GenProp0207 |
lipoprotein localization system lolABCDE~Bacterial lipoproteins have a modified amino terminal Cys residue with a covalently attached lipid moiety that serves as a membrane anchor. The lol system is responsible for moving lipoproteins from the periplasmic side of the inner membrane to the periplasmic side of the outer membrane. LolD is homologous to the ATP-binding cassette (ABC) transport family. LolC and LolE are homologous to each other (in species that have both rather than just one) and have several membrane-spanning segments, much like ABC transport permeases. However, the LolCDE complex differs from other ABC transporters in that is does not move a substrate across a membrane. Instead, it detaches lipoproteins from the inner membrane. LolA and LolB act to chaperone lipoproteins, including LolB itself, to the outer membrane. This system is less broadly distributed than the lgt/lsp/lnt system for lipoprotein N-terminal modification. |
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None - {{∅}} |
Unexplained |
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