GenProp0124 |
pantothenate biosynthesis from aspartate and 2-oxoisovalerate~This Genome Property tracks four proteins of pantothenate biosynthesis from aspartate. PanD, aspartate 1-decarboxylase, EC 4.1.1.11, makes beta-alanine. PanB, 3-methyl-2-oxobutanoate hydroxymethyltransferase, makes 2-dehydropantoate from 3-methyl-2-oxobutanoate. PanC, pantoate--beta-alanine ligase, EC 6.3.2.1, produces (R)-pantothenate from beta-alanine and (R)-pantoate. The genes for these three proteins tend to be clustered in bacterial genomes. The protein family distribution for a fourth component, PanE, is very different. The production of (R)-pantoate from 2-dehydropantoate can occur in more than one way (NADH or NADPH-dependent), and may be catalyzed by enzymes that may have additional important substrates (an example is the D-mandelate dehydrogenase of Enterococcus faecalis) and several such enzymes may be found in a genome. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
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