Evidence_74958 |
TIGR02962 HMM |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54162 |
cupin domain protein, unknown function |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75007 |
TIGR03178 HMM |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75006 |
TIGR03178 HMM |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75082 |
TIGR02961 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
GenProp0687 |
allantoin catabolism to oxamate and carbamoyl-phosphate~Allantoin ([(4S)-2,5-dioxoimidazolidin-4-yl]urea) is a breakdown product of urate and may be obtained by an endogenous urate catabolism pathway or by transport from the environment. This catabolism pathway avoids the production of urea (as in the pathway to glyoxalate -- GenProp0686) and instead produces ammonia by the action of allantoate amidohydrolase (3.5.3.9) and the breakdown of carbamoyl-phosphate by carbamate kinase (2.7.2.2). A by-product of this pathway is oxamate (oxalic monoamide) which is presumably excreted. |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Component_54063 |
OHCU decarboxylase |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75018 |
GenProp0687 GENPROP |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Evidence_72653 |
TIGR02965 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_51807 |
xanthine dehydrogenase, molybdopterin subunit |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_72651 |
TIGR02964 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75000 |
TIGR00746 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_74955 |
TIGR03164 HMM |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_74948 |
PF01014 HMM |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54134 |
cupin domain protein, unknown function |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
GenProp0700 |
purine catabolism via urate, xanthine and allantoin~This property is an overview of the complete catabolic pathways leading from intracellular guanine or adenine or extracellular xanthine through to the breakdown products of allantoin, oxamate or glyoxalate. |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Component_54047 |
allantoinase (3.5.2.5) |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54050 |
allantoate amidohydrolase (3.5.3.9) |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54049 |
allantoinase (3.5.2.5) |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75005 |
TIGR03176 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75056 |
TIGR03214 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_72652 |
TIGR02963 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54055 |
allantoin hydrolysis, initial |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54100 |
Urate biosynthesis via xanthine |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Evidence_75088 |
TIGR03214 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54097 |
xanthine conversion to urate (uric acid) |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75009 |
TIGR03173 HMM |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54133 |
uraD N-terminal domain/upstream protein |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75020 |
TIGR02961 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75083 |
TIGR03176 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75055 |
TIGR03212 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
GenProp0686 |
allantoin catabolism to glyoxalate and urea~(S)-allantoin ([(4S)-2,5-dioxoimidazolidin-4-yl]urea) is a breakdown product of urate and may be obtained by an endogenous urate catabolism pathway or by transport from the environment. Catabolism of allantoate consists of a three-step pathway resulting in glyoxalate. This is further processed to tartronate semi-aldehyde (2-hydroxy-3-oxopropanoate) and subsequently to either phyosphoglycerate or glycoaldehyde (in the pathway to the pyridoxine component of vitamin B6). Since many pathways result in glyoxalate, this genome property terminates at that compound although the downsream enzymes may be grouped into apparent operons in many organisms (i.e. E. coli). Degradation of allantoin results in the production of two molecules of urea which may be excreted or used as a source of ammonia in urease-containing organisms. |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Component_54046 |
source of (S)-allantoin |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54057 |
hydroxyisourate hydrolase (3.5.2.17) |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75017 |
GenProp0688 GENPROP |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54101 |
urate catabolism to allantoin |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54161 |
allantoin hydrolysis, final |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54053 |
carbamate kinase (2.7.2.2) |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_74946 |
PF04115 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75084 |
TIGR02967 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75003 |
TIGR03175 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
GenProp0688 |
urate catabolism to allantoin~Urate is the product of xanthine catabolism by either the xanthine dehydrogenase complex (GenProp0640) or xanthine oxidase. The purine ring system of urate is oxidized by uricase (urate oxidase) and the 6-membered ring is opened by hydroxyisourate hydrolase. The hydrolase may be unnecessary in some organisms as the hydroxyisourate will hydrolyze spontaneously, albeit an a slow rate. The resulting product (OHCU) then spontaneously decarboxylates, resulting in a mixture of (S)- and (R)-allantoin. For further catabolism, generally only (S)-allantoin is processed, so allantoin racemace is also typically found. An OHCU carboxylase has been discovered in Mus musculus which does have homologs in prokaryotes. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_51806 |
xanthine dehydrogenase, 2Fe2S/FAD subunit |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75004 |
GenProp0688 GENPROP |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75011 |
TIGR01178 HMM |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75019 |
GenProp0686 GENPROP |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Evidence_75086 |
GenProp0688 GENPROP |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
GenProp0698 |
xanthine catabolism to urate~The committed step in the catabolism of purines is the oxidation of the purine ring of xanthine (via hypoxanthine) to urate (uric acid). The xanthine may result from the deamination of guanine (or hypoxanthine from adenine), or may be imported via a permease. Several systems exist for the conversion of xanthine to urate including the XdhABC xanthine dehydrogenase complex (GenProp0640), xanthine oxidase and other less well-described oxidoreductases. |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Component_54054 |
source of allantoin |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
GenProp0640 |
xanthine dehydrogenase~Xanthine dehydrogenase is a molydbopterin-containing enzyme. It converts xanthine, from the purine pool, to urate, which is subsequently degraded. In bacteria, the enzyme usually is encoded as a small subunit, XdhA, that contains FAD and 2Fe2S cofactors and a large subunit, XdhB, that contains the molybdopterin cofactor. The accessory protein XdhC is usually but not always encoded next to the XdhAB gene pair. |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54102 |
allantoin catabolism |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Evidence_75016 |
GenProp0698 GENPROP |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
|
Evidence_75010 |
GenProp0640 GENPROP |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54051 |
ureidoglycolate dehydrogenase (1.1.1.54) |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_51808 |
xanthine dehydrogenase accessory protein XdhC |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Evidence_75087 |
TIGR02961 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54056 |
urate oxidase (uricase, 1.7.3.3) |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Component_54096 |
source of xanthine |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
Evidence_75015 |
TIGR03180 HMM |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|
Component_54048 |
ureidoglycolate lyase (4.3.2.3) |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
|