Laboratory of organic chemistry and biocatalysis

 Biocatalysis is an emerging tool for the synthesis of useful chemicals. Search for new specific enzymatic activities allows enlargement of the biocatalysts applications in organic synthesis.
 Bioconversion interests are numerous: synthesis of chiral compounds (generally formation of one single enantiomer , most of the time enzymatic reactions are stereoselective), more effective and less polluant processes (reduced use of organic solvent). In an ecologic point of view, using biocatalysts is a change for the better and part of the green chemistry development.
 green chemistry

 Research

Team
Research themes
Equipment
Publications

Team

 Group leader: Anne Zaparucha, professor, University of Evry Val d’Essonne. Contact: E-mail, Tel : 33(0)1 60 87 45 78

 Carine Vergne, research scientist, CEA. Contact: E-mail , Tel : 33(0)1 60 87 36 13

 Pierre-Loïc Saaidi, assistant professor, Université d’Evry Val d’Essonne. Contact: E-mail, Tel : 33(0)1 60 87 36 13

 Aurélie Fossey, chemistry technician, CEA. Contact: E-mail, Tel : 33(0)1 60 87 84 99

 Franck Bordier, PhD student, Universite d’Evry Val d’Essonne. Contact: E-mail, Tel : 33(0)1 60 87 84 99

 Damien Baud, PhD student, Universite d’Evry Val d’Essonne. Contact : E-mail , Tel : 33(0)1 60 87 84 99

 Anthony Flourieusse, undergraduate, IUT Orsay. Contact : E-mail , Tel : 33(0)1 60 87 84 99

Former members:
 Yanis Frikha, undergraduate, Ecole Supérieure de Chimie Physique et Electronique de Lyon.
 Julien Cuccaro, undergraduate, Ecole Supérieure de Chimie Physique et Electronique de Lyon.
 Shangwen Zhuang, undergraduat, Ecole Supérieure de Chimie Physique et Electronique de Lyon.
 Emeline Larondeau, undergraduate, Université d’Evry Val d’Essonne.

Introduction

 The laboratory (LCOB) was created in October 2008 to complete a multidisciplinary approach of new enzymatic bioconversion reactions identifications in bacteria, based on genomic analysis. These identifications would concern genes predicted by annotation and orphans of function, as well as gene orphan functions. The LCOB team works in strong collaboration with the others Genoscope’s teams especially with the team of the Laboratory for enzymatic cloning and screening LCAB which searchs for biocatalysts by large-scale screening of enzyme families.

We develop two axes:

• internal projects: targeting an enzymatic activity; the LCAB furnishes the candidate enzymes; we run a study of methodology, activity screening, selectivities survey and we examine the applications in organic synthesis in enzymatic and / or chemoenzymatic pathways.
• transverse projects: multidisciplinary approach (bioinformatic, biochemistry and chemistry) for new enzymatic activities survey.