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Prior-Knowledge Description Expectation Prediction Conclusion Leaf Statistics
UER00466 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1~1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 L-glutamate => 1 2-oxoglutarate + 1 LL-2,6-diaminopimelate. True - {{∅},{t}} True - {{t}} Confirmed presence
UER00020 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 2/3~1 L-2-succinylamino-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-succinyl-LL-2,6-diaminopimelate. True - {{∅},{t}} True - {{t}} Confirmed presence
UER00023 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 2/3~1 (S)-2-acetamido-6-oxopimelate + 1 L-glutamate => 1 2-oxoglutarate + 1 N-acetyl-LL-2,6-diaminopimelate. None - {{∅}} None - {{∅}} Unexplained
UCR02733 H(2)O + N-acetyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + acetate None - {{∅}} None - {{∅}} Unexplained
UCR02755 DL-2,6-diaminopimelate + H(2)O + NADP(+) = (S)-2-amino-6-oxopimelate + H(+) + NADPH + NH(3) True - {{∅},{t}} True - {{t}} Confirmed presence
UER00018 (S)-tetrahydrodipicolinate from L-aspartate: step 4/4~(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + [NADH or NADPH] => (S)-tetrahydrodipicolinate + H(2)O + [NAD(+) or NADP(+)]. True - {{∅},{t}} None - {{∅}} Missing
UER00024 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3~1 H(2)O + 1 N-acetyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 acetate. None - {{∅}} None - {{∅}} Unexplained
UCR00451 DL-2,6-diaminopimelate = CO(2) + L-lysine True - {{∅},{t}} True - {{t}} Confirmed presence
VariantPath-2-UER00018 True - {{∅},{t}} None - {{∅}} Missing
UER00017 (S)-tetrahydrodipicolinate from L-aspartate: step 3/4~1 L-aspartate 4-semialdehyde + 1 pyruvate => 1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(2)O. True - {{∅},{t}} True - {{t}} Confirmed presence
UER01028 None~1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(+) + 1 NADH => 1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 NAD(+). True - {{∅},{t}} None - {{∅}} Missing
MUER12 Meta-UER 12~1 ATP + 1 L-aspartate => 1 4-phospho-L-aspartate + 1 ADP. True - {{∅},{t}} True - {{t}} Confirmed presence
UCR04336 (S)-2-amino-6-oxopimelate = (S)-tetrahydrodipicolinate + H(2)O True - {{∅},{t}} None - {{∅}} Missing
UER00027 L-lysine from DL-2,6-diaminopimelate: step 1/1~1 DL-2,6-diaminopimelate => 1 CO(2) + 1 L-lysine. True - {{∅},{t}} True - {{t}} Confirmed presence
UER00022 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 1/3~1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 acetyl-CoA => 1 (S)-2-acetamido-6-oxopimelate + 1 CoA. None - {{∅}} None - {{∅}} Unexplained
UER00025 DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1~1 LL-2,6-diaminopimelate => 1 DL-2,6-diaminopimelate. True - {{∅},{t}} True - {{t}} Confirmed presence
VariantPath-4-UPA00034 True - {{∅},{t}} True - {{t}} Confirmed presence
UCR04475 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate True - {{∅},{t}} True - {{t}} Confirmed presence
UER00026 DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1~1 (S)-tetrahydrodipicolinate + 1 H(+) + 1 H(2)O + 1 NADPH + 1 NH(3) => 1 DL-2,6-diaminopimelate + 1 NADP(+). True - {{∅},{t}} True - {{t}} Confirmed presence
VariantPath-3-UPA00034 True - {{∅},{t}} True - {{t}} Confirmed presence
VariantPath-1-UPA00034 True - {{∅},{t}} True - {{t}} Confirmed presence
UCR04198 (S)-tetrahydrodipicolinate + H(2)O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH True - {{∅},{t}} None - {{∅}} Missing
ULS00009 DL-2,6-diaminopimelate from LL-2,6-diaminopimelate True - {{∅},{t}} True - {{t}} Confirmed presence
UCR02291 L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH True - {{∅},{t}} True - {{t}} Confirmed presence
UCR00480 ATP + L-aspartate = 4-phospho-L-aspartate + ADP True - {{∅},{t}} True - {{t}} Confirmed presence
VariantPath-2-UPA00034 None - {{∅}} None - {{∅},{t}} Unexplained
UCR04467 2-oxoglutarate + N-acetyl-LL-2,6-diaminopimelate = (S)-2-acetamido-6-oxopimelate + L-glutamate None - {{∅}} None - {{∅}} Unexplained
UPA00034 L-lysine biosynthesis via DAP pathway~Biosynthesis of L-lysine through the diaminopimelate (DAP) pathway. <br> The L-lysine is synthesized from L-aspartate and pyruvate through diaminopimelate via four variants. <br> This pathway is utilised by most bacteria, some archaea, some fungi, some algae, and higher plants.<br> In bacteria, DAP is not only a direct precursor of lysine, but it is also an important constituent of the cell wall peptidoglycan. <br> The DAP pathway is of special interest for pharmacology, since the absence of DAP in mammalian cells allows for the use of the DAP biosynthetic genes as a bacteria-specific drug target. <br> Most bacteria use only one of the four variants, although certain bacteria, such as <i>C. glutamicum </i> and <i>Bacillus macerans</i>, possess both the succinylase and dehydrogenase pathways. True - {{∅},{t}} True - {{t}} Confirmed presence
UER00021 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3~1 H(2)O + 1 N-succinyl-LL-2,6-diaminopimelate => 1 LL-2,6-diaminopimelate + 1 succinate. True - {{∅},{t}} True - {{t}} Confirmed presence
UCR04199 (S)-tetrahydrodipicolinate + H(2)O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH True - {{∅},{t}} None - {{∅}} Missing
ULS00008 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route) None - {{∅}} None - {{∅}} Unexplained
ULS00227 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route) True - {{∅},{t}} True - {{t}} Confirmed presence
MUER21 Meta-UER 21~1 4-phospho-L-aspartate + 1 H(+) + 1 NADPH => 1 L-aspartate 4-semialdehyde + 1 NADP(+) + 1 phosphate. True - {{∅},{t}} True - {{t}} Confirmed presence
UCR10147 L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(2)O True - {{∅},{t}} True - {{t}} Confirmed presence
UCR02734 H(2)O + N-succinyl-LL-2,6-diaminopimelate = LL-2,6-diaminopimelate + succinate True - {{∅},{t}} True - {{t}} Confirmed presence
UCR04365 (S)-tetrahydrodipicolinate + H(2)O + succinyl-CoA = CoA + L-2-succinylamino-6-oxopimelate True - {{∅},{t}} True - {{t}} Confirmed presence
ULS00011 L-lysine from DL-2,6-diaminopimelate True - {{∅},{t}} True - {{t}} Confirmed presence
ULS00006 (S)-tetrahydrodipicolinate from L-aspartate True - {{∅},{t}} True - {{t}} Confirmed presence
VariantPath-1-UER00018 True - {{∅},{t}} None - {{∅}} Missing
UCR07613 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-tetrahydrodipicolinate + H(2)O + L-glutamate True - {{∅},{t}} True - {{t}} Confirmed presence
UER00019 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3~1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 succinyl-CoA => 1 CoA + 1 L-2-succinylamino-6-oxopimelate. True - {{∅},{t}} True - {{t}} Confirmed presence
ULS00010 DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate True - {{∅},{t}} True - {{t}} Confirmed presence
UER01029 None~1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + 1 H(+) + 1 NADPH => 1 (S)-tetrahydrodipicolinate + 1 H(2)O + 1 NADP(+). True - {{∅},{t}} None - {{∅}} Missing
UCR02735 LL-2,6-diaminopimelate = DL-2,6-diaminopimelate True - {{∅},{t}} True - {{t}} Confirmed presence
UCR04364 (S)-tetrahydrodipicolinate + H(2)O + acetyl-CoA = (S)-2-acetamido-6-oxopimelate + CoA None - {{∅}} None - {{∅}} Unexplained
ULS00007 LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) True - {{∅},{t}} True - {{t}} Confirmed presence