Recruitment

May 2010- European MICROME project Post Doctoral Position in France.
The closing date is 30h May 2010.

 Context:
GENOSCOPE is both the French National Genome Centre, now part of the Genomic Institute of the Commissariat à l’Energie Atomique (CEA), as well as an independent research institute dedicated to high-throughput studies in biology, bioinformatics and systems biology. One of our research areas is that of prokaryote metabolism, including the study of bacterial communities, the search for novel enzymatic functions, metabolic reprogramming, and modelling. CEA is involved in the European MICROME project which began in December 2009 (http://www.microme.eu). This project aims to extend the scope of microbial genome annotation from functional assignment at the gene level, to the systematic generation of pathway assemblies and genome-scale metabolic models. Microme will provide a robust, scalable infrastructure integrating a curated repository of reference pathways with genome-scale constraint-based models and downstream applications in comparative genomics and biotechnology.

  Functions and responsabilities:
CEA is seeking to recruit a scientific curator for a demanding role in the assignment of functional Gene-Protein-Reaction (GPR) annotation, as well as the curation of metabolic pathways from reference organisms. In the first phase of the project Microme will be populated with reference data available from existing resources. Following this, all metabolic pathways of 4 reference bacterial genomes will be checked, corrected and completed as necessary. The curator will contribute to this work as well as to the expert curation of reference pathways across the full spectrum of species covered by Microme. He or she will work closely with other members of the MICROME consortium (of which there are 14), particularly with the Swiss-Prot group at the Swiss Institute of Bioinformatics (SIB) and with partners at the European Bioinformatics Institute (EBI).

 Qualifications and experience:
A university degree in life sciences and a broad knowledge in biochemistry and/or enzymology, and/or molecular biology are the minimum requirements. A higher degree (such as MSc/PhD) and/or relevant post-graduate experience are highly desirable. Previous experience in database curation is advantageous but not essential.Experience in using biological databases and sequence analysis tools is desirable. The successful candidate must be detail-oriented and must be able to quickly and accurately interpret scientific literature. The position requires excellent communication and organizational skills in order to interact well under time pressure within a team of software developers and biologists and with external partners.

 Job conditions:
This position is offered in the context of a European project for an initial period of one year, which may be renewed twice. Depending on the background and experience of the successful candidate, the monthly salary will be between 2400 to 2900 euros.

Interested candidates should send a letter of motivation, and a CV to:
Claudine Médigue
Anne Morgat

July 2009- PhD proposal/ Provided offer

Hosting Group: Laboratory of organic chemistry and biocatalysis
Group leader : Anne Zaparucha

• PhD proposal: “new nitrilase and racemase activities; application to the dynamic kinetic resolution of alpha-aminonitriles from Strecker synthesis”.
• Funding: : french doctoral contract.
• Education: : master in organic chemistry, bio organic chemistry or biochemistry with organic chemistry background. -The applicant should be highly motivated by the chemistry-biology interface approach. -Open mindedness and scientific curiosity required.
• Applications, extended CV and motivation letter, should be sent to: A. Zaparucha & C. Vergne

March 2008- Post-doctoral position. Provided offer

Details
 “Design and application of computational methods for metabolic reprogramming”
 Hosting Group : Computational Systems Biology (NeMo)
 Group leader : Vincent Schächter