CDSs classified by EGGNOG in COG category H
Acinetobacter baylyi ADP1 - chromosome ACIAD.1
H: METABOLISM -> Coenzyme transport and metabolism
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OG ID | OG function | Label | Gene | Product | COG | PFAM short name | KO |
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3NJWF | Belongs to the ribF family | ACIAD0023 | ribF | bifunctional protein [Includes: riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)] | COG0196 | FAD_syn, Flavokinase | K11753 |
3NKGB | O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway | ACIAD0044 | ubiG | 3-demethylubiquinone-9 3-methyltransferase and 2-octaprenyl-6-hydroxy phenol methylase | COG2227 | Methyltransf_23 | K00568 |
3NJD6 | Belongs to the NadC ModD family | ACIAD0062 | nadC | nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase) | COG0157 | QRPTase_C, QRPTase_N | K00767 |
3NJYV | Mandelate racemase / muconate lactonizing enzyme, C-terminal domain | ACIAD0128 | gudD | D-glucarate dehydratase | COG4948 | MR_MLE_C | K01706 |
3NJDK | Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate | ACIAD0247 | ribD | bifunctional protein [Includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase); 5-amino-6-(5- phosphoribosylamino)uracil reductase (HTP reductase) ] | COG1985, COG0117 | RibD_C, dCMP_cyt_deam_1 | K11752 |
3NJ7N | Lumazine binding domain | ACIAD0249 | ribC | riboflavin synthase alpha chain | COG0307 | Lum_binding | K00793 |
3NKAR | Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction | ACIAD0276 | thiC | hydroxymethylpyrimidine moiety synthesis in thiamin biosynthesis | COG0422 | ThiC-associated, ThiC_Rad_SAM | K03147 |
3NIRA | Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps | ACIAD0286 | hemC | porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) | COG0181 | Porphobil_deam, Porphobil_deamC | K01749 |
3NJF7 | Uroporphyrinogen-III synthase | ACIAD0287 | hemD | uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen- III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) | COG1587 | HEM4 | K01719 |
3NIFP | Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A | ACIAD0359 | coaE | dephosphocoenzyme A kinase | COG0237 | CoaE | K00859 |
3NIMA | FAD binding domain | ACIAD0381 | putative oxidoreductase; putative flavoprotein monooxygenase | FAD_binding_3 | |||
3NJ9G | Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) | ACIAD0384 | ubiE | S-adenosylmethionine : 2-DMK methyltransferase and 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase | COG2226 | Ubie_methyltran | K03183 |
3NJ05 | Putative methyltransferase | ACIAD0420 | putative methyltransferase | Methyltransf_4 | |||
3NIS7 | Involved in the biosynthesis of porphyrin-containing compound | ACIAD0432 | putative heme chaperone HemW like | HemN_C, Radical_SAM | |||
3NJ26 | Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | ACIAD0514 | folA | dihydrofolate reductase | COG0262 | DHFR_1 | K00287 |
3NJ9F | Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction | ACIAD0541 | ack | acetate kinase (propionate kinase) | COG0282 | Acetate_kinase | K00925 |
3NJX1 | Belongs to the P-Pant transferase superfamily | ACIAD0585 | putative holo-(acyl carrier protein) synthase 2 (AcpT) (phophopantetheinyltransferase) | COG2091 | ACPS | K06133 | |
3NJBF | Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell | ACIAD0596 | glnE | glutamine synthetase adenylyltransferase | COG1391 | GlnD_UR_UTase, GlnE | K00982 |
3NIXN | Belongs to the folylpolyglutamate synthase family | ACIAD0644 | folC | bifunctional protein [Includes: folylpolyglutamate synthase (FPGS); dihydrofolate synthase ]. | COG0285 | Mur_ligase_M | K11754 |
3NIF2 | Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate | ACIAD0651 | nadA | quinolinate synthetase A | COG0379 | NadA | K03517 |
3NIKM | chorismate binding enzyme | ACIAD0665 | pabB | p-aminobenzoate synthetase | COG0147 | Chorismate_bind | K01665 |
3NNKS | Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) | ACIAD0824 | gatC | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C | COG0721 | Glu-tRNAGln | K02435 |
3NII6 | Reduction of activated sulfate into sulfite | ACIAD0833 | putative 5'-adenylylsulfate reductase (APS reductase) (cysH-like) | COG0175 | PAPS_reduct | K00390 | |
3NJ23 | Biotin/lipoate A/B protein ligase family | ACIAD0841 | putative biotin--[acetyl-CoA-carboxylase] synthetase | COG1654, COG0340 | BPL_LplA_LipB | K03524 | |
3NJY2 | Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor | ACIAD0856 | bioA | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | COG0161 | Aminotran_3 | K00833 |
3NJ8J | Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway | ACIAD0858 | putative biotin biosynthesis protein (BioC) | COG0500 | Methyltransf_23 | K02169 | |
3NK0H | Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring | ACIAD0859 | bioD | dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS) | COG0132 | AAA_26 | K01935 |
3NJ39 | Phosphomethylpyrimidine kinase | ACIAD0875 | thiD | bifunctional protein [Includes: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)] | COG0351 | Phos_pyr_kin | K00941 |
3NIKS | Belongs to the ALAD family | ACIAD0923 | hemB | delta-aminolevulinic acid dehydratase (Porphobilinogen synthase) | COG0113 | ALAD | K01698 |
3NJ7S | Nicotinate phosphoribosyltransferase (NAPRTase) family | ACIAD0963 | nadV | nicotinamide phosphoribosyl transferase | NAPRTase | K03462 | |
3NNDK | FAD binding domain | ACIAD0984 | putative hydroxylase involved in salicylate metabolism (SalA-like) | COG0654 | FAD_binding_3, NAD_binding_8 | K00480 | |
3NJIB | Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate | ACIAD0997 | L-aspartate dehydrogenase (NadX) | COG1712 | DUF108, NAD_binding_3 | K06989 | |
3NIP9 | Thiamine pyrophosphate enzyme, central domain | ACIAD0999 | putative acetolactate synthase (IlvB-like) | COG0028 | TPP_enzyme_C, TPP_enzyme_M, TPP_enzyme_N | K01652 | |
3NKU5 | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | ACIAD1015 | lipA | lipoate synthase | COG0320 | LIAS_N, Radical_SAM | K03644 |
3NM04 | Nicotinamide mononucleotide transporter | ACIAD1033 | putative nucleoside/purine/pyrimidine transport protein (NMN family) (PnuC) | COG3201 | NMN_transporter | K03811 | |
3NJXP | Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) | ACIAD1062 | ppk | polyphosphate kinase | COG0855 | PP_kinase, PP_kinase_C, PP_kinase_N | K00937 |
3NQZY | Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation | ACIAD1071 | cobQ | cobyric acid synthase | COG1492 | CbiA, GATase_3 | K02232 |
3NJJG | Sulfate adenylyltransferase subunit 2 | ACIAD1072 | cysD | sulfate adenylyltransferase subunit 2 (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit) | COG0175 | PAPS_reduct | K00957 |
3NJ0B | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily | ACIAD1073 | cysN | ATP-sulfurylase, subunit 1 | COG2895 | GTP_EFTU | K00956 |
3NINP | Belongs to the 5-formyltetrahydrofolate cyclo-ligase family | ACIAD1116 | folN | 5-formyltetrahydrofolate cyclo-ligase | COG0212 | 5-FTHF_cyc-lig | K01934 |
3NK3B | FAD binding domain | ACIAD1127 | ubiH | ubiH protein, 2-octaprenyl-6-methoxyphynol hydroxylase, FAD/NAD(P)-binding | COG0654 | FAD_binding_3 | K03185 |
3NIR6 | Squalene epoxidase | ACIAD1128 | ubiF | 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase | FAD_binding_3 | ||
3NJVG | Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA | ACIAD1130 | putative methyltransferase | COG0313 | TP_methylase | K07056 | |
3NIUK | Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) | ACIAD1200 | putative thiamin-phosphate pyrophosphorylase (ThiE) | COG0352 | TMP-TENI | K00788 | |
3NJSW | Glutamate-1-semialdehyde aminotransferase | ACIAD1201 | hemL | glutamate-1-semialdehyde aminotransferase | COG0001 | Aminotran_3 | K01845 |
1RS1C | GNAT family acetyltransferase | ACIAD1279 | cphA | Cyanophycin synthetase | COG1181 | Mur_ligase_C, Mur_ligase_M, RimK | K03802 |
3NIEW | Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S | ACIAD1308 | thiG | thiamine biosynthesis protein, thiazole moiety | COG2022 | ThiG | K03149 |
3NPTY | ThiS family | ACIAD1309 | thiS | C-terminally thiocarboxylated form is intermediate sulfur donor in thiazole formation; part of ThiF/ThiS complex; complexes with ThiG also | COG2104 | ThiS | K03154 |
3NJWE | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family | ACIAD1327 | tkrA | Glyoxylate reductase / Glyoxylatereductase / Hydroxypyruvate reductase , 2-ketoaldonate reductase, broad specificity | COG1052 | 2-Hacid_dh, 2-Hacid_dh_C | K00090 |
3NIW6 | Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide | ACIAD1374 | ispU | undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) | COG0020 | Prenyltransf | K00806 |
3NJ8F | Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions | ACIAD1391 | rraA | Regulator of ribonuclease activity | COG0684 | RraA-like | K02553 |
3NKZM | Homocysteine S-methyltransferase | ACIAD1418 | putative homocysteine S-methyltransferase family protein | S-methyl_trans | |||
3NJZH | FAD binding domain | ACIAD1719 | pobA | p-hydroxybenzoate hydroxylase (4-hydroxybenzoate 3- monooxygenase) | COG0654 | FAD_binding_3 | K00481 |
3NT9V | Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity | ACIAD1734 | putative methyltransferase (EC 2.1.1.-) | LCM | |||
3NKIE | Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase | ACIAD1754 | mdcB | 2'-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase | COG1767 | CitG | K13930 |
3NN4M | Phosphoribosyl-dephospho-CoA transferase MdcG | ACIAD1758 | mdcG | phosphoribosyl-dephospho-CoA transferase (Holo-ACP synthase) | MdcG | K13934 | |
3NKPA | Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) | ACIAD1782 | ppk | polyphosphate kinase (Polyphosphoric acid kinase) (ATP- polyphosphate phosphotransferase) | COG0855 | PP_kinase, PP_kinase_C, PP_kinase_N | K00937 |
3NK2I | FAD binding domain | ACIAD1808 | putative monooxygenase | FAD_binding_3 | |||
3NJX7 | Probable molybdopterin binding domain | ACIAD1902 | moeA | molybdopterin biosynthesis protein | COG0303 | MoCF_biosynth, MoeA_C, MoeA_N | K03750 |
3NKK0 | Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) | ACIAD1903 | moaCB | bifunctional protein [Includes: molybdenum cofactor biosynthesis protein C; molybdenum cofactor biosynthesis protein B] | MoCF_biosynth, MoaC | ||
3NK9M | Molybdopterin converting factor, large subunit | ACIAD1904 | moaE | molybdopterin converting factor, large subunit | COG0314 | MoaE | K03635 |
3NPTK | ThiS family | ACIAD1905 | conserved hypothetical protein | ThiS | |||
3NKDX | Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate | ACIAD1906 | moaA | molybdopterin biosynthesis, protein A | COG2896 | Fer4_12, Mob_synth_C, Radical_SAM | K03639 |
3NKRG | Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor | ACIAD1907 | mobA | molybdopterin-guanine dinucleotide synthase | COG0746 | NTP_transf_3 | K03752 |
3NMYH | ATP-grasp in the biosynthetic pathway with Ter operon | ACIAD1963 | conserved hypothetical protein | ATPgrasp_Ter | |||
3NJIZ | DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity | ACIAD1970 | dnaX | DNA polymerase III, tau and gamma subunits (DNA elongation factor III) | COG2812 | DNA_pol3_delta2, DNA_pol3_gamma3 | K02343 |
3NJ4Q | Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway | ACIAD1980 | tal | transaldolase | COG0176 | TAL_FSA | K00616 |
3NK3F | Belongs to the carbohydrate kinase PfkB family | ACIAD1992 | fruK | 1-phosphofructokinase | COG1105 | PfkB | K00882 |
3NJ79 | Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) | ACIAD2011 | thiM | hydoxyethylthiazole kinase | COG2145 | HK | K00878 |
3NJFZ | Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme | ACIAD2037 | metK | methionine adenosyltransferase | COG1812, COG0192 | S-AdoMet_synt_C, S-AdoMet_synt_M, S-AdoMet_synt_N | K00789 |
3NJJH | Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism | ACIAD2045 | bioB | biotin synthetase | COG0502 | BATS, Radical_SAM | K01012 |
3NKIK | Iron-containing redox enzyme | ACIAD2095 | conserved hypothetical protein | Haem_oxygenas_2 | |||
3NKW9 | Aldolase/RraA | ACIAD2118 | putative demethylmenaquinone methyltransferase (bfnG) | RraA-like | |||
3NIJZ | Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP | ACIAD2231 | putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)(PpnK) | COG0061 | NAD_kinase | K00858 | |
3NNJP | COG0457 FOG TPR repeat | ACIAD2235 | conserved hypothetical protein | ||||
3NKK2 | Belongs to the Nudix hydrolase family | ACIAD2236 | putative bifunctional protein [Includes: dGTP-pyrophosphohydrolase; thiamine phosphate synthase] | COG0494, COG1051 | NUDIX, TMP-TENI | K03574 | |
3NKA8 | Permease for cytosine/purines, uracil, thiamine, allantoin | ACIAD2247 | putative permease | COG1953, COG1457 | Transp_cyt_pur | K03457 | |
3NJZS | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | ACIAD2275 | lipA | lipoate synthase | COG0320 | LIAS_N, Radical_SAM | K03644 |
3NIJA | May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine | ACIAD2282 | sahH | S-adenosyl-L-homocysteine hydrolase | COG0499 | AdoHcyase, AdoHcyase_NAD | K01251 |
3NIPN | 6-pyruvoyl tetrahydropterin synthase | ACIAD2353 | putative 6-pyruvoyl-tetrahydropterin synthase | COG0720 | PTPS | K01737 | |
3NJ95 | Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway | ACIAD2392 | rbsK | ribokinase | COG0524 | PfkB | K00852 |
3NK47 | Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol | ACIAD2405 | putative ubiquinone biosynthesis protein | COG2941 | COQ7 | K06134 | |
3NNNF | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) | ACIAD2407 | putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | COG0801 | HPPK | K00950 | |
3NNI7 | Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin | ACIAD2408 | folB | dihydroneopterin aldolase | COG1539 | FolB | K01633 |
3NIJ0 | COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 | ACIAD2411 | molybdopterin biosynthesis protein (moeB) OR thiamin-thiazole moiety synthesis (thiF) | COG0476 | ThiF | K21029 | |
3NIIN | Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation | ACIAD2422 | conserved hypothetical protein | COG1806 | Kinase-PPPase | K09773 | |
3NIYC | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate | ACIAD2455 | ubiA | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase) | COG0382 | UbiA | K03179 |
3NKMX | Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway | ACIAD2456 | ubiC | chorismate pyruvate lyase | COG3161 | Chor_lyase | K03181 |
3NIZ1 | component II | ACIAD2461 | trpG | bifunctional protein:[Includes: para-aminobenzoate synthase glutamine amidotransferase component II (ADC synthase); anthranilate synthase component II] | COG0512 | GATase | K01658 |
3NKQ6 | GTP cyclohydrolase | ACIAD2470 | folE | GTP cyclohydrolase I | COG0302 | GTP_cyclohydroI | K01495 |
3NIKI | Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | ACIAD2474 | hemE | uroporphyrinogen decarboxylase | COG0407 | URO-D | K01599 |
3NMAD | Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ | ACIAD2505 | pqqC | coenzyme PQQ synthesis protein C (Coenzyme PQQ synthesis protein I) | COG5424 | TENA_THI-4 | K06137 |
3NSYT | Iron-sulfur cluster-binding domain | ACIAD2507 | pqqE | coenzyme PQQ synthesis protein E (Coenzyme PQQ synthesis protein III) | COG0535 | Fer4_12, Radical_SAM, SPASM | K06139 |
3NIUI | Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate | ACIAD2577 | pdxJ | Pyridoxine 5'-phosphate synthase | COG0854 | PdxJ | K03474 |
3NJQX | Catalyzes the oxidation of L-aspartate to iminoaspartate | ACIAD2587 | nadB | L-aspartate oxidase (quinolinate synthetase B) | COG0029 | FAD_binding_2, Succ_DH_flav_C | K00278 |
3NIK0 | Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase | ACIAD2590 | pabC | 4-amino-4-deoxychorismate lyase | COG0115 | Aminotran_4 | K02619 |
3NIYT | Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds | ACIAD2600 | putative radical activating enzyme | COG0602 | Fer4_14, Radical_SAM | K10026 | |
3NITZ | Cytidylyltransferase-like | ACIAD2606 | nadM | nicotinamide/nicotinate-nucleotide adenylyltransferase | CTP_transf_like | ||
3NKB6 | Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate | ACIAD2667 | pdxB | erythronate-4-phosphate dehydrogenase | COG0111 | 2-Hacid_dh, 2-Hacid_dh_C, DUF3410 | K03473 |
3NMCH | chorismate binding enzyme | ACIAD2776 | fbsB | isochorismate synthetase | COG1169 | Chorismate_bind | K02361 |
3NK9R | Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle | ACIAD2842 | pckG | phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) | COG1274 | PEPCK_C, PEPCK_N | K01596 |
3NJMW | Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives | ACIAD2852 | folP | 7,8-dihydropteroate synthase | COG0294 | Pterin_bind | K00796 |
3NIYF | Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source | ACIAD2888 | nadE | NAD synthetase, NH3/glutamine-dependent | COG0388, COG0171 | CN_hydrolase, NAD_synthase | K01950 |
3NJTZ | Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate | ACIAD2893 | coaD | phosphopantetheine adenylyltransferase | COG0669 | CTP_transf_like | K00954 |
3NJ4K | Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) | ACIAD2900 | hemA | glutamyl tRNA reductase | COG0373 | GlutR_N, GlutR_dimer, Shikimate_DH | K02492 |
3NN4I | Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine | ACIAD2911 | panD | aspartate 1-decarboxylase precursor | COG0853 | Asp_decarbox | K01579 |
3NIMM | Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate | ACIAD2913 | ribB | 3,4 dihydroxy-2-butanone-4-phosphate synthase | COG0108 | DHBP_synthase | K02858 |
3NIWJ | Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate | ACIAD2927 | lipB | lipoate-protein ligase B (Lipoate biosynthesis protein B) | COG0321 | BPL_LplA_LipB | K03801 |
3NISX | Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme | ACIAD2934 | cysG | multifunctional protein [Includes: Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM); Precorrin-2 oxidase ; Ferrochelatase ] (Siroheme synthase) | COG0007, COG1648 | CysG_dimeriser, NAD_binding_7, TP_methylase | K02302 |
3NK0C | Belongs to the FPP GGPP synthase family | ACIAD2940 | ispB | octaprenyl-diphosphate synthase (Octaprenyl pyrophosphate synthetase) (OPP synthetase) | COG0142 | polyprenyl_synt | K02523 |
3NK6Z | Belongs to the FPP GGPP synthase family | ACIAD2968 | ispA | geranyltranstransferase (farnesyldiphosphate synthase) (FPP synthase) | COG0142 | polyprenyl_synt | K00795 |
3NIRN | Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) | ACIAD3010 | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase (4- (phosphohydroxy)-L-threonine dehydrogenase) | COG1995 | PdxA | K00097 |
3NJJJ | Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate | ACIAD3060 | panC | pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate activating enzyme) | COG0414 | Pantoate_ligase | K01918 |
3NIP8 | Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate | ACIAD3061 | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) | COG0413 | Pantoate_transf | K00606 |
3NNAE | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) | ACIAD3062 | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) | COG0801 | HPPK | K00950 |
3NIH2 | COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 | ACIAD3088 | putative tRNA threonylcarbamoyladenosine dehydratase (tcdA) | COG1179 | ThiF | K22132 | |
3NIUP | Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate | ACIAD3102 | ilvC | acetohydroxy acid isomeroreductase and 2-dehydropantoate 2-reductase | COG0059 | IlvC, IlvN | K00053 |
3NJ1B | acetolactate synthase | ACIAD3104 | ilvI | acetolactate synthase III, large subunit | COG0028 | TPP_enzyme_C, TPP_enzyme_M, TPP_enzyme_N | K01652 |
3NJ8G | Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine | ACIAD3125 | dfp | bifunctional protein [Includes: 4'-phosphopantothenoylcysteine decarboxylase; phosphopantothenoylcysteine synthetase, FMN-binding] | COG0452 | DFP, Flavoprotein | K13038 |
3NJ9J | Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 | ACIAD3135 | putative tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein mnmC | COG4121, COG0665 | DAO, Methyltransf_30 | K15461 | |
3NIWY | Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) | ACIAD3247 | dxs | 1-deoxyxylulose-5-phosphate synthase | COG1154 | DXP_synthase_N, Transket_pyr, Transketolase_C | K01662 |
3NJJB | Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate | ACIAD3249 | ribA | GTP cyclohydrolase II | COG0807 | GTP_cyclohydro2 | K01497 |
3NJJ9 | Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX | ACIAD3250 | hemF | coproporphyrinogen III oxidase | COG0408 | Coprogen_oxidas | K00228 |
3NJ4U | Catalyzes the ferrous insertion into protoporphyrin IX | ACIAD3255 | hemH | ferrochelatase | COG0276 | Ferrochelatase | K01772 |
3NJ61 | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family | ACIAD3278 | hprA | glycerate dehydrogenase | COG1052 | 2-Hacid_dh, 2-Hacid_dh_C | K00018 |
3NINV | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family | ACIAD3302 | serA | D-3-phosphoglycerate dehydrogenase | COG0111 | 2-Hacid_dh, 2-Hacid_dh_C | K00058 |
3NJ7P | Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) | ACIAD3501 | pdxH | pyridoxamine 5'-phosphate oxidase (acts also on pyridoxine phosphate and pyridoxine) | COG0259 | PNP_phzG_C, Putative_PNPOx | K00275 |
3NIX2 | Belongs to the prokaryotic GSH synthase family | ACIAD3518 | gshB | glutathione synthetase | COG0189 | GSH-S_ATP, GSH-S_N | K01920 |
3NK2I | FAD binding domain | ACIAD3540 | hpxO | FAD-dependent urate oxidase | FAD_binding_3 | K16839 | |
3NK8B | Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily | ACIAD3549 | gshA | gamma-glutamate-cysteine ligase | COG2918 | Glu_cys_ligase | K01919 |
3NJ8E | Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate | ACIAD3570 | ribB/A | bifunctional protein [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II] | COG0108, COG0807 | DHBP_synthase, GTP_cyclohydro2 | K14652 |
3NIEQ | Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin | ACIAD3571 | ribH | 6,7-dimethyl-8-ribityllumazine synthase (Lumazine synthase)(riboflavin synthase beta chain) | COG0054 | DMRL_synthase | K00794 |
3NKDN | Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 | ACIAD3573 | thiL | thiamin-monophosphate kinase | COG0611 | AIRS, AIRS_C | K00946 |
3NJ42 | Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle | ACIAD3627 | ppc | phosphoenolpyruvate carboxylase | COG1892, COG2352 | PEPcase | K01595 |