Thesis of Serge Smidtas

2007 nov.

Serge Smidtas

"Model and Analysis, Global and Local, of Heterogeneous Biological Interactions Networks (RIBH) Applied to Yeast."
  Serge Smidtas (mail) supported his thesis on Thursday, November 15th in Evry. His research was carried out in the “Computational Systems Biology” team led by Vincent Schächter (mail).

  This work studies biological in silico networks. It assesses the question of integration, formalism and modeling of biological networks and sub-networks. First, an integration tool called Cyclone was developed to simplify the access and analyse biological information of the Biocyc database. Then, a graph model framework to analyse heterogeneous networks, MIB (for Biological Interaction Model) is presented. Finally, these methods were used to study how sub-networks were linked together and to study network motifs in larger networks, and to study and model the metabolic pathway of galactose in yeast (Saccharomyces cerevisiae) that includes a heterogeneous feedback loop made of protein-protein interaction and transcriptional regulation.