GenProp0324 |
addiction module, RelE-RelB class~Toxin-antitoxin gene pairs, called addiction modules, are found often on plasmids but also on the chromosome. These modules can promote plasmid stability in populations by killing daughter cells that don't receive a copy of the plasmid during cell division. The phenomenon, called post-segregational killing, occurs because the antitoxin has a shorter biological half-life than the toxin. Some chromosomal toxin-antitoxin gene pairs appear to act in regulation of cellular processes and are not necessarily selfish genetic elements. The antitoxin generally is a transcription factor. The toxin may act in several ways This addiction module property describes the RelE system, where RelE acts by cleaving ribosome-associated transcripts. |
None - {{∅}} |
False - {{f}} |
Unconfirmed absence |
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