BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: a5ffe5074a63b58ed68ad8737ae63636.SwissProt.fasta
16 sequences; 6,695 total letters
Query= ACIAD0432
Length=386
Score E
Sequences producing significant alignments: (Bits) Value
P43899 Heme chaperone HemW [Haemophilus influenzae (strain ATCC 5... 360 3e-126
P52062 Heme chaperone HemW [Escherichia coli (strain K12)] 348 8e-122
Q8K928 Heme chaperone HemW [Buchnera aphidicola subsp. Schizaphis... 280 4e-95
P57615 Heme chaperone HemW [Buchnera aphidicola subsp. Acyrthosip... 276 2e-93
Q89A47 Putative heme chaperone HemW-like protein [Buchnera aphidi... 204 1e-65
P54304 Heme chaperone HemW [Bacillus subtilis (strain 168)] 186 1e-58
A5D7B1 Radical S-adenosyl methionine domain-containing protein 1,... 185 2e-57
Q9CGF7 Heme chaperone HemW [Lactococcus lactis subsp. lactis (str... 179 8e-56
Q9HA92 Radical S-adenosyl methionine domain-containing protein 1,... 180 9e-56
Q5SUV1 Radical S-adenosyl methionine domain-containing protein 1,... 179 2e-55
P73245 Heme chaperone HemW [Synechocystis sp. (strain PCC 6803 / ... 153 7e-46
A0A384LP51 Anaerobilin synthase [Escherichia coli O157:H7] 110 7e-30
P0A1E1 Oxygen-independent coproporphyrinogen III oxidase [Salmone... 104 6e-28
P32131 Oxygen-independent coproporphyrinogen III oxidase [Escheri... 101 7e-27
P33770 Coproporphyrinogen III oxidase, anaerobic 1 [Cereibacter s... 95.1 1e-24
Q796V8 Oxygen-independent coproporphyrinogen-III oxidase-like pro... 94.4 3e-24
>P43899 Heme chaperone HemW [Haemophilus influenzae (strain ATCC
51907 / DSM 11121 / KW20 / Rd)]
Length=383
Score = 360 bits (924), Expect = 3e-126
Identities = 191/378 (51%), Positives = 245/378 (65%), Gaps = 6/378 (2%)
Query 11 PLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHS 70
PLSLYIH+PWCV+KCPYCDFNSHA + + LQ L AD + +Q RK+HS
Sbjct 6 PLSLYIHIPWCVQKCPYCDFNSHAQKSDIPEQDYIYHLLQDLQADLQRFKDSIQQRKLHS 65
Query 71 VFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRL 130
+FIGGGTPSL SA+ +L ++I+ +DFE + EITLEANPGTVE + F Y+ AGI R+
Sbjct 66 IFIGGGTPSLFSAESIAYLLKEIKKQIDFEDNIEITLEANPGTVEAERFKGYVSAGIMRI 125
Query 131 SLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLK 190
S+G+QSF+ D L+RLGRIH++ A A+ LAK +G + N DLMHGL QTLE+AL DL+
Sbjct 126 SMGIQSFNDDKLQRLGRIHNAAEAKSAVNLAKVSGLKSFNLDLMHGLPNQTLEEALDDLR 185
Query 191 LAVDNGATHISWYQLTIEPNTVFFRTQPVLPQDEILEQIQRQGEQYLKAQGFSNYEVSAW 250
A++ HISWYQLTIEPNT+F P LP D+ L I QG Q L G+ YE SA+
Sbjct 186 QAIELSPPHISWYQLTIEPNTMFAYRPPKLPDDDALWDIFEQGHQLLTMAGYQQYETSAY 245
Query 251 RKEK-PSAHNLNYWQFGDYLAIGAGAHGKVTQPDG-VYRFQKTRLPKDYLAKVPAEHV-Q 307
K HNLNYW+FGDYLAIG GAHGK+T P G + RF KT+ PK YL E++ +
Sbjct 246 AKAGFQCKHNLNYWRFGDYLAIGCGAHGKLTFPTGEITRFSKTKHPKGYLR---GEYLYE 302
Query 308 WKRIEADELPFEFMMNALRLNEGVATNLYEQRTGLSLVDIEPALNALRQKKLLVNDPERI 367
K + + PFEF MN RL E V +E TGLS ++ ++ Q+ +V + +
Sbjct 303 EKNVPKIDRPFEFFMNRFRLLEAVPKQEFEDYTGLSQSAVKNQIDFAIQQNYIVENADSW 362
Query 368 ACTEQGHLFLNSVLEEFL 385
TE G LFLN +LE FL
Sbjct 363 QITEHGKLFLNELLELFL 380
>P52062 Heme chaperone HemW [Escherichia coli (strain K12)]
Length=378
Score = 348 bits (894), Expect = 8e-122
Identities = 187/378 (49%), Positives = 237/378 (63%), Gaps = 10/378 (3%)
Query 11 PLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHS 70
PLSLYIH+PWCV+KCPYCDFNSHA+ Y+Q L+ D + V + QGR++ +
Sbjct 6 PLSLYIHIPWCVQKCPYCDFNSHALKGEVP----HDDYVQHLLNDLDNDVAYAQGREVKT 61
Query 71 VFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRL 130
+FIGGGTPSL+S Q L + +RA + D EIT+EANPGTVE D F DY AG+NR+
Sbjct 62 IFIGGGTPSLLSGPAMQTLLDGVRARLPLAADAEITMEANPGTVEADRFVDYQRAGVNRI 121
Query 131 SLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLK 190
S+GVQSF ++ L+RLGRIH + A A KLA G N DLMHGL Q+LE+AL DL+
Sbjct 122 SIGVQSFSEEKLKRLGRIHGPQEAKRAAKLASGLGLRSFNLDLMHGLPDQSLEEALGDLR 181
Query 191 LAVDNGATHISWYQLTIEPNTVFFRTQPVLPQDEILEQIQRQGEQYLKAQGFSNYEVSAW 250
A++ H+SWYQLTIEPNT+F PVLP D+ L I QG Q L A G+ YE SA+
Sbjct 182 QAIELNPPHLSWYQLTIEPNTLFGSRPPVLPDDDALWDIFEQGHQLLTAAGYQQYETSAY 241
Query 251 RKE-KPSAHNLNYWQFGDYLAIGAGAHGKVTQPDG-VYRFQKTRLPKDYLAKVPAEHVQW 308
K HNLNYW+FGDY+ IG GAHGKVT PDG + R KTR P+ ++ +++
Sbjct 242 AKPGYQCQHNLNYWRFGDYIGIGCGAHGKVTFPDGRILRTTKTRHPRGFM---QGRYLES 298
Query 309 KR-IEADELPFEFMMNALRLNEGVATNLYEQRTGLSLVDIEPALNALRQKKLLVNDPERI 367
+R +EA + PFEF MN RL E + TGL I P L+ + L +
Sbjct 299 QRDVEATDKPFEFFMNRFRLLEAAPRVEFIAYTGLCEDVIRPQLDEAIAQGYLTECADYW 358
Query 368 ACTEQGHLFLNSVLEEFL 385
TE G LFLNS+LE FL
Sbjct 359 QITEHGKLFLNSLLELFL 376
>Q8K928 Heme chaperone HemW [Buchnera aphidicola subsp. Schizaphis
graminum (strain Sg)]
Length=376
Score = 280 bits (717), Expect = 4e-95
Identities = 147/377 (39%), Positives = 233/377 (62%), Gaps = 9/377 (2%)
Query 11 PLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHS 70
P+SLYIH+PWC++KC YCDF S+ S E++Y+ L+ D E + ++ R+I+S
Sbjct 6 PISLYIHIPWCIKKCGYCDFYSYVNK----SFIPEKEYIDHLLKDLEKDLSLIKEREINS 61
Query 71 VFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRL 130
+FIGGGTPSL+ + + + +I+ ++ EIT+EANP T+E+ F +Y ++GINR
Sbjct 62 IFIGGGTPSLLKSSSIKKMMREIKKRINISNTAEITIEANPTTLEYKRFFNYKKSGINRF 121
Query 131 SLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLK 190
S+GVQ+F+ D L+++ R ++ AI A++ K+ + N D+M+GL Q+L+ LLDL+
Sbjct 122 SIGVQTFNSDLLKKIERTYNKREAILAVEEIKKIN-KNFNLDIMYGLPNQSLKDVLLDLQ 180
Query 191 LAVDNGATHISWYQLTIEPNTVFFRTQPVLPQDEILEQIQRQGEQYLKAQGFSNYEVSAW 250
AV THISWYQLT+EPNT F+ + LP + + ++ +GE++LK G+ YE+S++
Sbjct 181 YAVKYNPTHISWYQLTLEPNTPFYVKKLNLPNENNIFKMLVEGEKFLKQSGYKKYEISSY 240
Query 251 RK-EKPSAHNLNYWQFGDYLAIGAGAHGKVTQPDG-VYRFQKTRLPKDYLAKVPAEHVQW 308
K HNLNYW FGDY+ IG AHGK+TQ +G + R K + D++ +H +
Sbjct 241 AKLNYECQHNLNYWNFGDYIGIGCSAHGKITQINGDIIRTIKNKNINDFMNGKYLKHKNF 300
Query 309 KRIEADELPFEFMMNALRLNEGVATNLYEQRTGLSLVDIEPALNALRQKKLLVNDPERIA 368
+ + PFE+ MN RL + V +E+RT ++ I+ + +K L N +
Sbjct 301 --VLKKDKPFEYFMNIFRLYKPVLKRQFEERTNINQNYIKEKIKKAIEKGYLKNKIDFWD 358
Query 369 CTEQGHLFLNSVLEEFL 385
T++G +FLNS+L+ FL
Sbjct 359 TTKKGKMFLNSLLKIFL 375
>P57615 Heme chaperone HemW [Buchnera aphidicola subsp. Acyrthosiphon
pisum (strain APS)]
Length=376
Score = 276 bits (705), Expect = 2e-93
Identities = 145/377 (38%), Positives = 230/377 (61%), Gaps = 9/377 (2%)
Query 11 PLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHS 70
P+SLYIH+PWC++KC YCDF S+ + + E +Y++ L+ DFE + + R I++
Sbjct 6 PISLYIHIPWCLKKCGYCDFYSYV----SKEIIPENKYIEHLLRDFERDLSLINNRNINT 61
Query 71 VFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRL 130
+FIGGGTPSL+ + L I+ ++ EI++EANP T+E+ F Y +GINR
Sbjct 62 IFIGGGTPSLLKNTSIKNLLNGIKKRKIISKNIEISIEANPKTLEYQNFIQYKNSGINRF 121
Query 131 SLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLK 190
SLG+Q+F+ L+++ R ++S++A+ AI +K+ + +N DLM+GL Q+LE+AL DL+
Sbjct 122 SLGIQTFNSKMLKKIERTYNSKDAMNAIIESKKIS-DNINLDLMYGLPGQSLEEALSDLQ 180
Query 191 LAVDNGATHISWYQLTIEPNTVFFRTQPVLPQDEILEQIQRQGEQYLKAQGFSNYEVSAW 250
+A+ +HISWYQLTIEPNTVF+ + P +++ + +G++ LK G+ YE+S++
Sbjct 181 IAIQCNPSHISWYQLTIEPNTVFYAKKIQTPHQDVVFNMLIEGDKLLKKAGYKKYEISSY 240
Query 251 RK-EKPSAHNLNYWQFGDYLAIGAGAHGKVTQPDG-VYRFQKTRLPKDYLAKVPAEHVQW 308
K HNLNYW FGDY+ IG G+HGK+TQ +G + R K + D+L+ V
Sbjct 241 SKFNYQCQHNLNYWNFGDYIGIGCGSHGKITQKNGEIIRTIKNKNINDFLSGKYINSVY- 299
Query 309 KRIEADELPFEFMMNALRLNEGVATNLYEQRTGLSLVDIEPALNALRQKKLLVNDPERIA 368
++ + FE+ MN RL + + + + T + IE + Q+ L+N +
Sbjct 300 -QVSKRDKIFEYFMNVFRLYKPIFKKHFRENTNIEESFIEKNIQIAIQEGFLINQSDCWH 358
Query 369 CTEQGHLFLNSVLEEFL 385
T++G FLNS+LE FL
Sbjct 359 TTKKGKNFLNSLLEIFL 375
>Q89A47 Putative heme chaperone HemW-like protein [Buchnera aphidicola
subsp. Baizongia pistaciae (strain Bp)]
Length=374
Score = 204 bits (519), Expect = 1e-65
Identities = 126/377 (33%), Positives = 199/377 (53%), Gaps = 10/377 (3%)
Query 12 LSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHSV 71
L LYI++PW ++ Y DF P + E++Y+ L+ D + V R I+++
Sbjct 4 LGLYINIPWPTKRYKYHDFK---FPEYKKKIN-EKKYIHHLLQDLKKDSLLVPNRTINTI 59
Query 72 FIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRLS 131
FIGG P+ ++L +KI+ ++ ++ E T+E + + Y + GINR S
Sbjct 60 FIGGIAPNFFKLTSIKYLLKKIKNIIPISKNAENTIEFHISKLSEKKIFYYKKFGINRFS 119
Query 132 LGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLKL 191
+ +Q+FDQ L ++H S+N + IK F+ +N DL++GL +Q+L++ALLDLK
Sbjct 120 IRIQTFDQKKFNSLSKVHISKNILHKIKKINIEKFKNINLDLIYGLPKQSLQEALLDLKT 179
Query 192 AVDNGATHISWYQLTIEPNTVFFRTQPVLPQDEILEQIQRQGEQYLKAQGFSNYEVSAWR 251
A+ HISW + IE N ++ I+ +I QGE+ LK G+ YE+S++
Sbjct 180 AISLKPNHISWCEFYIEKNNNNYKNLSKSCNLNIIWKIFLQGEKLLKKSGYKKYEISSYS 239
Query 252 KEK-PSAHNLNYWQFGDYLAIGAGAHGKVTQPDGVYRFQKTRLPKDYLAKVPAEHVQWKR 310
K HNLNYW+FGDYL IG AHGK+TQ +G + KT K+ L K +K
Sbjct 240 KTNYQCLHNLNYWKFGDYLGIGCNAHGKITQKNG--KIIKTIKNKN-LKKFMNGKYTYKN 296
Query 311 --IEADELPFEFMMNALRLNEGVATNLYEQRTGLSLVDIEPALNALRQKKLLVNDPERIA 368
I L EF MN LRLN + +++ T +S I+ + ++ L+ +
Sbjct 297 HIISKKNLSLEFFMNRLRLNTPIYRKDFKKYTYISEFYIKNEIKQAIEQNYLIETKKYWK 356
Query 369 CTEQGHLFLNSVLEEFL 385
T +G FL+S+LE F+
Sbjct 357 MTSKGIQFLDSLLEIFI 373
>P54304 Heme chaperone HemW [Bacillus subtilis (strain 168)]
Length=379
Score = 186 bits (472), Expect = 1e-58
Identities = 122/383 (32%), Positives = 186/383 (49%), Gaps = 19/383 (5%)
Query 13 SLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHSVF 72
S YIH+P+C C YCDFN + + + + +YL AL + + + ++F
Sbjct 3 SAYIHIPFCEHICHYCDFNKYFIQSQPVD-----EYLNALEQEMINTIAKTGQPDLKTIF 57
Query 73 IGGGTPSLISAQGYQWLFEKIRALVDFEQDC-EITLEANPGTVEHDPFADYLEAGINRLS 131
IGGGTP+ +S + + L + I ++ D E +EANP + + EAG+NRLS
Sbjct 58 IGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSAEKLKILKEAGVNRLS 117
Query 132 LGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLKL 191
GVQ+F+ D LE++GR+H ++ + + A++ GFE ++ DLM GL QTL+ +
Sbjct 118 FGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLMFGLPGQTLKHLEHSINT 177
Query 192 AVDNGATHISWYQLTIEPNTVFFRTQPV----LPQDEILEQIQRQGEQYLKAQGFSNYEV 247
A+ A H S Y L +EP TVF+ LP E ++ ++A G YE+
Sbjct 178 ALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAEMYEIVMSKMEAHGIHQYEI 237
Query 248 SAWRKE-KPSAHNLNYWQFGDYLAIGAGAHGKVTQPDGVYRFQKTRLPKDYLAKVPAEHV 306
S + K S HNL YW Y GAGAHG + G R K Y+ + +
Sbjct 238 SNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYI----GGTRTVNVGPVKHYIDLIAEKGF 293
Query 307 QWK---RIEADELPFEFMMNALRLNEGVATNLYEQRTGLSLVDIEPA-LNALRQKKLLVN 362
++ + +E E M LR GV+ + ++ G SL + P+ L L +K L+ N
Sbjct 294 PYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSLDGLFPSVLKDLAEKGLIHN 353
Query 363 DPERIACTEQGHLFLNSVLEEFL 385
+ T QG L N V FL
Sbjct 354 SESAVYLTHQGKLLGNEVFGAFL 376
>A5D7B1 Radical S-adenosyl methionine domain-containing protein
1, mitochondrial [Bos taurus]
Length=442
Score = 185 bits (469), Expect = 2e-57
Identities = 130/395 (33%), Positives = 203/395 (51%), Gaps = 21/395 (5%)
Query 7 PAEIPLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGR 66
P +LY+H P+C ++C YC+FN + +P G L + LV + +T ++ R
Sbjct 35 PGSQRAALYVHWPYCEKRCSYCNFNKY-IPRGVDEAALRR----CLVIEAQTLLRLSGVR 89
Query 67 KIHSVFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAG 126
++ SVF GGGTPSL S + E + D E+TLEANP + A + AG
Sbjct 90 RVESVFFGGGTPSLASPHTVAAVLEAVAQAAHLPADSEVTLEANPTSASGSRLAAFGAAG 149
Query 127 INRLSLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQAL 186
+NRLS+G+QS D L+ LGR HS+ +A++ + A++ RV+ DLM GL Q + L
Sbjct 150 VNRLSIGLQSLDDTELQLLGRTHSARDALQTLAEAQRLFPGRVSVDLMLGLPAQQVGPWL 209
Query 187 LDLKLAVDNGATHISWYQLTIEPNTVFFR--TQPVL--PQDEILEQIQRQGEQYLKAQGF 242
L+ + H+S YQL++E T F Q L P E+ ++ ++G L+ GF
Sbjct 210 RQLQGLLRCCDDHVSLYQLSLERGTTLFTQVQQGALPAPDPELAAEMYQEGRAVLREAGF 269
Query 243 SNYEVSAW-RKEKPSAHNLNYWQFGDYLAIGAGAHGK-VTQPDGVYRFQ---KTRLPKDY 297
YEVS + R S HN YWQ G YL +G GAHG+ + Q G + + +T P +
Sbjct 270 RQYEVSNFARNGALSTHNWTYWQCGQYLGVGPGAHGRFIPQGAGGHTREARIQTLEPDSW 329
Query 298 LAKVPA-EHVQWKRIEADELPF--EFMMNALRLNEGVATNLYEQ-RTGLSLVDIEPA--- 350
+ +V H +R+ EL E + LR + G+ ++Q L+L D+ A
Sbjct 330 MKEVMLFGHGTRRRVPLSELELLEEVLAMGLRTDVGITHQHWQQFEPQLTLWDLFGASKE 389
Query 351 LNALRQKKLLVNDPERIACTEQGHLFLNSVLEEFL 385
+ L+++ LL+ D + C+ +G L+S+L L
Sbjct 390 VKELQEQGLLLLDHRGLRCSWEGLAVLDSLLLSLL 424
Score = 21.9 bits (45), Expect = 0.47
Identities = 23/98 (23%), Positives = 40/98 (41%), Gaps = 22/98 (22%)
Query 177 LSQQTLEQALLDLKLAVDNGATHISWYQLTIEPNTVFFRTQPVLPQDEILEQIQRQGEQY 236
LS+ L + +L + L D G TH W Q EP + + + ++++Q QG
Sbjct 346 LSELELLEEVLAMGLRTDVGITHQHWQQF--EPQLTLW---DLFGASKEVKELQEQGLLL 400
Query 237 LKAQGFS-NYE----------------VSAWRKEKPSA 257
L +G ++E AW++ PS+
Sbjct 401 LDHRGLRCSWEGLAVLDSLLLSLLSRLQEAWQQRTPSS 438
>Q9CGF7 Heme chaperone HemW [Lactococcus lactis subsp. lactis
(strain IL1403)]
Length=379
Score = 179 bits (453), Expect = 8e-56
Identities = 121/386 (31%), Positives = 195/386 (51%), Gaps = 28/386 (7%)
Query 11 PLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHS 70
P S Y H+P+C C YCDF + + Y+++L+ +F++ + K+ +
Sbjct 5 PNSAYFHIPFCSHICYYCDFAKVLMTGQPIDA-----YIESLIEEFQS----FEIEKLRT 55
Query 71 VFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRL 130
++IGGGTPS++SAQ + L I +D E E T+EANPG + + ++ +NR+
Sbjct 56 IYIGGGTPSVLSAQQLERLLTAIAEQLDLEVLEEFTVEANPGDLSDEVIKVLADSAVNRI 115
Query 131 SLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLK 190
SLGVQ+F+ L+++GR H+ ++++ K+AGFE + DL++ L QT+E D++
Sbjct 116 SLGVQTFNNALLKKIGRTHTEVQVYDSVERLKKAGFENITIDLIYALPGQTMEMVKSDVE 175
Query 191 LAVDNGATHISWYQLTIEPNTVFFRTQP----VLPQDEILEQIQRQGEQYLKAQGFSNYE 246
++ H++ Y L +E +TVF Q LP ++ + L G+++YE
Sbjct 176 KFLELKLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAKNGYNHYE 235
Query 247 VSAWRKEK-PSAHNLNYWQFGDYLAIGAGAHGKVTQPDGVYRFQKTRLPKDYLAKVPAEH 305
VS + S HN+ YW +Y IGAGA G + G+ R++ YL P E
Sbjct 236 VSNFGLPGFESKHNITYWDNEEYYGIGAGASGYLA---GI-RYKNLGPVHHYLKAAPTE- 290
Query 306 VQWKRIEADELP-----FEFMMNALRLNEGVATNLYEQRTGLSLVDI-EPALNALRQKKL 359
KRI + L E M LR GV +E + S + + L +KL
Sbjct 291 ---KRINEEVLSKKSQIEEEMFLGLRKKSGVLVEKFENKFKCSFEKLYGEQITELINQKL 347
Query 360 LVNDPERIACTEQGHLFLNSVLEEFL 385
L ND +RI T++G N+V E+FL
Sbjct 348 LYNDRQRIHMTDKGFELGNNVFEKFL 373
>Q9HA92 Radical S-adenosyl methionine domain-containing protein
1, mitochondrial [Homo sapiens]
Length=442
Score = 180 bits (457), Expect = 9e-56
Identities = 127/392 (32%), Positives = 199/392 (51%), Gaps = 23/392 (6%)
Query 7 PAEIPLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQ-ALVADFETQVKFVQG 65
PA +LY+H P+C ++C YC+FN + + LE+ +Q LV + +T ++
Sbjct 35 PAGRRAALYVHWPYCEKRCSYCNFNKY------IPRRLEEAAMQKCLVTEAQTLLRLSGV 88
Query 66 RKIHSVFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEA 125
+++ SVF GGGTPSL S + E + D E+TLEANP + A++ A
Sbjct 89 QRVESVFFGGGTPSLASPHTVAAVLEAVAQAAHLPADLEVTLEANPTSAPGSRLAEFGAA 148
Query 126 GINRLSLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQA 185
G+NRLS+G+QS D L LGR HS+ +A+ + A++ RV+ DLM GL Q +
Sbjct 149 GVNRLSIGLQSLDDTELRLLGRTHSACDALRTLAEARRLFPGRVSVDLMLGLPAQQVGPW 208
Query 186 LLDLKLAVDNGATHISWYQLTIEPNTVFF----RTQPVLPQDEILEQIQRQGEQYLKAQG 241
L L+ + + H+S YQL++E T F R P E+ ++ ++G L+ G
Sbjct 209 LGQLQELLHHCDDHLSLYQLSLERGTALFAQVQRGALPAPDPELAAEMYQRGRAVLREAG 268
Query 242 FSNYEVSAW-RKEKPSAHNLNYWQFGDYLAIGAGAHGKVTQPDGVYRFQKTRL----PKD 296
F YEVS + R S HN YWQ G YL +G GAHG+ ++ R+ P +
Sbjct 269 FHQYEVSNFARNGALSTHNWTYWQCGQYLGVGPGAHGRFMPQGAGGHTREARIQTLEPDN 328
Query 297 YLAKVPA-EHVQWKRIEAD--ELPFEFMMNALRLNEGVATNLYEQ-RTGLSLVDIEPA-- 350
++ +V H KR+ EL E + LR + G+ ++Q L+L D+ A
Sbjct 329 WMKEVMLFGHGTRKRVPLGRLELLEEVLALGLRTDVGITHQHWQQFEPQLTLWDVFGANK 388
Query 351 -LNALRQKKLLVNDPERIACTEQGHLFLNSVL 381
+ L ++ LL D + C+ +G L+S+L
Sbjct 389 EVQELLERGLLQLDHRGLRCSWEGLAVLDSLL 420
>Q5SUV1 Radical S-adenosyl methionine domain-containing protein
1, mitochondrial [Mus musculus]
Length=442
Score = 179 bits (455), Expect = 2e-55
Identities = 133/386 (34%), Positives = 199/386 (52%), Gaps = 23/386 (6%)
Query 13 SLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKIHSVF 72
+LY+H P+C ++C YC+FN + +P G E LV + T ++ +++ SVF
Sbjct 41 ALYVHWPYCEKRCSYCNFNKY-IPRGVE----EGTVRNCLVTEARTLLRLSGVQRVESVF 95
Query 73 IGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRLSL 132
GGGTPSL S + E + V D E+TLEANP + A + AG+NRLS+
Sbjct 96 FGGGTPSLASPHTVAAVLEAVAQEVYLPADSEVTLEANPTSAPGPRLAAFGAAGVNRLSI 155
Query 133 GVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLKLA 192
G+QS D L+ LGR HS+ +A+ + A+ RV+ DLM GL Q +E L L+
Sbjct 156 GLQSLDDAELQLLGRTHSASDALRTLAEARLLFPGRVSVDLMLGLPAQKVEPWLQQLQKL 215
Query 193 VDNGATHISWYQLTIEPNTVFFR-----TQPVLPQDEILEQIQRQGEQYLKAQGFSNYEV 247
+ + H+S YQLT+E T F T P P ++ ++ ++G L+ GF YEV
Sbjct 216 LYHCDDHLSLYQLTLERGTSLFAQVQQGTLPA-PDPDLAAEMYQEGRTVLRDAGFRQYEV 274
Query 248 SAW-RKEKPSAHNLNYWQFGDYLAIGAGAHGK-VTQPDGVYRFQ---KTRLPKDYLAKVP 302
S + R S HN YWQ G YL IG GAHG+ V Q G + + +T P +++ +V
Sbjct 275 SNFARNGALSTHNWTYWQCGQYLGIGPGAHGRFVPQGTGGHTREARIQTLEPDNWMKEVT 334
Query 303 A-EHVQWK--RIEADELPFEFMMNALRLNEGVATNLYEQ-RTGLSLVDIEPA---LNALR 355
H K R+ EL E + LR + GV ++Q L+L D+ A + L
Sbjct 335 LFGHGTRKCVRLGKLELLEEVLAMGLRTDVGVTHQHWQQFEPQLTLWDVFGASKEVEELL 394
Query 356 QKKLLVNDPERIACTEQGHLFLNSVL 381
+ LL+ D + C+ +G L+S+L
Sbjct 395 AQGLLLLDYRGLRCSWEGLAVLDSLL 420
>P73245 Heme chaperone HemW [Synechocystis sp. (strain PCC 6803
/ Kazusa)]
Length=412
Score = 153 bits (387), Expect = 7e-46
Identities = 107/336 (32%), Positives = 163/336 (49%), Gaps = 23/336 (7%)
Query 10 IPLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLE-LEQQYLQALVADFETQVKFVQGRKI 68
+P + YIH+P+C ++C YCDF +L+L+ +Y++A+ + Q QG+ +
Sbjct 8 MPTAAYIHIPFCRQRCFYCDFPIAVTGFQSLTLDGWVGEYVEAVCREIAGQQH--QGQPL 65
Query 69 HSVFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGIN 128
+VF GGGTPSL+ G + + + + D EI++E +PGT + Y GIN
Sbjct 66 QTVFFGGGTPSLLPITGLEKILLAVDQYLGIAPDAEISIEIDPGTFDQVQLQGYKNLGIN 125
Query 129 RLSLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLD 188
R SLGVQ+F + L GR H + +A+ + E + DL+ GL +QT
Sbjct 126 RFSLGVQAFQDNLLALCGRHHRRRDIDQALTAIAKENIENWSLDLITGLPEQTAADWHSS 185
Query 189 LKLAVDNGATHISWYQLTIEPNTVF----FRTQPVLPQDEILEQIQRQGEQYLKAQGFSN 244
L LA+ G HIS Y L +EP TVF R + +P E R G++ L GF +
Sbjct 186 LTLALAAGPKHISCYDLVLEPQTVFDKWEQRGKLAVPPPERSADFYRHGQEVLTQAGFHH 245
Query 245 YEVSAW-RKEKPSAHNLNYWQFGDYLAIGAGA--------HGKVTQPDGVYRFQKTRLPK 295
YE+S + R HN YW+ Y +G GA G+ +G Y++ ++ L +
Sbjct 246 YEISNYGRPGHQCRHNQIYWRNLPYYGLGMGATSYIDGKRFGRPRTRNGYYQWLESWLNQ 305
Query 296 DYLAKVPAEHVQWKRIEADELPFEFMMNALRLNEGV 331
+P E R+ E E +M LRL GV
Sbjct 306 G--CPIPGE-----RVSPLENLLESLMLGLRLTAGV 334
>A0A384LP51 Anaerobilin synthase [Escherichia coli O157:H7]
Length=445
Score = 110 bits (274), Expect = 7e-30
Identities = 76/274 (28%), Positives = 123/274 (45%), Gaps = 13/274 (5%)
Query 14 LYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFV--QGRKIHSV 71
+Y+H+P+C C +C F + A + Y AL+ + E + V Q IH+V
Sbjct 60 VYLHIPFCATHCTFCGFYQNRFNEDACA-----HYTDALIREIEMEADSVLHQSAPIHAV 114
Query 72 FIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGINRLS 131
+ GGGTPS +SA + +R + DCEIT+E + + L+AG NR S
Sbjct 115 YFGGGTPSALSAHDLARIITTLREKLPLAPDCEITIEGRVLNFDAERIDACLDAGANRFS 174
Query 132 LGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLKL 191
+G+QSF+ +++ R AI ++ + V DL+ GL Q + DL +
Sbjct 175 IGIQSFNSKIRKKMARTSDGPTAIAFMESLVKRDRAAVVCDLLFGLPGQDAQTWGEDLAI 234
Query 192 AVDNGATHISWYQLTIEPNTVFFRT----QPVLPQDEILEQIQRQGEQYLKAQGFSNYEV 247
A D G + Y L + NT + + +P + QG ++ G+
Sbjct 235 ARDIGLDGVDLYALNVLSNTPLGKAVENGRTTVPSPAERRDLYLQGCDFMDDAGWRCISN 294
Query 248 SAWRK--EKPSAHNLNYWQFGDYLAIGAGAHGKV 279
S W + + + +NL Q D LA G+GA G +
Sbjct 295 SHWGRTTRERNLYNLLIKQGADCLAFGSGAGGSI 328
>P0A1E1 Oxygen-independent coproporphyrinogen III oxidase [Salmonella
typhimurium (strain LT2 / SGSC1412 / ATCC 700720)]
Length=457
Score = 104 bits (260), Expect = 6e-28
Identities = 98/393 (25%), Positives = 162/393 (41%), Gaps = 27/393 (7%)
Query 9 EIPLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKI 68
E PLSLY+H+P+C + C +C N + QYL AL + + R +
Sbjct 50 ERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKA----DQYLDALEQEIRHRAPLFADRHV 105
Query 69 HSVFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGIN 128
+ GGGTP+ ++ L +R F D EI++E +P +E D G N
Sbjct 106 SQLHWGGGTPTYLNKAQISRLMTLLRENFHFNTDAEISIEVDPREIELDVLDHLRAEGFN 165
Query 129 RLSLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLD 188
RLS+GVQ F+++ + R E + A+ GF N DL++GL +QT E
Sbjct 166 RLSMGVQDFNKEVQRLVNREQDEEFIFALLNHARDIGFTSTNIDLIYGLPKQTPESFAFT 225
Query 189 LKLAVDNGATHISWYQLTIEPNTVFFRTQPVLPQD------------EILEQIQRQGEQY 236
LK + +S + P T+F + + D E + + + G Q+
Sbjct 226 LKRVTELNPDRLSVFNYAHLP-TLFAAQRKIKDADLPSAQQKLDILQETIVSLTQAGYQF 284
Query 237 LKAQGFS--NYEVSAWRKEKPSAHNL-NYWQFGDYLAIGAGAHGKVTQPDGVYRFQKTRL 293
+ F+ + E++ ++E N Y GD +G G DG + QK L
Sbjct 285 IGMDHFARPDDELAVAQREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDGYMQNQK-EL 343
Query 294 PKDYLAKVPAEHVQWKRI--EADELPFEFMMNALRLNEGVATNLYEQRTGLSLVDI---- 347
+ Y + W+ I D+ ++ AL N + N EQ+ GL +
Sbjct 344 KRYYQQVDERGNALWRGITLTRDDCIRRDVIKALICNFRLDFNAVEQQWGLHFAEYFAED 403
Query 348 EPALNALRQKKLLVNDPERIACTEQGHLFLNSV 380
L+ L + L+ + I T +G L + ++
Sbjct 404 LQLLSPLAKDGLVDISEKGIQVTAKGRLLIRNI 436
Score = 18.1 bits (35), Expect = 7.6
Identities = 6/15 (40%), Positives = 9/15 (60%), Gaps = 0/15 (0%)
Query 5 LNPAEIPLSLYIHMP 19
LNP + + Y H+P
Sbjct 232 LNPDRLSVFNYAHLP 246
>P32131 Oxygen-independent coproporphyrinogen III oxidase [Escherichia
coli (strain K12)]
Length=457
Score = 101 bits (252), Expect = 7e-27
Identities = 63/215 (29%), Positives = 99/215 (46%), Gaps = 5/215 (2%)
Query 9 EIPLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQGRKI 68
E PLSLY+H+P+C + C +C N + QYL AL + + GR +
Sbjct 50 ERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKA----DQYLDALEQEIVHRAPLFAGRHV 105
Query 69 HSVFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYLEAGIN 128
+ GGGTP+ ++ L + +R F D EI++E +P +E D G N
Sbjct 106 SQLHWGGGTPTYLNKAQISRLMKLLRENFQFNADAEISIEVDPREIELDVLDHLRAEGFN 165
Query 129 RLSLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLD 188
RLS+GVQ F+++ + R E + A++ GF N DL++GL +QT E
Sbjct 166 RLSMGVQDFNKEVQRLVNREQDEEFIFALLNHAREIGFTSTNIDLIYGLPKQTPESFAFT 225
Query 189 LKLAVDNGATHISWYQLTIEPNTVFFRTQPVLPQD 223
LK + +S + P T+F + + D
Sbjct 226 LKRVAELNPDRLSVFNYAHLP-TIFAAQRKIKDAD 259
Score = 18.1 bits (35), Expect = 7.6
Identities = 6/15 (40%), Positives = 9/15 (60%), Gaps = 0/15 (0%)
Query 5 LNPAEIPLSLYIHMP 19
LNP + + Y H+P
Sbjct 232 LNPDRLSVFNYAHLP 246
>P33770 Coproporphyrinogen III oxidase, anaerobic 1 [Cereibacter
sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)]
Length=452
Score = 95.1 bits (235), Expect = 1e-24
Identities = 62/207 (30%), Positives = 105/207 (51%), Gaps = 14/207 (7%)
Query 5 LNPAEIPLSLYIHMPWCVRKCPYCDFNSHAVPNGALSLELEQQYLQALVADFETQVKFVQ 64
L+PA +P+S+Y+H+P+C R C +C + G +L + Y+ L+ + E + +
Sbjct 45 LDPA-VPISVYVHVPFCERLCWFCACRTQ----GTQTLAPVEAYVGTLLQELELVKQHLP 99
Query 65 -GRKIHSVFIGGGTPSLISAQGYQWLFEKIRALVDFEQDCEITLEANPGTVEHDPFADYL 123
G K + GGGTP+++S + L + I+A++ F +D E ++E +P V+
Sbjct 100 AGVKAGRLHWGGGTPTILSPELIHKLAQAIKAVIPFAEDYEFSVEIDPMMVDEPKIRALS 159
Query 124 EAGINRLSLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLE 183
E G+NR S+G+Q F +GR EN ++ ++ G +N DL++GL Q E
Sbjct 160 EEGMNRASIGIQDFTDIVQNAIGREQPFENTKACVETLRRYGVHSLNTDLVYGLPHQNRE 219
Query 184 Q--ALLD--LKLAVDN----GATHISW 202
A +D L L D G H+ W
Sbjct 220 SLAATIDKVLSLRPDRVAIFGYAHVPW 246
Score = 21.9 bits (45), Expect = 0.48
Identities = 13/58 (22%), Positives = 24/58 (41%), Gaps = 3/58 (5%)
Query 134 VQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTLEQALLDLKL 191
+ F+Q +L+ + +IE +L G D +HG + +E + D L
Sbjct 328 ISKFEQGYLQNTAATAAYIKSIEEGRLPGYRGHRMTEEDYLHG---RAIEMIMCDFFL 382
Score = 21.2 bits (43), Expect = 0.83
Identities = 6/20 (30%), Positives = 11/20 (55%), Gaps = 0/20 (0%)
Query 5 LNPAEIPLSLYIHMPWCVRK 24
L P + + Y H+PW ++
Sbjct 231 LRPDRVAIFGYAHVPWMAKR 250
Score = 20.0 bits (40), Expect = 1.9
Identities = 10/25 (40%), Positives = 13/25 (52%), Gaps = 0/25 (0%)
Query 148 IHSSENAIEAIKLAKQAGFERVNAD 172
I E A A +L + GFER+ D
Sbjct 263 IERHELANLAARLFTEGGFERIGID 287
>Q796V8 Oxygen-independent coproporphyrinogen-III oxidase-like
protein HemZ [Bacillus subtilis (strain 168)]
Length=501
Score = 94.4 bits (233), Expect = 3e-24
Identities = 86/337 (26%), Positives = 151/337 (45%), Gaps = 41/337 (12%)
Query 12 LSLYIHMPWCVRKCPYCDFNSHAVPNGA-------LSLELEQQYLQALVADFETQVKFVQ 64
+S+YI +P+C KC YC F ++A+ A L E Q + + + +
Sbjct 171 VSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDV------ 224
Query 65 GRKIHSVFIGGGTPSLISAQGYQWLFEK-IRALVDFEQDCEITLEAN-PGTVEHDPFADY 122
K+ +++ GGGTP+ I+A+ L+E+ +R+ D + EIT+EA P T+ + A
Sbjct 225 --KVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVL 282
Query 123 LEAGINRLSLGVQSFDQDHLERLGRIHSSENAIEAIKLAKQAGFERVNADLMHGLSQQTL 182
+ I+R+S+ QS++ + L+ +GR H+ E IE L++Q G +N DL+ GL + +
Sbjct 283 NKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLIIGLPGEGV 342
Query 183 EQALLDL----KLAVDNGATHISWYQLTIEPNTVFFRTQPVLPQDEILEQIQRQGEQYLK 238
++ L KL ++ H ++ E T V ++E+ Q+ + K
Sbjct 343 KEFRHSLSETEKLMPESLTVHTLSFKRASE-MTRNKHKYKVAGREEV-SQMMEDAVAWTK 400
Query 239 AQGFSNYEVSAWRKEKPSAHNLNYWQFGD--------------YLAIGAGAHGKVTQPD- 283
G+ Y + + + N+ Y G + IG GA K D
Sbjct 401 EHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDT 460
Query 284 -GVYRFQKTRLPKDYLAKVPAEHVQWKRIEADELPFE 319
+ F + PK Y + EH ++I+ E FE
Sbjct 461 GKITHFANPKDPKSYNERF--EHYTDEKIKYLEQIFE 495
Lambda K H a alpha
0.321 0.137 0.413 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1980720
Database: a5ffe5074a63b58ed68ad8737ae63636.SwissProt.fasta
Posted date: Jun 1, 2024 6:24 PM
Number of letters in database: 6,695
Number of sequences in database: 16
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
