BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: e0efd052a78d4cce23d059f71b8bfd42.SwissProt.fasta
25 sequences; 6,871 total letters
Query= ACIAD0515
Length=281
Score E
Sequences producing significant alignments: (Bits) Value
Q6FER7 Thymidylate synthase [Acinetobacter baylyi (strain ATCC 33... 588 0.0
B7I4U0 Thymidylate synthase [Acinetobacter baumannii (strain AB00... 555 0.0
B7H0P4 Thymidylate synthase [Acinetobacter baumannii (strain AB30... 555 0.0
A5WHY0 Thymidylate synthase [Psychrobacter sp. (strain PRwf-1)] 440 7e-161
Q1Q8B2 Thymidylate synthase [Psychrobacter cryohalolentis (strain... 416 3e-151
Q9I6F1 Thymidylate synthase [Pseudomonas aeruginosa (strain ATCC ... 382 3e-138
Q02U73 Thymidylate synthase [Pseudomonas aeruginosa (strain UCBPP... 382 3e-138
B7V2Q5 Thymidylate synthase [Pseudomonas aeruginosa (strain LESB58)] 382 3e-138
Q8PCE7 Thymidylate synthase [Xanthomonas campestris pv. campestri... 380 8e-138
Q4UR35 Thymidylate synthase [Xanthomonas campestris pv. campestri... 380 8e-138
Q8PP46 Thymidylate synthase [Xanthomonas axonopodis pv. citri (st... 380 8e-138
A1KVB3 Thymidylate synthase [Neisseria meningitidis serogroup C /... 380 1e-137
A6UYE6 Thymidylate synthase [Pseudomonas aeruginosa (strain PA7)] 380 2e-137
Q9JY72 Thymidylate synthase [Neisseria meningitidis serogroup B (... 380 2e-137
Q9JT57 Thymidylate synthase [Neisseria meningitidis serogroup A /... 379 3e-137
O33380 Thymidylate synthase [Neisseria gonorrhoeae] 368 9e-133
Q9RAM7 Thymidylate synthase [Methylobacillus flagellatus (strain ... 360 1e-129
P0A884 Thymidylate synthase [Escherichia coli (strain K12)] 348 5e-125
P48464 Thymidylate synthase [Shigella flexneri] 348 7e-125
P11044 Thymidylate synthase 2 [Bacillus subtilis (strain 168)] 335 7e-120
P9WFR9 Thymidylate synthase ThyA [Mycobacterium tuberculosis (str... 333 4e-119
P78029 Thymidylate synthase [Mycoplasma pneumoniae (strain ATCC 2... 320 2e-113
P00469 Thymidylate synthase [Lacticaseibacillus casei] 317 4e-112
P0A0M5 Thymidylate synthase [Staphylococcus aureus] 312 6e-110
P07607 Thymidylate synthase [Mus musculus] 294 4e-103
>Q6FER7 Thymidylate synthase [Acinetobacter baylyi (strain ATCC
33305 / BD413 / ADP1)]
Length=280
Score = 588 bits (1516), Expect = 0.0
Identities = 280/280 (100%), Positives = 280/280 (100%), Gaps = 0/280 (0%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL
Sbjct 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY
Sbjct 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY
Sbjct 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP
Sbjct 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV
Sbjct 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
>B7I4U0 Thymidylate synthase [Acinetobacter baumannii (strain
AB0057)]
Length=280
Score = 555 bits (1431), Expect = 0.0
Identities = 261/280 (93%), Positives = 273/280 (98%), Gaps = 0/280 (0%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
MR YLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLS+GFPLLTTKKVHFRSIVIELL
Sbjct 1 MRAYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSKGFPLLTTKKVHFRSIVIELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTNV+YL+D+KV+IWDEWATAEQTARFGRPE ELGPVYGHQWRNFGAT+N+DG+Y
Sbjct 61 WFLKGDTNVKYLQDNKVTIWDEWATAEQTARFGRPEHELGPVYGHQWRNFGATKNADGTY 120
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQD KLSCQLY
Sbjct 121 NQDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDNKLSCQLY 180
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQA+LQLTREP
Sbjct 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAKLQLTREP 240
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
LPLCQLKLNPE+ D+FDFKFEDIEIV Y+SHPAIKAPVAV
Sbjct 241 LPLCQLKLNPEVKDIFDFKFEDIEIVGYESHPAIKAPVAV 280
>B7H0P4 Thymidylate synthase [Acinetobacter baumannii (strain
AB307-0294)]
Length=280
Score = 555 bits (1431), Expect = 0.0
Identities = 261/280 (93%), Positives = 273/280 (98%), Gaps = 0/280 (0%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
MR YLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLS+GFPLLTTKKVHFRSIVIELL
Sbjct 1 MRAYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSKGFPLLTTKKVHFRSIVIELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTNV+YL+D+KV+IWDEWATAEQTARFGRPE ELGPVYGHQWRNFGAT+N+DG+Y
Sbjct 61 WFLKGDTNVKYLQDNKVTIWDEWATAEQTARFGRPEHELGPVYGHQWRNFGATKNADGTY 120
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQD KLSCQLY
Sbjct 121 NQDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDNKLSCQLY 180
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQA+LQLTREP
Sbjct 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAKLQLTREP 240
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
LPLCQLKLNPE+ D+FDFKFEDIEIV Y+SHPAIKAPVAV
Sbjct 241 LPLCQLKLNPEVKDIFDFKFEDIEIVGYESHPAIKAPVAV 280
>A5WHY0 Thymidylate synthase [Psychrobacter sp. (strain PRwf-1)]
Length=286
Score = 440 bits (1131), Expect = 7e-161
Identities = 205/277 (74%), Positives = 235/277 (85%), Gaps = 0/277 (0%)
Query 4 YLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLWFL 63
YLDL++++ D+G +KGDRTGTGTRS FG Q+RFDL GFPLLTTKKVH +SI EL WFL
Sbjct 10 YLDLIRYVRDHGTEKGDRTGTGTRSHFGAQLRFDLKDGFPLLTTKKVHMKSITYELFWFL 69
Query 64 KGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSYKND 123
KGDT+V+YL+DH V IW+EW+TAEQTARFGRPEGELGP+YGHQWRN+GAT+ DG Y D
Sbjct 70 KGDTHVKYLQDHGVRIWNEWSTAEQTARFGRPEGELGPIYGHQWRNYGATKAEDGRYNQD 129
Query 124 GFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLYQRS 183
G DQ+ +I +IK+NPNSRRLIVSGWNP EA QVALPPCHTLFQFFV DGKLSCQLYQRS
Sbjct 130 GVDQVVEVIEQIKSNPNSRRLIVSGWNPAEATQVALPPCHTLFQFFVADGKLSCQLYQRS 189
Query 184 ADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREPLPL 243
AD+FLGVPFNIASY+LLTHMIAQVC L VG+F+WTGGD HLY NH +Q QL+RE L
Sbjct 190 ADLFLGVPFNIASYSLLTHMIAQVCDLEVGEFIWTGGDCHLYQNHIDQVNEQLSREAYEL 249
Query 244 CQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
+L LNPEI D+FDF F+DI + YQSHPAIKAPVAV
Sbjct 250 PKLWLNPEIKDIFDFTFDDIRVEGYQSHPAIKAPVAV 286
>Q1Q8B2 Thymidylate synthase [Psychrobacter cryohalolentis (strain
ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)]
Length=290
Score = 416 bits (1068), Expect = 3e-151
Identities = 193/279 (69%), Positives = 227/279 (81%), Gaps = 0/279 (0%)
Query 2 RTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLW 61
+ YLDLL+ +L+ G +KGDRTGTGT S FG Q+RF+L+ GFPLLTTKKVH +SI ELLW
Sbjct 12 QAYLDLLRLVLNEGTEKGDRTGTGTLSHFGAQLRFNLADGFPLLTTKKVHLKSITYELLW 71
Query 62 FLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSYK 121
FL G T+V YL+ + V IW+EWAT+EQTARF RP G+LGP+YGHQWRN+GAT +DG Y
Sbjct 72 FLNGSTHVDYLQQNGVRIWNEWATSEQTARFNRPAGDLGPIYGHQWRNYGATTTADGQYN 131
Query 122 NDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLYQ 181
+DG DQI ++ +IKTNPNSRRLIVSGWNP EA QVALPPCHTLFQFFV D KLSCQLYQ
Sbjct 132 SDGVDQIAQVVEQIKTNPNSRRLIVSGWNPGEADQVALPPCHTLFQFFVADNKLSCQLYQ 191
Query 182 RSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREPL 241
RSAD+FLGVPFNIASYA+LTHM+AQVC L VG+F+WTGGD H+Y NH EQ +LQLTR
Sbjct 192 RSADLFLGVPFNIASYAMLTHMVAQVCNLEVGEFIWTGGDCHIYQNHREQVELQLTRSLY 251
Query 242 PLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
L L LNP + D+F F +EDI + Y+SHPAIKA VAV
Sbjct 252 TLPTLALNPNVKDIFAFNYEDISVDGYESHPAIKAQVAV 290
>Q9I6F1 Thymidylate synthase [Pseudomonas aeruginosa (strain ATCC
15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
1C / PRS 101 / PAO1)]
Length=264
Score = 382 bits (980), Expect = 3e-138
Identities = 187/280 (67%), Positives = 219/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+ ++G K DRTGTGT SVFGHQMRFDL+ GFPL+TTKK H +SIV ELL
Sbjct 1 MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKG TN+ YLK+H VSIWDEWA G+LGPVYG+QWR++ A DG +
Sbjct 61 WFLKGSTNIAYLKEHGVSIWDEWADEN---------GDLGPVYGYQWRSWPAP---DGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI L+ +K NP+SRRLIVS WNP ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 109 ----IDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQV GL G+F+WTGGD HLYANH EQA LQLTREP
Sbjct 165 QRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTGGDCHLYANHLEQADLQLTREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
LPL +KLNPE+ DLFDF+FED E+V Y++HP IKAPVAV
Sbjct 225 LPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPVAV 264
>Q02U73 Thymidylate synthase [Pseudomonas aeruginosa (strain UCBPP-PA14)]
Length=264
Score = 382 bits (980), Expect = 3e-138
Identities = 187/280 (67%), Positives = 219/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+ ++G K DRTGTGT SVFGHQMRFDL+ GFPL+TTKK H +SIV ELL
Sbjct 1 MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKG TN+ YLK+H VSIWDEWA G+LGPVYG+QWR++ A DG +
Sbjct 61 WFLKGSTNIAYLKEHGVSIWDEWADEN---------GDLGPVYGYQWRSWPAP---DGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI L+ +K NP+SRRLIVS WNP ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 109 ----IDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQV GL G+F+WTGGD HLYANH EQA LQLTREP
Sbjct 165 QRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTGGDCHLYANHLEQADLQLTREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
LPL +KLNPE+ DLFDF+FED E+V Y++HP IKAPVAV
Sbjct 225 LPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPVAV 264
>B7V2Q5 Thymidylate synthase [Pseudomonas aeruginosa (strain LESB58)]
Length=264
Score = 382 bits (980), Expect = 3e-138
Identities = 187/280 (67%), Positives = 219/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+ ++G K DRTGTGT SVFGHQMRFDL+ GFPL+TTKK H +SIV ELL
Sbjct 1 MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKG TN+ YLK+H VSIWDEWA G+LGPVYG+QWR++ A DG +
Sbjct 61 WFLKGSTNIAYLKEHGVSIWDEWADEN---------GDLGPVYGYQWRSWPAP---DGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI L+ +K NP+SRRLIVS WNP ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 109 ----IDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQV GL G+F+WTGGD HLYANH EQA LQLTREP
Sbjct 165 QRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTGGDCHLYANHLEQADLQLTREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
LPL +KLNPE+ DLFDF+FED E+V Y++HP IKAPVAV
Sbjct 225 LPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPVAV 264
>Q8PCE7 Thymidylate synthase [Xanthomonas campestris pv. campestris
(strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 /
P 25)]
Length=264
Score = 380 bits (977), Expect = 8e-138
Identities = 184/280 (66%), Positives = 218/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YL+LLQH+L+ G +K DRTGTGTRSVFG QMRFDL+ GFPL+TTKK+H RSI+ ELL
Sbjct 1 MKPYLELLQHVLEYGAEKSDRTGTGTRSVFGWQMRFDLNAGFPLVTTKKLHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFL+GDTN+ YLKD++V IWDEWA A G+LGPVYG QWR + +
Sbjct 61 WFLQGDTNIAYLKDNQVRIWDEWADAN---------GDLGPVYGKQWRRWTGPDGVE--- 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQ++WL++EIK NP+SRRL++S WN E Q+AL PCH+LFQF+V DGKLSCQLY
Sbjct 109 ----IDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVDGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRS D+FLGVPFNIASYALLTHM+AQ GLGVGDFV T GD HLY+NHFEQA+ QLTR P
Sbjct 165 QRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFEQAREQLTRTP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
PL L+LNP++TDLF F+FEDI I Y HPAIKAPVAV
Sbjct 225 RPLPTLRLNPDVTDLFAFRFEDIAIDGYDPHPAIKAPVAV 264
>Q4UR35 Thymidylate synthase [Xanthomonas campestris pv. campestris
(strain 8004)]
Length=264
Score = 380 bits (977), Expect = 8e-138
Identities = 184/280 (66%), Positives = 218/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YL+LLQH+L+ G +K DRTGTGTRSVFG QMRFDL+ GFPL+TTKK+H RSI+ ELL
Sbjct 1 MKPYLELLQHVLEYGAEKSDRTGTGTRSVFGWQMRFDLNAGFPLVTTKKLHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFL+GDTN+ YLKD++V IWDEWA A G+LGPVYG QWR + +
Sbjct 61 WFLQGDTNIAYLKDNQVRIWDEWADAN---------GDLGPVYGKQWRRWTGPDGVE--- 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQ++WL++EIK NP+SRRL++S WN E Q+AL PCH+LFQF+V DGKLSCQLY
Sbjct 109 ----IDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVDGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRS D+FLGVPFNIASYALLTHM+AQ GLGVGDFV T GD HLY+NHFEQA+ QLTR P
Sbjct 165 QRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFEQAREQLTRTP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
PL L+LNP++TDLF F+FEDI I Y HPAIKAPVAV
Sbjct 225 RPLPTLRLNPDVTDLFAFRFEDIAIDGYDPHPAIKAPVAV 264
>Q8PP46 Thymidylate synthase [Xanthomonas axonopodis pv. citri
(strain 306)]
Length=264
Score = 380 bits (977), Expect = 8e-138
Identities = 184/280 (66%), Positives = 216/280 (77%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YL+LLQH+LD+G +K DRTGTGTRSVFG QMRFDL+ GFPL+TTKK+H RSI+ ELL
Sbjct 1 MKPYLELLQHVLDHGAEKSDRTGTGTRSVFGWQMRFDLNDGFPLVTTKKLHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTN+ YL DH+V IWDEWA G+LGPVYG QWR + +
Sbjct 61 WFLKGDTNIGYLSDHQVRIWDEWAD---------DNGDLGPVYGKQWRRWTGPDGVE--- 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQ++WL++EIK NP+SRRL++S WN E Q+AL PCH+LFQF+V +GKLSCQLY
Sbjct 109 ----IDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVNGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRS D+FLGVPFNIASYALLTHM+AQ GLGVGDFV T GD HLY+NHFEQA+ QLTR P
Sbjct 165 QRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFEQAREQLTRTP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
L L+LNPE+TDLF F+FEDI I Y HPAIKAPVAV
Sbjct 225 RALPSLRLNPEVTDLFAFRFEDIAIEGYDPHPAIKAPVAV 264
>A1KVB3 Thymidylate synthase [Neisseria meningitidis serogroup
C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)]
Length=264
Score = 380 bits (976), Expect = 1e-137
Identities = 187/280 (67%), Positives = 217/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+LDNG DK DRTGTGTRSVFG+QMRFDL +GFPLLTTKK+H RSI+ ELL
Sbjct 1 MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTN++YLKD+ VSIWDEWA G+LGPVYG+QWRN+ A DG +
Sbjct 61 WFLKGDTNIKYLKDNNVSIWDEWADEN---------GDLGPVYGYQWRNWPAP---DGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI ++ +IK NP+SRRLIVS WNP ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 109 ----IDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQVCGL G+FV T GD HLY NHFEQA LQL REP
Sbjct 165 QRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
L +K+NPE+ DLF FKFED E+ Y HP IKA V+V
Sbjct 225 RALPVMKINPEVKDLFSFKFEDFELEGYDPHPHIKAAVSV 264
>A6UYE6 Thymidylate synthase [Pseudomonas aeruginosa (strain PA7)]
Length=264
Score = 380 bits (975), Expect = 2e-137
Identities = 186/280 (66%), Positives = 219/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+ ++G K DRTGTGT SVFG+QMRFDL+ GFPL+TTKK H +SIV ELL
Sbjct 1 MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGYQMRFDLAAGFPLVTTKKCHLKSIVHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFL+G TN+ YLK+H VSIWDEWA G+LGPVYG+QWR++ A DG +
Sbjct 61 WFLQGSTNIAYLKEHGVSIWDEWADEN---------GDLGPVYGYQWRSWPAP---DGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI L+ +K NP+SRRLIVS WNP ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 109 ----IDQIANLMTMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQV GL G+F+WTGGD HLYANH EQA LQLTREP
Sbjct 165 QRSADIFLGVPFNIASYALLTLMVAQVAGLRPGEFIWTGGDCHLYANHLEQADLQLTREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
LPL +KLNPE+ DLFDF+FED E+V YQ+HP IKAPVAV
Sbjct 225 LPLPSMKLNPEVKDLFDFRFEDFELVGYQAHPHIKAPVAV 264
>Q9JY72 Thymidylate synthase [Neisseria meningitidis serogroup
B (strain MC58)]
Length=264
Score = 380 bits (975), Expect = 2e-137
Identities = 187/280 (67%), Positives = 217/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+LDNG DK DRTGTGTRSVFG+QMRFDL +GFPLLTTKK+H RSI+ ELL
Sbjct 1 MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTN++YLKD+ VSIWDEWA G+LGPVYG+QWRN+ A DG +
Sbjct 61 WFLKGDTNIKYLKDNNVSIWDEWADEN---------GDLGPVYGYQWRNWPAP---DGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI ++ +IK NP+SRRLIVS WNP ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 109 ----IDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQVCGL G+FV T GD HLY NHFEQA LQL REP
Sbjct 165 QRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
L +K+NPE+ DLF FKFED E+ Y HP IKA V+V
Sbjct 225 RALPVMKINPEVKDLFSFKFEDFELEGYDPHPHIKAAVSV 264
>Q9JT57 Thymidylate synthase [Neisseria meningitidis serogroup
A / serotype 4A (strain DSM 15465 / Z2491)]
Length=264
Score = 379 bits (973), Expect = 3e-137
Identities = 187/280 (67%), Positives = 217/280 (78%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+LDNG DK DRTGTGTRSVFG+QMRFDL +GFPLLTTKK+H RSI+ ELL
Sbjct 1 MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTN++YLKD+ VSIWDEWA G+LGPVYG+QWRN+ A DG +
Sbjct 61 WFLKGDTNIKYLKDNNVSIWDEWADEN---------GDLGPVYGYQWRNWPAP---DGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI ++ +IK NP+SRRLIVS WNP ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 109 ----IDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQVCGL G+FV T GD HLY NHFEQA LQL REP
Sbjct 165 QRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
L +K+NPE+ DLF FKFED E+ Y HP IKA V+V
Sbjct 225 RALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAAVSV 264
>O33380 Thymidylate synthase [Neisseria gonorrhoeae]
Length=265
Score = 368 bits (944), Expect = 9e-133
Identities = 184/281 (65%), Positives = 215/281 (77%), Gaps = 17/281 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL++H+LDNG DK DRTGTGT SVFG+QMRFDL +GFPLLTTKK+H RSI+ ELL
Sbjct 1 MKAYLDLMRHVLDNGTDKSDRTGTGTLSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWD-EWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGS 119
WFLKGDTN++YLKD+ VSIWD EWA G+LGPVYG+QWR++ A DG
Sbjct 61 WFLKGDTNIKYLKDNNVSIWDDEWADEN---------GDLGPVYGYQWRSWPAP---DGR 108
Query 120 YKNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQL 179
+ DQI ++ +IK NP+SRRLIVS WNP ++ALPPCH LFQF+V DG LSCQL
Sbjct 109 H----IDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGNLSCQL 164
Query 180 YQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTRE 239
YQRSAD+FLGVPFNIASYALLT M+AQVCGL G+FV T GD HLY NHFEQA LQL RE
Sbjct 165 YQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLERE 224
Query 240 PLPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
P L +K+NPE+ DLF FKFED E+ Y HP IKA V+V
Sbjct 225 PRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVVSV 265
>Q9RAM7 Thymidylate synthase [Methylobacillus flagellatus (strain
KT / ATCC 51484 / DSM 6875)]
Length=264
Score = 360 bits (923), Expect = 1e-129
Identities = 176/280 (63%), Positives = 213/280 (76%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ Y DL++H+L+ G K DRTGTGT SVFG+QMRFDLS+GFPLLTTKKVH +SI+ ELL
Sbjct 1 MKVYHDLMRHVLEQGHKKEDRTGTGTLSVFGYQMRFDLSEGFPLLTTKKVHLKSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFL+G TN+ YLK++ V+IWDEWA AE G LGPVYG+QWRN+ DG +
Sbjct 61 WFLQGSTNIAYLKENGVTIWDEWADAE---------GNLGPVYGYQWRNW---PKPDGGH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI +I IK NP+SRRLIVS WN + ++ LPPCH FQF+V DGKLSCQLY
Sbjct 109 ----IDQISEVIAAIKRNPDSRRLIVSAWNVADVDKMKLPPCHAFFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSAD+FLGVPFNIASYALLT M+AQVC L +GDFV T GD H+Y NH EQ + QL+REP
Sbjct 165 QRSADIFLGVPFNIASYALLTMMVAQVCDLKLGDFVHTLGDAHIYLNHLEQVKEQLSREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
PL +++NPE+ D+F F+FED + +YQSHPAIKAPVAV
Sbjct 225 YPLPVMRINPEVKDIFAFRFEDFTLENYQSHPAIKAPVAV 264
>P0A884 Thymidylate synthase [Escherichia coli (strain K12)]
Length=264
Score = 348 bits (893), Expect = 5e-125
Identities = 167/280 (60%), Positives = 205/280 (73%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YL+L+Q +LD G K DRTGTGT S+FGHQMRF+L GFPL+TTK+ H RSI+ ELL
Sbjct 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFL+GDTN+ YL ++ V+IWDEWA G+LGPVYG QWR A DG +
Sbjct 61 WFLQGDTNIAYLHENNVTIWDEWADEN---------GDLGPVYGKQWR---AWPTPDGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI ++N++K +P+SRR+IVS WN E ++AL PCH FQF+V DGKLSCQLY
Sbjct 109 ----IDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRS DVFLG+PFNIASYALL HM+AQ C L VGDFVWTGGDTHLY+NH +Q LQL+REP
Sbjct 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
PL +L + + +FD++FED EI Y HP IKAPVA+
Sbjct 225 RPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264
>P48464 Thymidylate synthase [Shigella flexneri]
Length=264
Score = 348 bits (892), Expect = 7e-125
Identities = 166/280 (59%), Positives = 205/280 (73%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YL+L+Q +LD G K DRTGTGT S+FGHQMRF+L GFPL+TTK+ H RSI+ ELL
Sbjct 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFL+GDTN+ YL ++ V+IWDEWA G+LGPVYG QWR A DG +
Sbjct 61 WFLQGDTNIAYLHENNVTIWDEWADEN---------GDLGPVYGKQWR---AWPTPDGRH 108
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
DQI ++N++K +P+SRR+IVS WN E ++AL PCH FQF+V DGKLSCQLY
Sbjct 109 ----IDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRS DVFLG+PFNIASYALL HM+AQ C L VGDFVWTGGDTHLY+NH +Q LQL+REP
Sbjct 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
PL +L + + +FD++FED EI Y HP +KAPVA+
Sbjct 225 RPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGVKAPVAI 264
>P11044 Thymidylate synthase 2 [Bacillus subtilis (strain 168)]
Length=264
Score = 335 bits (859), Expect = 7e-120
Identities = 168/280 (60%), Positives = 204/280 (73%), Gaps = 16/280 (6%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ Y D +H+L++G KGDRTGTGT S FG+QMRF+L +GFP+LTTKK+HF+SI ELL
Sbjct 1 MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPMLTTKKLHFKSIAHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSY 120
WFLKGDTNV+YL+++ V IW+EWA GELGPVYG QWR++ + +DG
Sbjct 61 WFLKGDTNVRYLQENGVRIWNEWADEN---------GELGPVYGSQWRSW---RGADG-- 106
Query 121 KNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLY 180
+ DQI LI +IKTNPNSRRLIVS WN E ++ALPPCH LFQF+V DGKLSCQLY
Sbjct 107 --ETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLSCQLY 164
Query 181 QRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREP 240
QRSADVFLGVPFNIASYALLT +IA V GL G+F+ T GD H+Y NH EQ LQL R+
Sbjct 165 QRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNLQLERDV 224
Query 241 LPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
PL QL+ ++ +F+F FED I DY HP IK V+V
Sbjct 225 RPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV 264
>P9WFR9 Thymidylate synthase ThyA [Mycobacterium tuberculosis
(strain ATCC 25618 / H37Rv)]
Length=266
Score = 333 bits (854), Expect = 4e-119
Identities = 161/277 (58%), Positives = 205/277 (74%), Gaps = 17/277 (6%)
Query 4 YLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLWFL 63
Y DLL+ +L+ G K DRTGTGTRS+FG QMR+DLS GFPLLTTKKVHF+S+ ELLWFL
Sbjct 7 YEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFL 66
Query 64 KGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSYKND 123
+GD+N+ +L +H V+IWDEWA+ GELGP+YG QWR++ A +
Sbjct 67 RGDSNIGWLHEHGVTIWDEWAS---------DTGELGPIYGVQWRSWPAPSG-------E 110
Query 124 GFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLYQRS 183
DQI ++ ++T+P+SRR+IVS WN E ++ALPPCH FQF+V DG+LSCQLYQRS
Sbjct 111 HIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRS 170
Query 184 ADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREPLPL 243
AD+FLGVPFNIASYALLTHM+A GL VG+F+WTGGD H+Y NH EQ +LQL+REP P
Sbjct 171 ADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPY 230
Query 244 CQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
+L L + +F++ +EDI + +Y HPAIKAPVAV
Sbjct 231 PKLLL-ADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV 266
>P78029 Thymidylate synthase [Mycoplasma pneumoniae (strain ATCC
29342 / M129 / Subtype 1)]
Length=287
Score = 320 bits (819), Expect = 2e-113
Identities = 159/300 (53%), Positives = 208/300 (69%), Gaps = 33/300 (11%)
Query 1 MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELL 60
M+ YLDL +++L++G + +RT T VFG+QM FD+S+ FPLLTTKKVH++SIV ELL
Sbjct 1 MQQYLDLARYVLEHGKYRPNRTDTAGIGVFGYQMHFDISKHFPLLTTKKVHWKSIVHELL 60
Query 61 WFLKGDTNVQYLKDHKVSIWDEWA--------------------TAEQTARFGRPEGELG 100
WF+KGDTN++YL D+KV+IW+EW Q A+F + G LG
Sbjct 61 WFIKGDTNIKYLVDNKVNIWNEWPYESFKKSPHFNGESQKEFIERIRQDAKFAQQFGNLG 120
Query 101 PVYGHQWRNFGATQNSDGSYKNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALP 160
PVYG QWR+F +G DQ+K +I +IK NP SRRLIVS WNPNE Q+ LP
Sbjct 121 PVYGKQWRDF------------NGVDQLKKVIAQIKVNPFSRRLIVSSWNPNEVDQMLLP 168
Query 161 PCHTLFQFFVQDGKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGG 220
PCH+L+QF+VQDG+LSCQLYQRS D+FLG+PFNIASY+LL +++A+ L G FV T G
Sbjct 169 PCHSLYQFYVQDGQLSCQLYQRSGDIFLGIPFNIASYSLLVYLVAKETNLKPGSFVHTIG 228
Query 221 DTHLYANHFEQAQLQLTREPLPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
D H+Y NH EQ +LQLTR+P PL ++ L + +FD++F+DIE+VDY HP IK VAV
Sbjct 229 DAHIYENHLEQIKLQLTRQPKPLPKVVLKSD-KSIFDYQFDDIELVDYDHHPTIKGEVAV 287
>P00469 Thymidylate synthase [Lacticaseibacillus casei]
Length=316
Score = 317 bits (813), Expect = 4e-112
Identities = 167/318 (53%), Positives = 205/318 (64%), Gaps = 48/318 (15%)
Query 4 YLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLWFL 63
YLDL + +LD G K DRT TGT S+FGHQMRFDLS+GFPLLTTKKV F I ELLWFL
Sbjct 6 YLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFL 65
Query 64 KGDTNVQYLKDHKVSIWDEWATA-------------------------------EQTARF 92
GDTN+++L H+ IWDEWA E+ A+F
Sbjct 66 HGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEEMAKF 125
Query 93 ----------GRPEGELGPVYGHQWRNFGATQNSDGSYKNDGFDQIKWLINEIKTNPNSR 142
G+LG VYG QWR + + K D DQ+ +I +IKT+P SR
Sbjct 126 DDRVLHDDAFAAKYGDLGLVYGSQWRAWHTS-------KGDTIDQLGDVIEQIKTHPYSR 178
Query 143 RLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLYQRSADVFLGVPFNIASYALLTH 202
RLIVS WNP + +ALPPCHTL+QF+V DGKLS QLYQRSAD+FLGVPFNIASYALLTH
Sbjct 179 RLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTH 238
Query 203 MIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREPLPLCQLKLNPEITDLFDFKFED 262
++A CGL VG+F+ T GD HLY NH +Q + QL+R P P L+LNP+ D+FDF +D
Sbjct 239 LVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKD 298
Query 263 IEIVDYQSHPAIKAPVAV 280
I++++Y +PAIKAPVAV
Sbjct 299 IKLLNYDPYPAIKAPVAV 316
>P0A0M5 Thymidylate synthase [Staphylococcus aureus]
Length=318
Score = 312 bits (799), Expect = 6e-110
Identities = 157/318 (49%), Positives = 208/318 (65%), Gaps = 49/318 (15%)
Query 4 YLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLWFL 63
Y L + IL+ G + DRT TGT S FGHQ+RFDL++GFPLLTTKKV F+ + ELLWF+
Sbjct 9 YHGLCEEILEIGNRRDDRTHTGTISKFGHQLRFDLTKGFPLLTTKKVSFKLVATELLWFI 68
Query 64 KGDTNVQYLKDHKVSIWDEWATAEQTAR-------------------------------- 91
KGDTN+QYL + +IW+EWA
Sbjct 69 KGDTNIQYLLKYNNNIWNEWAFENYVQSDDYHGPDMTDFGHRSQQDPEFNEQYKEEMKKF 128
Query 92 ---------FGRPEGELGPVYGHQWRNFGATQNSDGSYKNDGFDQIKWLINEIKTNPNSR 142
F + G LG VYG QWR++ ++ +G++ +DQ+K +I +IKTNPNSR
Sbjct 129 KERILNDDAFAKKYGNLGNVYGKQWRDW---EDKNGNH----YDQLKSVIQQIKTNPNSR 181
Query 143 RLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLYQRSADVFLGVPFNIASYALLTH 202
R IVS WNP E +ALPPCHT+FQF+VQ+GKL+CQLYQRSAD+FLGVPFNIASYALLTH
Sbjct 182 RHIVSAWNPTEIDSMALPPCHTMFQFYVQEGKLNCQLYQRSADIFLGVPFNIASYALLTH 241
Query 203 MIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREPLPLCQLKLNPEITDLFDFKFED 262
++A+ CGL VG+F+ T GD H+Y+NH + QL+R+ QLK+N + +FD +ED
Sbjct 242 LVAKECGLEVGEFIHTFGDAHIYSNHMDAIHTQLSRDSYLPPQLKINTD-KSIFDINYED 300
Query 263 IEIVDYQSHPAIKAPVAV 280
+E+++Y+SHPAIKAP+AV
Sbjct 301 LELINYESHPAIKAPIAV 318
>P07607 Thymidylate synthase [Mus musculus]
Length=307
Score = 294 bits (753), Expect = 4e-103
Identities = 149/281 (53%), Positives = 190/281 (68%), Gaps = 4/281 (1%)
Query 4 YLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLWFL 63
YL ++HIL G K DRTGTGT SVFG Q R+ L FPLLTTK+V ++ ++ ELLWF+
Sbjct 27 YLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFI 86
Query 64 KGDTNVQYLKDHKVSIWDEWATAEQTARFG---RPEGELGPVYGHQWRNFGAT-QNSDGS 119
KG TN + L V IWD + + G R EG+LGPVYG QWR+FGA ++ D
Sbjct 87 KGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSD 146
Query 120 YKNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQL 179
Y G DQ++ +I+ IKTNP+ RR+I+ WNP + +ALPPCH L QF+V +G+LSCQL
Sbjct 147 YSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQL 206
Query 180 YQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTRE 239
YQRS D+ LGVPFNIASYALLT+MIA + GL GDFV T GD H+Y NH E ++QL RE
Sbjct 207 YQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQRE 266
Query 240 PLPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV 280
P P +LK+ ++ + DFK ED +I Y HP IK +AV
Sbjct 267 PRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV 307
Lambda K H a alpha
0.324 0.141 0.452 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 1332864
Database: e0efd052a78d4cce23d059f71b8bfd42.SwissProt.fasta
Posted date: Jun 1, 2024 8:15 AM
Number of letters in database: 6,871
Number of sequences in database: 25
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
