| Prior-Knowledge | Description | Expectation | Prediction | Conclusion | Leaf Statistics |
|---|---|---|---|---|---|
| Component_54374 | ergothioneine biosynthesis protein EgtC | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Component_54375 | glutamate--cysteine ligase family protein | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Evidence_75354 | TIGR03440 HMM | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Component_54373 | ergothioneine biosynthesis protein EgtB | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Evidence_75355 | TIGR03442 HMM | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Evidence_75356 | TIGR03444 HMM | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Component_54372 | ergothioneine biosynthesis methyltransferase EgtD | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Component_63981 | ergothioneine biosynthesis PLP-binding protein EgtE | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| GenProp0752 | ergothioneine biosynthesis~In actinobacteria, ergothioneine biosynthesis begins with EgtD, a SAM-dependent enzyme that trimethylates the histidine alpha-amino group to produce hercynine, the histidine-betaine. EgtA gamma-ligates Cys to Glu, as occurs in glutathione biosynthesis. Next, EgtB attaches hercynine to gammaglutamyl cysteine, with sulfur attachment to the histidine-derived ring. EgtC then releases glutamate . Finally, EgtE, a pyridoxal phosphate-dependent enzyme related to selenocysteine lyase, cleaves the hercynylcysteine sulfoxide to leave ergothioneine. Ergothioneine production is known also in cyanobacteria and mushrooms, and is predicted to be more widely distributed. | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Evidence_85732 | TIGR04343 HMM | None - {{∅}} | False - {{f}} | Unconfirmed absence | |
| Evidence_75353 | TIGR03438 HMM | None - {{∅}} | False - {{f}} | Unconfirmed absence |