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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
Component_60637 pseudaminic acid CMP-transferase None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_82208 TIGR03590 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_75336 TIGR01173 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_82203 TIGR03587 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_84971 TIGR03990 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Component_54360 glutamine--fructose-6-phosphate transaminase (isomerizing) None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_82206 TIGR03588 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_84972 TIGR03991 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Component_60633 pseudaminic acid biosynthesis aminotransferase PseC None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_75334 TIGR01135 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Component_60647 pseudaminic acid biosynthesis associated methylase None - {{∅}} False - {{f}} Unconfirmed absence
Component_60635 possible pseudaminic acid biosynthesis UDP hydrolase None - {{∅}} False - {{f}} Unconfirmed absence
Component_60631 source of UDP-N-acetyl-D-glucosamine None - {{∅}} True - {{t}} Unconfirmed presence
Component_54361 phosphoglucosamine mutase None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_82207 TIGR03589 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Component_60636 pseudaminic acid synthase (pyruvate condensing enzyme) None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_82200 TIGR03584 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_82201 TIGR03585 HMM None - {{∅}} False - {{f}} Unconfirmed absence
GenProp0750 UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate~This pathway converts fructose-6-phosphate in four steps to activated N-acetylglucosamine. GlmS produces glucosamine-6-phosphate. GlmM isomerizes this product to glucosamine-1-phosphate. GlmU, which is bifunctional, adds an acetyl group from acetyl-CoA, then acts as N-acetylglucosamine-1-phosphate uridylyltransferase. The product, UDP-N-acetyl-D-glucosamine, is then used both for murein biosynthesis and (in species with LPS) for lipopolysaccharide biosynthesis. None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_75335 TIGR01455 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_82202 TIGR03586 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Component_60634 possible pseudaminic acid biosynthesis N-acetyl transferase None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_82188 GenProp0750 GENPROP None - {{∅}} True - {{t}} Unconfirmed presence
GenProp0796 CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine~Pseudaminic acid is a component of the O-antigen of certain pseudomonas strains [1] as well as the glycosylation modification of Campylobacter and Helicobacter flagellins [2], but is clearly more widely distributed. The proposed biosynthetic pathway involves the dehydration/isomerization of UDP-D-GlcNAc to UDP-4-keto-6-deoxy-GlcNAc by PseB, a transamination at position 4 by PseC. The PseH protein is similar to acetyltransferases and is presumed to carry out transfer to the C-4 amine. PseH itself is occasionally missing. Often in this case, the PseG protein contains an passable acetyltransferase domain. The function of PseG when PseH is present is unknown, it may complex with PseH, or ot may be responsible for the UDP-hydrolysis that clearly must happen but is not currently assigned to an enzyme with a conserved domain for this reaction. PseI carries out the condensation with phosphoenolpyruvate to create pseudaminic acid, a reaction analagous to the carried out by NeuB in the biosynthesis of neuraminic acid (GenProp0792). PseF carries out the transfer of CMP onto pseudaminic acid to yield the most common product. In Campylobacter, the biosynthetic cluster is accompanied by the PseA protein, a homolog of WbuX and is responsible for the conversion of the N-acetyl group at position 7 into the acetimidino group. PseA is accompanied by two genes, WbuY and WbuZ which are reported to provide ammonia for the reaction (GenProp0794). Other proteins are found associated with this cluster including methylases and possible formyltransferases and deacetylases. Thus, a range of closely related structures are likely produced as mature products in various lineages. None - {{∅}} False - {{f}} Unconfirmed absence
Component_60632 UDP-GlcNAc C6-dehydratase/C4-reductase None - {{∅}} False - {{f}} Unconfirmed absence
Component_54362 glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine diphosphorylase None - {{∅}} True - {{t}} Unconfirmed presence