GenProp0250 |
thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly~This property describes de novo synthesis of the thiazole moiety of thiamine, hydroxyethylthiazole (HET). This requires more distinct proteins than that of the pyrimidine moeity, hydromethylpyrimidine (HMP). Phosphorylated forms of HET and HMP are connected by ThiE as thiamine phosphate and converted eventually to the active form thiamine pyrophosphate, TPP. HET biosynthesis requires the small ThiS protein, the C-terminus of which becomes modified transiently by a sulfur atom from cysteine. ThiG is required, along with either ThiH in species where tyrosine is a precursor or ThiO in species where glycine is a precursor. ThiF, although required biosynthetically, is not readily separated from MoeB, a molybdopterin biosynthesis protein, and so is not built into the rule as a required component. Either IscS or NifS must be present, but this requirement also is not included in the rule. The ThiI gene is required, but also serves in formation of a tRNA modified site in species that do not make HET. This property represents and alternative to HET uptake as a means to obtain the thiazole component for thiamine biosynthesis. |
None - {{∅}} |
Both - {{t},{f}} |
Unconfirmed contradictory |
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