BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 31bf8ee04cd3a8bcc0b340e42b015262.SwissProt.fasta
19 sequences; 10,405 total letters
Query= ACIAD2550
Length=974
Score E
Sequences producing significant alignments: (Bits) Value
O87386 Sarcosine oxidase subunit alpha [Rhizobium meliloti (strai... 515 2e-170
Q9AGP1 Sarcosine oxidase subunit alpha [Arthrobacter sp] 436 2e-140
Q46337 Sarcosine oxidase subunit alpha [Corynebacterium sp. (stra... 435 4e-140
Q9WY54 Aminomethyltransferase [Thermotoga maritima (strain ATCC 4... 195 4e-58
A5IKL0 Aminomethyltransferase [Thermotoga petrophila (strain ATCC... 194 1e-57
B1L9U1 Aminomethyltransferase [Thermotoga sp. (strain RQ2)] 193 1e-57
B9K6R7 Aminomethyltransferase [Thermotoga neapolitana (strain ATC... 193 2e-57
B8D1D7 Aminomethyltransferase [Halothermothrix orenii (strain H 1... 186 3e-55
Q67N36 Aminomethyltransferase [Symbiobacterium thermophilum (stra... 185 2e-54
A4J2F6 Aminomethyltransferase [Desulforamulus reducens (strain AT... 176 1e-51
Q9AGP8 Dimethylglycine oxidase [Arthrobacter globiformis] 154 1e-41
Q63342 Dimethylglycine dehydrogenase, mitochondrial [Rattus norve... 144 2e-38
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial [Homo sapiens] 143 7e-38
P27248 Aminomethyltransferase [Escherichia coli (strain K12)] 125 5e-34
P28337 Aminomethyltransferase, mitochondrial [Gallus gallus] 120 3e-32
P54260 Aminomethyltransferase, mitochondrial [Solanum tuberosum] 119 1e-31
P49364 Aminomethyltransferase, mitochondrial [Pisum sativum] 113 1e-29
P49363 Aminomethyltransferase, mitochondrial [Flaveria pringlei] 111 6e-29
Q8CFA2 Aminomethyltransferase, mitochondrial [Mus musculus] 108 3e-28
>O87386 Sarcosine oxidase subunit alpha [Rhizobium meliloti (strain
1021)]
Length=987
Score = 515 bits (1327), Expect = 2e-170
Identities = 337/1008 (33%), Positives = 526/1008 (52%), Gaps = 73/1008 (7%)
Query 12 PYGSMIDRTQVIEFEFDQQKYQGFAGDTIASALIANQRWVMSRSFKYHRPRAPLTMAGQD 71
P ++DR + F FD + QG GDT+ASAL+AN R ++ RSFKYHRPR LT +
Sbjct 7 PKRGLVDRNVPLSFTFDGRPMQGLEGDTLASALLANGRMLVGRSFKYHRPRGILTAGAAE 66
Query 72 ANTLIQLPE----EANVLADTTEIQPQLRAAGQNFSGSLLKDSDAFLGKFSKFMPVGFYY 127
N L+ + E N A E+ L A QN SL D A G S F+ GFYY
Sbjct 67 PNALVTVGRGGRAEPNTRATMQELYEGLEARSQNRWPSLAFDIGALNGLLSPFLGAGFYY 126
Query 128 RAFYKPKGVW-KLWEPLIRKKAGLGVLDLNFEPEYYDKAYLFHDVVVVGGGPAGLQAALS 186
+ F P +W KL+EP+IR+ AGLG +P+ Y+K++ D++V+G GP GL AAL+
Sbjct 127 KTFMWPAPLWEKLYEPVIRRAAGLGKASYEADPDAYEKSWAHCDLLVIGAGPTGLAAALT 186
Query 187 AAEQGAKVLLVEQEKLLGGSLNYARFDVEGVVADQLREQLVNAVTAHANIQVMTQAVCNA 246
A GA+V+LV++ L GGSL ++G A + + + N+QV+ +
Sbjct 187 AGRAGARVILVDEGSLPGGSLLSDTATIDGKAAADFARDTSDELRSMPNVQVLVRTTAFG 246
Query 247 WFTDHYLPVIQG--------------KRMYKVRAKQCIVASGSFDQPVIFRNNDLPGVIL 292
W+ + ++ +R++++ A + ++A+G+ ++P++F ND PGV++
Sbjct 247 WYDGNVFGAVERVQKHVREPASHLPVERLWRIVAGKALLATGAEERPLVFGGNDRPGVMM 306
Query 293 TSAVQRLIKLYAVKPGQKVVILTGHDDGYLAALDMLEAGIDVVAVVDLREIPSNKEAYGA 352
A++ + Y V PG+ I T +D GY A ++ AG+DVVA+VD R + + G
Sbjct 307 AGAMRAYLNRYGVAPGRTPAIFTTNDTGYTLAQELEAAGVDVVAIVDSRPA-AGVDYRGK 365
Query 353 VKAKNVACYLGSTVFEALHDKTMHRVHGVDIRKIVSEGQVAEDAKKLDCDVLCMSSGYMP 412
+ A G+ +A+ +H HG I D L M+ G+ P
Sbjct 366 ARLVREAVVCGTKGGKAISAIEVH--HGGRTETIA-------------VDALAMAGGFDP 410
Query 413 VYQLLCQAGGKLSYNDQKAEFHLSGLPQGLHVTGSVEGIHAIEQVVEHAKYTGTLAAQHA 472
+ L C GGK ++ +KA F G +GL V G + + A A
Sbjct 411 IIHLACHRGGKPVWSAEKAAFLAPGSLKGLEVAGGAAATTGLAACLGEGA-----ARAEA 465
Query 473 LGQPLNVQSSSNTVLK---NNPVNFPWPIFAHP--KGKEFVDFDEDLQIRDIVNATKSGY 527
+ + L + V+K + P P+++ P K K FVDF D+ ++DI A + GY
Sbjct 466 IVRELGLPCPPVAVVKVESEEGIRSPAPLWSIPGIKDKAFVDFQNDVHLKDIGLAVREGY 525
Query 528 RDVQLVKRFSTVGMGPSQGRHSALPTARLVAKSTQRSVSETGVTTARPPFTVEKLAHVAG 587
V+L KR++T GM QG+ S + L+AK+ S +E G TT RP +T + G
Sbjct 526 SHVELAKRYTTSGMATDQGKLSNVNAIGLIAKARGVSPAEVGTTTFRPFYTPVSFGALTG 585
Query 588 ----RSFDPYRQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRL--QHIENEVKHVRNQ 641
F P R++P+H + GA + G W R +++ + R + +E EV +VR
Sbjct 586 AHTGHHFQPVRKSPLHDWAKKHGAVFVETGLWYRSSWFPRSGERTWRESVEREVLNVRKN 645
Query 642 VGMIDVSTLGGLEIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARL 701
G+ DVS LG +EI G D+AEF+NR+Y F KLPVGK RY +M E G + DDG +RL
Sbjct 646 AGLCDVSMLGKIEITGSDAAEFLNRVYCNAFLKLPVGKARYGLMLREDGFIYDDGTTSRL 705
Query 702 SEHHFYVTATTSGVDRIYQQMLKWNAQ--W-RLNLDITNVTTALAAVNIAGPQSRAVMQK 758
E+ F++T TT+ + L++ AQ W +L++ + ++T A + IAGP++R ++QK
Sbjct 706 EENRFFMTTTTAYAAGVMNH-LEFCAQVLWPQLDVRLASITDQWAQMAIAGPKARMILQK 764
Query 759 VCHDVDLSNAAFSYLGVREGSIQGIPVR--ILRVGFVGELGYEIHFPARYGEFMWNHLMQ 816
+ D D+S+AAF +L +E S+ G + + R+ F GEL YE+ PA YGE + + L++
Sbjct 765 IV-DEDISDAAFPFLAAKEVSLFGGALHGCLFRISFSGELAYELAVPAGYGESIADALLE 823
Query 817 AGQAFDIKPFGVESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIA 876
AG+ I P+GVE+ +LR+EKGH + + +G P ++ G V+ KP FVGK A
Sbjct 824 AGKDHGIMPYGVETLSVLRIEKGH-VTHNEINGTIVPADLGFGKMVSAGKPDFVGK---A 879
Query 877 ILEQQ----PLKRKLVSFV-LDKSQEKPLEGHIVLEG-----EDISGNITSCEYSPTLDK 926
+L+++ P + +LV V LD Q HI+ +G E+ G +TS YSP +
Sbjct 880 MLQREGLTAPDRPQLVGVVPLDPQQSFRSGSHILAKGAAATLENDEGYVTSSAYSPHVGS 939
Query 927 IIGMAYVGIGQSEVGQQFPI-RVEKGAMVHATVVKAPFYDPANRRQEI 973
I +A V G++ G++ + G A + F+DP N R +
Sbjct 940 TIALALVRNGRNRHGEEVLVWSGLHGESTPARLCNPVFFDPQNERLHV 987
>Q9AGP1 Sarcosine oxidase subunit alpha [Arthrobacter sp]
Length=967
Score = 436 bits (1121), Expect = 2e-140
Identities = 312/1019 (31%), Positives = 493/1019 (48%), Gaps = 100/1019 (10%)
Query 1 MSNSVLQRLPHPYG--SMIDRTQVIEFEFDQQKYQGFAGDTIASALIANQRWVMSRSFKY 58
MS + RLP + IDR + + D ++ F GDT+ASA++AN + S
Sbjct 1 MSQNKSYRLPAEQSPAARIDRGEALVLSVDGKQLDAFRGDTVASAMLANGQRSCGNSMYL 60
Query 59 HRPRAPLTMAGQDANTLIQLPEEANVLADTTEIQPQLRAAGQNFSGSLLKDSDAFLGKFS 118
RPR + ++ N L+ + + + + N S +LL+
Sbjct 61 DRPRGIFSAGVEEPNALVTVAARHEEDINESMLAATTVPVTANLSATLLR---------- 110
Query 119 KFMPVGFYYRAFYKPKGVWKLWEPLIRKKAGLGVLDLNFEPEYYDKAYLFHDVVVVGGGP 178
GLGVLD + +P YYD ++ DV+VVG GP
Sbjct 111 ------------------------------GLGVLDPSTDPAYYDHVHVHTDVLVVGAGP 140
Query 179 AGLQAALSAAEQGAKVLLVEQEKLLGGSLNYARFD-VEGVVADQLREQLVNAVTAHANIQ 237
AGL AA A+ GA+VLL+++ GGSL A + ++G A + + + A
Sbjct 141 AGLAAAREASRSGARVLLLDERAEAGGSLRDAAGEQIDGQDAAAWIDATAAELASAAETT 200
Query 238 VMTQAVCNAWFTDHYLPVIQGK---------------RMYKVRAKQCIVASGSFDQPVIF 282
+ + + +Y+ Q + R++ +RA Q ++A+G+ ++P++F
Sbjct 201 HLQRTTVLGSYDANYVIAAQRRTVHLDAPSGAGVSRERIWHIRANQVVLATGAHERPIVF 260
Query 283 RNNDLPGVILTSAVQRLIKLYAVKPGQKVVILTGHDDGYLAALDMLEAGIDVVAVVDLRE 342
+NND PG++L AV+ + Y V+ G ++V+ T +D Y D+ +G VVAVVD R
Sbjct 261 QNNDRPGIMLAGAVRSYLNRYGVRAGTRIVVATTNDSAYPLVADLAASG-GVVAVVDART 319
Query 343 IPSNK--EAYGAVKAKNVACYLGSTVFEALHDKTMHRVHGVDIRKIVSEGQVAEDAKKLD 400
S EA GA V GS V + +++ + V + ++ + ++ ++ +
Sbjct 320 TVSAAAAEAVGA----GVRVITGSVVADTEANES-GELSAVVVAELGEDRELGAP-QRFE 373
Query 401 CDVLCMSSGYMPVYQLLCQAGGKLSYNDQKAEFHLSGLPQGLHVTGSVEGIHAIEQVVEH 460
DVL ++ G+ PV L Q GKL ++ F H+ G++ G+ +
Sbjct 374 ADVLAVAGGFNPVVHLHSQRQGKLVWDTSIHAFVPDTAVANQHLAGALTGLFDTASALST 433
Query 461 AKYTGTLAAQHALGQPLNVQSSSNTVLKNNPVNFPWPIFAHPK---------GKEFVDFD 511
TG AA A + + + V P P++ P FVD
Sbjct 434 GAATGAAAATAAGFERIAQVPQALAV----PAGEARPVWLVPSLNGDQAANYTTHFVDLQ 489
Query 512 EDLQIRDIVNATKSGYRDVQLVKRFSTVGMGPSQGRHSALPTARLVAKSTQ-RSVSETGV 570
D + D++ AT +G V+ +KR++++ QG+ S + ++A + +E G
Sbjct 490 RDQTVSDVLRATGAGLESVEHIKRYTSISTANDQGKTSGVAAIGVIAAVLGIENPAEIGT 549
Query 571 TTARPPFTVEKLAHVAGRS----FDPYRQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAH 626
TT R P+T A +AGR+ DP R TPMH+ H+ GA G W+R ++
Sbjct 550 TTFRAPYTPVSFAALAGRTRGALLDPARITPMHSWHLAHGAAFEDVGQWKRAWYFPQDGE 609
Query 627 RLQH-IENEVKHVRNQVGMIDVSTLGGLEIRGPDSAEFINRLYTFGFTKLPVGKTRYAVM 685
+ + E K VR+ VGM+D +TLG +EIRG D+AEF+NR+YT G+TKL VG RY VM
Sbjct 610 DMDAAVYRESKAVRDSVGMLDATTLGKIEIRGKDAAEFLNRIYTNGYTKLKVGMARYGVM 669
Query 686 SNEHGVVIDDGVAARLSEHHFYVTATTSGVDRIYQQMLKW-NAQW-RLNLDITNVTTALA 743
G+V DDGV RL+E F + TT G + + +W +W L++ T+VT LA
Sbjct 670 CKADGMVFDDGVTLRLAEDRFLMHTTTGGAAGVLDWLEEWLQTEWPELDVTCTSVTEQLA 729
Query 744 AVNIAGPQSRAVMQKVCHDVDLSNAAFSYLGVREGSI-QGIPVRILRVGFVGELGYEIHF 802
V + GP+SR V+ K+ +D+SN AF ++ R+ ++ GI RI R+ F GEL YEI
Sbjct 730 TVAVVGPRSRDVVAKLASGLDVSNEAFKFMSFRDVTLDSGIEARISRISFSGELAYEIAI 789
Query 803 PARYGEFMWNHLMQAGQAFDIKPFGVESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAV 862
P+ +G +W + AGQ F+I P+G E+ +LR EKG II+ QDTDG PQ+ + W V
Sbjct 790 PSWHGLRVWKDVFAAGQEFNITPYGTETMHVLRAEKGFIIVGQDTDGTVTPQDAGMEWVV 849
Query 863 ARNKPWFVGKRSIAILEQQPLKRK-LVSFVLDKSQEKPLEG-HIVLEG-------EDISG 913
++ K FVGKRS A + RK LVS + + + EG +V +G + G
Sbjct 850 SKLKD-FVGKRSFARADNLREDRKHLVSVLPVDTTLRLAEGAALVADGAVETGGCTPMEG 908
Query 914 NITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGAMVHATVVKAPFYDPANRRQE 972
+TS SP L + G+A + G+S +G+ V G +V V +DP R++
Sbjct 909 WVTSSYNSPALGRTFGLALIKNGRSRIGEVLKTPV-NGQLVDVLVSDLVLFDPEGSRRD 966
>Q46337 Sarcosine oxidase subunit alpha [Corynebacterium sp. (strain
P-1)]
Length=967
Score = 435 bits (1118), Expect = 4e-140
Identities = 309/1019 (30%), Positives = 491/1019 (48%), Gaps = 100/1019 (10%)
Query 1 MSNSVLQRLPHPYG--SMIDRTQVIEFEFDQQKYQGFAGDTIASALIANQRWVMSRSFKY 58
MS + RLP + IDR + + D ++ + F GDT+ASA++AN + S
Sbjct 1 MSQNTSYRLPAEQSPAARIDRGEALVLTVDGKQLEAFRGDTVASAMLANGQRACGNSMYL 60
Query 59 HRPRAPLTMAGQDANTLIQLPEEANVLADTTEIQPQLRAAGQNFSGSLLKDSDAFLGKFS 118
RPR + ++ N L+ + + + + N S +LL+
Sbjct 61 DRPRGIFSAGVEEPNALVTVEARHEQDINESMLAATTVPVTANLSATLLR---------- 110
Query 119 KFMPVGFYYRAFYKPKGVWKLWEPLIRKKAGLGVLDLNFEPEYYDKAYLFHDVVVVGGGP 178
GLGVLD + +P YYD ++ DV+VVG GP
Sbjct 111 ------------------------------GLGVLDPSTDPAYYDHVHVHTDVLVVGAGP 140
Query 179 AGLQAALSAAEQGAKVLLVEQEKLLGGSLNYARFD-VEGVVADQLREQLVNAVTAHANIQ 237
AGL AA A+ GA+VLL+++ GGSL A + ++G A + V + A
Sbjct 141 AGLAAAREASRSGARVLLLDERAEAGGSLRDAAGEQIDGQDAAAWIDATVAELAAAEETT 200
Query 238 VMTQAVCNAWFTDHYLPVIQGK---------------RMYKVRAKQCIVASGSFDQPVIF 282
+ + + +Y+ +Q + R++ +RA Q ++A+G+ ++P++F
Sbjct 201 HLQRTTVLGSYDANYVVAVQRRTVHLDGPSGAGVSRERIWHIRANQVVLATGAHERPIVF 260
Query 283 RNNDLPGVILTSAVQRLIKLYAVKPGQKVVILTGHDDGYLAALDMLEAGIDVVAVVDLRE 342
NND PG++L AV+ + Y V+ G ++V+ T +D Y D+ +G VVAV+D R
Sbjct 261 ENNDRPGIMLAGAVRSYLNCYGVRAGSQIVVATTNDSAYPLVADLAASG-GVVAVIDART 319
Query 343 IPSNK--EAYGAVKAKNVACYLGSTVFEALHDKTMHRVHGVDIRKIVSEGQVAEDAKKLD 400
S EA GA V GS V + +++ + V + ++ + ++ E ++ +
Sbjct 320 TVSAAAAEAVGA----GVRVITGSVVVDTEANES-GELSAVIVAELGEDRELGEP-QRFE 373
Query 401 CDVLCMSSGYMPVYQLLCQAGGKLSYNDQKAEFHLSGLPQGLHVTGSVEGIHAIEQVVEH 460
DVL ++ G+ PV L Q GKL ++ F H+ G++ G+ +
Sbjct 374 ADVLAVAGGFNPVVHLHSQRQGKLVWDTSIHAFVPDAAVANQHLAGALTGLFDTASALST 433
Query 461 AKYTGTLAAQHALGQPLNVQSSSNTVLKNNPVNFPWPIFAHPK---------GKEFVDFD 511
G AA A + + + V P P++ P FVD
Sbjct 434 GAAVGAAAATAAGFERIAQVPQALPV----PAGETRPVWLVPSLNGDQATNYTTHFVDLQ 489
Query 512 EDLQIRDIVNATKSGYRDVQLVKRFSTVGMGPSQGRHSALPTARLVAKSTQ-RSVSETGV 570
D + D++ AT +G V+ +KR++++ QG+ S + ++A + +E G
Sbjct 490 RDQTVSDVLRATGAGLESVEHIKRYTSISTANDQGKTSGVAAIGVIAAVLGIENPAEIGT 549
Query 571 TTARPPFTVEKLAHVAGRS----FDPYRQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAH 626
TT R P+T A +AGR+ DP R TPMH+ H+ GA G W+R ++
Sbjct 550 TTFRAPYTPVAFAALAGRTRGELLDPARITPMHSWHLAQGAKFEDVGQWKRAWYFPQDGE 609
Query 627 RLQH-IENEVKHVRNQVGMIDVSTLGGLEIRGPDSAEFINRLYTFGFTKLPVGKTRYAVM 685
+ + E VR VGM+D +TLG +EIRG D+AEF+NR+YT G+TKL VG RY VM
Sbjct 610 DMDAAVYRECAAVRESVGMLDATTLGKIEIRGADAAEFLNRIYTNGYTKLKVGMARYGVM 669
Query 686 SNEHGVVIDDGVAARLSEHHFYVTATTSGVDRIYQQMLKW-NAQW-RLNLDITNVTTALA 743
G+V DDGV RL+E F + TT G + + +W +W L++ T+VT LA
Sbjct 670 CKADGMVFDDGVTLRLAEDRFLMHTTTGGAAGVLDWLEEWLQTEWPELDVTCTSVTEQLA 729
Query 744 AVNIAGPQSRAVMQKVCHDVDLSNAAFSYLGVREGSI-QGIPVRILRVGFVGELGYEIHF 802
V + GP+SR V+ K+ +D+SN AF ++ ++ ++ GI RI R+ F GEL YEI
Sbjct 730 TVAVVGPRSRDVVAKLVTGLDVSNDAFKFMSFQDVTLDSGIEARISRISFSGELAYEIAI 789
Query 803 PARYGEFMWNHLMQAGQAFDIKPFGVESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAV 862
P+ +G +W + AGQ F+I P+G E+ +LR EKG II+ QDTDG PQ+ + W V
Sbjct 790 PSWHGLRVWEDVYAAGQEFNITPYGTETMHVLRAEKGFIIVGQDTDGTVTPQDAGMEWVV 849
Query 863 ARNKPWFVGKRSIAILEQQPLKRK-LVSFV-------LDKSQEKPLEGHIVLEG-EDISG 913
++ K FVGKRS + + RK LVS + L + +G + EG + G
Sbjct 850 SKLKD-FVGKRSFSREDNLREDRKHLVSVLPVDTALRLAEGAALVADGAVETEGCTPMEG 908
Query 914 NITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGAMVHATVVKAPFYDPANRRQE 972
+TS SP L + G+A + G+S +G+ V G +V V +DP R++
Sbjct 909 WVTSSYNSPALGRTFGLALIKNGRSRIGEVLKTPV-NGQLVDVLVSDLVLFDPEGSRRD 966
>Q9WY54 Aminomethyltransferase [Thermotoga maritima (strain ATCC
43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)]
Length=364
Score = 195 bits (495), Expect = 4e-58
Identities = 119/378 (31%), Positives = 203/378 (54%), Gaps = 16/378 (4%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++TP+ +HVE GA M+ W+ P +Y I EV VR VGM DVS +G
Sbjct 2 KRTPLFEKHVELGAKMVDFAGWEMPLYYTS-------IFEEVMAVRKSVGMFDVSHMGEF 54
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
++GP++ FI+ L T F+ LP GK Y+VM NE+G +IDD V ++S + +
Sbjct 55 LVKGPEAVSFIDFLITNDFSSLPDGKAIYSVMCNENGGIIDDLVVYKVSPDEALMVVNAA 114
Query 714 GVDRIYQQMLKWNAQWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSYL 773
+++ + + + + +++++N++ A + GP+++ +Q++ D +Y
Sbjct 115 NIEKDFNWIKSHSKNF--DVEVSNISDTTALIAFQGPKAQETLQELVED---GLEEIAYY 169
Query 774 GVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQRL 833
R+ + G+ + R G+ GE G+E+ A+ +W+ LM + D +P G+ ++ +
Sbjct 170 SFRKSIVAGVETLVSRTGYTGEDGFELMLEAKNAPKVWDALMNLLRKIDGRPAGLGARDV 229
Query 834 LRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLVSFVLD 893
RLE +++ QD D T+P EV L W V NK FVGK ++ + ++ ++RKLV+ L
Sbjct 230 CRLEATYLLYGQDMDENTNPFEVGLSWVVKLNKD-FVGKEAL-LKAKEKVERKLVALEL- 286
Query 894 KSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGAM 953
+ +G+ VL+ + G ITS +SPTL K I +A V ++G Q + G +
Sbjct 287 SGKRIARKGYEVLKNGERVGEITSGNFSPTLGKSIALALVS-KSVKIGDQLGVVFPGGKL 345
Query 954 VHATVVKAPFYDPANRRQ 971
V A VVK PFY + RR+
Sbjct 346 VEALVVKKPFYRGSVRRE 363
>A5IKL0 Aminomethyltransferase [Thermotoga petrophila (strain
ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)]
Length=364
Score = 194 bits (492), Expect = 1e-57
Identities = 120/378 (32%), Positives = 202/378 (53%), Gaps = 16/378 (4%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++TP+ +HV GA M+ W+ P +Y I EV VR VGM DVS +G
Sbjct 2 KRTPLFEKHVGLGAKMVDFAGWEMPLYYTS-------IFEEVMAVRKSVGMFDVSHMGEF 54
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
++GP++ FI+ L T F+ LP GK Y+VM NE+G +IDD V ++S + +
Sbjct 55 LVKGPEAVSFIDFLITNDFSSLPDGKAIYSVMCNENGGIIDDLVVYKVSPDEALMVVNAA 114
Query 714 GVDRIYQQMLKWNAQWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSYL 773
+++ + + + + +++I N++ A + GP+++ +Q++ D S +Y
Sbjct 115 NIEKDFNWIKSHSKNF--DVEILNISDTTALIAFQGPEAQETLQELVED---SLEEIAYY 169
Query 774 GVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQRL 833
R+ + G+ + R G+ GE G+E+ A+ +W+ LM + D +P G+ ++ +
Sbjct 170 SFRKSIVAGVEALVSRTGYTGEDGFELMLEAKDAPKVWDALMNLLRKIDGRPAGLGARDV 229
Query 834 LRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLVSFVLD 893
RLE +++ QD D T+P EV L W V +K FVGK ++ + ++ ++RKLV+ L
Sbjct 230 CRLEATYLLYGQDMDESTNPLEVGLSWVVKLDKD-FVGKEAL-LKAKEKVERKLVALEL- 286
Query 894 KSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGAM 953
+ +G+ VL+ + G ITS +SPTL K I +A V +VG Q + G +
Sbjct 287 SGKRIARKGYEVLKNGERVGEITSGNFSPTLGKSIALALVS-KSVKVGDQLEVAFPGGKL 345
Query 954 VHATVVKAPFYDPANRRQ 971
V A VVK PFY + RR+
Sbjct 346 VEALVVKKPFYRGSVRRE 363
Score = 20.4 bits (41), Expect = 6.0
Identities = 13/37 (35%), Positives = 18/37 (49%), Gaps = 6/37 (16%)
Query 142 PLIRKKAGLGVLDLNFE----PEYYDKAYLFHDVVVV 174
PL K GLG ++F P YY +F +V+ V
Sbjct 5 PLFEKHVGLGAKMVDFAGWEMPLYYTS--IFEEVMAV 39
>B1L9U1 Aminomethyltransferase [Thermotoga sp. (strain RQ2)]
Length=364
Score = 193 bits (491), Expect = 1e-57
Identities = 118/378 (31%), Positives = 203/378 (54%), Gaps = 16/378 (4%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++TP+ +HVE GA M+ W+ P +Y I EV VR VGM DVS +G
Sbjct 2 KRTPLFEKHVELGAKMVDFAGWEMPLYYTS-------IFEEVMAVRKSVGMFDVSHMGEF 54
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
++GP++ FI+ L T F+ LP GK Y+VM NE+G +IDD V ++S + +
Sbjct 55 LVKGPEAVSFIDFLITNNFSSLPDGKALYSVMCNENGGIIDDLVVYKVSPDEALMVVNAA 114
Query 714 GVDRIYQQMLKWNAQWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSYL 773
+++ + + + + N++++N++ A + GP+++ +Q++ D S +Y
Sbjct 115 NIEKDFNWIKSHSKNF--NVEVSNISDTTALIAFQGPRAQEALQELVED---SLEEIAYY 169
Query 774 GVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQRL 833
++ + G+ + R G+ GE G+E+ A+ +W+ LM + D +P G+ ++ +
Sbjct 170 SFKKSIVAGVEAIVSRTGYTGEDGFELMIEAKNSPKVWDALMNLLRKIDGRPAGLGARDV 229
Query 834 LRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLVSFVLD 893
RLE +++ QD D T+P EV L W V +K FVGK ++ + ++ ++RKLV+ L
Sbjct 230 CRLEATYLLYGQDMDENTNPFEVGLSWVVKLDKD-FVGKEAL-LKAKEKVERKLVALEL- 286
Query 894 KSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGAM 953
+ +G+ V + + G ITS +SPTL K I +A V ++G Q + G +
Sbjct 287 SGKRIARKGYEVSKNGERVGEITSGNFSPTLGKSIALALVS-KSVKIGDQLGVVFPGGKL 345
Query 954 VHATVVKAPFYDPANRRQ 971
V A VVK PFY + RR+
Sbjct 346 VEALVVKKPFYRGSVRRE 363
>B9K6R7 Aminomethyltransferase [Thermotoga neapolitana (strain
ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)]
Length=363
Score = 193 bits (490), Expect = 2e-57
Identities = 128/379 (34%), Positives = 205/379 (54%), Gaps = 19/379 (5%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++TP++ +HV GA M+ W P +Y I EV VR VG+ DVS +G +
Sbjct 2 KRTPLYERHVALGAKMVDFAGWIMPLYYSS-------IFEEVMAVRKSVGVFDVSHMGEI 54
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
+ G ++ +F+N L T F+ +P GK Y VM NE G ++DD V R+S + +
Sbjct 55 VVEGQETVDFVNFLVTNDFSAIPEGKAMYTVMCNETGGIVDDLVVYRISHEKAIMVVNAA 114
Query 714 GVDRIYQQMLKWNAQWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSYL 773
+++ Y + +K +A+ N+++ NV+ A V GP+S+ +Q+V VD+ Y
Sbjct 115 NIEKDY-EWIKVHAK-NFNVEVRNVSDETALVAFQGPKSQETLQRV---VDIDLEGIGYY 169
Query 774 GVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQRL 833
+ G + G V + R G+ GE G+E+ A +W+ L++ D KP G+ ++ +
Sbjct 170 SFQWGRLDGERVLVSRTGYTGEDGFELMMNAESAAKIWDTLVEIAGNVDGKPAGLGARDV 229
Query 834 LRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLVSFVLD 893
RLE +++ QD D T+P EV L W V NK FVGK ++ L+++ ++RKLV+ L
Sbjct 230 CRLEASYLLYGQDMDESTNPFEVGLSWVVKMNKD-FVGKEALLKLKEK-VERKLVALEL- 286
Query 894 KSQEKPLEGHIVL-EGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGA 952
+ +G+ VL EG+++ G ITS +SPTL K I +A V + G + + V G
Sbjct 287 SGRRIARKGYTVLKEGKEV-GKITSGNFSPTLGKSIALALVS-RCVKTGDRLEV-VFPGK 343
Query 953 MVHATVVKAPFYDPANRRQ 971
V A VVK PFY + RR+
Sbjct 344 NVEAHVVKKPFYRGSVRRE 362
Score = 22.7 bits (47), Expect = 1.1
Identities = 13/51 (25%), Positives = 24/51 (47%), Gaps = 3/51 (6%)
Query 245 NAWFTDHYLPVIQGKRMYKVRAKQCIVASGSFDQPVIFRNNDLPGVILTSA 295
N T+ + + +GK MY V C G D V++R + +++ +A
Sbjct 66 NFLVTNDFSAIPEGKAMYTV---MCNETGGIVDDLVVYRISHEKAIMVVNA 113
>B8D1D7 Aminomethyltransferase [Halothermothrix orenii (strain
H 168 / OCM 544 / DSM 9562)]
Length=357
Score = 186 bits (473), Expect = 3e-55
Identities = 119/370 (32%), Positives = 189/370 (51%), Gaps = 15/370 (4%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++TP+ H E GA ++ W P Y I E K VRNQ G+ DVS +G +
Sbjct 2 KKTPLFEIHKELGARLIEFHGWSMPVQYTS-------IIEEHKAVRNQCGLFDVSHMGEI 54
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
+ GP + E + ++ T +L G+ Y M + G +IDD + L + + + S
Sbjct 55 LVEGPGALESLQKIVTNNVARLKKGQVLYTPMCKDDGGIIDDLLVYCLGQDKYLMVVNAS 114
Query 714 GVDRIYQQMLKWNAQWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSYL 773
+++ + ++ N+ R ++ N + A + + GP S+ +++KV V+L + F
Sbjct 115 NIEKDFN-WVRDNSNQRT--EVVNESDNYALLALQGPNSKKILEKVS-SVNLDSLKF--Y 168
Query 774 GVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQRL 833
G+++G V I R G+ GELGYE++ +W LM+AG + P G+ ++
Sbjct 169 NFTTGTLKGAEVLISRTGYTGELGYELYLSPDKAVEVWQALMEAGSDLGLIPAGLGARDT 228
Query 834 LRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLVSFVLD 893
LRLEKG+ + D D THP E LGW V +K F+GKR++ +++ L RKLV F L
Sbjct 229 LRLEKGYCLYGNDIDENTHPLEAGLGWTVKFDKASFIGKRALLKYKEEGLSRKLVGFKL- 287
Query 894 KSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGAM 953
K + P G+ + + D G +TS SPTL + IGM YV ++ G+ I V A
Sbjct 288 KGRGIPRHGYPIKDNGDQIGVVTSGSMSPTLSEGIGMGYVRYDKATPGESITIVVRNRA- 346
Query 954 VHATVVKAPF 963
+ VVK PF
Sbjct 347 ITGEVVKLPF 356
Score = 22.7 bits (47), Expect = 1.1
Identities = 11/53 (21%), Positives = 25/53 (47%), Gaps = 2/53 (4%)
Query 101 NFSGSLLKDSDAFLGKFSKFMPVGFYYRAFYKPKGVWKLWEPLIRKKAGLGVL 153
NF+ LK ++ + + +G Y + P ++W+ L+ + LG++
Sbjct 169 NFTTGTLKGAEVLISRTGYTGELG--YELYLSPDKAVEVWQALMEAGSDLGLI 219
>Q67N36 Aminomethyltransferase [Symbiobacterium thermophilum (strain
T / IAM 14863)]
Length=375
Score = 185 bits (469), Expect = 2e-54
Identities = 114/381 (30%), Positives = 203/381 (53%), Gaps = 15/381 (4%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++TP++ H++ GA M+P G W+ P Y + E + VR G+ DVS +G
Sbjct 6 KRTPLYELHLKLGARMVPFGGWEMPVQYSS-------VIEEHRAVREAAGLFDVSHMGEF 58
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
E+RGP + + I + T KL VG+ +YA+M E+G V+DD + RL EH +++
Sbjct 59 EVRGPQALDLIQLVSTNDAAKLAVGRVQYALMCYENGTVVDDILIYRLDEHRYWLVVNAG 118
Query 714 GVDRIYQQMLKWNAQWRL-NLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSY 772
+ ++ + + L NL++ + + +A + + GP++ ++Q + V LS +
Sbjct 119 NTQKDWEWINTARERAGLHNLELIDRSAEIALLALQGPKAEEILQPLATGVVLSQLE-PF 177
Query 773 LGVREGSIQGIPVRIL-RVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQ 831
+ ++ G+P +L R G+ GE G+EI+ A +W L++AG + P G+ ++
Sbjct 178 SLAKNVTVSGVPTLVLSRTGYTGEDGFEIYVKAEDVAALWEALLEAGDEQGLLPCGLGAR 237
Query 832 RLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPW-FVGKRSIAILEQQPLKRKLVSF 890
LR E + + +P E LG+AV K F+G+ ++A +++Q RKLV
Sbjct 238 DTLRFEAKLPLYGHEISDQHNPLEAGLGFAVKLKKGVDFIGRDALARIKEQGPTRKLVGI 297
Query 891 -VLDKSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVE 949
++D+ P +G+ V G ++ G +T+ +SPTL+K I +AYV + S VG + + +
Sbjct 298 EMIDRG--VPRQGYPVAVGGEVVGEVTTGSFSPTLEKNIALAYVPVAHSAVGTEVEV-II 354
Query 950 KGAMVHATVVKAPFYDPANRR 970
+G + A VV+ PFY +RR
Sbjct 355 RGRALKARVVETPFYRSPHRR 375
>A4J2F6 Aminomethyltransferase [Desulforamulus reducens (strain
ATCC BAA-1160 / DSM 100696 / MI-1)]
Length=364
Score = 176 bits (447), Expect = 1e-51
Identities = 115/374 (31%), Positives = 199/374 (53%), Gaps = 21/374 (6%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++TP++ H+ AGA M+ G W P Y + I E + VR+ G+ DVS +G +
Sbjct 5 KRTPLYNIHLAAGAKMVEFGGWLMPVQY-------EGIIAEHQAVRSAAGLFDVSHMGEI 57
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
+I GP + EF+ RL T ++L G Y+ M N G +DD + +L + + + S
Sbjct 58 QISGPTAREFVQRLVTNDISRLKPGCAIYSPMCNPQGGTVDDLLVYQLEDQQYLLVVNAS 117
Query 714 GVDRIYQQMLKWNAQWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNA-AFSY 772
D+ + ++ +Q ++I NV+ + + GPQ+ ++Q++ VDLS+ +F +
Sbjct 118 NTDKDFHWIV---SQQVPGVEIQNVSEVTCQLALQGPQAEKILQRLTA-VDLSHIKSFCF 173
Query 773 LGVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQR 832
+ G+++GI I R G+ GE G+E++FPA + E +W +M G ++P G+ ++
Sbjct 174 V---YGAVEGIHCLISRTGYTGEAGFELYFPASHAERVWQAIMATGATDGLRPVGLGARD 230
Query 833 LLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLVSF-V 891
LR E + + P LGW V NKP FVGK + ++ +LV +
Sbjct 231 TLRFEACLALYGHELTDDISPLMAGLGWTVKFNKPEFVGKEPLLKQKEAGTTYQLVGLEM 290
Query 892 LDKSQEKPLEGHIVL-EGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEK 950
+D+ P +G+ + EG+++ G ITS ++PTL K +G+ YV I ++VG++ I V +
Sbjct 291 IDRG--IPRQGYAIFKEGQEV-GWITSGTFAPTLGKNMGLGYVEIPFADVGKELNIMV-R 346
Query 951 GAMVHATVVKAPFY 964
+ A +VK PFY
Sbjct 347 NKPLKARIVKKPFY 360
Score = 21.9 bits (45), Expect = 2.0
Identities = 12/31 (39%), Positives = 16/31 (52%), Gaps = 3/31 (10%)
Query 435 LSGLPQGLHVTGSVEGIHAIEQVVEHAKYTG 465
LS + V G+VEGIH + + YTG
Sbjct 165 LSHIKSFCFVYGAVEGIHCL---ISRTGYTG 192
>Q9AGP8 Dimethylglycine oxidase [Arthrobacter globiformis]
Length=830
Score = 154 bits (390), Expect = 1e-41
Identities = 119/401 (30%), Positives = 178/401 (44%), Gaps = 28/401 (7%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENE------------------- 634
R +P HA+H E GA + AG W+RP ++ A L+ + E
Sbjct 431 RVSPFHARHKELGAFFLEAGGWERPYWFEANAALLKEMPAEWLPPARDAWSGMFSSPIAA 490
Query 635 --VKHVRNQVGMIDVSTLGGLEIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVV 692
R V M D++ L LE+ GP + + + L T K P G Y ++ + G V
Sbjct 491 AEAWKTRTAVAMYDMTPLKRLEVSGPGALKLLQELTTADLAKKP-GAVTYTLLLDHAGGV 549
Query 693 IDDGVAARLSEHHFYVTATTSGVDRIYQQMLKWNAQWRLNLD---ITNVTTALAAVNIAG 749
D ARLSE F + A + +++ + Q D + + T + + G
Sbjct 550 RSDITVARLSEDTFQLGANGNIDTAYFERAARHQTQSGSATDWVQVRDTTGGTCCIGLWG 609
Query 750 PQSRAVMQKVCHDVDLSNAAFSYLGVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEF 809
P +R ++ KV D D +N Y + I GIPV +R+ +VGELG+E++ A G+
Sbjct 610 PLARDLVSKVSDD-DFTNDGLKYFRAKNVVIGGIPVTAMRLSYVGELGWELYTSADNGQR 668
Query 810 MWNHLMQAGQAFDIKPFGVESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWF 869
+W+ L QAGQ F + G + LRLEKG+ D P E LG+AV K F
Sbjct 669 LWDALWQAGQPFGVIAAGRAAFSSLRLEKGYRSWGTDMTTEHDPFEAGLGFAVKMAKESF 728
Query 870 VGKRSIAILEQQPLKRKLVSFVLDKSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIG 929
+GK ++ ++ R+L +D + L V E G +TS Y T+ K I
Sbjct 729 IGKGALEGRTEEASARRLRCLTIDDGRSIVLGKEPVFYKEQAVGYVTSAAYGYTVAKPIA 788
Query 930 MAYVGIGQSEVGQQFPIRVEKGAMVHATVVKAPFYDPANRR 970
+Y+ G VG I G + ATV + P YDP R
Sbjct 789 YSYLP-GTVSVGDSVDIEY-FGRRITATVTEDPLYDPKMTR 827
Score = 20.0 bits (40), Expect = 8.5
Identities = 9/23 (39%), Positives = 11/23 (48%), Gaps = 0/23 (0%)
Query 485 TVLKNNPVNFPWPIFAHPKGKEF 507
TVL P+N P +H G F
Sbjct 32 TVLDQGPLNMPGGSTSHAPGLVF 54
>Q63342 Dimethylglycine dehydrogenase, mitochondrial [Rattus norvegicus]
Length=857
Score = 144 bits (364), Expect = 2e-38
Identities = 108/354 (31%), Positives = 170/354 (48%), Gaps = 25/354 (7%)
Query 614 NWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGLEIRGPDSAEFINRLYTFGFT 673
NW RP + +E K V +VG+ID+S G I+G DS + ++ L
Sbjct 506 NWFRP------------VGSEYKQVMQRVGVIDLSPFGKFNIKGQDSTQLLDHLCANVIP 553
Query 674 KLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTSGVDRIYQQMLKWNAQWRL-- 731
K VG T + M G V + + S F + T SG + L+W + +
Sbjct 554 K--VGFTNISHMLTPRGRVYAELTVSHQSPGEFLLI-TGSGSEL---HDLRWIEEAAVRG 607
Query 732 --NLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSYLGVREGSIQGIPVRILR 789
+++I N+T L + +AGP +R V+QK+ + DLS+ F +L + I IPV +R
Sbjct 608 GYDVEIRNITDELGVLGVAGPYARRVLQKLTSE-DLSDDVFKFLQTKSLKISDIPVTAIR 666
Query 790 VGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQRLLRLEKGHIIISQDTDG 849
+ + GELG+E++ ++ +M AGQ I FG + LRLEK + +
Sbjct 667 ISYTGELGWELYHRREDSAALYERIMNAGQEEGIDNFGTYALNALRLEKAFRAWGSEMNC 726
Query 850 MTHPQEVDLGWAVARNKPW-FVGKRSIAILEQQPLKRKLVSFVLDKSQEKPLEGHIVLEG 908
T+P E L + + NKP F GK+++ ++ + LKR+LV L P V
Sbjct 727 DTNPLEAGLDYFIKLNKPADFTGKQALKQIKAKGLKRRLVCLTLATDDVDPEGNESVWYK 786
Query 909 EDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRVEKGAMVHATVVKAP 962
+ GN TS YS ++ K + AYV + SEVGQQ + + G AT+++ P
Sbjct 787 GKVIGNTTSGSYSYSIQKSLAFAYVPVELSEVGQQVEVEL-LGKNYPATIIQEP 839
>Q9UI17 Dimethylglycine dehydrogenase, mitochondrial [Homo sapiens]
Length=866
Score = 143 bits (360), Expect = 7e-38
Identities = 106/376 (28%), Positives = 180/376 (48%), Gaps = 19/376 (5%)
Query 601 QHVEAGATMMPAGNWQRPAFYGDAAHRLQH------------IENEVKHVRNQVGMIDVS 648
Q +E+ +M W++P ++ Q+ + +E K V +V + D+S
Sbjct 476 QRLESKCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLS 535
Query 649 TLGGLEIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYV 708
G I+G DS ++ L+ K VG T + M G V + + S F +
Sbjct 536 PFGKFNIKGQDSIRLLDHLFANVIPK--VGFTNISHMLTPKGRVYAELTVSHQSPGEFLL 593
Query 709 TATTSGVDRIYQQMLKWNA-QWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSN 767
T SG + + ++ A + +++I N+T L + +AGPQ+R V+QK+ + DLS+
Sbjct 594 I-TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSE-DLSD 651
Query 768 AAFSYLGVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFG 827
F +L + + IPV +R+ + GELG+E++ +++ +M AGQ I FG
Sbjct 652 DVFKFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFG 711
Query 828 VESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPW-FVGKRSIAILEQQPLKRK 886
+ LRLEK + + T+P E L + V NKP F+GK+++ ++ + LKR+
Sbjct 712 TYAMNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRR 771
Query 887 LVSFVLDKSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPI 946
LV L P + + GN TS YS ++ K + AYV + SEVGQQ +
Sbjct 772 LVCLTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEV 831
Query 947 RVEKGAMVHATVVKAP 962
+ G A +++ P
Sbjct 832 EL-LGKNYPAVIIQEP 846
>P27248 Aminomethyltransferase [Escherichia coli (strain K12)]
Length=364
Score = 125 bits (314), Expect = 5e-34
Identities = 109/383 (28%), Positives = 174/383 (45%), Gaps = 50/383 (13%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
+QTP++ QH GA M+ W P YG +E VR GM DVS + +
Sbjct 3 QQTPLYEQHTLCGARMVDFHGWMMPLHYGSQI-------DEHHAVRTDAGMFDVSHMTIV 55
Query 654 EIRGPDSAEFINRLYTFGFTKLPV-GKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATT 712
++RG + EF+ L KL GK Y+ M N G VIDD + +E F + +
Sbjct 56 DLRGSRTREFLRYLLANDVAKLTKSGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNS 115
Query 713 SGVDRIYQQMLKWNAQWR--LNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLS--NA 768
+ ++ L W Q ++IT V L+ + + GP ++A + +D
Sbjct 116 A----TREKDLSWITQHAEPFGIEIT-VRDDLSMIAVQGPNAQAKAATLFNDAQRQAVEG 170
Query 769 AFSYLGVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGV 828
+ GV+ G + I G+ GE GYEI P W L++AG +KP G+
Sbjct 171 MKPFFGVQAGDLF-----IATTGYTGEAGYEIALPNEKAADFWRALVEAG----VKPCGL 221
Query 829 ESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPW------FVGKRSIAILEQQP 882
++ LRLE G + Q+ D P ++GW +A W F+G+ ++ + +++
Sbjct 222 GARDTLRLEAGMNLYGQEMDETISPLAANMGWTIA----WEPADRDFIGREALEV-QREH 276
Query 883 LKRKLVSFVLDKSQEKPLEGHIVLEGEDISGN-----ITSCEYSPTLDKIIGMAYV--GI 935
KLV V+ +++ L + + D GN ITS +SPTL I +A V GI
Sbjct 277 GTEKLVGLVM--TEKGVLRNELPVRFTDAQGNQHEGIITSGTFSPTLGYSIALARVPEGI 334
Query 936 GQSEVGQ----QFPIRVEKGAMV 954
G++ + Q + P++V K V
Sbjct 335 GETAIVQIRNREMPVKVTKPVFV 357
>P28337 Aminomethyltransferase, mitochondrial [Gallus gallus]
Length=392
Score = 120 bits (302), Expect = 3e-32
Identities = 105/375 (28%), Positives = 158/375 (42%), Gaps = 19/375 (5%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
+QTP+ A H G M+P W P YG H+E+ + H R + DVS +
Sbjct 23 KQTPLDALHRARGGRMVPFAGWSLPVQYGRG-----HLESHL-HTRRHCSLFDVSHMLQT 76
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
+ G D F+ L +L G+ +++NE G ++DD + +E H YV +
Sbjct 77 RVYGRDRVRFLESLVVGDIAELRPGQGTLTLLTNERGDIVDDLIVTNTAEDHLYVVSNAG 136
Query 714 GVDRIYQQMLKWNAQWR-LNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSNAAFSY 772
D+ M A+ R D+ + A + GP V+Q D DL+ F
Sbjct 137 CADKDRAVMEGRAAELRAAGGDVHLEVSGQRAAGVQGPSMAQVLQAGLPD-DLTKLTF-- 193
Query 773 LGVREGSIQGIP-VRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGVESQ 831
+ ++ G+P R+ R G+ GE G EI PA + L+ + + P G+ ++
Sbjct 194 MTSTATTVFGVPGCRVTRCGYTGEDGVEISVPAGRAVELAERLLGCPEVW---PAGLAAR 250
Query 832 RLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQ---PLKRKLV 888
LRLE G + D D T P E L W + + + + AI+ +Q KRK V
Sbjct 251 DSLRLEAGLCLYGNDIDESTTPVEAGLLWTLGKRRRTAMDFPGAAIIMEQVKEKPKRKRV 310
Query 889 SFVLDKSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPIRV 948
+P + EG + G +TS SP+L K I M YV S G + V
Sbjct 311 GLTSVGPPLRPPAAILGPEGTPV-GTVTSGCPSPSLGKNIAMGYVQAAHSRPGTTLTVEV 369
Query 949 EKGAMVHATVVKAPF 963
K A V K PF
Sbjct 370 RK-KQHPALVTKMPF 383
>P54260 Aminomethyltransferase, mitochondrial [Solanum tuberosum]
Length=406
Score = 119 bits (298), Expect = 1e-31
Identities = 107/382 (28%), Positives = 171/382 (45%), Gaps = 31/382 (8%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++T ++ HV G M+P W P Y D+ I + + R + DVS + GL
Sbjct 36 KKTVLYDFHVVNGGKMVPFAGWSMPIQYKDS------IMDSTVNCRENGSLFDVSHMCGL 89
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
++G D+ F+ +L L G V +NE G IDD V +++ H Y+
Sbjct 90 SLKGKDTIPFLEKLVIADVAGLAPGTGSLTVFTNEKGGAIDDSVVTKVTNDHIYLVVNAG 149
Query 714 GVDR----IYQQMLKWNAQWRLNLDIT-NVTTALAAVNIAGPQSRAVMQKVCHDVDLSNA 768
D+ I + M + ++ D++ ++ + + + GP + V+Q + D DLS
Sbjct 150 CRDKDLAHIEEHMKSFKSK---GGDVSWHIHDERSLLALQGPLAAPVLQYLTKD-DLSKM 205
Query 769 AFSYLGVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGV 828
F V + I G P + R G+ GE G+EI P+ + L++ + I+ G+
Sbjct 206 YFGEFRVLD--INGAPCFLTRTGYTGEDGFEISVPSENALDLAKALLEKSEG-KIRLTGL 262
Query 829 ESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVA---RNKPWFVGKRSI-AILEQQPLK 884
++ LRLE G + D + T P E L WA+ R + F+G I +E+ P
Sbjct 263 GARDSLRLEAGLCLYGNDMEQHTTPVEAGLTWAIGKRRRAEGGFLGAEVILKQIEEGPKI 322
Query 885 RKLVSFVLDKSQEKPLEGHIVLE---GEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVG 941
R++ F S P H ++ G++I G ITS +SP L K I M YV G + G
Sbjct 323 RRVGFF----SSGPPPRSHSEIQDSNGQNI-GEITSGGFSPCLKKNIAMGYVKTGNHKAG 377
Query 942 QQFPIRVEKGAMVHATVVKAPF 963
I V +G V K PF
Sbjct 378 TNVKI-VIRGKSYDGVVTKMPF 398
>P49364 Aminomethyltransferase, mitochondrial [Pisum sativum]
Length=408
Score = 113 bits (283), Expect = 1e-29
Identities = 99/377 (26%), Positives = 165/377 (44%), Gaps = 21/377 (6%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++T ++ HV G M+P W P Y D+ I + + R + DVS + GL
Sbjct 37 KKTVLYDFHVAHGGKMVPFAGWSMPIQYKDS------IMDSTLNCRQNGSLFDVSHMCGL 90
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
++G D F+ +L L G V +NE G IDD V ++++ H Y+
Sbjct 91 SLKGKDVVSFLEKLVIADVAALAHGTGTLTVFTNEKGGAIDDSVITKVTDDHLYLVVNAG 150
Query 714 GVDR----IYQQMLKWNAQWRLNLDIT-NVTTALAAVNIAGPQSRAVMQKVCHDVDLSNA 768
D+ I + M + A+ D++ ++ + + + GP + V+Q + + DLS
Sbjct 151 CRDKDLAHIEEHMKAFKAK---GGDVSWHIHDERSLLALQGPLAAPVLQHLTKE-DLSKL 206
Query 769 AFSYLGVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGV 828
F V + I G + R G+ GE G+EI P+ +G + L++ + I+ G+
Sbjct 207 YFGEFRVLD--INGSQCFLTRTGYTGEDGFEISVPSEHGVELAKALLEKSEG-KIRLTGL 263
Query 829 ESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLV 888
++ LRLE G + D + P E L WA+ + + G ++ +Q +
Sbjct 264 GARDSLRLEAGLCLYGNDLEQHITPIEAGLTWAIGKRRRAEGGFLGADVILKQLADGPSI 323
Query 889 SFVLDKSQEKPLEGH--IVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFPI 946
V S P H I EG + G +TS +SP L K I + YV G + G + I
Sbjct 324 RRVGFISSGPPPRSHSEIQDEGGNNIGEVTSGGFSPCLKKNIAIGYVKSGLHKAGTKVKI 383
Query 947 RVEKGAMVHATVVKAPF 963
+ +G V K PF
Sbjct 384 -IIRGKQNEGVVTKMPF 399
>P49363 Aminomethyltransferase, mitochondrial [Flaveria pringlei]
Length=407
Score = 111 bits (277), Expect = 6e-29
Identities = 100/387 (26%), Positives = 169/387 (44%), Gaps = 28/387 (7%)
Query 594 RQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTLGGL 653
++T ++ HV G M+P W P Y D+ I + R + DVS + GL
Sbjct 36 KKTVLYDFHVANGGKMVPFAGWSMPIQYKDS------IMESTINCRENGSLFDVSHMCGL 89
Query 654 EIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTATTS 713
++G D F+ +L L G V +NE G IDD V ++++ H Y+
Sbjct 90 SLKGKDCVPFLEKLVVADVAGLRPGTGSLTVFTNEKGGAIDDSVITKVTDDHIYLVVNAG 149
Query 714 GVDR----IYQQMLKWNAQWRLNLDIT-NVTTALAAVNIAGPQSRAVMQKVCHDVDLSNA 768
D+ I + M + A+ D++ ++ + + + GP + + +Q + + DLS
Sbjct 150 CRDKDLAHIEEHMKAFKAK---GGDVSWHIYDERSLLALQGPLAGSTLQHLTKE-DLSKM 205
Query 769 AFSYLGVREGSIQGIPVRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPFGV 828
F + + I G + R G+ GE G+EI P+ + +++ + ++ G+
Sbjct 206 YFGDFRIID--INGSKCFLTRTGYTGEDGFEISVPSENAVDLAKAILEKSEG-KVRLTGL 262
Query 829 ESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPWFVGKRSIAILEQQPLKRKLV 888
++ LRLE G + D + P E L WA+ + + G ++ +Q +
Sbjct 263 GARDSLRLEAGLCLYGNDMEQHITPVEAGLTWAIGKRRRAEGGFLGADVILKQIADGPAI 322
Query 889 SFVLDKSQEKPLEGHIVLE---GEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQFP 945
V S P H ++ GE+I G +TS +SP L K IGM YV G + G +
Sbjct 323 RRVGLFSTGPPARSHSEIQNEKGENI-GEVTSGGFSPCLKKNIGMGYVKSGLHKPGTKLK 381
Query 946 IRVEKGAMVHATVVKAPF-----YDPA 967
I V +G +V K PF Y PA
Sbjct 382 I-VIRGKTYEGSVTKMPFVPTKYYKPA 407
>Q8CFA2 Aminomethyltransferase, mitochondrial [Mus musculus]
Length=403
Score = 108 bits (271), Expect = 3e-28
Identities = 99/380 (26%), Positives = 168/380 (44%), Gaps = 23/380 (6%)
Query 591 DPYRQTPMHAQHVEAGATMMPAGNWQRPAFYGDAAHRLQHIENEVKHVRNQVGMIDVSTL 650
D R+TP++ H+ G M+ W P Y D+ H+++ + H R + DVS +
Sbjct 31 DVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDS-----HVDSHL-HTRRHCSLFDVSHM 84
Query 651 GGLEIRGPDSAEFINRLYTFGFTKLPVGKTRYAVMSNEHGVVIDDGVAARLSEHHFYVTA 710
+I G D + + + +L + ++ +NE G ++DD + + SE H YV +
Sbjct 85 LQTKIFGCDRVKLLESVVVGDIAELRPNQGTLSLFTNEAGGILDDLIVSNTSEGHLYVVS 144
Query 711 TTSGVDR---IYQQMLKWNAQWRLNLDITNVTTALAAVNIAGPQSRAVMQKVCHDVDLSN 767
D+ + Q +K L++ + V AL A + GP + V+Q D D+
Sbjct 145 NAGCRDKDLALMQDKVKEFQNRGLDVGLEVVENALLA--LQGPTATQVLQAGVTD-DMKK 201
Query 768 AAFSYLGVREGSIQGIP-VRILRVGFVGELGYEIHFPARYGEFMWNHLMQAGQAFDIKPF 826
F V E + G+ R+ R G+ GE G EI PA + L++ ++K
Sbjct 202 LPFMTSAVME--VFGVSGCRVTRCGYTGEDGVEISVPATGAVHLATTLLKNP---EVKLA 256
Query 827 GVESQRLLRLEKGHIIISQDTDGMTHPQEVDLGWAVARNKPW---FVGKRSIAILEQQPL 883
G+ ++ LRLE G + D D T P E L W + + + F G + I + +
Sbjct 257 GLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRIAMDFPGAKIIVPQLKGEV 316
Query 884 KRKLVSFVLDKSQEKPLEGHIVLEGEDISGNITSCEYSPTLDKIIGMAYVGIGQSEVGQQ 943
+R+ V + + + + + EG + G +TS SP+L K + M YV S G Q
Sbjct 317 QRRRVGLICEGAPVRAHSPILNTEG-TVIGTVTSGCPSPSLKKNVAMGYVPFKYSRPGTQ 375
Query 944 FPIRVEKGAMVHATVVKAPF 963
+ V + + V K PF
Sbjct 376 LLVEVRRKQQM-TVVSKMPF 394
Lambda K H a alpha
0.320 0.136 0.404 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 8468210
Database: 31bf8ee04cd3a8bcc0b340e42b015262.SwissProt.fasta
Posted date: May 9, 2024 11:48 PM
Number of letters in database: 10,405
Number of sequences in database: 19
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
