Comparative Genomics

ACIAD1581 / SwissProt Alignments

BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: ebf04d09a9fd349c129d119ec30b3d8c.SwissProt.fasta
           21 sequences; 4,448 total letters



Query= ACIAD1581

Length=206
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

P94548 Fatty acid metabolism regulator protein [Bacillus subtilis...  54.7    8e-13
Q5HKQ1 Biofilm operon icaADBC HTH-type negative transcriptional r...  50.1    3e-11
Q8GLC6 Biofilm operon icaADBC HTH-type negative transcriptional r...  50.1    3e-11
P9WMC0 HTH-type transcriptional regulator EthR [Mycobacterium tub...  48.9    1e-10
P9WMC1 HTH-type transcriptional regulator EthR [Mycobacterium tub...  48.9    1e-10
Q7TVI1 HTH-type transcriptional regulator EthR [Mycobacterium bov...  48.9    1e-10
P0ACT9 HTH-type transcriptional regulator UidR [Shigella flexneri]    48.5    1e-10
P0ACT6 HTH-type transcriptional regulator UidR [Escherichia coli ...  48.5    1e-10
P0ACT7 HTH-type transcriptional regulator UidR [Escherichia coli ...  48.5    1e-10
P0ACT8 HTH-type transcriptional regulator UidR [Escherichia coli ...  48.5    1e-10
Q6GDD9 Biofilm operon icaADBC HTH-type negative transcriptional r...  48.1    2e-10
Q7A352 Biofilm operon icaADBC HTH-type negative transcriptional r...  48.1    2e-10
Q7A2K5 Biofilm operon icaADBC HTH-type negative transcriptional r...  48.1    2e-10
A6QKF4 Biofilm operon icaADBC HTH-type negative transcriptional r...  48.1    2e-10
Q9RQQ0 Biofilm operon icaADBC HTH-type negative transcriptional r...  48.1    2e-10
O32228 Uncharacterized HTH-type transcriptional regulator YvaF [B...  47.8    2e-10
O31560 Uncharacterized HTH-type transcriptional regulator YfiR [B...  47.0    5e-10
P94423 Uncharacterized HTH-type transcriptional regulator YcnC [B...  47.4    5e-10
A0R666 HTH-type transcriptional regulator EthR [Mycolicibacterium...  46.6    7e-10
P95251 Transcriptional repressor Mce3R [Mycobacterium tuberculosi...  47.0    9e-10
P0ACU2 HTH-type transcriptional regulator RutR [Escherichia coli ...  46.2    9e-10


>P94548 Fatty acid metabolism regulator protein [Bacillus subtilis 
(strain 168)]
Length=194

 Score = 54.7 bits (130),  Expect = 8e-13
 Identities = 30/99 (30%), Positives = 54/99 (55%), Gaps = 5/99 (5%)

Query  15   QERQAKRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIG  74
            ++++ K   ++ AAV++  E G+H + +  +AK  G++  TIY Y  NKE +L++  +  
Sbjct  2    KQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIYLYFKNKEDILISLFKEK  61

Query  75   LQQLIEAAKDVEKQSISGFEKL-----RRFLFLYGCRNL  108
            + Q IE  ++  K+  +  EKL     + F  L G  NL
Sbjct  62   MGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNL  100


>Q5HKQ1 Biofilm operon icaADBC HTH-type negative transcriptional 
regulator IcaR [Staphylococcus epidermidis (strain ATCC 35984 
/ RP62A)]
Length=185

 Score = 50.1 bits (118),  Expect = 3e-11
 Identities = 26/84 (31%), Positives = 50/84 (60%), Gaps = 3/84 (4%)

Query  21   RDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIE  80
            +D ++  A+ +F+E+G+  T+LDD++KS+ I K ++Y++  NKE++    VE      I+
Sbjct  2    KDKIIDNAITLFSEKGYDGTTLDDISKSVNIKKASLYYHYDNKEEIYRKSVENCFNYFID  61

Query  81   --AAKDVEKQSISG-FEKLRRFLF  101
                   +  SI G ++ L +F+F
Sbjct  62   FLLRNHDDNYSIDGLYQFLFKFIF  85


>Q8GLC6 Biofilm operon icaADBC HTH-type negative transcriptional 
regulator IcaR [Staphylococcus epidermidis]
Length=185

 Score = 50.1 bits (118),  Expect = 3e-11
 Identities = 26/84 (31%), Positives = 50/84 (60%), Gaps = 3/84 (4%)

Query  21   RDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIE  80
            +D ++  A+ +F+E+G+  T+LDD++KS+ I K ++Y++  NKE++    VE      I+
Sbjct  2    KDKIIDNAITLFSEKGYDGTTLDDISKSVNIKKASLYYHYDNKEEIYRKSVENCFNYFID  61

Query  81   --AAKDVEKQSISG-FEKLRRFLF  101
                   +  SI G ++ L +F+F
Sbjct  62   FLLRNHDDNYSIDGLYQFLFKFIF  85


>P9WMC0 HTH-type transcriptional regulator EthR [Mycobacterium 
tuberculosis (strain CDC 1551 / Oshkosh)]
Length=216

 Score = 48.9 bits (115),  Expect = 1e-10
 Identities = 26/75 (35%), Positives = 42/75 (56%), Gaps = 7/75 (9%)

Query  23   AVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCV-------EIGL  75
            A+L  A  +  ++     S+DD+AK  GIS+PT Y Y  +KE VLLT +       ++ L
Sbjct  28   AILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMAL  87

Query  76   QQLIEAAKDVEKQSI  90
            Q L E   D +++++
Sbjct  88   QTLAENPADTDRENM  102


>P9WMC1 HTH-type transcriptional regulator EthR [Mycobacterium 
tuberculosis (strain ATCC 25618 / H37Rv)]
Length=216

 Score = 48.9 bits (115),  Expect = 1e-10
 Identities = 26/75 (35%), Positives = 42/75 (56%), Gaps = 7/75 (9%)

Query  23   AVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCV-------EIGL  75
            A+L  A  +  ++     S+DD+AK  GIS+PT Y Y  +KE VLLT +       ++ L
Sbjct  28   AILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMAL  87

Query  76   QQLIEAAKDVEKQSI  90
            Q L E   D +++++
Sbjct  88   QTLAENPADTDRENM  102


>Q7TVI1 HTH-type transcriptional regulator EthR [Mycobacterium 
bovis (strain ATCC BAA-935 / AF2122/97)]
Length=216

 Score = 48.9 bits (115),  Expect = 1e-10
 Identities = 26/75 (35%), Positives = 42/75 (56%), Gaps = 7/75 (9%)

Query  23   AVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCV-------EIGL  75
            A+L  A  +  ++     S+DD+AK  GIS+PT Y Y  +KE VLLT +       ++ L
Sbjct  28   AILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMAL  87

Query  76   QQLIEAAKDVEKQSI  90
            Q L E   D +++++
Sbjct  88   QTLAENPADTDRENM  102


>P0ACT9 HTH-type transcriptional regulator UidR [Shigella flexneri]
Length=196

 Score = 48.5 bits (114),  Expect = 1e-10
 Identities = 23/57 (40%), Positives = 35/57 (61%), Gaps = 0/57 (0%)

Query  11  EKKEQERQAKRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVL  67
           +  + E Q  R  +L AA +IF+E GFHS S+  + KS  IS  T+YH+  +KE ++
Sbjct  3   DNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALI  59


>P0ACT6 HTH-type transcriptional regulator UidR [Escherichia coli 
(strain K12)]
Length=196

 Score = 48.5 bits (114),  Expect = 1e-10
 Identities = 23/57 (40%), Positives = 35/57 (61%), Gaps = 0/57 (0%)

Query  11  EKKEQERQAKRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVL  67
           +  + E Q  R  +L AA +IF+E GFHS S+  + KS  IS  T+YH+  +KE ++
Sbjct  3   DNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALI  59


>P0ACT7 HTH-type transcriptional regulator UidR [Escherichia coli 
O6:H1 (strain CFT073 / ATCC 700928 / UPEC)]
Length=196

 Score = 48.5 bits (114),  Expect = 1e-10
 Identities = 23/57 (40%), Positives = 35/57 (61%), Gaps = 0/57 (0%)

Query  11  EKKEQERQAKRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVL  67
           +  + E Q  R  +L AA +IF+E GFHS S+  + KS  IS  T+YH+  +KE ++
Sbjct  3   DNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALI  59


>P0ACT8 HTH-type transcriptional regulator UidR [Escherichia coli 
O157:H7]
Length=196

 Score = 48.5 bits (114),  Expect = 1e-10
 Identities = 23/57 (40%), Positives = 35/57 (61%), Gaps = 0/57 (0%)

Query  11  EKKEQERQAKRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVL  67
           +  + E Q  R  +L AA +IF+E GFHS S+  + KS  IS  T+YH+  +KE ++
Sbjct  3   DNMQTEAQPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALI  59


>Q6GDD9 Biofilm operon icaADBC HTH-type negative transcriptional 
regulator IcaR [Staphylococcus aureus (strain MRSA252)]
Length=186

 Score = 48.1 bits (113),  Expect = 2e-10
 Identities = 23/81 (28%), Positives = 46/81 (57%), Gaps = 0/81 (0%)

Query  21   RDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIE  80
            +D ++  A+ +F+E+G+  T+LDD+AKS+ I K ++Y++  +K+ +    V+     L  
Sbjct  2    KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNN  61

Query  81   AAKDVEKQSISGFEKLRRFLF  101
                 + +S    + L +FLF
Sbjct  62   IIMMNQNKSNYSIDALYQFLF  82


>Q7A352 Biofilm operon icaADBC HTH-type negative transcriptional 
regulator IcaR [Staphylococcus aureus (strain N315)]
Length=186

 Score = 48.1 bits (113),  Expect = 2e-10
 Identities = 23/81 (28%), Positives = 46/81 (57%), Gaps = 0/81 (0%)

Query  21   RDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIE  80
            +D ++  A+ +F+E+G+  T+LDD+AKS+ I K ++Y++  +K+ +    V+     L  
Sbjct  2    KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNN  61

Query  81   AAKDVEKQSISGFEKLRRFLF  101
                 + +S    + L +FLF
Sbjct  62   IIMMNQNKSNYSIDALYQFLF  82


>Q7A2K5 Biofilm operon icaADBC HTH-type negative transcriptional 
regulator IcaR [Staphylococcus aureus (strain Mu50 / ATCC 
700699)]
Length=186

 Score = 48.1 bits (113),  Expect = 2e-10
 Identities = 23/81 (28%), Positives = 46/81 (57%), Gaps = 0/81 (0%)

Query  21   RDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIE  80
            +D ++  A+ +F+E+G+  T+LDD+AKS+ I K ++Y++  +K+ +    V+     L  
Sbjct  2    KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNN  61

Query  81   AAKDVEKQSISGFEKLRRFLF  101
                 + +S    + L +FLF
Sbjct  62   IIMMNQNKSNYSIDALYQFLF  82


>A6QKF4 Biofilm operon icaADBC HTH-type negative transcriptional 
regulator IcaR [Staphylococcus aureus (strain Newman)]
Length=186

 Score = 48.1 bits (113),  Expect = 2e-10
 Identities = 23/81 (28%), Positives = 46/81 (57%), Gaps = 0/81 (0%)

Query  21   RDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIE  80
            +D ++  A+ +F+E+G+  T+LDD+AKS+ I K ++Y++  +K+ +    V+     L  
Sbjct  2    KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNN  61

Query  81   AAKDVEKQSISGFEKLRRFLF  101
                 + +S    + L +FLF
Sbjct  62   IIMMNQNKSNYSIDALYQFLF  82


>Q9RQQ0 Biofilm operon icaADBC HTH-type negative transcriptional 
regulator IcaR [Staphylococcus aureus (strain NCTC 8325 / 
PS 47)]
Length=186

 Score = 48.1 bits (113),  Expect = 2e-10
 Identities = 23/81 (28%), Positives = 46/81 (57%), Gaps = 0/81 (0%)

Query  21   RDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIE  80
            +D ++  A+ +F+E+G+  T+LDD+AKS+ I K ++Y++  +K+ +    V+     L  
Sbjct  2    KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNN  61

Query  81   AAKDVEKQSISGFEKLRRFLF  101
                 + +S    + L +FLF
Sbjct  62   IIMMNQNKSNYSIDALYQFLF  82


>O32228 Uncharacterized HTH-type transcriptional regulator YvaF 
[Bacillus subtilis (strain 168)]
Length=190

 Score = 47.8 bits (112),  Expect = 2e-10
 Identities = 45/187 (24%), Positives = 92/187 (49%), Gaps = 20/187 (11%)

Query  24   VLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLIEAAK  83
            +L    ++  ++GF S +++D+A +LG SK T+Y Y  +K+Q++   VE  + ++ +  +
Sbjct  5    ILAETFRLIKQKGF-SFTMNDLAAALGTSKRTLYAYYSSKDQLVEAVVEQFIAEMKQIER  63

Query  84   DV-EKQSISGFEKLRRFLFL----YGCRNLDDFGRCVILTHDDALSKEGLVKFKALKRVV  138
            D+ E +S++  EK+++ L          N+          +D  L+ +  +K    +  +
Sbjct  64   DIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKYHYDAWLTLDAFIK---EEWAI  120

Query  139  HEALLNIIRDAQLDQSINAEHDPKILAATLTGAINWSAKWYNPNGVLSKE----ETIQKM  194
              ALLN  +  +  ++IN    P +      G+IN   + Y+P   L  +    E ++ +
Sbjct  121  VLALLNECKQQKRIRNIN----PDLFVHMYIGSIN---QVYDPEYPLKHQFTTGEVLESI  173

Query  195  VDILTYG  201
            VD+L  G
Sbjct  174  VDVLFNG  180


>O31560 Uncharacterized HTH-type transcriptional regulator YfiR 
[Bacillus subtilis (strain 168)]
Length=205

 Score = 47.0 bits (110),  Expect = 5e-10
 Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 2/81 (2%)

Query  12  KKEQERQAKRDAVLLAAVK-IFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTC  70
           K  +E + KR A +L A K +F  +GF  T++ DV +  G S+  +Y Y  + E++    
Sbjct  4   KVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGFSRGGVYLYFSSTEEMFRRI  63

Query  71  VEIGLQQ-LIEAAKDVEKQSI  90
           +E GL + L +  K  E QS+
Sbjct  64  IETGLDEGLRKLDKSAEHQSV  84


>P94423 Uncharacterized HTH-type transcriptional regulator YcnC 
[Bacillus subtilis (strain 168)]
Length=292

 Score = 47.4 bits (111),  Expect = 5e-10
 Identities = 23/70 (33%), Positives = 43/70 (61%), Gaps = 0/70 (0%)

Query  20  KRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLI  79
           K+  +LLAA K+F+E+ F S S+  +A+   +SK +IY    +KE +LL  +    +Q++
Sbjct  4   KKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLFQSKEDLLLELLSFNQKQMV  63

Query  80  EAAKDVEKQS  89
            AA  +++ +
Sbjct  64  AAASRLQENT  73


>A0R666 HTH-type transcriptional regulator EthR [Mycolicibacterium 
smegmatis (strain ATCC 700084 / mc(2)155)]
Length=217

 Score = 46.6 bits (109),  Expect = 7e-10
 Identities = 21/50 (42%), Positives = 32/50 (64%), Gaps = 0/50 (0%)

Query  23  AVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVE  72
           A+L  A ++   + F   S+DD+AK  GIS+PT Y Y  +KE VLL+ ++
Sbjct  26  AILATAQRLLETKKFAEISVDDLAKGAGISRPTFYFYFPSKEAVLLSLID  75


>P95251 Transcriptional repressor Mce3R [Mycobacterium tuberculosis 
(strain ATCC 25618 / H37Rv)]
Length=406

 Score = 47.0 bits (110),  Expect = 9e-10
 Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 0/70 (0%)

Query  20  KRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLLTCVEIGLQQLI  79
           ++  +L  AV +F E+GFHS  L+D+A++ G++   +Y +  NK+ +L   +  G  Q  
Sbjct  15  RKKQILDQAVGLFIERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQ  74

Query  80  EAAKDVEKQS  89
            A +  E ++
Sbjct  75  SARRLTEGET  84


 Score = 34.3 bits (77),  Expect = 1e-05
 Identities = 12/49 (24%), Positives = 28/49 (57%), Gaps = 0/49 (0%)

Query  19   AKRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVL  67
            ++ + +L A  ++F  QG+ + +  ++ K  GI+ P +Y    +K+ +L
Sbjct  218  SRYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAIL  266


>P0ACU2 HTH-type transcriptional regulator RutR [Escherichia coli 
(strain K12)]
Length=212

 Score = 46.2 bits (108),  Expect = 9e-10
 Identities = 20/57 (35%), Positives = 36/57 (63%), Gaps = 0/57 (0%)

Query  12  KKEQERQAKRDAVLLAAVKIFNEQGFHSTSLDDVAKSLGISKPTIYHYLGNKEQVLL  68
           K+ +   AK+ A+L AA+  F++ GFH T L+ +A+  G+SK  + +Y  +KE + +
Sbjct  11  KRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYI  67



Lambda      K        H        a         alpha
   0.321    0.137    0.397    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 591855


  Database: ebf04d09a9fd349c129d119ec30b3d8c.SwissProt.fasta
    Posted date:  Jun 3, 2024  3:28 AM
  Number of letters in database: 4,448
  Number of sequences in database:  21



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40