Comparative Genomics

ACIAD0337 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: 24ca4e99537bdf75082c8d690008ebeb.SwissProt.fasta
           6 sequences; 3,308 total letters



Query= ACIAD0337

Length=305
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

Q12797 Aspartyl/asparaginyl beta-hydroxylase [Homo sapiens]           75.1    2e-18
Q8BSY0 Aspartyl/asparaginyl beta-hydroxylase [Mus musculus]           71.6    2e-17
Q28056 Aspartyl/asparaginyl beta-hydroxylase [Bos taurus]             70.1    7e-17
Q6ICH7 Aspartate beta-hydroxylase domain-containing protein 2 [Ho...  69.3    8e-17
Q5HZW3 Aspartate beta-hydroxylase domain-containing protein 2 [Ra...  64.3    3e-15
Q80VP9 Aspartate beta-hydroxylase domain-containing protein 2 [Mu...  63.5    6e-15


>Q12797 Aspartyl/asparaginyl beta-hydroxylase [Homo sapiens]
Length=758

 Score = 75.1 bits (183),  Expect = 2e-18
 Identities = 49/171 (29%), Positives = 79/171 (46%), Gaps = 10/171 (6%)

Query  58   ETQHFKDLKILDENWEMIRDEARALYDQGGIKASSTYNDLGFNSFFKTGWKRFYLKWYDS  117
            ET + + +K L+ NW++IRDE  A+ D    KA   +     N   K  W +F L     
Sbjct  580  ETGYTELVKSLERNWKLIRDEGLAVMD----KAKGLFLPEDENLREKGDWSQFTLWQQGR  635

Query  118  AHPSAAELCPKTTALLKTLPSIKAAM-----FTELAPNSRLVRHRDPYAGSLRYHLGLIT  172
             + +A +  PKT  LL+  P           ++ + P + +  H  P    LR HLGL+ 
Sbjct  636  RNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVI  695

Query  173  PNDDRCFIDVDGQRYSWRDGESVVFDETYIHYAENTTDQNRIIFFADVERP  223
            P +  C I    +  +W +G+ ++FD+++ H         R+IF  DV  P
Sbjct  696  PKEG-CKIRCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHP  745


>Q8BSY0 Aspartyl/asparaginyl beta-hydroxylase [Mus musculus]
Length=741

 Score = 71.6 bits (174),  Expect = 2e-17
 Identities = 48/171 (28%), Positives = 78/171 (46%), Gaps = 10/171 (6%)

Query  58   ETQHFKDLKILDENWEMIRDEARALYDQGGIKASSTYNDLGFNSFFKTGWKRFYLKWYDS  117
            ET + + +K L+ NW++IRDE   + D    KA   +     N   K  W +F L     
Sbjct  563  ETGYTELVKSLERNWKLIRDEGLMVMD----KAKGLFLPEDENLREKGDWSQFTLWQQGR  618

Query  118  AHPSAAELCPKTTALLKTLPSIKAAM-----FTELAPNSRLVRHRDPYAGSLRYHLGLIT  172
             + +A +  PKT ALL+              ++ + P + +  H  P    LR HLGL+ 
Sbjct  619  KNENACKGAPKTCALLEKFSETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVI  678

Query  173  PNDDRCFIDVDGQRYSWRDGESVVFDETYIHYAENTTDQNRIIFFADVERP  223
            P +  C I    +  +W +G+ ++FD+++ H         R+IF  DV  P
Sbjct  679  PKEG-CKIRCANETRTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHP  728


>Q28056 Aspartyl/asparaginyl beta-hydroxylase [Bos taurus]
Length=754

 Score = 70.1 bits (170),  Expect = 7e-17
 Identities = 47/171 (27%), Positives = 77/171 (45%), Gaps = 10/171 (6%)

Query  58   ETQHFKDLKILDENWEMIRDEARALYDQGGIKASSTYNDLGFNSFFKTGWKRFYLKWYDS  117
            ET + + +K L+ NW++IRDE  A  D    +    +     N   K  W +F L     
Sbjct  576  ETGYTELVKSLERNWKLIRDEGLAAMD----RTHGLFLPEDENLREKGDWSQFTLWQQGR  631

Query  118  AHPSAAELCPKTTALLKTLPSIKAAM-----FTELAPNSRLVRHRDPYAGSLRYHLGLIT  172
             + +A +  PKT +LL   P           ++ + P + +  H  P    LR HLGL+ 
Sbjct  632  KNENACKGAPKTCSLLDKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVI  691

Query  173  PNDDRCFIDVDGQRYSWRDGESVVFDETYIHYAENTTDQNRIIFFADVERP  223
            P +  C I    +  +W +G+ ++FD+++ H         R+IF  DV  P
Sbjct  692  PKEG-CKIRCANETRTWEEGKVLIFDDSFEHEVWQDAASFRLIFIVDVWHP  741


>Q6ICH7 Aspartate beta-hydroxylase domain-containing protein 2 
[Homo sapiens]
Length=369

 Score = 69.3 bits (168),  Expect = 8e-17
 Identities = 52/189 (28%), Positives = 82/189 (43%), Gaps = 14/189 (7%)

Query  45   MYMFSKVPNQPYIETQHFK-DLKILDENWEMIRDEARALYDQGGIKASSTYNDLGFNSFF  103
            ++    +P  PY      K D+++L+ N++ I  E   LY        S       NS  
Sbjct  167  VFFLPDLPTTPYFSRDAQKHDVEVLERNFQTILCEFETLYK--AFSNCSLPQGWKMNSTP  224

Query  104  KTGWKRFYLKWYDSAHPSAAELCPKTTALLKTLPSIKA------AMFTELAPNSRLVRHR  157
               W  FYL       P     CP+T  LL +L +         A  + L+P + +  H 
Sbjct  225  SGEWFTFYLVNQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHY  284

Query  158  DPYAGSLRYHLGLITPNDDRCFIDVDGQRYSWRDGESVVFDETYIHYA---ENTTDQNRI  214
             P    +R HLGL TPN   C + V G+   W +G  ++FD++++H A    +  D  R+
Sbjct  285  GPTNIRIRCHLGLKTPNG--CELVVGGEPQCWAEGRCLLFDDSFLHAAFHEGSAEDGPRV  342

Query  215  IFFADVERP  223
            +F  D+  P
Sbjct  343  VFMVDLWHP  351


>Q5HZW3 Aspartate beta-hydroxylase domain-containing protein 2 
[Rattus norvegicus]
Length=343

 Score = 64.3 bits (155),  Expect = 3e-15
 Identities = 50/189 (26%), Positives = 81/189 (43%), Gaps = 14/189 (7%)

Query  45   MYMFSKVPNQPYIETQHFK-DLKILDENWEMIRDEARALYDQGGIKASSTYNDLGFNSFF  103
            ++    +P  PY      K D+++L+ N++ I  E  ALY        S       NS  
Sbjct  141  VFFLPDLPTTPYFPRDAQKHDVELLERNFQAILCEFEALYK--AFSNCSLPQGWKVNSTP  198

Query  104  KTGWKRFYLKWYDSAHPSAAELCPKTTALLKTLPSIKA------AMFTELAPNSRLVRHR  157
               W  F         P     CP+T  LL +L +         A  + L+P + +  H 
Sbjct  199  SGEWFTFDFVSQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHY  258

Query  158  DPYAGSLRYHLGLITPNDDRCFIDVDGQRYSWRDGESVVFDETYIH---YAENTTDQNRI  214
             P    +R HLGL TPN   C + V G+   W +G  ++FD++++H   +  +  D  R+
Sbjct  259  GPTNIRIRCHLGLKTPNG--CELVVGGEPQCWAEGRCLLFDDSFLHTSFHEGSAEDGPRV  316

Query  215  IFFADVERP  223
            +F  D+  P
Sbjct  317  VFMVDLWHP  325


>Q80VP9 Aspartate beta-hydroxylase domain-containing protein 2 
[Mus musculus]
Length=343

 Score = 63.5 bits (153),  Expect = 6e-15
 Identities = 50/189 (26%), Positives = 80/189 (42%), Gaps = 14/189 (7%)

Query  45   MYMFSKVPNQPYIETQHFK-DLKILDENWEMIRDEARALYDQGGIKASSTYNDLGFNSFF  103
            ++    +P  PY      K D+++L+ N++ I  E   LY        S       NS  
Sbjct  141  VFFLPDLPTTPYFSRDAQKHDVELLERNFQAILCEFETLYK--AFSNCSLPQGWKVNSTP  198

Query  104  KTGWKRFYLKWYDSAHPSAAELCPKTTALLKTLPSIKA------AMFTELAPNSRLVRHR  157
               W  F         P     CP+T  LL +L +         A  + L+P + +  H 
Sbjct  199  SGEWFTFDFVSQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHY  258

Query  158  DPYAGSLRYHLGLITPNDDRCFIDVDGQRYSWRDGESVVFDETYIHYA---ENTTDQNRI  214
             P    +R HLGL TPN   C + V G+   W +G  ++FD++++H A    +  D  R+
Sbjct  259  GPTNIRIRCHLGLKTPNG--CELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGSAEDGPRV  316

Query  215  IFFADVERP  223
            +F  D+  P
Sbjct  317  VFMVDLWHP  325



Lambda      K        H        a         alpha
   0.328    0.142    0.450    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 799100


  Database: 24ca4e99537bdf75082c8d690008ebeb.SwissProt.fasta
    Posted date:  Jun 1, 2024  5:28 AM
  Number of letters in database: 3,308
  Number of sequences in database:  6



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40