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Home page > Sequencing > Projects > Microorganisms > Acinetobacter baylyi > Explore metabolism > Catabolic islands

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Like Pseudomonas species, Acinetobacter baylyi ADP1 is able to modify the diverse structures of many aromatic compounds to common intermediates that can feed into central pathways. About 20% of the genes of the strain ADP1 can be reasonably associated with catabolic functions. It is interesting to note that almost all of these genes are located in five major “islands of catabolic diversity”, within one quarter of the overall genome. The evolutionary basis for this extraordinary clustering is unknown but may be related to the propensity of DNA containing the genes to undergo frequent and extensive tandem duplication.

Table: Some substrates involved in Acinetobacter baylyi ADP1 catabolic pathways.

Compounds Final products Related species Gene name ACIAD number Cluster
Alkanesulfonates Sulfite + Aldehyde Pseudomonas putida ssu 0034-0038 -
Vanillate Protocatechuate Acinetobacter baylyi ADP1 van 0978-0983 ; 0988 I
Betaine Betaine aldehyde Escherichia coli bet 1008-1012 I
Acetoin Acetate Klebsiella pneumoniae aco 1014 ; 1017-1022 I
Urea Ammonia Bordetella bronchiseptia ure 1088-1096 -
Salicylate esters Catechol Acinetobacter baylyi ADP1 sal 1424-1427 II
Aryl esters Catechol Acinetobacter baylyi ADP1 are 1428-1431 II
Benzoate Catechol Acinetobacter calcoaceticus ben 1433-1440 II
Catechol Succinate + Acetyl CoA Acinetobacter calcoaceticus cat 1442-1451 II
Alkanesulfonates Sulfite + Aldehyde Y. pestis ; Pseudomonas sp. ssu-like 1505 ; 1518 ; 1527 III
Dibenzothiophene Hydroxybiphenyl + Sulfite Rhodococcus sp. IGTS8 sox 1510-1512 III
Sulfuric esters Sulfate + Phenol/Alcohol Pseudomonas putida ats 1586-1588 ; 1592-1593 ; 1600-1601 III
Nitriles Aliphatic amides Pseudomonas chlororaphis nth 1614-1616 III
Amidase Ammoniac + Acide Pseudomonas chlororaphis amdA 1618 III
Protocatechuate (transporter) Pseudomonas syringae pcaT-like 1651 IV
Dicarboxylic acids Succinate + Acetyl CoA Acinetobacter baylyi ADP1 dca 1688-1698 IV
Protocatechuate Succinate + Acetyl CoA Acinetobacter baylyi ADP1 pca 1702-1712 IV
Quinate Protocatechuate Acinetobacter baylyi ADP1 qui 1713-1716 IV
p-hydroxybenzoate Protocatechuate Acinetobacter calcoaceticus pob 1717-1719 IV
Chlorogenate Quinate + Caffeate Acinetobacter baylyi ADP1 hca 1720 IV
Caffeate Protocatechuate Acinetobacter baylyi ADP1 hca 1722-1728 IV
Malonate Acetate Klebsiella pneumoniae mdc 1753-1762 IV
Nitrate/Nitrite Ammonia Ralstonia solanacearum nas 1908-1914 V
Sarcosine Glycine + Formaldehyde Corynebacterium sp. sox 2550-2552 -
Anthranilate Catechol Acinetobacter baylyi ADP1 ant 2669-2671 -
Alkanesulfonate Sulfite + Aldehyde Pseudomonas aeruginosa msu 3470-3472 -
Last update on 9 October 2007

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