BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 2549b0d4fcf34076388d81741b1268a3.SwissProt.fasta
31 sequences; 12,596 total letters
Query= ACIAD0802
Length=404
Score E
Sequences producing significant alignments: (Bits) Value
P96709 Uncharacterized MFS-type transporter YdgK [Bacillus subtil... 217 1e-69
P28246 Bicyclomycin resistance protein [Escherichia coli (strain ... 207 3e-66
P45123 Bicyclomycin resistance protein homolog [Haemophilus influ... 199 9e-63
P37597 Inner membrane transport protein YdhC [Escherichia coli (s... 130 4e-37
Q31UW4 Multidrug resistance protein MdtL [Shigella boydii serotyp... 130 4e-37
B2TUR5 Multidrug resistance protein MdtL [Shigella boydii serotyp... 130 4e-37
B7L855 Multidrug resistance protein MdtL [Escherichia coli (strai... 130 4e-37
A7ZTR5 Multidrug resistance protein MdtL [Escherichia coli O139:H... 130 4e-37
P31462 Multidrug resistance protein MdtL [Escherichia coli (strai... 130 4e-37
Q8FBV0 Multidrug resistance protein MdtL [Escherichia coli O6:H1 ... 130 6e-37
B7N2F5 Multidrug resistance protein MdtL [Escherichia coli O81 (s... 130 6e-37
B1LL36 Multidrug resistance protein MdtL [Escherichia coli (strai... 129 1e-36
B7NF27 Multidrug resistance protein MdtL [Escherichia coli O17:K5... 129 1e-36
Q0SYP9 Multidrug resistance protein MdtL [Shigella flexneri serot... 129 1e-36
B7NR12 Multidrug resistance protein MdtL [Escherichia coli O7:K1 ... 129 2e-36
Q1R4M4 Multidrug resistance protein MdtL [Escherichia coli (strai... 129 2e-36
Q0TAZ8 Multidrug resistance protein MdtL [Escherichia coli O6:K15... 129 2e-36
A1AHP3 Multidrug resistance protein MdtL [Escherichia coli O1:K1 ... 129 2e-36
B7MGD1 Multidrug resistance protein MdtL [Escherichia coli O45:K1... 129 2e-36
B7UMH7 Multidrug resistance protein MdtL [Escherichia coli O127:H... 129 2e-36
Q328Z8 Multidrug resistance protein MdtL [Shigella dysenteriae se... 128 3e-36
P31442 Multidrug resistance protein D [Escherichia coli (strain K... 123 2e-34
P32482 Chloramphenicol resistance protein [Pseudomonas aeruginosa] 117 3e-32
P0AEY8 Multidrug transporter MdfA [Escherichia coli (strain K12)] 110 7e-30
P39386 Multidrug resistance protein MdtM [Escherichia coli (strai... 110 9e-30
D0CCT2 Chloramphenicol resistance protein CraA [Acinetobacter bau... 110 1e-29
D5B5U5 Multidrug transporter MdfA [Yersinia pestis (strain Z176003)] 100 4e-26
D0JKF6 Multidrug transporter MdfA [Yersinia pestis (strain D106004)] 100 4e-26
D0JUX5 Multidrug transporter MdfA [Yersinia pestis (strain D182038)] 100 4e-26
B3FWT8 Efflux pump rdc3 [Metacordyceps chlamydosporia] 98.6 3e-25
C5H884 Efflux pump radE [Floropilus chiversii] 93.2 2e-23
>P96709 Uncharacterized MFS-type transporter YdgK [Bacillus subtilis
(strain 168)]
Length=402
Score = 217 bits (552), Expect = 1e-69
Identities = 132/388 (34%), Positives = 214/388 (55%), Gaps = 6/388 (2%)
Query 13 AWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPIS 72
A LL +L LGPL+IDMYLP+ P++A+D S ++V +L A +GL IGQL+ GP+S
Sbjct 12 ALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSASASLVQLSLTACLVGLTIGQLIVGPVS 71
Query 73 DRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDV 132
D GR+KPL + + L+ ++S C L+ N +L+ AR +Q G+V++RA +RD
Sbjct 72 DAQGRRKPLLICIFLFALSSLFCALSPNITTLVAARFLQGFTASAGLVLSRAIVRDVFTG 131
Query 133 QGSAQAFSSMMIVMGIAPIAAPALGA--FVLEFFHWQAIFWILALIGCISLVCIHFFFIE 190
+ ++ FS +M++ +AP+ AP G +L F W IF +L +IG + ++ I E
Sbjct 132 RELSKFFSLLMVITAVAPMVAPMTGGAILLLPFATWHTIFHVLMIIGFLLVLLIALRLKE 191
Query 191 TLVPEKRLRLSLNQVFTLYIAIFKDASFR-FPMFAGCLTGGVLFSYISSASAVLMDQYGL 249
TL EKR+ S+ ++ KD SF + + G + GG F+Y+S V D YG+
Sbjct 192 TLPLEKRIPSSIGTSVKTMGSLLKDRSFMGYALTVGFIHGG-SFAYVSGTPFVYQDIYGV 250
Query 250 SQQQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSGLLIHAP 309
S Q F+ FG N L II S + + + L+I I A VL++ +IH P
Sbjct 251 SPQVFSILFGINGLAIISGSFIIGRFGGIIHEKSLLRI-AVITAMIATAVLLTMTMIHGP 309
Query 310 IVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLI 369
+ ++ +F+ + +GM + LAM +QG RAG+ASA++G + G + L+
Sbjct 310 LATLVISIFIYMITIGMVLTSTFTLAMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINE 369
Query 370 WNALFNMGLMMLLFSGVGVIAIFVVARQ 397
A+ MG +M + + +G +A F + ++
Sbjct 370 TTAV-PMGAIMFVTAVIGSLAFFGLTKE 396
>P28246 Bicyclomycin resistance protein [Escherichia coli (strain
K12)]
Length=396
Score = 207 bits (528), Expect = 3e-66
Identities = 122/370 (33%), Positives = 194/370 (52%), Gaps = 2/370 (1%)
Query 8 RQYST-AWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQL 66
RQ+S+ A + +L LL L PLSIDMYLPALP ++ FGV TL Y LG A+GQL
Sbjct 4 RQHSSFAIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSTQMTLSTYILGFALGQL 63
Query 67 VYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAI 126
+YGP++D GRK + G ++ A+ +C LA+ LI R L V+ A +
Sbjct 64 IYGPMADSFGRKPVVLGGTLVFAAAAVACALANTIDQLIVMRFFHGLAAAAASVVINALM 123
Query 127 RDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHF 186
RD + ++ S +M+V IAP+ AP +G +VL + W IFWILAL ++ I F
Sbjct 124 RDIYPKEEFSRMMSFVMLVTTIAPLMAPIVGGWVLVWLSWHYIFWILALAAILASAMIFF 183
Query 187 FFIETLVPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQ 246
ETL PE+R + + A+F+ M A + +FS++S+ V ++
Sbjct 184 LIKETLPPERRQPFHIRTTIGNFAALFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIEI 243
Query 247 YGLSQQQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSGLLI 306
++ + F Y F N + + +++ N + V R+ L + G +IQ A +++S LL
Sbjct 244 NHVAPENFGYYFALNIVFLFVMTIFNSRFVRRIGALNMFRSGLWIQFIMAAWMVISALL- 302
Query 307 HAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLN 366
++ G+ V + M NAMA+ + + AGTAS++ G+ +F G + G LL+
Sbjct 303 GLGFWSLVVGVAAFVGCVSMVSSNAMAVILDEFPHMAGTASSLAGTFRFGIGAIVGALLS 362
Query 367 FLIWNALFNM 376
+N+ + M
Sbjct 363 LATFNSAWPM 372
Score = 22.3 bits (46), Expect = 0.70
Identities = 18/85 (21%), Positives = 30/85 (35%), Gaps = 12/85 (14%)
Query 166 WQAIFWILALIGCISLVCIHFFFI------------ETLVPEKRLRLSLNQVFTLYIAIF 213
W + + A +GC+S+V + + +L R + L +A F
Sbjct 307 WSLVVGVAAFVGCVSMVSSNAMAVILDEFPHMAGTASSLAGTFRFGIGAIVGALLSLATF 366
Query 214 KDASFRFPMFAGCLTGGVLFSYISS 238
A A C T +LF +S
Sbjct 367 NSAWPMIWSIAFCATSSILFCLYAS 391
>P45123 Bicyclomycin resistance protein homolog [Haemophilus influenzae
(strain ATCC 51907 / DSM 11121 / KW20 / Rd)]
Length=398
Score = 199 bits (505), Expect = 9e-63
Identities = 121/400 (30%), Positives = 217/400 (54%), Gaps = 11/400 (3%)
Query 6 LNRQYST-AWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIG 64
+N+Q ST +I+ L +L+ L P +DMYLP+ ++A+D VS V +TL ++ G+A G
Sbjct 1 MNQQKSTFIFILTLGILSMLPPFGVDMYLPSFLEIAKDLDVSPEQVQHTLTSFAYGMAFG 60
Query 65 QLVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARA 124
QL +GP D GRK + +G+ + + + ++ + R +Q G VV++ A
Sbjct 61 QLFWGPFGDSFGRKPIILLGVIVGALTALVLTEINSVGNFTALRFVQGFFGAAPVVLSGA 120
Query 125 AIRDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCI 184
+RD ++ S++ +V +AP+ AP +G ++++FFHW AIF++++L+G ++ +
Sbjct 121 LLRDLFSKDQLSKVMSTITLVFMLAPLVAPIIGGYIVKFFHWHAIFYVISLVGLLAAALV 180
Query 185 HFFFIETLVPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLM 244
F ET E R+ L LN + ++ ++K MFA + G LF+++++ S V +
Sbjct 181 FFIIPETHKKENRIPLRLNIIARNFLLLWKQKEVLGYMFAASFSFGGLFAFVTAGSIVYI 240
Query 245 DQYGLSQQQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSGL 304
YG+ QF Y F N + +I S LN + V+++ L+I IQ + ++++ L
Sbjct 241 GIYGVPVDQFGYFFMMNIVTMIFASFLNSRFVTKVGAETMLRIALAIQFLSGMWLILTAL 300
Query 305 LIHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVL 364
L M + G+ V + NAMA A+ + AGTA++++GS++FA G + G L
Sbjct 301 LDLGFWPMAI-GVAFFVGPNPVISSNAMASALERCPQMAGTANSLIGSVRFAVGAIMGSL 359
Query 365 LNFLIWNA----LFNMGLMMLLFSGVGVIA-IFVVARQLK 399
+ + + LF MG ++ + V+A F+ +R LK
Sbjct 360 VASMKMDTAAPMLFTMGACVV----ISVLAYYFLTSRNLK 395
>P37597 Inner membrane transport protein YdhC [Escherichia coli
(strain K12)]
Length=403
Score = 130 bits (328), Expect = 4e-37
Identities = 94/364 (26%), Positives = 173/364 (48%), Gaps = 23/364 (6%)
Query 14 WIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISD 73
+++ LA L+ LG L+ DMYLPA + D + V+ +L + G A QL++GP+SD
Sbjct 7 FLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSD 66
Query 74 RIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQ 133
R GRK L +GLT++ + S + +N +L+ R +QA+G C VI +A + D Q
Sbjct 67 RYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQ 126
Query 134 GSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETLV 193
+ F+++M ++G++P AP LG+++L F WQAIF L I + ++ I + L
Sbjct 127 KVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFW-----LK 181
Query 194 PEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQ------Y 247
P + R + T + + + ++R + F++++ + +L +
Sbjct 182 PTTKARNNSQDGLT-FTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI 240
Query 248 GLS--QQQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSGLL 305
GLS Q A+ G + K+L+ L L + + + +G +
Sbjct 241 GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSV---------IATWAAGFI 291
Query 306 IHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLL 365
H +V ++ + G P +A A+ G A+A+ ++Q LA +++
Sbjct 292 SHVSLVEILIPFCVMAIANGAIYPIVVAQALRPFPHATGRAAALQNTLQLGLCFLASLVV 351
Query 366 NFLI 369
++LI
Sbjct 352 SWLI 355
>Q31UW4 Multidrug resistance protein MdtL [Shigella boydii serotype
4 (strain Sb227)]
Length=391
Score = 130 bits (327), Expect = 4e-37
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPASPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B2TUR5 Multidrug resistance protein MdtL [Shigella boydii serotype
18 (strain CDC 3083-94 / BS512)]
Length=391
Score = 130 bits (327), Expect = 4e-37
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPASPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B7L855 Multidrug resistance protein MdtL [Escherichia coli (strain
55989 / EAEC)]
Length=391
Score = 130 bits (327), Expect = 4e-37
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAAPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>A7ZTR5 Multidrug resistance protein MdtL [Escherichia coli O139:H28
(strain E24377A / ETEC)]
Length=391
Score = 130 bits (327), Expect = 4e-37
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMAMMGIAVLMLSLFILKETRPASPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>P31462 Multidrug resistance protein MdtL [Escherichia coli (strain
K12)]
Length=391
Score = 130 bits (327), Expect = 4e-37
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPAAPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>Q8FBV0 Multidrug resistance protein MdtL [Escherichia coli O6:H1
(strain CFT073 / ATCC 700928 / UPEC)]
Length=391
Score = 130 bits (326), Expect = 6e-37
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLNFPWQSLFWTMAIMGVAVLMLSLFILKETRPAAPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B7N2F5 Multidrug resistance protein MdtL [Escherichia coli O81
(strain ED1a)]
Length=391
Score = 130 bits (326), Expect = 6e-37
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLNFPWQSLFWTMAIMGVAVLMLSLFILKETRPAAPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B1LL36 Multidrug resistance protein MdtL [Escherichia coli (strain
SMS-3-5 / SECEC)]
Length=391
Score = 129 bits (324), Expect = 1e-36
Identities = 105/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIAVLMLSLFILKETRPAAPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B7NF27 Multidrug resistance protein MdtL [Escherichia coli O17:K52:H18
(strain UMN026 / ExPEC)]
Length=391
Score = 129 bits (324), Expect = 1e-36
Identities = 105/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIAVLMLSLFILKETRPAAPTNSD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>Q0SYP9 Multidrug resistance protein MdtL [Shigella flexneri serotype
5b (strain 8401)]
Length=391
Score = 129 bits (324), Expect = 1e-36
Identities = 105/386 (27%), Positives = 175/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKMADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGSALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A++G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWAMAMMGIAVLMLSLFILKETRPASPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTFSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B7NR12 Multidrug resistance protein MdtL [Escherichia coli O7:K1
(strain IAI39 / ExPEC)]
Length=391
Score = 129 bits (323), Expect = 2e-36
Identities = 104/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIAILMLSLFILKETRPAAPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIIALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I +A
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFIA 376
>Q1R4M4 Multidrug resistance protein MdtL [Escherichia coli (strain
UTI89 / UPEC)]
Length=391
Score = 129 bits (323), Expect = 2e-36
Identities = 105/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIALLMLSLFILKETRPAAPTTSD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>Q0TAZ8 Multidrug resistance protein MdtL [Escherichia coli O6:K15:H31
(strain 536 / UPEC)]
Length=391
Score = 129 bits (323), Expect = 2e-36
Identities = 105/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIAVLMLSLFILKETRPAAPAASD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>A1AHP3 Multidrug resistance protein MdtL [Escherichia coli O1:K1
/ APEC]
Length=391
Score = 129 bits (323), Expect = 2e-36
Identities = 105/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIALLMLSLFILKETRPAAPTTSD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B7MGD1 Multidrug resistance protein MdtL [Escherichia coli O45:K1
(strain S88 / ExPEC)]
Length=391
Score = 129 bits (323), Expect = 2e-36
Identities = 105/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIALLMLSLFILKETRPAAPTTSD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>B7UMH7 Multidrug resistance protein MdtL [Escherichia coli O127:H6
(strain E2348/69 / EPEC)]
Length=391
Score = 129 bits (323), Expect = 2e-36
Identities = 105/386 (27%), Positives = 174/386 (45%), Gaps = 31/386 (8%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETL-------- 192
+ + I P+ AP LG ++ F WQ++FW +A +G L+ F ET
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIAVLMLSLFILKETRPAAPTTSD 190
Query 193 VPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQ 252
P + LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 191 KPRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFERG 238
Query 253 QFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAPI 310
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 239 EYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPSH 291
Query 311 VMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIW 370
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 292 AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVVG 350
Query 371 NALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 351 IGAWNMLIGILIACSIVSLLLIMFVA 376
>Q328Z8 Multidrug resistance protein MdtL [Shigella dysenteriae
serotype 1 (strain Sd197)]
Length=391
Score = 128 bits (321), Expect = 3e-36
Identities = 103/387 (27%), Positives = 178/387 (46%), Gaps = 33/387 (9%)
Query 21 LTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKP 80
L L P IDMYL LP++A D S A + Y G+A L G ++DR GRK
Sbjct 11 LVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPV 70
Query 81 LYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFS 140
G L++IAS C LA+ + R +Q LG V+A A +RD LD + A+ S
Sbjct 71 AIPGAALFIIASVFCSLAETSTLFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLS 130
Query 141 SMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETLVP------ 194
+ + I P+ AP LG ++ F WQ++FW +A++G I+++ + F ++ P
Sbjct 131 LLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMAIMG-IAVLMLSLFILKETRPAAPAAS 189
Query 195 ---EKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQ 251
+ LN+ F + I L+ V+ ++++++ +LM+ G +
Sbjct 190 DKSRENSESLLNRFFLSRVVI------------TTLSVSVILTFVNTSPVLLMEIMGFER 237
Query 252 QQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSG--LLIHAP 309
++A A G+ + S + + + L I T ++ L +G L +
Sbjct 238 GEYATIMALTA-GVSMTVSFSTPFALGIFKPRTLMI------TSQVLFLAAGITLAVSPS 290
Query 310 IVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLI 369
+ + G+ L +G + AM+ A+ RAG AS+ +G Q CG + L ++
Sbjct 291 HAISLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAVV 349
Query 370 WNALFNMGL-MMLLFSGVGVIAIFVVA 395
+NM + +++ S V ++ I VA
Sbjct 350 GIGAWNMLIGILIACSIVSLLLIMFVA 376
>P31442 Multidrug resistance protein D [Escherichia coli (strain
K12)]
Length=394
Score = 123 bits (309), Expect = 2e-34
Identities = 116/408 (28%), Positives = 191/408 (47%), Gaps = 30/408 (7%)
Query 6 LNRQYSTAWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQ 65
+ RQ + +++L LL A+G ++ +Y+PA+ MA D V V + + AY L + Q
Sbjct 1 MKRQRNVNLLLMLVLLVAVGQMAQTIYIPAIADMARDLNVREGAVQSVMGAYLLTYGVSQ 60
Query 66 LVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAA 125
L YGPISDR+GR+ + VG++++++A+ V + LI A +Q +G VG V+AR
Sbjct 61 LFYGPISDRVGRRPVILVGMSIFMLATLVAVTTSSLTVLIAASAMQGMGTGVGGVMARTL 120
Query 126 IRDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIH 185
RD + A S + + + ++P+ AP +G + ++W+A + L L+ C +
Sbjct 121 PRDLYERTQLRHANSLLNMGILVSPLLAPLIGGLLDTMWNWRACYLFL-LVLCAGVT--- 176
Query 186 FFFIETLVPEKR-LRLSLNQVFTLYIAIFKDASFR--FPMFAGCLTGGVLFSYISSASAV 242
F + +PE R + ++ T Y +F ++ F M G L G F + S V
Sbjct 177 -FSMARWMPETRPVDAPRTRLLTSYKTLFGNSGFNCYLLMLIGGLAGIAAF---EACSGV 232
Query 243 LMDQ-YGLSQQQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLV 301
LM GLS + F + + R STL + + L+
Sbjct 233 LMGAVLGLSSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSV---------ICCLL 283
Query 302 SGLLIHAP----IVMVMTGLF---LAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQ 354
+GLL+ P ++ V T L L G GM P A + AM AGTA A++G +Q
Sbjct 284 AGLLMWIPDWFGVMNVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQ 343
Query 355 -FACGLLAGVLLNFLIWNALFNMGLMMLLFSGVGVIAIFVVARQLKLQ 401
G+LA L L ++GL+M L + V+ +A ++ Q
Sbjct 344 NIGSGVLAS-LSAMLPQTGQGSLGLLMTLMGLLIVLCWLPLATRMSHQ 390
>P32482 Chloramphenicol resistance protein [Pseudomonas aeruginosa]
Length=419
Score = 117 bits (294), Expect = 3e-32
Identities = 96/367 (26%), Positives = 174/367 (47%), Gaps = 14/367 (4%)
Query 1 MSESRLNRQYS-TAWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFL 59
MS + +YS A ++LL+ L L +DMYLPA+P M G + + + TL Y +
Sbjct 1 MSSKNFSWRYSLAATVLLLSPFDLLASLGMDMYLPAVPFMPNALGTTASTIQLTLTTYLV 60
Query 60 GLAIGQLVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGV 119
+ GQL++GP+SDR+GR+ L G YV+AS L + + RI+QA G +
Sbjct 61 MIGAGQLLFGPLSDRLGRRPVLLGGGLAYVVASMGLALTSSAEVFLGLRILQACGASACL 120
Query 120 VIARAAIRD-RLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGC 178
V A +RD + S + + ++ + P P LGA V + W+AIF L L G
Sbjct 121 VSTFATVRDIYAGREESNVIYGILGSMLAMVPAVGPLLGALVDMWLGWRAIFAFLGL-GM 179
Query 179 ISLVCIHFFFIETLVPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISS 238
I+ + F PE R++ ++ + K +F G F + S
Sbjct 180 IAASAAAWRF----WPETRVQRVAGLQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSI 235
Query 239 ASAVLMDQYGLSQQQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALV 298
A ++M + G+SQ F+ F A+ ++ + +++ + + L++G + GA++
Sbjct 236 APGLMMGRQGVSQLGFSLLFATVAIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVL 295
Query 299 VLVSGLLIHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACG 358
+ ++ + ++ + ++L G+G+ A A++++ G+ G + G++
Sbjct 296 LAITEIWALQSVLGFIAPMWLV--GIGV----ATAVSVAPNGALRG-FDHVAGTVTAVYF 348
Query 359 LLAGVLL 365
L GVLL
Sbjct 349 CLGGVLL 355
>P0AEY8 Multidrug transporter MdfA [Escherichia coli (strain K12)]
Length=410
Score = 110 bits (276), Expect = 7e-30
Identities = 99/413 (24%), Positives = 182/413 (44%), Gaps = 31/413 (8%)
Query 2 SESRLNRQYSTAWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGL 61
S +RL RQ + + + L L + DM P + + E + V ++ AY G
Sbjct 7 SGARLGRQ-ALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGG 65
Query 62 AIGQLVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVI 121
Q + GP+SDRIGR+ + G+ +++ + +LA N R +Q + C +
Sbjct 66 MFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAV 125
Query 122 ARAAIRDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISL 181
AAI++ + + + M V IAP+ P +GA + W+ +F + A + IS
Sbjct 126 GYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAALAAIS- 184
Query 182 VCIHFFFIETLVPEKRLR----LSLNQVFTLYIAIFKDASFRFPMFAGCLTGGV----LF 233
FF ++ +PE R LSL ++ Y + K+ F AG L G L
Sbjct 185 ----FFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRF----VAGALALGFVSLPLL 236
Query 234 SYISSASAVLMDQYGLSQQQFAY----AFGFNALGIIILSSLNKKLVSRLSTLQRLKIGG 289
++I+ + +++ LS ++ FG G ++L+ +L SR + + +GG
Sbjct 237 AWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLA----RLTSRRTVRSLIIMGG 292
Query 290 FIQLTGALVVLVSGLLIHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAI 349
+ + G LV + ++ + + GL + G+G+ + L + GT SA
Sbjct 293 WPIMIGLLVAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAA 352
Query 350 MGSMQFACGLLAGVLLNFLIW----NALFNMGLMMLLFSGVGVIAIFVVARQL 398
MG +Q G+ ++ W N LFN+ ++ + ++ IF+ +Q+
Sbjct 353 MGMLQMLI-FTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQM 404
>P39386 Multidrug resistance protein MdtM [Escherichia coli (strain
K12)]
Length=410
Score = 110 bits (275), Expect = 9e-30
Identities = 95/386 (25%), Positives = 167/386 (43%), Gaps = 15/386 (4%)
Query 16 MLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRI 75
M L L LS D+ P + + DF ++ + Y G Q + GP+SDRI
Sbjct 16 MALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRI 75
Query 76 GRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGS 135
GR+ L G ++ +A A+ + + + AR IQ C + +++
Sbjct 76 GRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKG 135
Query 136 AQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETLVPE 195
+ + + ++ IAPI P GA ++ F HW+ +F I+A++G IS V + ET V
Sbjct 136 IKLMAIITSIVLIAPIIGPLSGAALMHFMHWKVLFAIIAVMGFISFVGLLLAMPET-VKR 194
Query 196 KRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQQFA 255
+ S V + +F + F F L+ + S+++ + +L+D L+ QFA
Sbjct 195 GAVPFSAKSVLRDFRNVFCNRLFLFGAATISLSYIPMMSWVAVSPVILIDAGSLTTSQFA 254
Query 256 Y----AFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSGLLIHAPIV 311
+ FG +I+ +++ + V + + + IQL G +++V LL +
Sbjct 255 WTQVPVFG----AVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLSLLIVGNLLSPHVWL 310
Query 312 MVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMGSMQFACGLLAGVLLNFLIWN 371
+ G L G+G+ P + GT SA + +M + V + +W
Sbjct 311 WSVLGTSLYAFGIGLIFPTLFRFTLFSNKLPKGTVSASL-NMVILMVMSVSVEIGRWLW- 368
Query 372 ALFNMGLM--MLLFSGVGVIAIFVVA 395
FN G + LL GVI +F +A
Sbjct 369 --FNGGRLPFHLLAVVAGVIVVFTLA 392
>D0CCT2 Chloramphenicol resistance protein CraA [Acinetobacter
baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG
19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 /
81)]
Length=413
Score = 110 bits (274), Expect = 1e-29
Identities = 84/324 (26%), Positives = 160/324 (49%), Gaps = 9/324 (3%)
Query 30 DMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAIGQLVYGPISDRIGRKKPLYVGLTLYV 89
D+ PA+ + EDFGVS +++ Y LG A + GP+SDR+GRKK L G+ +
Sbjct 36 DLIQPAMLAITEDFGVSATWAPSSMSFYLLGGASVAWLLGPLSDRLGRKKVLLSGVLFFA 95
Query 90 IASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQGSAQAFSSMMIVMGIA 149
+ +L + R +Q +G V + AAI++ + + + + M + +A
Sbjct 96 LCCFLILLTRQIEHFLTLRFLQGIGLSVISAVGYAAIQENFAERDAIKVMALMANISLLA 155
Query 150 PIAAPALGAFVLEFFHWQAIFWILALIGCISLVCIHFFFIETLVPEKRLRLS---LNQVF 206
P+ P LGAF++++ W F +AL+ +S V ++ +P ++ ++ + +F
Sbjct 156 PLLGPVLGAFLIDYVSWHWGFVAIALLALLSWV-----GLKKQMPSHKVSVTKQPFSYLF 210
Query 207 TLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVLMDQYGLSQQQFAYAFGFNALGII 266
+ +F + F A L G L +I+ + +L+D+ L+ Q+ A LG+I
Sbjct 211 DDFKKVFSNRQFLGLTLALPLVGMPLMLWIALSPIILVDELKLTSVQYGLAQFPVFLGLI 270
Query 267 ILSSLNKKLVSRLSTLQRLKIGGFIQLTGALVVLVSGLLIHAPIVMVMTGLFLAVSGLGM 326
+ + + K++ RL+ + + IG I LTG L++++ + I ++ G+ L G G+
Sbjct 271 VGNIVLIKIIDRLALGKTVLIGLPIMLTGTLILILGVVWQAYLIPCLLIGMTLICFGEGI 330
Query 327 TGPNAMALA-MSQQGSRAGTASAI 349
+ A MS + S+ A+A+
Sbjct 331 SFSVLYRFALMSSEVSKGTVAAAV 354
Score = 26.6 bits (57), Expect = 0.033
Identities = 39/160 (24%), Positives = 66/160 (41%), Gaps = 14/160 (9%)
Query 236 ISSASAVLMDQYGLSQQQFAYAFGFNALGIIILSSLNKKLVSRLSTLQRLKIGGFIQLTG 295
I A + + +G+S + F LG ++ L L RL + L G
Sbjct 38 IQPAMLAITEDFGVSATWAPSSMSFYLLGGASVAWLLGPLSDRLGRKKVLLSGVLFFALC 97
Query 296 ALVVLVSGLLIHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTA---SAIMGS 352
++L++ + H +T FL G+G++ +A+ A Q+ A A+M +
Sbjct 98 CFLILLTRQIEH-----FLTLRFL--QGIGLSVISAVGYAAIQENFAERDAIKVMALMAN 150
Query 353 MQFACGLLAGVLLNFLI----WNALFNMGLMMLLFSGVGV 388
+ LL VL FLI W+ F ++ L S VG+
Sbjct 151 ISLLAPLLGPVLGAFLIDYVSWHWGFVAIALLALLSWVGL 190
>D5B5U5 Multidrug transporter MdfA [Yersinia pestis (strain Z176003)]
Length=409
Score = 100 bits (248), Expect = 4e-26
Identities = 90/394 (23%), Positives = 169/394 (43%), Gaps = 7/394 (2%)
Query 4 SRLNRQYSTAWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAI 63
+RL R+ + + + L L ++ DM P + + +F S V ++ AY G
Sbjct 9 TRLGRR-ALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMF 67
Query 64 GQLVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIAR 123
Q + GP+SDR GR+ + G+ +V+ + +L ++ I R +Q +G C +
Sbjct 68 LQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGY 127
Query 124 AAIRDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVC 183
A I++ + + + M V IAP+ P GA ++ WQ +F + A++G IS
Sbjct 128 ATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAG 187
Query 184 IHFFFIETLVPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVL 243
+ ET K +LS+ ++ Y + + F A L ++I+ + +L
Sbjct 188 LWRAMPET-ASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVIL 246
Query 244 MDQYGLSQQQFAYAFGFNALGIIILSSLN-KKLVSRLSTLQRLKIGGFIQLTGALVVLVS 302
+ LS ++ G +I+ +L +L + S Q ++ G + G ++ S
Sbjct 247 ISGEQLSTFEYG-ILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGS 305
Query 303 GLLIHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMG---SMQFACGL 359
L + + GL L G+G+ + L + GT SA MG M F G+
Sbjct 306 TLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGI 365
Query 360 LAGVLLNFLIWNALFNMGLMMLLFSGVGVIAIFV 393
+ + FN+ +M +G++ +F+
Sbjct 366 ELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFI 399
>D0JKF6 Multidrug transporter MdfA [Yersinia pestis (strain D106004)]
Length=409
Score = 100 bits (248), Expect = 4e-26
Identities = 90/394 (23%), Positives = 169/394 (43%), Gaps = 7/394 (2%)
Query 4 SRLNRQYSTAWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAI 63
+RL R+ + + + L L ++ DM P + + +F S V ++ AY G
Sbjct 9 TRLGRR-ALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMF 67
Query 64 GQLVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIAR 123
Q + GP+SDR GR+ + G+ +V+ + +L ++ I R +Q +G C +
Sbjct 68 LQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGY 127
Query 124 AAIRDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVC 183
A I++ + + + M V IAP+ P GA ++ WQ +F + A++G IS
Sbjct 128 ATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAG 187
Query 184 IHFFFIETLVPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVL 243
+ ET K +LS+ ++ Y + + F A L ++I+ + +L
Sbjct 188 LWRAMPET-ASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVIL 246
Query 244 MDQYGLSQQQFAYAFGFNALGIIILSSLN-KKLVSRLSTLQRLKIGGFIQLTGALVVLVS 302
+ LS ++ G +I+ +L +L + S Q ++ G + G ++ S
Sbjct 247 ISGEQLSTFEYG-ILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGS 305
Query 303 GLLIHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMG---SMQFACGL 359
L + + GL L G+G+ + L + GT SA MG M F G+
Sbjct 306 TLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGI 365
Query 360 LAGVLLNFLIWNALFNMGLMMLLFSGVGVIAIFV 393
+ + FN+ +M +G++ +F+
Sbjct 366 ELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFI 399
>D0JUX5 Multidrug transporter MdfA [Yersinia pestis (strain D182038)]
Length=409
Score = 100 bits (248), Expect = 4e-26
Identities = 90/394 (23%), Positives = 169/394 (43%), Gaps = 7/394 (2%)
Query 4 SRLNRQYSTAWIMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVANTLPAYFLGLAI 63
+RL R+ + + + L L ++ DM P + + +F S V ++ AY G
Sbjct 9 TRLGRR-ALLFPLCLVLFEFAAYIANDMIQPGMLAVVAEFNASVEWVPTSMTAYLAGGMF 67
Query 64 GQLVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIAR 123
Q + GP+SDR GR+ + G+ +V+ + +L ++ I R +Q +G C +
Sbjct 68 LQWLLGPLSDRRGRRPVMLAGVAFFVVTCLAILLVNSIEQFIAMRFLQGIGLCFIGAVGY 127
Query 124 AAIRDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVC 183
A I++ + + + M V IAP+ P GA ++ WQ +F + A++G IS
Sbjct 128 ATIQESFEEAVCIKITALMANVALIAPLLGPLAGAALIHVAPWQTMFVLFAVLGAISFAG 187
Query 184 IHFFFIETLVPEKRLRLSLNQVFTLYIAIFKDASFRFPMFAGCLTGGVLFSYISSASAVL 243
+ ET K +LS+ ++ Y + + F A L ++I+ + +L
Sbjct 188 LWRAMPET-ASLKGEKLSVANMWRDYKQVLANRRFLCGSLALGFASLPLLAWIAQSPVIL 246
Query 244 MDQYGLSQQQFAYAFGFNALGIIILSSLN-KKLVSRLSTLQRLKIGGFIQLTGALVVLVS 302
+ LS ++ G +I+ +L +L + S Q ++ G + G ++ S
Sbjct 247 ISGEQLSTFEYG-ILQVPIFGALIIGNLTLARLSGKTSIPQLIRYGAGPMIVGLMIAAGS 305
Query 303 GLLIHAPIVMVMTGLFLAVSGLGMTGPNAMALAMSQQGSRAGTASAIMG---SMQFACGL 359
L + + GL L G+G+ + L + GT SA MG M F G+
Sbjct 306 TLYSSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDISKGTVSAAMGMISMMIFTLGI 365
Query 360 LAGVLLNFLIWNALFNMGLMMLLFSGVGVIAIFV 393
+ + FN+ +M +G++ +F+
Sbjct 366 ELAKVAYLWGDSRGFNLFNLMSGLLWLGLVMVFI 399
>B3FWT8 Efflux pump rdc3 [Metacordyceps chlamydosporia]
Length=539
Score = 98.6 bits (244), Expect = 3e-25
Identities = 60/191 (31%), Positives = 93/191 (49%), Gaps = 3/191 (2%)
Query 7 NRQYSTAW--IMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVAN-TLPAYFLGLAI 63
N S W I ++ L+T PL+ M+ PA+PQ+ +DF A ++ + Y LGLA
Sbjct 90 NWTLSKKWLNISVVGLITFNVPLASSMFAPAVPQLLQDFHTDNASLSTFVVSVYILGLAA 149
Query 64 GQLVYGPISDRIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIAR 123
G L+ P+S+ GR +VG L++I + +C LA N L+ R + L G + I
Sbjct 150 GPLILAPMSELYGRLNVYHVGNVLFIIFTVACGLATNINMLVAFRFLAGLVGAAPIAIGA 209
Query 124 AAIRDRLDVQGSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILALIGCISLVC 183
I D ++Q A S + + P P +G F+ + W+ IFW+LA+I +
Sbjct 210 GTIADVTNLQQRGTAMSIWSLGPLLGPSIGPVIGGFLAQAAGWRWIFWLLAIIAGAVAII 269
Query 184 IHFFFIETLVP 194
F ET P
Sbjct 270 SFFVLQETHAP 280
Score = 23.5 bits (49), Expect = 0.32
Identities = 20/82 (24%), Positives = 33/82 (40%), Gaps = 7/82 (9%)
Query 139 FSSMMIVMGIAPIAAPALGAFVLEFFHWQA--IFWILALIG-CISLVCIHFFFIETLVPE 195
F M + G+ P G V W + ++A IG CI +CI+ + ++T
Sbjct 410 FPPMFMAGGLLPAGLFMYGWAVQHHVQWAVPLLGTLIAGIGICIISICINTYLVDTFTMY 469
Query 196 KRLRLS----LNQVFTLYIAIF 213
L+ L VF + +F
Sbjct 470 AASALAASAVLRSVFAAVLPLF 491
>C5H884 Efflux pump radE [Floropilus chiversii]
Length=538
Score = 93.2 bits (230), Expect = 2e-23
Identities = 80/297 (27%), Positives = 133/297 (45%), Gaps = 31/297 (10%)
Query 15 IMLLALLTALGPLSIDMYLPALPQMAEDFGVSTAMVAN-TLPAYFLGLAIGQLVYGPISD 73
+ +L+++T + PL+ M+ P +PQ+ DF + +A + Y LGLA G LV P+S+
Sbjct 99 VAVLSIITFMVPLASSMFAPGIPQVLSDFDTNNPSLATFVVSVYILGLAAGPLVLAPMSE 158
Query 74 RIGRKKPLYVGLTLYVIASASCVLADNEWSLIFARIIQALGGCVGVVIARAAIRDRLDVQ 133
GR +VG L++I + +C L+ N LI R + L G + I I D +Q
Sbjct 159 LYGRVVIYHVGNVLFIIFTVACALSTNMNMLIAFRFLCGLVGAGPIAIGGGTIADLTTLQ 218
Query 134 GSAQAFSSMMIVMGIAPIAAPALGAFVLEFFHWQAIFWILAL----IGCISLVCIHFFFI 189
A S + + P P G F+ + W+ IFW+LA+ I L+ +
Sbjct 219 QRGTAMSVWSLGPLLGPSVGPVAGGFLSQAEGWRWIFWVLAITAGVITIAGLLVLRETHP 278
Query 190 ETLVPEKRLRL-----SLN-------QVF--TLYIAIFKDASFRFPMFAGCLTGGV---- 231
TL+ K RL ++N QV TL++ S + CL V
Sbjct 279 GTLLERKTRRLRKETGNMNLRSKLDLQVAPRTLFLRSIVRPSKLLVLSPICLVLSVYSAF 338
Query 232 ----LFSYISSASAVLMDQYGLSQQQFA---YAFGFNAL-GIIILSSLNKKLVSRLS 280
++ IS+ + V D YG S+ A G L G+++ ++ +++ RL+
Sbjct 339 VYAMIYFMISTFTFVFQDNYGFSEGIVGLVYIALGLGMLFGVVVQQAIGNRIMKRLA 395
Lambda K H a alpha
0.332 0.142 0.423 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 3800959
Database: 2549b0d4fcf34076388d81741b1268a3.SwissProt.fasta
Posted date: Jun 2, 2024 4:28 PM
Number of letters in database: 12,596
Number of sequences in database: 31
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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