GenProp0814 |
urea utilization~This property encompasses two separate urea catabolism pathways, the nickel-dependent urease pathway and the urea carboxylase/allophanate hydrolase pathway. |
Both - {{t,f}} |
Both - {{t},{f}} |
Ambiguous contradictory |
|
Component_241 |
urease, gamma subunit |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
Evidence_75313 |
TIGR03411 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_51515 |
urea carboxylase |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_51516 |
allophanate hydrolase |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
GenProp0481 |
urea carboxylase/allophanate hydrolase pathway~This two-step, ATP-dependent pathway for urea hydrolysis is an alternative to urease. Urease requires a transporter and accessory proteins to produce its nickel metallocenter, while this two-step system uses biotin. Urea carboxylase acts first in this pathway, requiring ATP and bicarbonate as substrates. Allophanate hydrolase acts next, but note that this enzyme may be found in systems that do not contain a urea carboxylase. In yeasts such as Saccaromyces cerevisiae, the two activities of this pathway are encoded in a fusion protein, designated urea amidolyase. This pathway appears to function primarily for the purpose of obtaining nitrogen in the form of ammonia. A pair of uncharacterized, tandem, homologous genes, restricted to organisms with this system and adjacent to the known genes, has been added to this Genome Property. |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_84401 |
GenProp0481 GENPROP |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54339 |
urea ABC transporter, ATP-binding protein UrtD |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_68289 |
TIGR02713 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54337 |
urea ABC transporter, permease protein UrtB |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_84608 |
TIGR03669 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54367 |
urea carboxylase-associated protein 2 |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54366 |
urea carboxylase-associated protein 1 |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75310 |
TIGR03407 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_85071 |
PF03253 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75344 |
TIGR03425 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_215 |
TIGR01792 HMM |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
Component_54338 |
urea ABC transporter, permease protein UrtC |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_208 |
TIGR00192 HMM |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
Evidence_207 |
PF00449 HMM |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
Component_239 |
alpha-subunit, N-terminal domain |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
Evidence_75314 |
TIGR03410 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_240 |
urease, beta subunit |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
Evidence_53069 |
TIGR00802 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75343 |
TIGR03424 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_210 |
PF01774 HMM |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|
Evidence_75311 |
TIGR03409 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_209 |
TIGR00193 HMM |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
Evidence_75345 |
TIGR03427 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_84403 |
GenProp0743 GENPROP |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54340 |
urea ABC transporter, ATP-binding protein UrtE |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_244 |
urease accessory protein UreF |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|
Component_246 |
urease, alpha subunit |
Both - {{t,f}} |
True - {{t}} |
Ambiguous presence |
|
GenProp0743 |
urea ABC transporter UrtABCDE~This property represents a conserved five-gene operon for an ABC transporter with a substrate-binding protein, two permeases, and two ATP-binding cassette proteins. All five genes from this operon are detected in Burkholderia mallei, at very high confidence levels, by means of the partial phylogenetic profiling algorithm (PMID:16930487) vs. a profile for urease, and the operon occurs next to urease genes in B. mallei and most other species. In Cyanobacteria, high-affinity urea transport is shown to be eliminated by mutations to any of several different proteins in this system (PMID:11929526). |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_242 |
urease accessory protein UreD |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|
Component_243 |
urease accessory protein UreE |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|
Component_245 |
urease accessory protein UreG |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|
Evidence_68288 |
TIGR02712 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75312 |
TIGR03408 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_62827 |
a urea transporter |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_84607 |
TIGR03622 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_62826 |
a urea degradation pathway |
Both - {{t,f}} |
Both - {{t},{f}} |
Ambiguous contradictory |
|
Evidence_213 |
TIGR00101 HMM |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|
Component_54336 |
urea ABC transporter, periplasmic binding protein |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_84402 |
GenProp0051 GENPROP |
Both - {{t,f}} |
Both - {{t},{f}} |
Ambiguous contradictory |
|
Evidence_84609 |
TIGR03727 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
GenProp0051 |
urease~Urease is a multi-subunit, nickel-containing enzyme required for the hydrolysis of urea to carbon dioxide and ammonia [1]. Its three structural genes are located in an unidirectionally transcribed gene cluster consisting either as separate alpha, beta, and gamma subunits, or as in Helicobacter pylori, a fusion of beta and gamma subunits [2]. Associated with these structural subunits are accessory factors functioning to assemble and incorporate its nickel-containing metallocenter [3]. This property predicts a urease system to be present if both its three structural subunits and four accessory proteins are all found. In Bacillus subtilis, the accessory proteins are not found by homology but urease function has been shown experimentally. This finding raises the question of what alternative mechanism can enable the assembly of functional urease. |
Both - {{t,f}} |
Both - {{t},{f}} |
Ambiguous contradictory |
|
Component_54368 |
ABC transporter periplasmic binding protein, urea carboxylase region |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_211 |
PF02814 HMM |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|
Component_40711 |
nickel transporter (UreH) |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_212 |
PF01730 HMM |
Both - {{t,f}} |
False - {{f}} |
Ambiguous absence |
|