This is the directory for the public data of the Genetic Map ============================================================ In the Nature-1995 directory you will find the text files for the maps that will appear in the paper : "The Genethon human genetic linkage map" -------------------------------------- Nature (In press) Dib Colette, Faure Sabine, Fizames Cecile, Samson Delphine, Drouot Nathalie, Vignal Alain, Millasseau Philippe, Marc Sophie, Hazan Jamile, Lathrop Mark, Gyapay Gabor, Morissette Jean, Weissenbach Jean If you use information from these files please quote this paper as mentionned above. Abstract : The spectacular increase in successful linkage studies in a anumber of higher eucaryotes during recent years has essentially resulted from major improvement in reference genetic linkage maps which presently consist of short tandem repeat polymorphisms of simple sequences or microsatellites. We report here the last version of te Geneton Human Linkage Map. This map consists of 5264 short tandem (AC/TG)n repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3699 cM and comprises 2335 positions of which 2032 could be ordered with an odds ratio of at least 1000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and only 1% remains in intervals above 10 cM. Detailled features of this map are provided in a extended reprint available on request and are accessible through the Genethon ftp server (ftp.genethon.fr) In the Nature-Genetics-1994 directory you will find the text files for the maps that will appear in the paper : "The 1993-1994 Genethon human genetic linkage map" ------------------------------------------------ Nature Genetics (volume 7 - special issue - june 1994) Gyapay Gabor, Morissette Jean, Vignal Alain, Dib Colette, Fizames Cecile, Millasseau Philippe,Marc Sophie, Bernardi Georgio, Lathrop Marc, Weissenbach Jean Abstract : A genetic linkage map of the human genome has been constructed using 2066 (AC)n short tandem repeats, 60% of which show a heterozygosity of over 0.7. The map is based on the genotyping of 8 large CEPH families. Statistical linkage analysis placed these markers in the 23 linkage groups. The map includes 1266 intervals and spans a total distance of 3690 cM. A total of 1041 markers could be ordered with odds ratios above 1000:1. About 56% of this map is at a distance of 1 cM or less from one of its markers. In the genotypes directory you will find the linkage files (pedfiles and datafiles) corresponding to the 2066 markers and the alleles files corresponding to the 2066 markers. The sequences in this directory are in the EMBL format. - Gmap.embl.33 : sequences in EMBL rel 33 - Gmap.embl.34 : sequences in EMBL rel 34 - Gmap.embl.36 : sequences in EMBL rel 36 - Gmap.embl.37 : sequences in EMBL rel 37