from intracellular guanine or adenine or extracellular xanthine through to the breakdown products of allantoin, oxamate or glyoxalate. None - {{∅}} None - {{∅},{t}} Unexplained
Component_54047 allantoinase (3.5.2.5) None - {{∅}} True - {{t}} Unconfirmed presence
Component_54050 allantoate amidohydrolase (3.5.3.9) None - {{∅}} None - {{∅}} Unexplained
Component_54049 allantoinase (3.5.2.5) None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75005 TIGR03176 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_75056 TIGR03214 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_72652 TIGR02963 HMM None - {{∅}} None - {{∅}} Unexplained
Component_54055 allantoin hydrolysis, initial None - {{∅}} None - {{∅}} Unexplained
Component_54100 Urate biosynthesis via xanthine None - {{∅}} None - {{∅},{t}} Unexplained
Evidence_75088 TIGR03214 HMM None - {{∅}} None - {{∅}} Unexplained
Component_54097 xanthine conversion to urate (uric acid) None - {{∅}} None - {{∅}} Unexplained
Evidence_75009 TIGR03173 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Component_54133 uraD N-terminal domain/upstream protein None - {{∅}} None - {{∅}} Unexplained
Evidence_75020 TIGR02961 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_75083 TIGR03176 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_75055 TIGR03212 HMM None - {{∅}} None - {{∅}} Unexplained
GenProp0686 allantoin catabolism to glyoxalate and urea~(S)-allantoin ([(4S)-2,5-dioxoimidazolidin-4-yl]urea) is a breakdown product of urate and may be obtained by an endogenous urate catabolism pathway or by transport from the environment. Catabolism of allantoate consists of a three-step pathway resulting in glyoxalate. This is further processed to tartronate semi-aldehyde (2-hydroxy-3-oxopropanoate) and subsequently to either phyosphoglycerate or glycoaldehyde (in the pathway to the pyridoxine component of vitamin B6). Since many pathways result in glyoxalate, this genome property terminates at that compound although the downsream enzymes may be grouped into apparent operons in many organisms (i.e. E. coli). Degradation of allantoin results in the production of two molecules of urea which may be excreted or used as a source of ammonia in urease-containing organisms. None - {{∅}} None - {{∅},{t}} Unexplained
Component_54046 source of (S)-allantoin None - {{∅}} True - {{t}} Unconfirmed presence
Component_54057 hydroxyisourate hydrolase (3.5.2.17) None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75017 GenProp0688 GENPROP None - {{∅}} True - {{t}} Unconfirmed presence
Component_54101 urate catabolism to allantoin None - {{∅}} True - {{t}} Unconfirmed presence
Component_54161 allantoin hydrolysis, final None - {{∅}} None - {{∅}} Unexplained
Component_54053 carbamate kinase (2.7.2.2) None - {{∅}} None - {{∅}} Unexplained
Evidence_74946 PF04115 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_75084 TIGR02967 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_75003 TIGR03175 HMM None - {{∅}} None - {{∅}} Unexplained
GenProp0688 urate catabolism to allantoin~Urate is the product of xanthine catabolism by either the xanthine dehydrogenase complex (GenProp0640) or xanthine oxidase. The purine ring system of urate is oxidized by uricase (urate oxidase) and the 6-membered ring is opened by hydroxyisourate hydrolase. The hydrolase may be unnecessary in some organisms as the hydroxyisourate will hydrolyze spontaneously, albeit an a slow rate. The resulting product (OHCU) then spontaneously decarboxylates, resulting in a mixture of (S)- and (R)-allantoin. For further catabolism, generally only (S)-allantoin is processed, so allantoin racemace is also typically found. An OHCU carboxylase has been discovered in Mus musculus which does have homologs in prokaryotes. None - {{∅}} True - {{t}} Unconfirmed presence
Component_51806 xanthine dehydrogenase, 2Fe2S/FAD subunit None - {{∅}} None - {{∅}} Unexplained
Evidence_75004 GenProp0688 GENPROP None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75011 TIGR01178 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75019 GenProp0686 GENPROP None - {{∅}} None - {{∅},{t}} Unexplained
Evidence_75086 GenProp0688 GENPROP None - {{∅}} True - {{t}} Unconfirmed presence
GenProp0698 xanthine catabolism to urate~The committed step in the catabolism of purines is the oxidation of the purine ring of xanthine (via hypoxanthine) to urate (uric acid). The xanthine may result from the deamination of guanine (or hypoxanthine from adenine), or may be imported via a permease. Several systems exist for the conversion of xanthine to urate including the XdhABC xanthine dehydrogenase complex (GenProp0640), xanthine oxidase and other less well-described oxidoreductases. None - {{∅}} None - {{∅},{t}} Unexplained
Component_54054 source of allantoin None - {{∅}} True - {{t}} Unconfirmed presence
GenProp0640 xanthine dehydrogenase~Xanthine dehydrogenase is a molydbopterin-containing enzyme. It converts xanthine, from the purine pool, to urate, which is subsequently degraded. In bacteria, the enzyme usually is encoded as a small subunit, XdhA, that contains FAD and 2Fe2S cofactors and a large subunit, XdhB, that contains the molybdopterin cofactor. The accessory protein XdhC is usually but not always encoded next to the XdhAB gene pair. None - {{∅}} None - {{∅}} Unexplained
Component_54102 allantoin catabolism None - {{∅}} None - {{∅},{t}} Unexplained
Evidence_75016 GenProp0698 GENPROP None - {{∅}} None - {{∅},{t}} Unexplained
Evidence_75010 GenProp0640 GENPROP None - {{∅}} None - {{∅}} Unexplained
Component_54051 ureidoglycolate dehydrogenase (1.1.1.54) None - {{∅}} None - {{∅}} Unexplained
Component_51808 xanthine dehydrogenase accessory protein XdhC None - {{∅}} None - {{∅}} Unexplained
Evidence_75087 TIGR02961 HMM None - {{∅}} None - {{∅}} Unexplained
Component_54056 urate oxidase (uricase, 1.7.3.3) None - {{∅}} True - {{t}} Unconfirmed presence
Component_54096 source of xanthine None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75015 TIGR03180 HMM None - {{∅}} None - {{∅}} Unexplained
Component_54048 ureidoglycolate lyase (4.3.2.3) None - {{∅}} None - {{∅}} Unexplained