BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 1f0482ad85301d76c74593faec4326e0.SwissProt.fasta
           16 sequences; 6,132 total letters



Query= ACIAD3573

Length=306
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P0AGG1 Thiamine-monophosphate kinase [Escherichia coli O6:H1 (str...  251     2e-85
P0AGG0 Thiamine-monophosphate kinase [Escherichia coli (strain K12)]  251     2e-85
Q8XE87 Thiamine-monophosphate kinase [Escherichia coli O157:H7]       248     2e-84
P55881 Thiamine-monophosphate kinase [Salmonella typhimurium (str...  245     2e-83
Q57190 Thiamine-monophosphate kinase [Haemophilus influenzae (str...  244     5e-83
P57532 Thiamine-monophosphate kinase [Buchnera aphidicola subsp. ...  208     6e-69
Q8K9A5 Thiamine-monophosphate kinase [Buchnera aphidicola subsp. ...  206     7e-68
O27447 Thiamine-monophosphate kinase [Methanothermobacter thermau...  171     3e-54
Q54757 Thiamine-monophosphate kinase [Synechococcus elongatus (st...  168     2e-53
O05514 Thiamine-monophosphate kinase [Bacillus subtilis (strain 1...  157     3e-49
Q2FSV9 Thiamine-monophosphate kinase [Methanospirillum hungatei J...  148     4e-46
O67883 Thiamine-monophosphate kinase [Aquifex aeolicus (strain VF5)]  129     1e-38
P31905 Carbamoyl dehydratase HypE [Cupriavidus necator (strain AT...  62.8    2e-14
P31906 Carbamoyl dehydratase HypE [Bradyrhizobium diazoefficiens ...  55.1    7e-12
P07244 Phosphoribosylamine--glycine ligase / Phosphoribosylformyl...  42.4    1e-07
P20772 Phosphoribosylamine--glycine ligase / Phosphoribosylformyl...  42.0    2e-07


>P0AGG1 Thiamine-monophosphate kinase [Escherichia coli O6:H1 
(strain CFT073 / ATCC 700928 / UPEC)]
Length=325

 Score = 251 bits (640),  Expect = 2e-85
 Identities = 153/320 (48%), Positives = 201/320 (63%), Gaps = 18/320 (6%)

Query  3    EFSVIDQYFSR--SLLQDEELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAI  60
            EFS+I +YF R  S   D ELG+GDD ALLN P  Q L I TDTLVAG HF  D     +
Sbjct  5    EFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDIDPADL  64

Query  61   GWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTT  120
             +K++AVNLSD+AAMGA P  + LAL+LP VD  WL +FS  L+D  + + + LIGGDTT
Sbjct  65   AYKALAVNLSDLAAMGADPAWLTLALTLPDVDEAWLESFSDSLFDLLNYYDMQLIGGDTT  124

Query  121  QSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSRLQ----QRL  176
            + P L++T+   G++   +A+ RSGA+ GD++ V+G  GD+A GLA L +RLQ    +  
Sbjct  125  RGP-LSMTLGIHGFVPMGRALTRSGAKPGDWIYVTGTPGDSAAGLAILQNRLQVADAKDA  183

Query  177  DY-------PTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLPI-D  228
            DY       P+PR   GQ L+ LA+S ID+SDGL  DLGHI+KAS  GAR+ L  LP  D
Sbjct  184  DYLIKRHLRPSPRILQGQALRDLANSAIDLSDGLISDLGHIVKASDCGARIDLALLPFSD  243

Query  229  PLLASLESEQKWQYALAGGDDYELCFTISPQHYEKL--LRQPLNISITKIGEITAQ-QDL  285
             L   +E EQ  ++AL+GG+DYELCFT+   +   L      L +  T IG++TA  + L
Sbjct  244  ALSRHVEPEQALRWALSGGEDYELCFTVPELNRGALDVALGHLGVPFTCIGQMTADIEGL  303

Query  286  SFEYQGQDYPLQLKGYQHFA  305
             F   G+   L  KGY HFA
Sbjct  304  CFIRDGEPVTLDWKGYDHFA  323


>P0AGG0 Thiamine-monophosphate kinase [Escherichia coli (strain 
K12)]
Length=325

 Score = 251 bits (640),  Expect = 2e-85
 Identities = 153/320 (48%), Positives = 201/320 (63%), Gaps = 18/320 (6%)

Query  3    EFSVIDQYFSR--SLLQDEELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAI  60
            EFS+I +YF R  S   D ELG+GDD ALLN P  Q L I TDTLVAG HF  D     +
Sbjct  5    EFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDIDPADL  64

Query  61   GWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTT  120
             +K++AVNLSD+AAMGA P  + LAL+LP VD  WL +FS  L+D  + + + LIGGDTT
Sbjct  65   AYKALAVNLSDLAAMGADPAWLTLALTLPDVDEAWLESFSDSLFDLLNYYDMQLIGGDTT  124

Query  121  QSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSRLQ----QRL  176
            + P L++T+   G++   +A+ RSGA+ GD++ V+G  GD+A GLA L +RLQ    +  
Sbjct  125  RGP-LSMTLGIHGFVPMGRALTRSGAKPGDWIYVTGTPGDSAAGLAILQNRLQVADAKDA  183

Query  177  DY-------PTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLPI-D  228
            DY       P+PR   GQ L+ LA+S ID+SDGL  DLGHI+KAS  GAR+ L  LP  D
Sbjct  184  DYLIKRHLRPSPRILQGQALRDLANSAIDLSDGLISDLGHIVKASDCGARIDLALLPFSD  243

Query  229  PLLASLESEQKWQYALAGGDDYELCFTISPQHYEKL--LRQPLNISITKIGEITAQ-QDL  285
             L   +E EQ  ++AL+GG+DYELCFT+   +   L      L +  T IG++TA  + L
Sbjct  244  ALSRHVEPEQALRWALSGGEDYELCFTVPELNRGALDVALGHLGVPFTCIGQMTADIEGL  303

Query  286  SFEYQGQDYPLQLKGYQHFA  305
             F   G+   L  KGY HFA
Sbjct  304  CFIRDGEPVTLDWKGYDHFA  323


>Q8XE87 Thiamine-monophosphate kinase [Escherichia coli O157:H7]
Length=325

 Score = 248 bits (633),  Expect = 2e-84
 Identities = 152/320 (48%), Positives = 200/320 (63%), Gaps = 18/320 (6%)

Query  3    EFSVIDQYFSR--SLLQDEELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAI  60
            EFS+I +YF R  S   D ELG+GDD ALLN P  Q L I TDTLVAG HF  D     +
Sbjct  5    EFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDIDPADL  64

Query  61   GWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTT  120
             +K++AVNLSD+AAMGA P  + LAL+LP VD  WL +FS  L+D  + + + LIGGDTT
Sbjct  65   AYKALAVNLSDLAAMGADPAWLTLALTLPDVDEAWLESFSDSLFDLLNYYDMQLIGGDTT  124

Query  121  QSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSRLQ----QRL  176
            + P L++T+   G++   +A+ RSGA+ GD++ V+G  GD+A GLA L +RLQ    +  
Sbjct  125  RGP-LSMTLGIHGFVPMGRALTRSGAKPGDWIYVTGTPGDSAAGLAILQNRLQVADAKDA  183

Query  177  DY-------PTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLPI-D  228
            DY       P+PR   GQ L+ LA+S ID+SDGL  DLGHI+KAS  GAR+ L  LP  D
Sbjct  184  DYLIKRHLRPSPRILQGQALRDLANSAIDLSDGLISDLGHIVKASDCGARIDLALLPFSD  243

Query  229  PLLASLESEQKWQYALAGGDDYELCFTISPQHYEKL--LRQPLNISITKIGEITAQ-QDL  285
             L   +  EQ  ++AL+GG+DYELCFT+   +   L      L +  T IG++TA  + L
Sbjct  244  ALSRHVVPEQALRWALSGGEDYELCFTVPELNRGALDVALGHLGVPFTCIGQMTADIEGL  303

Query  286  SFEYQGQDYPLQLKGYQHFA  305
             F   G+   L  KGY HFA
Sbjct  304  CFIRDGEPVTLDWKGYDHFA  323


>P55881 Thiamine-monophosphate kinase [Salmonella typhimurium 
(strain LT2 / SGSC1412 / ATCC 700720)]
Length=325

 Score = 245 bits (626),  Expect = 2e-83
 Identities = 149/320 (47%), Positives = 199/320 (62%), Gaps = 18/320 (6%)

Query  3    EFSVIDQYFSR--SLLQDEELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAI  60
            EFS+I +YF R  S   D E G+GDD ALLN P  Q L I TDTLVAG HF  D     +
Sbjct  5    EFSLIARYFDRVRSSRLDVETGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDIDPADL  64

Query  61   GWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTT  120
             +K++AVNLSD+AAMGA P  + LAL+LP+VD  WL AFS  L+   + + + LIGGDTT
Sbjct  65   AYKALAVNLSDLAAMGADPAWLTLALTLPEVDEPWLEAFSDSLFALLNYYDMQLIGGDTT  124

Query  121  QSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSRLQ-------  173
            + P L++T+   GYI   +A+ RSGA+ GD++ V+G  GD+A GLA L +RLQ       
Sbjct  125  RGP-LSMTLGIHGYIPAGRALKRSGAKPGDWIYVTGTPGDSAAGLAVLQNRLQVSEETDA  183

Query  174  ----QRLDYPTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLP-ID  228
                QR   PTPR   GQ L+ +AS+ ID+SDGL  DLGHI+KAS  GAR+ +D LP  D
Sbjct  184  HYLIQRHLRPTPRILHGQALRDIASAAIDLSDGLISDLGHIVKASGCGARVDVDALPKSD  243

Query  229  PLLASLESEQKWQYALAGGDDYELCFTISPQHYEKL--LRQPLNISITKIGEITAQ-QDL  285
             ++  ++  Q  ++AL+GG+DYELCFT+   +   L      L +  T IG+++A  + L
Sbjct  244  AMMRHVDDGQALRWALSGGEDYELCFTVPELNRGALDVAIGQLGVPFTCIGQMSADIEGL  303

Query  286  SFEYQGQDYPLQLKGYQHFA  305
            +F   G       KGY HFA
Sbjct  304  NFVRDGMPVTFDWKGYDHFA  323


>Q57190 Thiamine-monophosphate kinase [Haemophilus influenzae 
(strain ATCC 51907 / DSM 11121 / KW20 / Rd)]
Length=328

 Score = 244 bits (624),  Expect = 5e-83
 Identities = 145/323 (45%), Positives = 200/323 (62%), Gaps = 20/323 (6%)

Query  1    MAEFSVIDQYFSRSLLQDE--ELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAH  58
            M EF +I +YF + +L D+  +L +GDD AL++ P   QL I TDT+V   HF    S  
Sbjct  3    MGEFDLIKRYFQQQILVDDSVQLSIGDDCALVSVPENYQLAITTDTMVENTHFLPTISPE  62

Query  59   AIGWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGD  118
             + +K+VA NLSD+AAMGA+P  + LAL+LP VD +W++ FS  L     Q+ V LIGGD
Sbjct  63   DLAYKAVATNLSDLAAMGAQPKWVSLALTLPNVDENWISTFSQSLLHTLKQYNVTLIGGD  122

Query  119  TTQSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAH--LGSR-----  171
            TT+  +L+IT+TA G++EK++ ICR  AQ+GD + VS  +GD+A GL    LG       
Sbjct  123  TTKG-NLSITITAQGFVEKNKGICRHKAQIGDLIYVSSTLGDSAAGLTQILLGKSAVDSD  181

Query  172  ---LQQRLDYPTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLPI-  227
               LQQR   PTPR ELGQ L G+A   ID+SDGL  DLGHIL+ S   A + L  LP+ 
Sbjct  182  DVFLQQRHLRPTPRIELGQALIGIAHVAIDLSDGLISDLGHILERSQCSAEVELTALPLS  241

Query  228  DPLLASLESEQKWQYALAGGDDYELCFTISPQHYEKL-LR-QPLNISITKIGEITAQ-QD  284
              +L   +  Q  Q+AL+GG+DYELCFTI P++ ++L LR + LN+  T IG+I  +  D
Sbjct  242  SSILNKYDRTQAEQFALSGGEDYELCFTIPPEYKDELELRLKKLNVPCTCIGKINEKCGD  301

Query  285  LSFEYQGQDYPLQL---KGYQHF  304
             S  +     P+ +    G+ HF
Sbjct  302  FSPRFLRDGKPVNITFSSGFDHF  324


>P57532 Thiamine-monophosphate kinase [Buchnera aphidicola subsp. 
Acyrthosiphon pisum (strain APS)]
Length=323

 Score = 208 bits (530),  Expect = 6e-69
 Identities = 122/319 (38%), Positives = 192/319 (60%), Gaps = 18/319 (6%)

Query  3    EFSVIDQYFSRSLLQD--EELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAI  60
            EF +I +YF R+  +D  E  G+GDDSAL+  P    L I TDTLV G HF  + S   +
Sbjct  5    EFEIISKYFKRNQKKDVNEIKGIGDDSALIKIPKNNILAISTDTLVEGTHFLKNISPEDL  64

Query  61   GWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTT  120
            G+K+VAVNLSD+AAMGA+P    L++++P+ ++ WL  FS+  +   +++ V LIGGDT 
Sbjct  65   GYKTVAVNLSDLAAMGAEPKWTTLSITMPESNNIWLKKFSSSFFKILNKYNVRLIGGDTN  124

Query  121  QSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGL-----------AHLG  169
            +   L+IT++  G ++K  A+ RS A +GD + V+G +G++A GL            ++ 
Sbjct  125  RG-SLSITLSMYGLLKKQIALLRSNANIGDLIYVTGTLGESAAGLFLLKKNIFIKNVNIR  183

Query  170  SRLQQRLDYPTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLPIDP  229
            + L ++   P PR   G  L+ +A++ ID+SDGL  DL HIL  S  GA + L+++PI  
Sbjct  184  NYLIKKHLNPIPRVSEGMALRKIANAAIDLSDGLIADLDHILNDSQCGANINLNKIPISK  243

Query  230  -LLASLESEQKWQYALAGGDDYELCFTISPQHYEKL--LRQPLNISITKIGEIT-AQQDL  285
             L+ + +S+    +AL  G+DYELCFTIS ++ +KL  +++   ++ T IG IT  +Q  
Sbjct  244  VLIDNFQSQNYLNWALNVGEDYELCFTISKKNIDKLKIIKKKFLVNFTCIGYITPIEQGF  303

Query  286  SFEYQGQDYPLQLKGYQHF  304
            +     +    + KG+ HF
Sbjct  304  NLFDNQKKIIFKKKGFNHF  322


>Q8K9A5 Thiamine-monophosphate kinase [Buchnera aphidicola subsp. 
Schizaphis graminum (strain Sg)]
Length=323

 Score = 206 bits (523),  Expect = 7e-68
 Identities = 124/320 (39%), Positives = 191/320 (60%), Gaps = 20/320 (6%)

Query  3    EFSVIDQYFSRSLLQDEEL--GVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAI  60
            EF +I ++F     +D+    G+GDDSAL+  P    L I TDTLV G+HF  + +   +
Sbjct  5    EFEIISKFFKNHQKKDKNQIKGIGDDSALIKIPKNNLLAISTDTLVEGKHFLKNITPKDL  64

Query  61   GWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTT  120
             +KSVAVNLSD+AAMGAKP  I L++++P+ D  WL +FS   +   +++ ++LIGGDT 
Sbjct  65   AYKSVAVNLSDLAAMGAKPTWITLSITMPKSDSVWLKSFSKSFFKILNKYKLNLIGGDTN  124

Query  121  QSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSR---------  171
              P L+IT++  G IE   A+ R  A+ GD + ++G +G++A GL+ L  +         
Sbjct  125  SGP-LSITLSIYGLIEGKNALLRGNAKNGDLIYITGNLGESAAGLSLLQKKTFLKNVKIC  183

Query  172  --LQQRLDYPTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLPIDP  229
              L ++   P PR   G  L+ +A++ IDISDGL  DLGHILK S  GA + L+ +PI  
Sbjct  184  NYLIKKHLKPIPRISEGIALRNIANAAIDISDGLISDLGHILKNSKCGADINLNTIPISK  243

Query  230  LLA-SLESEQKWQYALAGGDDYELCFTISPQHYEKL---LRQPLNISITKIGEIT-AQQD  284
            +L  + + ++   +AL  G+DYELCFTIS ++ +KL   +++ + I  T IG IT A++ 
Sbjct  244  ILTDNFKIDEYLNWALNSGEDYELCFTISKKNIKKLNVAIKKKI-IKCTCIGYITSAEKG  302

Query  285  LSFEYQGQDYPLQLKGYQHF  304
            L+     +    +  G+ HF
Sbjct  303  LNLIQNQKKIIFKKSGFNHF  322


>O27447 Thiamine-monophosphate kinase [Methanothermobacter thermautotrophicus 
(strain ATCC 29096 / DSM 1053 / JCM 10044 / 
NBRC 100330 / Delta H)]
Length=327

 Score = 171 bits (432),  Expect = 3e-54
 Identities = 109/323 (34%), Positives = 177/323 (55%), Gaps = 23/323 (7%)

Query  1    MAEFSVIDQYFSRSLL---QDEELGVGDDSALLNPPSGQQ-LVICTDTLVAGRHFPLDTS  56
            + E  +I +  SR+       E +G+GDD+AL++  +G++ LV+ +D L+  RHFP    
Sbjct  8    LGEKKLISRIISRARSVFGSSEVMGLGDDAALID--AGEEFLVLTSDLLLETRHFPDPER  65

Query  57   AHAIGWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIG  116
               +GWK+V VN+SD+AAMG++P   +L+++LP ++ ++  +   G+ + C  +   LIG
Sbjct  66   PRDMGWKTVTVNMSDLAAMGSRPEGFILSVALPDLELEFFDSLMDGVIEACCHYQAPLIG  125

Query  117  GDTTQSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGS------  170
            GDT ++  + ++ TA+G  EK   + +SGA+ GD V V+G +G  A G   + S      
Sbjct  126  GDTNEADEIILSGTAIGRAEKDMVLMKSGARPGDLVAVTGPLGVGAAGTELILSGRDTGG  185

Query  171  --RLQQRLDYPTPRCELGQTL--KGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLP  226
                 +R   P  R E G  L   GL SS  DI+DGL  +LG ++ AS  G R+  D+LP
Sbjct  186  FENAVERSLRPVARIEEGLILAESGLVSSATDITDGLVSELGELMDASGTGMRIYEDRLP  245

Query  227  ID---PLLASLESEQKWQYALAGGDDYELCFTISPQHYEKLLRQPLNISITKIGEITAQQ  283
            +    P +AS+      + AL  G+D+EL FT  P   E+L      + +  IGE+T   
Sbjct  246  LGREVPEIASILGRDPLELALYYGEDFELVFTAPPTGMEELSDM---MELHVIGEVTVGG  302

Query  284  DLSF-EYQGQDYPLQLKGYQHFA  305
             +   +  G  Y L ++GY+H +
Sbjct  303  GIEMVDKDGVTYKLHVRGYEHLS  325


>Q54757 Thiamine-monophosphate kinase [Synechococcus elongatus 
(strain ATCC 33912 / PCC 7942 / FACHB-805)]
Length=327

 Score = 168 bits (426),  Expect = 2e-53
 Identities = 118/301 (39%), Positives = 164/301 (54%), Gaps = 24/301 (8%)

Query  24   GDDSALLNPPSGQQLVICTDTLVAGRHFP-LDTSAHAIGWKSVAVNLSDIAAMGAKPHSI  82
            GDD+A+L PP+GQQLV+ +D LV G HF    T   AIGW++ A NLSD+AAMGA P  I
Sbjct  28   GDDAAILTPPAGQQLVVSSDVLVEGIHFSEATTPPAAIGWRAAAANLSDLAAMGATPAGI  87

Query  83   LLALSLPQVDH-DWLAAFSAGLYDCCDQFGVHLIGGDTTQSPHLTITVTALGYIEKHQAI  141
             LAL+LP      WL     GL  C  Q+   LIGGD ++SP  T+ VTALG++  ++ I
Sbjct  88   TLALALPSDRRLSWLQQIYQGLDRCLKQYDCPLIGGDLSRSPTATLAVTALGWVNPNRVI  147

Query  142  CRSGAQVGDYVVVSGQIGDAAYGLAHLGSR--LQQRL--------DYPTPRCELGQTLKG  191
             RS AQVGD+++ +G  G +  GL HL     L + L          P PR ++   L  
Sbjct  148  RRSTAQVGDWIMATGTHGLSRLGLGHLLGEWTLAEPLRDQAIAAHQAPKPRLDVVPLLAR  207

Query  192  LAS-------SMIDISDGLAQDLGHILKASHVGARLRLDQLPIDPLLASLESEQKWQYAL  244
                      + +D SDGLA  +  I +AS VGA   ++ LP+ P   S + ++  Q AL
Sbjct  208  SQPAGTVWRVAGMDSSDGLADAVLQICRASQVGA--VIEALPL-PATTSFDRDRLIQAAL  264

Query  245  AGGDDYELCFTISPQHYEKLLRQPLNISITKIGEITAQQDLSFEYQGQDYPLQL-KGYQH  303
             GG+D+EL   +SP   + LL + L      IG+IT +  +      +   L L +G+QH
Sbjct  265  YGGEDFELVLCLSPDWAQALL-ELLGEQAQVIGQITEKPVVQLRLSDRTEILSLDRGFQH  323

Query  304  F  304
            F
Sbjct  324  F  324


>O05514 Thiamine-monophosphate kinase [Bacillus subtilis (strain 
168)]
Length=325

 Score = 157 bits (398),  Expect = 3e-49
 Identities = 115/325 (35%), Positives = 173/325 (53%), Gaps = 22/325 (7%)

Query  1    MAEFSVIDQYFSRSLLQDE-ELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLD-TSAH  58
            M EF +I     R++     ++G+GDD+AL     G Q ++C DT+V   HF L  +S  
Sbjct  1    MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVDTMVEDVHFKLHYSSPE  60

Query  59   AIGWKSVAVNLSDIAAMGAKPHSILLALSLPQV-DHDWLAAFSAGLYDCCDQFGVHLIGG  117
             IG+K++AVN+SDIAAMG  P   L++L++P       + A   G+ +    + + LIGG
Sbjct  61   DIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAMYEGMNELAKLYHMDLIGG  120

Query  118  DTTQSPH-LTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSRLQQR-  175
            DT  +   L +TVT +G IEK QA  RS A+  D V V+G+IG +A GL+ L      + 
Sbjct  121  DTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTGEIGSSAAGLSLLLEETNPQN  180

Query  176  ----LDY-------PTPRCELGQTLKGL-ASSMIDISDGLAQDLGHILKASHVGARLRLD  223
                 DY       P PR  +G+       +++ D+SDGLA +L  I +AS V   +   
Sbjct  181  SSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSDGLASELNEIAEASCVSIEIVES  240

Query  224  QLPIDPLLASLESEQKWQYALAGGDDYELCFTISPQHYEKLLRQ--PLNISITKIGEI--  279
             LPI   L  L    K ++AL GG+D+EL  T+S + +E L ++   L++ ITKIG +  
Sbjct  241  MLPIHSDLPKLHPNWK-EWALFGGEDFELTGTVSNEEWEVLKQECAALHLPITKIGYVRE  299

Query  280  TAQQDLSFEYQGQDYPLQLKGYQHF  304
              +  +  +       L+ KGY HF
Sbjct  300  KTKSKVILKTDQTSMILEKKGYNHF  324


>Q2FSV9 Thiamine-monophosphate kinase [Methanospirillum hungatei 
JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)]
Length=286

 Score = 148 bits (374),  Expect = 4e-46
 Identities = 106/280 (38%), Positives = 141/280 (50%), Gaps = 17/280 (6%)

Query  25   DDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAIGWKSVAVNLSDIAAMGAKPHSILL  84
            DD A+L  P G  LV  TD L     FP   +   IGW SVAV +SDIAAMGA+P  I+L
Sbjct  21   DDCAILTLPCGA-LVTSTDMLHERSDFPAGMTGWQIGWMSVAVTISDIAAMGAEPLQIVL  79

Query  85   ALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTTQSPHLTITVTALGYIEKHQAICRS  144
            A+ L   +   LA    G   CCD +G    GGD      LTI  T +G I   + + R 
Sbjct  80   AIGLDTEER--LAEIVLGAQACCDTYGAVYAGGDLDAHSELTIVSTGVGIIRDGEPVRRG  137

Query  145  GAQVGDYVVVSGQIGDAAYGLAHLGSRLQQRLDYPTPRCELGQTLK-GLASSMIDISDGL  203
            GA+ GD + V+G +G A  GL    SR  + L  P PR   G   +   A +M+DISDGL
Sbjct  138  GAKPGDIICVTGTLGRAILGLTG-DSRFWKDLCEPQPRVREGTVARLAGAHAMMDISDGL  196

Query  204  AQDLGHILKASHVGARLRLDQLPIDPLLASLESEQKWQYALAGGDDYELCFTISPQHYEK  263
            A  L  I   SHVG  +   ++P+ P     + +   + AL GG D+EL F IS +  + 
Sbjct  197  AISLYDIAAESHVGMEISSGRIPLPP---EADVQVALEAALYGGGDFELLFFISEEKMKN  253

Query  264  LLRQPLNISITKIGEITAQQDLSFEYQGQDYPLQLKGYQH  303
                 L I +T+IG ++  + L     G + P   KGY H
Sbjct  254  -----LTIPVTQIGRVS--EGLKITMDGMELP--KKGYLH  284


>O67883 Thiamine-monophosphate kinase [Aquifex aeolicus (strain 
VF5)]
Length=306

 Score = 129 bits (324),  Expect = 1e-38
 Identities = 94/318 (30%), Positives = 167/318 (53%), Gaps = 31/318 (10%)

Query  1    MAEFSVIDQYFSRSLLQDEELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAI  60
            + EF +ID    ++L   E   +GDD+A +   S ++L++ TD L  G HF       A+
Sbjct  6    LGEFGLID-LIKKTL---ESKVIGDDTAPVEYCS-KKLLLTTDVLNEGVHFLRSYIPEAV  60

Query  61   GWKSVAVNLSDIAAMGAKPHSILLALSLPQ-VDHDWLAAFSAGLYDCCDQFGVHLIGGDT  119
            GWK+++VN+SD+ A G  P   L++L+LP+ ++  ++  F  G+   C+ +   ++GG+ 
Sbjct  61   GWKAISVNVSDVIANGGLPKWALISLNLPEDLEVSYVERFYIGVKRACEFYKCEVVGGNI  120

Query  120  TQSPHLTITVTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHL----------G  169
            ++S  + I+V  +G  E  + + R GA++GD V VSG +GD+  GL  L           
Sbjct  121  SKSEKIGISVFLVG--ETERFVGRDGARLGDSVFVSGTLGDSRAGLELLLMEKEEYEPFE  178

Query  170  SRLQQRLDYPTPRCELGQTLKGLASSMIDISDGLAQDLGHILKASHVGARLRLDQLPID-  228
              L QR   PT R +  + ++  A++ +DISDGL  D  H+ + S V   +  ++LP+  
Sbjct  179  LALIQRHLRPTARIDYVKHIQKYANASMDISDGLVADANHLAQRSGVKIEILSEKLPLSN  238

Query  229  --PLLASLESEQKWQYALAGGDDYELCFTISPQHYEKLLRQPLNISITKIGEITAQQDLS  286
               +      +   +YAL GG+DY+L FT   + +   L       +T+IG +   + + 
Sbjct  239  ELKMYCEKYGKNPIEYALFGGEDYQLLFTHPKERWNPFL------DMTEIGRVEEGEGVF  292

Query  287  FEYQGQDYPLQLKGYQHF  304
             + +     ++ KG++HF
Sbjct  293  VDGK----KVEPKGWKHF  306


>P31905 Carbamoyl dehydratase HypE [Cupriavidus necator (strain 
ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 
337)]
Length=351

 Score = 62.8 bits (151),  Expect = 2e-14
 Identities = 66/232 (28%), Positives = 101/232 (44%), Gaps = 30/232 (13%)

Query  18   DEELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAIGWKSVAVNLSDIAAMGA  77
            +E L  G+D A    P+G ++V+ TD  V     PL      IG  SV   ++D+A  GA
Sbjct  45   NEWLRQGNDQAAFAMPAGARMVMATDAHVVS---PLFFPGGDIGSLSVHGTINDVAMAGA  101

Query  78   KP----HSILLALSLPQVDHDWLAAFSAGLYDCCDQFGVHLIGGDTT-----QSPHLTIT  128
            KP     S +L    P  D   +    AG      + GV ++ GDT      +   + IT
Sbjct  102  KPLYLAASFILEEGFPLADLKRIVESMAG---AAREAGVPIVTGDTKVVEQGKGDGVFIT  158

Query  129  VTALGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSRLQQRLDYPTPRCELGQT  188
             T +G +     I  +GA+ GD +++SG +G+  +G+A L  R  + L++ T        
Sbjct  159  TTGVGVVPAGILIDGAGARPGDAILLSGTMGE--HGVAILSKR--ESLEFDTEIRSDSAA  214

Query  189  LKGLASSMIDI-----------SDGLAQDLGHILKASHVGARLRLDQLPIDP  229
            L  L + M+ +             GLA  L  I   S VG  L    +P+ P
Sbjct  215  LHDLVAQMLAVVPGVRVLRDPTRGGLATTLNEISSQSGVGMVLDEAAIPVLP  266


>P31906 Carbamoyl dehydratase HypE [Bradyrhizobium diazoefficiens 
(strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 
/ USDA 110)]
Length=346

 Score = 55.1 bits (131),  Expect = 7e-12
 Identities = 60/234 (26%), Positives = 104/234 (44%), Gaps = 26/234 (11%)

Query  18   DEELGVGDDSALLNPPSGQQLVICTDTLVAGRHFPLDTSAHAIGWKSVAVNLSDIAAMGA  77
            +E L  G+D +  +  +G+ +V+ TD  V     PL      IG  +V   ++DIA  GA
Sbjct  40   NEWLARGNDQSAFDVRAGR-MVMTTDGYVVS---PLFFPGGNIGSLAVHGTVNDIAMAGA  95

Query  78   KPHSILLALSLPQ-VDHDWLAAFSAGLYDCCDQFGVHLIGGDTT-----QSPHLTITVTA  131
            KP  +  +  + +      L   +  +     +  VH+I GDT      ++  L I+   
Sbjct  96   KPLYLSASFIIEEGFRFADLKLIAESMGAAAREADVHIITGDTKVVERGKADGLFISTAG  155

Query  132  LGYIEKHQAICRSGAQVGDYVVVSGQIGDAAYGLAHLGSRLQQRLDYPTPRCELGQTLKG  191
            +G +     +    A+VGD V++SG +GD  +G+A +  R  Q L + T       +L  
Sbjct  156  VGVVPDGLDLSAEKARVGDRVLISGTLGD--HGVAIMSKR--QNLAFETEIVSDSASLHD  211

Query  192  LASSMIDIS------------DGLAQDLGHILKASHVGARLRLDQLPIDPLLAS  233
            L + M+                GLA  L  I + S++G  L  + +P+ P +A+
Sbjct  212  LVARMVQAGGRGIRLMRDPTRGGLAATLNEIAQQSNLGFHLLEEAIPVKPGVAA  265


>P07244 Phosphoribosylamine--glycine ligase / Phosphoribosylformylglycinamidine 
cyclo-ligase [Saccharomyces cerevisiae (strain 
ATCC 204508 / S288c)]
Length=802

 Score = 42.4 bits (98),  Expect = 1e-07
 Identities = 36/139 (26%), Positives = 59/139 (42%), Gaps = 16/139 (12%)

Query  38   LVICTDTLVAGRHFPLDTSAH-AIGWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWL  96
            LV  TD +        +T  H  +G   VA+N++D+   GA+P   L   +   +D    
Sbjct  507  LVGATDGVGTKLIIAQETGIHNTVGIDLVAMNVNDLVVQGAEPLFFLDYFATGALDIQVA  566

Query  97   AAFSAGLYDCCDQFGVHLIGGDTTQSP------HLTITVTALGYIEKHQAICRSGAQVGD  150
            + F +G+ + C Q G  L+GG+T++ P      H     TA+G + +   + +       
Sbjct  567  SDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDILPKINEMAA-  625

Query  151  YVVVSGQIGDAAYGLAHLG  169
                    GD   GLA  G
Sbjct  626  --------GDVLLGLASSG  636


 Score = 20.8 bits (42),  Expect = 0.80
 Identities = 15/46 (33%), Positives = 22/46 (48%), Gaps = 10/46 (22%)

Query  243  ALAGGDDYELCFTISPQHYE-------KLLRQPLNISITKIGEITA  281
            AL GG+  E+     P HY+        +LRQ +   + KI E+ A
Sbjct  583  ALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDI---LPKINEMAA  625


 Score = 17.3 bits (33),  Expect = 9.7
 Identities = 14/53 (26%), Positives = 27/53 (51%), Gaps = 4/53 (8%)

Query  256  ISPQHYEKLLRQPLNISITK-IGEITAQQDLSFEY-QGQDYPLQ--LKGYQHF  304
            I P   ++ ++   +I +TK  GE   +Q +  ++ +G +  L   + GY HF
Sbjct  162  IIPSSIDESVQAIKDIMVTKQFGEEAGKQVVIEQFLEGDEISLLTIVDGYSHF  214


>P20772 Phosphoribosylamine--glycine ligase / Phosphoribosylformylglycinamidine 
cyclo-ligase [Schizosaccharomyces pombe (strain 
972 / ATCC 24843)]
Length=788

 Score = 42.0 bits (97),  Expect = 2e-07
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 1/89 (1%)

Query  38   LVICTDTLVAGRHFPLDTSAH-AIGWKSVAVNLSDIAAMGAKPHSILLALSLPQVDHDWL  96
            LV  TD + +     L  + H  +G   VA+N++D+   GA+P   L   +   +D    
Sbjct  491  LVSATDGVGSKLLIALSLNKHDTVGIDLVAMNVNDLVVQGAEPLIFLDYFATGSLDLKVS  550

Query  97   AAFSAGLYDCCDQFGVHLIGGDTTQSPHL  125
             +F  G+   C Q G  L+GG+T++ P L
Sbjct  551  TSFVEGVVKGCKQAGCALVGGETSEMPGL  579



Lambda      K        H        a         alpha
   0.321    0.138    0.416    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 1393420


  Database: 1f0482ad85301d76c74593faec4326e0.SwissProt.fasta
    Posted date:  May 12, 2024  12:40 AM
  Number of letters in database: 6,132
  Number of sequences in database:  16



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40