GenProp1064 |
ovothiol biosynthesis~The first step in ovothiol A biosynthesis is conversion of cysteine and histidine to 5-histidylcysteine sulfoxide conjugate by 5-histidylcysteine sulfoxide synthase. The conjugate is trimmed by a currently unknown mechanism (perhaps different enzymes in different species) to 5-thiohistidine, and is N-methylated at the pi position of the imidazole ring. Many OvaA (5-histidylcysteine sulfoxide synthase) have an additional C-terminal methyltransferase domain likely to provide this methyltransferase activity. Ovothiols B and C differ from ovothiol A by having additional methylations of the histidine-derived amino group. |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|