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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
Evidence_47982 TIGR00973 HMM True - {{t}} True - {{t}} Confirmed presence
Component_35624 acetohydroxyacid synthase, small subunit None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_47984 TIGR00170 HMM True - {{t}} True - {{t}} Confirmed presence
Evidence_47978 TIGR00465 HMM True - {{t}} True - {{t}} Confirmed presence
Evidence_47981 TIGR01123 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Component_35628 3-isopropylmalate dehydratase, large subunit True - {{t}} True - {{t}} Confirmed presence
Evidence_48002 TIGR02088 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Component_35629 3-isopropylmalate dehydrogenase True - {{t}} True - {{t}} Confirmed presence
Evidence_47985 TIGR00171 HMM True - {{t}} True - {{t}} Confirmed presence
Component_35631 3-isopropylmalate dehydratase, small subunit True - {{t}} True - {{t}} Confirmed presence
Evidence_48001 TIGR02087 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_48006 TIGR02090 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_47994 TIGR02084 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_47980 TIGR01122 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Component_35625 ketol-acid reductoisomerase True - {{t}} True - {{t}} Confirmed presence
Evidence_47983 TIGR00970 HMM None - {{∅}} False - {{f}} Unconfirmed absence
Evidence_47977 TIGR00119 HMM None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_47979 TIGR00110 HMM True - {{t}} True - {{t}} Confirmed presence
Component_35630 branched-chain amino acid aminotransferase None - {{∅}} True - {{t}} Unconfirmed presence
Evidence_47976 TIGR00118 HMM True - {{t}} True - {{t}} Confirmed presence
Evidence_48000 TIGR02086 HMM None - {{∅}} False - {{f}} Unconfirmed absence
GenProp0164 leucine biosynthesis from pyruvate and acetyl-CoA~The branched amino acid leucine is biosynthesized from the central intermediary metabolites pyruvate and acetyl-CoA via a seven step pathway. Four of these steps are shared with the valine and isoleucine pathways, although specialized versions of these enzymes may exist in certain species which have a narrowed substrate range or amino acid-specific regulatory mechanisms. The product of the third step in this pathway, 2-oxoisovalerate is a branchpoint metabolite required for the biosynthesis of Coenzyme A, branched-chain fatty acids and valine. Similarly, the product of the first step, (S)-2-acetolactate is common to the pathway to (R,R)-2,3-butanediol in the mixed-acid fermentation of pyruvate. The first step of the pathway, acetolactate synthase, requires thiamine pyrophosphate and two molecules of pyruvate, one of which is decarboxylated to the acetoacetate adduct, 2-(alpha-hydroxyethyl)-ThPP. The acetyl-CoA required for the fourth step, 2-isopropylmalate synthase, may also derive from this ThPP adduct by oxidation. True - {{t}} True - {{t}} Confirmed presence
Component_35627 2-isopropylmalate synthase True - {{t}} True - {{t}} Confirmed presence
Evidence_47986 TIGR00169 HMM True - {{t}} True - {{t}} Confirmed presence
Component_35626 dihydroxy-acid dehydratase True - {{t}} True - {{t}} Confirmed presence
Component_35623 acetohydroxyacid synthase, large subunit True - {{t}} True - {{t}} Confirmed presence
Evidence_47992 TIGR02083 HMM None - {{∅}} False - {{f}} Unconfirmed absence