| UPA00028 |
(R)-pantothenate biosynthesis~Biosynthesis of (R)-pantothenate, also called vitamin B5 or D-pantothenic acid. (R)-pantothenate results from the condensation of beta-alanine and D-pantoate. (R)-pantothenate is found in the 4'-phosphopantetheine moieties of CoA (coenzyme A) and of the acyl carrier protein of lipid synthesis. Micro- organisms and plants must synthesize pantothenate, while animals obtain this essential nutriment from their diet. Pantothenate biosynthesis pathway offers targets for developping drugs against microbial pathogen. |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
| UER00005 |
(R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1~1 (R)-pantoate + 1 ATP + 1 beta-alanine => 1 (R)-pantothenate + 1 AMP + 1 diphosphate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UER00003 |
(R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2~1 3-methyl-2-oxobutanoate + 1 5,10-methylene-THF + 1 H(2)O => 1 2-dehydropantoate + 1 5,6,7,8-tetrahydrofolate. |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UCR00489 |
L-aspartate = CO(2) + beta-alanine |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| ULS00003 |
(R)-pantoate from 3-methyl-2-oxobutanoate |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
| ULS00004 |
(R)-pantothenate from (R)-pantoate and beta-alanine |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
| UER00004 |
(R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2~1 2-dehydropantoate + 1 H(+) + 1 NADPH => 1 (R)-pantoate + 1 NADP(+). |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
| UER00002 |
beta-alanine from L-aspartate: step 1/1~1 L-aspartate => 1 CO(2) + 1 beta-alanine. |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| VariantPath-1-UPA00028 |
|
None - {{∅}} |
None - {{∅},{t}} |
Unexplained |
|
| UCR02472 |
(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH |
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
| VariantPath-2-UPA00028 |
|
None - {{∅}} |
True - {{t}} |
Unconfirmed presence |
|
| ULS00002 |
beta-alanine from L-aspartate |
None - {{∅}} |
None - {{∅}} |
Unexplained |
|
| UCR02473 |
(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|
| UCR01226 |
3-methyl-2-oxobutanoate + 5,10-methylene-THF + H(2)O = 2-dehydropantoate + 5,6,7,8-tetrahydrofolate |
True - {{t}} |
True - {{t}} |
Confirmed presence |
|