| GenProp0491 |
recFOR recombination pathway~RecFOR is a system for homologous recombination, a nearly universal housekeeping process especially important for repair. RecFOR acts independently from the RecBCD system, or the AddAB system that replaces RecBCD in certain lineages, and the presence of RecFOR is actually positively correlated with the presence of RecBCD/AddAB, so these two presynaptic systems that act in loading RecA may be regarded as complementary. RecFOR especially repairs single-stranded gaps while RecBCD/AddAB repairs double-stranded DNA ends, although roles for RecFOR in double stranded break repair are shown in discussion of RecN and RecQ function and of recBCD mutants. RecFOR systems often are assisted in an early step by the exonuclease RecJ. Following strand exchange by RecA, Holliday junction resolution may be done by RuvABC or RecG. The action of the RecFOR pathway involves formation of RecOR complexes, and RecFR complexes, but no complex of all three. Of the three genes, either RecO or RecF may be missing while the other two components are present, but RecR must be present in genomes with any part of this system. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
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