| UPA00363 |
L-leucine degradation~Degradation of L-leucine, one of the three main branched chain amino-acids (BCAAs), along with L-valine and L-isoleucine. In plants, branched-chain amino-acids are synthesized in chloroplasts, whereas the degradation takes place in mitochondria. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| ULS00427 |
(S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| UER00860 |
(S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3~1 3-isovaleryl-CoA + 1 FAD => 1 3-methylcrotonyl-CoA + 1 FADH2. |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| ULS00425 |
4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR02085 |
(S)-3-hydroxy-3-methylglutaryl-CoA = 3-methylglutaconyl-CoA + H(2)O |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| ULS00426 |
3-isovaleryl-CoA from 4-methyl-2-oxopentanoate |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| UER00861 |
(S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3~1 3-methylcrotonyl-CoA + 1 ATP + 1 bicarbonate => 1 3-methylglutaconyl-CoA + 1 ADP + 1 phosphate. |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| UER00858 |
4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route): step 1/1~1 H(2)O + 1 L-leucine + 1 NAD(+) => 1 4-methyl-2-oxopentanoate + 1 H(+) + 1 NADH + 1 NH(3). |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UER00862 |
(S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3~1 3-methylglutaconyl-CoA + 1 H(2)O => 1 (S)-3-hydroxy-3-methylglutaryl-CoA. |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| ULS00424 |
4-methyl-2-oxopentanoate from L-leucine (aminotransferase route) |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UCR01090 |
2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UCR01651 |
4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-isovaleryl-CoA + CO(2) + H(+) + NADH |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| UER00859 |
3-isovaleryl-CoA from 4-methyl-2-oxopentanoate: step 1/1~1 4-methyl-2-oxopentanoate + 1 CoA + 1 NAD(+) => 1 3-isovaleryl-CoA + 1 CO(2) + 1 H(+) + 1 NADH. |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| UER00857 |
4-methyl-2-oxopentanoate from L-leucine (aminotransferase route): step 1/1~1 2-oxoglutarate + 1 L-leucine => 1 4-methyl-2-oxopentanoate + 1 L-glutamate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UCR04095 |
3-isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2 |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| VariantPath-1-UPA00363 |
|
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-2-UPA00363 |
|
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UCR04138 |
3-methylcrotonyl-CoA + ATP + bicarbonate = 3-methylglutaconyl-CoA + ADP + phosphate |
True - {{∅},{t}} |
None - {{∅}} |
Missing |
|
| UCR01088 |
H(2)O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH(3) |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|