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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
Evidence_59182 TIGR01854 HMM None - {{∅}} None - {{∅}} Unexplained
Component_46774 UDP-N-acetylglucosamine O-acyltransferase None - {{∅}} None - {{∅}} Unexplained
Evidence_74763 TIGR00466 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_59196 TIGR02208 HMM None - {{∅}} None - {{∅}} Unexplained
GenProp0204 KDO(2)-lipid A (Re LPS) biosynthesis and delivery~Lipid A is a component of the outer leaflet of the outer membrane of most gram-negative bacteria. It is one of three regions of bacterial lipopolysaccharide (LPS), along with the oligosaccharide core and the repeating O-antigen. In some strains, O-antigen may be missing and the lipid A-containing material may be designated lipooligosaccharide (LOS). Lipid A consists of a disaccharide (often beta-D-GlcN-(1-->6)-D-GlcN) with four attached acyl groups. Lipid A is attached to a 3-deoxy-D-manno-oct-2-ulosonic acid (KDO), a sugar moeity that becomes part of the LPS oligosaccharide inner core. Two of acyl groups of lipid A are then modified by further acylations into branched structures; acylation varies somewhat by species, and sometimes according to conditions within a species. The inner core typically contains at least two KDO and two heptose residues. The outer core and O-antigen regions are far more variable, and their biosynthesis is modeled in this property. LPS biosynthesis mutational studies have shown that, in a number of species, lipid A with two KDO residues but no additional residues of the inner core is the minimum required form of LPS for viability, called Re LPS or Re endotoxin. This genome property describes a set of well-conserved enzymes for biosynthesis of KDO(2)-lipid A that resembles but is not necessarily identical to the Re endotoxin of E. coli (nor as active in endotoxin assays), as well as a transporter, or flippase, responsible in most Proteobacteria for positioning lipid A in the outer membrane. None - {{∅}} None - {{∅}} Unexplained
Evidence_75336 TIGR01173 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_84971 TIGR03990 HMM None - {{∅}} None - {{∅}} Unexplained
Component_54360 glutamine--fructose-6-phosphate transaminase (isomerizing) None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_59186 TIGR01362 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_59181 TIGR01853 HMM None - {{∅}} None - {{∅}} Unexplained
Component_46793 acylate lauroyl-lipid IV-A None - {{∅}} None - {{∅}} Unexplained
Evidence_84972 TIGR03991 HMM None - {{∅}} None - {{∅}} Unexplained
Component_46792 add lauroyl to lipid IV-A None - {{∅}} None - {{∅}} Unexplained
Evidence_84974 PF06230 HMM None - {{∅}} None - {{∅}} Unexplained
Component_46776 UDP-3-0-acyl N-acetylglucosamine deacetylase None - {{∅}} None - {{∅}} Unexplained
Evidence_59179 TIGR00215 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_75334 TIGR01135 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Component_46775 lipid-A-disaccharide synthase None - {{∅}} None - {{∅}} Unexplained
Component_46778 UDP-2,3-diacylglucosamine hydrolase None - {{∅}} None - {{∅}} Unexplained
Component_46783 KDO 8-P phosphatase None - {{∅}} None - {{∅}} Unexplained
Component_54361 phosphoglucosamine mutase None - {{∅}} True - {{t}} Unconfirmed presence
Component_46779 tetraacyldisaccharide 4'-kinase None - {{∅}} None - {{∅}} Unexplained
Component_46782 KDO-8 phosphate synthetase None - {{∅}} None - {{∅}} Unexplained
Component_60603 Source of UDP-N-acetylglucosamine None - {{∅}} True - {{t}} Unconfirmed presence
GenProp0750 UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate~This pathway converts fructose-6-phosphate in four steps to activated N-acetylglucosamine. GlmS produces glucosamine-6-phosphate. GlmM isomerizes this product to glucosamine-1-phosphate. GlmU, which is bifunctional, adds an acetyl group from acetyl-CoA, then acts as N-acetylglucosamine-1-phosphate uridylyltransferase. The product, UDP-N-acetyl-D-glucosamine, is then used both for murein biosynthesis and (in species with LPS) for lipopolysaccharide biosynthesis. None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75335 TIGR01455 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_59178 TIGR01852 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_59183 TIGR00682 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_59195 TIGR02207 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_82145 GenProp0750 GENPROP None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_59180 TIGR00325 HMM None - {{∅}} None - {{∅}} Unexplained
Component_46781 transferase None - {{∅}} None - {{∅}} Unexplained
Component_53878 KDO cytidylyltransferase None - {{∅}} None - {{∅}} Unexplained
Evidence_65812 PF03279 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_59187 TIGR01670 HMM None - {{∅}} None - {{∅}} Unexplained
Evidence_59188 TIGR02203 HMM None - {{∅}} None - {{∅}} Unexplained
Component_46784 lipid A exporter MsbA None - {{∅}} None - {{∅}} Unexplained
Component_46777 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase None - {{∅}} None - {{∅}} Unexplained
Component_54362 glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine diphosphorylase None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_59185 PF04413 HMM None - {{∅}} None - {{∅}} Unexplained