BLASTP 2.12.0+


Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.



Database: fde401b1a2eb7661ff3c4beeb3843928.SwissProt.fasta
           23 sequences; 5,958 total letters



Query= ACIAD3249

Length=201
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

Q6F7N4 GTP cyclohydrolase-2 [Acinetobacter baylyi (strain ATCC 33...  400     4e-148
B0V709 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain AYE)]    372     1e-136
A3M9B0 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain ATCC...  372     1e-136
B2HZQ0 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain ACICU)]  372     1e-136
B7GVX4 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain AB30...  372     1e-136
B0VQB7 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain SDF)]    371     1e-136
B7IA66 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain AB00...  370     6e-136
A8FTP1 GTP cyclohydrolase-2 [Shewanella sediminis (strain HAW-EB3)]   230     9e-81 
A1S528 GTP cyclohydrolase-2 [Shewanella amazonensis (strain ATCC ...  230     1e-80 
A3QFR4 GTP cyclohydrolase-2 [Shewanella loihica (strain ATCC BAA-...  230     1e-80 
Q0HHF8 GTP cyclohydrolase-2 [Shewanella sp. (strain MR-4)]            227     1e-79 
Q8EDD1 GTP cyclohydrolase-2 [Shewanella oneidensis (strain MR-1)]     226     3e-79 
Q12P94 GTP cyclohydrolase-2 [Shewanella denitrificans (strain OS2...  226     3e-79 
P0A7I7 GTP cyclohydrolase-2 [Escherichia coli (strain K12)]           216     4e-75 
Q7MGG3 Riboflavin biosynthesis intermediates N-glycosidase / GTP ...  194     2e-64 
P51695 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cycloh...  192     2e-63 
P50855 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cycloh...  191     7e-63 
Q9FN89 Inactive 3,4-dihydroxy-2-butanone 4-phosphate synthase / G...  180     1e-57 
P47924 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cycloh...  172     3e-54 
P43525 GTP cyclohydrolase-2 [Azospirillum brasilense]                 166     3e-53 
O68248 GTP cyclohydrolase-2 [Sulfurospirillum multivorans]            152     1e-50 
O08315 GTP cyclohydrolase-2 [Helicobacter pylori (strain ATCC 700...  152     3e-50 
P51618 GTP cyclohydrolase-2 [Photobacterium phosphoreum]              139     4e-45 


>Q6F7N4 GTP cyclohydrolase-2 [Acinetobacter baylyi (strain ATCC 
33305 / BD413 / ADP1)]
Length=200

 Score = 400 bits (1029),  Expect = 4e-148
 Identities = 199/200 (99%), Positives = 200/200 (100%), Gaps = 0/200 (0%)

Query  1    VAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60
            +AIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA
Sbjct  1    MAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60

Query  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120
            FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL
Sbjct  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120

Query  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180
            LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN
Sbjct  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180

Query  181  EQYLKTKKERMAHLYQKDDF  200
            EQYLKTKKERMAHLYQKDDF
Sbjct  181  EQYLKTKKERMAHLYQKDDF  200


>B0V709 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain 
AYE)]
Length=200

 Score = 372 bits (954),  Expect = 1e-136
 Identities = 180/198 (91%), Positives = 191/198 (96%), Gaps = 0/198 (0%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            IEF+ATSKLPT FG+FNISVFQDPVTGEEHVALSKGLE  PTGPVLVR+HSECLTGDAFA
Sbjct  3    IEFIATSKLPTAFGEFNISVFQDPVTGEEHVALSKGLENPPTGPVLVRVHSECLTGDAFA  62

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            SLKCDCGPQLQATQKLIN+ GQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL
Sbjct  63   SLKCDCGPQLQATQKLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
            NLPADARRYDMCSIMLDHL+VK+VKLITNNPLK++AL D GINV+DRVPLTVG+NPFNEQ
Sbjct  123  NLPADARRYDMCSIMLDHLKVKEVKLITNNPLKIQALKDQGINVVDRVPLTVGRNPFNEQ  182

Query  183  YLKTKKERMAHLYQKDDF  200
            YLKTK+ERM HLYQKDDF
Sbjct  183  YLKTKRERMDHLYQKDDF  200


>A3M9B0 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain 
ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)]
Length=200

 Score = 372 bits (954),  Expect = 1e-136
 Identities = 180/198 (91%), Positives = 191/198 (96%), Gaps = 0/198 (0%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            IEF+ATSKLPT FG+FNISVFQDPVTGEEHVALSKGLE  PTGPVLVR+HSECLTGDAFA
Sbjct  3    IEFIATSKLPTAFGEFNISVFQDPVTGEEHVALSKGLENPPTGPVLVRVHSECLTGDAFA  62

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            SLKCDCGPQLQATQKLIN+ GQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL
Sbjct  63   SLKCDCGPQLQATQKLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
            NLPADARRYDMCSIMLDHL+VK+VKLITNNPLK++AL D GINV+DRVPLTVG+NPFNEQ
Sbjct  123  NLPADARRYDMCSIMLDHLKVKEVKLITNNPLKIQALKDQGINVVDRVPLTVGRNPFNEQ  182

Query  183  YLKTKKERMAHLYQKDDF  200
            YLKTK+ERM HLYQKDDF
Sbjct  183  YLKTKRERMDHLYQKDDF  200


>B2HZQ0 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain 
ACICU)]
Length=200

 Score = 372 bits (954),  Expect = 1e-136
 Identities = 180/198 (91%), Positives = 191/198 (96%), Gaps = 0/198 (0%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            IEF+ATSKLPT FG+FNISVFQDPVTGEEHVALSKGLE  PTGPVLVR+HSECLTGDAFA
Sbjct  3    IEFIATSKLPTAFGEFNISVFQDPVTGEEHVALSKGLENPPTGPVLVRVHSECLTGDAFA  62

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            SLKCDCGPQLQATQKLIN+ GQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL
Sbjct  63   SLKCDCGPQLQATQKLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
            NLPADARRYDMCSIMLDHL+VK+VKLITNNPLK++AL D GINV+DRVPLTVG+NPFNEQ
Sbjct  123  NLPADARRYDMCSIMLDHLKVKEVKLITNNPLKIQALKDQGINVVDRVPLTVGRNPFNEQ  182

Query  183  YLKTKKERMAHLYQKDDF  200
            YLKTK+ERM HLYQKDDF
Sbjct  183  YLKTKRERMDHLYQKDDF  200


>B7GVX4 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain 
AB307-0294)]
Length=200

 Score = 372 bits (954),  Expect = 1e-136
 Identities = 180/198 (91%), Positives = 191/198 (96%), Gaps = 0/198 (0%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            IEF+ATSKLPT FG+FNISVFQDPVTGEEHVALSKGLE  PTGPVLVR+HSECLTGDAFA
Sbjct  3    IEFIATSKLPTAFGEFNISVFQDPVTGEEHVALSKGLENPPTGPVLVRVHSECLTGDAFA  62

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            SLKCDCGPQLQATQKLIN+ GQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL
Sbjct  63   SLKCDCGPQLQATQKLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
            NLPADARRYDMCSIMLDHL+VK+VKLITNNPLK++AL D GINV+DRVPLTVG+NPFNEQ
Sbjct  123  NLPADARRYDMCSIMLDHLKVKEVKLITNNPLKIQALKDQGINVVDRVPLTVGRNPFNEQ  182

Query  183  YLKTKKERMAHLYQKDDF  200
            YLKTK+ERM HLYQKDDF
Sbjct  183  YLKTKRERMDHLYQKDDF  200


>B0VQB7 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain 
SDF)]
Length=200

 Score = 371 bits (953),  Expect = 1e-136
 Identities = 180/198 (91%), Positives = 191/198 (96%), Gaps = 0/198 (0%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            IEF+ATSKLPT FG+FNISVFQDPVTGEEHVALSKGLE  PT PVLVR+HSECLTGDAFA
Sbjct  3    IEFIATSKLPTAFGEFNISVFQDPVTGEEHVALSKGLENPPTDPVLVRVHSECLTGDAFA  62

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            SLKCDCGPQLQATQKLIN+ GQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL
Sbjct  63   SLKCDCGPQLQATQKLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
            NLPADARRYDMCSIMLDHL+VK+VKLITNNPLK++AL D GINV+DRVPLTVG+NPFNEQ
Sbjct  123  NLPADARRYDMCSIMLDHLKVKEVKLITNNPLKIQALKDQGINVVDRVPLTVGRNPFNEQ  182

Query  183  YLKTKKERMAHLYQKDDF  200
            YLKTK+ERMAHLYQKDDF
Sbjct  183  YLKTKRERMAHLYQKDDF  200


>B7IA66 GTP cyclohydrolase-2 [Acinetobacter baumannii (strain 
AB0057)]
Length=200

 Score = 370 bits (949),  Expect = 6e-136
 Identities = 179/198 (90%), Positives = 190/198 (96%), Gaps = 0/198 (0%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            IEF+ATSKLPT FG+FNISVFQDPVTGEEHVALSKGLE  PTGPVLVR+HSECLTGDAFA
Sbjct  3    IEFIATSKLPTAFGEFNISVFQDPVTGEEHVALSKGLENPPTGPVLVRVHSECLTGDAFA  62

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            SLKCDCGPQLQATQKLIN+ GQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL
Sbjct  63   SLKCDCGPQLQATQKLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
            NLPADARRYDMCSIMLDHL+VK+VKLITNNPLK++AL D GINV+DRVPLTVG+NPFNE 
Sbjct  123  NLPADARRYDMCSIMLDHLKVKEVKLITNNPLKIQALKDQGINVVDRVPLTVGRNPFNEH  182

Query  183  YLKTKKERMAHLYQKDDF  200
            YLKTK+ERM HLYQKDDF
Sbjct  183  YLKTKRERMDHLYQKDDF  200


>A8FTP1 GTP cyclohydrolase-2 [Shewanella sediminis (strain HAW-EB3)]
Length=205

 Score = 230 bits (587),  Expect = 9e-81
 Identities = 117/200 (59%), Positives = 149/200 (75%), Gaps = 1/200 (1%)

Query  1    VAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60
            ++I++VA+SKLPT +G F +  F+D  TG+EHVAL+ G   A T P+L RIHSECLTGDA
Sbjct  1    MSIKYVASSKLPTPWGVFTMHGFEDSDTGKEHVALTLGTLDANT-PILGRIHSECLTGDA  59

Query  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120
              SL+CDCG QLQ   + I + GQG ILYLRQEGRGIGL NKIRAY LQDQG +TV+AN 
Sbjct  60   LFSLRCDCGFQLQTAMQNIAEAGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANE  119

Query  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180
             L  PAD R+YDM   M++ + +KQVKL+TNNP K+KA+ +LGI V++R+PL VGKN +N
Sbjct  120  RLGFPADMRKYDMILPMMEKIGIKQVKLMTNNPRKVKAMKELGIEVVERIPLQVGKNRYN  179

Query  181  EQYLKTKKERMAHLYQKDDF  200
            E YLKTK   + H+  +  F
Sbjct  180  EGYLKTKSTELGHMMSEYHF  199


>A1S528 GTP cyclohydrolase-2 [Shewanella amazonensis (strain ATCC 
BAA-1098 / SB2B)]
Length=205

 Score = 230 bits (586),  Expect = 1e-80
 Identities = 114/200 (57%), Positives = 152/200 (76%), Gaps = 1/200 (1%)

Query  1    VAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60
            ++I++VATSKLPT +G F +  F+D  TG+EHVAL+ G +++   PVL RIHSECLTGDA
Sbjct  1    MSIKYVATSKLPTPWGVFAMHGFEDSETGKEHVALTFG-DLSGDAPVLGRIHSECLTGDA  59

Query  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120
              SL+CDCG QLQ   + I + G+G ILYLRQEGRGIGL NKIRAY LQD+G +TV+AN 
Sbjct  60   LFSLRCDCGFQLQTAMQRIAETGRGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANE  119

Query  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180
             L   AD R+YDM + ML HL + +VKL+TNNP K+ A+ D+G++V++RVPL VGKN +N
Sbjct  120  QLGFAADMRKYDMIAPMLAHLGISRVKLMTNNPRKVNAMKDVGMDVVERVPLQVGKNRYN  179

Query  181  EQYLKTKKERMAHLYQKDDF  200
            E YLKTK +++ H+  ++ F
Sbjct  180  EAYLKTKSDKLGHMMSEEHF  199


>A3QFR4 GTP cyclohydrolase-2 [Shewanella loihica (strain ATCC 
BAA-1088 / PV-4)]
Length=205

 Score = 230 bits (586),  Expect = 1e-80
 Identities = 119/200 (60%), Positives = 149/200 (75%), Gaps = 1/200 (1%)

Query  1    VAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60
            ++I++VATSKLPT +G F +  F+D  TG+EHVAL+ G E+  + P+L RIHSECLTGDA
Sbjct  1    MSIKYVATSKLPTPWGVFAMHGFEDTETGKEHVALTFG-ELDASQPILGRIHSECLTGDA  59

Query  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120
              SL+CDCG QLQ   + I + GQG ILYLRQEGRGIGL NKIRAY LQDQG +TV+AN 
Sbjct  60   LFSLRCDCGFQLQTAMQNIAEAGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANE  119

Query  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180
             L   AD R+YDM   ML+ + V+QVKL+TNNP K+KA+ +LGI VI+RVPL VGKN +N
Sbjct  120  RLGFAADMRKYDMIKPMLEKIGVQQVKLMTNNPRKVKAMKELGIAVIERVPLQVGKNRYN  179

Query  181  EQYLKTKKERMAHLYQKDDF  200
            E YLKTK   + H+  +  F
Sbjct  180  EAYLKTKSTELGHMMSEYHF  199


>Q0HHF8 GTP cyclohydrolase-2 [Shewanella sp. (strain MR-4)]
Length=203

 Score = 227 bits (579),  Expect = 1e-79
 Identities = 115/200 (58%), Positives = 147/200 (74%), Gaps = 1/200 (1%)

Query  1    VAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60
            ++I++VATSKLPT +G F +  F+D  TG+EHVAL+ G  ++   PVL RIHSECLTGDA
Sbjct  1    MSIKYVATSKLPTPWGVFAMHGFEDTETGKEHVALTFGT-LSSDAPVLGRIHSECLTGDA  59

Query  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120
              SL+CDCG QLQ   + I + G G ILYLRQEGRGIGL NKIRAY LQD+G +TV+AN 
Sbjct  60   LFSLRCDCGFQLQTAMQNIAETGSGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANE  119

Query  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180
             L  PAD R+YDM   ML+ + VK V+L+TNNP K+KA+ ++GI V++RVPL VGKN +N
Sbjct  120  QLGFPADMRKYDMIQPMLEQIGVKHVRLMTNNPRKVKAMKEIGIEVVERVPLQVGKNRYN  179

Query  181  EQYLKTKKERMAHLYQKDDF  200
            E YLKTK   + H+  +  F
Sbjct  180  EAYLKTKSTELGHMMSEYHF  199


>Q8EDD1 GTP cyclohydrolase-2 [Shewanella oneidensis (strain MR-1)]
Length=203

 Score = 226 bits (577),  Expect = 3e-79
 Identities = 115/200 (58%), Positives = 147/200 (74%), Gaps = 1/200 (1%)

Query  1    VAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60
            ++I++VATSKLPT +G F +  F+D  TG+EHVAL+ G  ++   PVL RIHSECLTGDA
Sbjct  1    MSIKYVATSKLPTPWGVFAMHGFEDTETGKEHVALTFG-SLSSDEPVLGRIHSECLTGDA  59

Query  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120
              SL+CDCG QLQ   + I + G G ILYLRQEGRGIGL NKIRAY LQD+G +TV+AN 
Sbjct  60   LFSLRCDCGFQLQTAMQNIAETGSGFILYLRQEGRGIGLLNKIRAYELQDKGANTVEANE  119

Query  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180
             L  PAD R+YDM   ML+ + VK V+L+TNNP K+KA+ ++GI V++RVPL VGKN +N
Sbjct  120  QLGFPADMRKYDMIQPMLEKIGVKHVRLMTNNPRKVKAMKEIGIEVVERVPLQVGKNRYN  179

Query  181  EQYLKTKKERMAHLYQKDDF  200
            E YLKTK   + H+  +  F
Sbjct  180  EAYLKTKSTELGHMMSEYHF  199


>Q12P94 GTP cyclohydrolase-2 [Shewanella denitrificans (strain 
OS217 / ATCC BAA-1090 / DSM 15013)]
Length=205

 Score = 226 bits (577),  Expect = 3e-79
 Identities = 117/200 (59%), Positives = 146/200 (73%), Gaps = 1/200 (1%)

Query  1    VAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA  60
            ++I ++ATSKLPT +G F++  F+D  TG+EHVAL+ G E  P+  +L RIHSECLTGDA
Sbjct  1    MSINYIATSKLPTPWGVFSMHGFEDTQTGKEHVALTFG-EWQPSHAILGRIHSECLTGDA  59

Query  61   FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL  120
              SL+CDCG QLQ   + I + GQG ILYLRQEGRGIGL NKIRAY LQD G +TV+AN 
Sbjct  60   LFSLRCDCGFQLQTAMQNIAEAGQGFILYLRQEGRGIGLLNKIRAYELQDAGANTVEANE  119

Query  121  LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN  180
             L   AD R+YDM + ML+ + V QVKL+TNNP K+KA+ DLGI V +RVPL VGKN +N
Sbjct  120  RLGFDADMRKYDMIAPMLEKIAVTQVKLMTNNPRKVKAMQDLGIVVAERVPLQVGKNRYN  179

Query  181  EQYLKTKKERMAHLYQKDDF  200
            E YLKTK   + H+  +  F
Sbjct  180  EAYLKTKSTELGHMMSEHHF  199


>P0A7I7 GTP cyclohydrolase-2 [Escherichia coli (strain K12)]
Length=196

 Score = 216 bits (549),  Expect = 4e-75
 Identities = 109/192 (57%), Positives = 140/192 (73%), Gaps = 1/192 (1%)

Query  6    VATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASLK  65
            VA +KLPT +GDF +  F++  TG +HVAL  G +I+   PVL R+HSECLTGDA  SL+
Sbjct  6    VAEAKLPTPWGDFLMVGFEELATGHDHVALVYG-DISGHTPVLARVHSECLTGDALFSLR  64

Query  66   CDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLP  125
            CDCG QL+A    I + G+G++LY RQEGR IGL NKIRAYALQDQG+DTV+AN  L   
Sbjct  65   CDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFA  124

Query  126  ADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQYLK  185
            AD R + +C+ M   L V +V+L+TNNP K++ LT+ GIN+++RVPL VG+NP NE YL 
Sbjct  125  ADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLD  184

Query  186  TKKERMAHLYQK  197
            TK E+M HL  K
Sbjct  185  TKAEKMGHLLNK  196


>Q7MGG3 Riboflavin biosynthesis intermediates N-glycosidase / 
GTP cyclohydrolase-2 [Vibrio vulnificus (strain YJ016)]
Length=367

 Score = 194 bits (492),  Expect = 2e-64
 Identities = 99/196 (51%), Positives = 133/196 (68%), Gaps = 1/196 (1%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            ++F+ ++KLPT++G F +  F +  TG+EH+AL  G +I      L+R+HSECLTGDA  
Sbjct  169  VQFIDSAKLPTQWGTFQMYGFIEKATGKEHLALVYG-DIEQQAAPLIRLHSECLTGDALF  227

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            S +CDCG QL    + I   G GV+LYLRQEGRGIGL NKIRAY LQD G DTV+AN  L
Sbjct  228  SARCDCGFQLAKALQNIVAEGAGVLLYLRQEGRGIGLINKIRAYHLQDDGADTVEANEQL  287

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
               AD R Y  C  +L  L +++V+L+TNNP K+KAL    I V +RVPL  G NP N Q
Sbjct  288  GFGADMRDYAFCRGILSFLGIERVRLMTNNPRKVKALQLANIEVTERVPLQEGNNPHNHQ  347

Query  183  YLKTKKERMAHLYQKD  198
            YL+TK +++ H++ ++
Sbjct  348  YLRTKADKLGHMFDRN  363


>P51695 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase-2 
[Bacillus amyloliquefaciens]
Length=398

 Score = 192 bits (489),  Expect = 2e-63
 Identities = 95/184 (52%), Positives = 129/184 (70%), Gaps = 0/184 (0%)

Query  11   LPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASLKCDCGP  70
            LPT FG F +  + + V G+EH+A   G     +GPVLVR+HSECLTGD FAS +CDCGP
Sbjct  212  LPTDFGTFRVYGYTNEVDGKEHLAFVMGDVPFNSGPVLVRVHSECLTGDVFASHRCDCGP  271

Query  71   QLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLPADARR  130
            QL A  + I + G+GV+LYLRQEGRGIGL NK++AY LQ+QG+DTV+AN  L    D R 
Sbjct  272  QLHAALRQIAEEGRGVLLYLRQEGRGIGLINKLKAYRLQEQGYDTVEANEALGFLPDLRN  331

Query  131  YDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQYLKTKKER  190
            Y + + +L  L V+ +KL+TNNP K+  L   G+++ DRVPL +  +  N+QYL+TK ++
Sbjct  332  YGIGAQILRDLGVQHMKLLTNNPRKIAGLEGYGLSISDRVPLQMEASEHNKQYLQTKMKK  391

Query  191  MAHL  194
            + HL
Sbjct  392  LGHL  395


>P50855 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase-2 
[Actinobacillus pleuropneumoniae]
Length=401

 Score = 191 bits (485),  Expect = 7e-63
 Identities = 94/193 (49%), Positives = 130/193 (67%), Gaps = 1/193 (1%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            ++ ++  K+PTK+G+F    F + ++G+EHVAL KG ++     VL RIHSECLTGDAF 
Sbjct  208  VKQISVVKMPTKYGEFMAHSFVEVISGKEHVALVKG-DLTDGEQVLARIHSECLTGDAFG  266

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLL  122
            S +CDCG Q  A    I   G+GVILYLRQEGRGIGL NK+RAY LQD+G DTV+AN+ L
Sbjct  267  SQRCDCGQQFAAAMTQIEQEGRGVILYLRQEGRGIGLINKLRAYELQDKGMDTVEANVAL  326

Query  123  NLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQ  182
                D R Y + + M   L VK ++L+TNNP K++ L + G+N++ R P+ V  N  +  
Sbjct  327  GFKEDEREYYIGAQMFQQLGVKSIRLLTNNPAKIEGLKEQGLNIVAREPIIVEPNKNDID  386

Query  183  YLKTKKERMAHLY  195
            YLK K+ +M H++
Sbjct  387  YLKVKQIKMGHMF  399


>Q9FN89 Inactive 3,4-dihydroxy-2-butanone 4-phosphate synthase 
/ GTP cyclohydrolase-2 [Arabidopsis thaliana]
Length=509

 Score = 180 bits (456),  Expect = 1e-57
 Identities = 90/198 (45%), Positives = 130/198 (66%), Gaps = 2/198 (1%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            +E +  S+LPTK+G F    ++  + G E++AL KG  +     +LVR+HSECLTGD F 
Sbjct  307  VERITVSRLPTKWGLFQAYCYRSKLDGTENIALVKG-NVGNGEDILVRVHSECLTGDIFG  365

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLR-QEGRGIGLTNKIRAYALQDQGHDTVDANLL  121
            S +CDCG QL    +LI   G+GV++YLR  EGRGIGL +K+RAY LQD+GHDTV AN+ 
Sbjct  366  SARCDCGNQLDLAMELIEKEGRGVVVYLRGHEGRGIGLGHKLRAYNLQDEGHDTVQANVE  425

Query  122  LNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNE  181
            L L  D+R Y + + ML  + V+ ++L+TNNP K   L   G+ V+ RVP+       N 
Sbjct  426  LGLSIDSREYGIGAQMLRDIGVRTMRLMTNNPAKFTGLKGYGLAVVGRVPVVTPITKENR  485

Query  182  QYLKTKKERMAHLYQKDD  199
            +Y++TK+++M H+Y  D+
Sbjct  486  RYMETKRKKMGHIYISDN  503


>P47924 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase-2 
[Arabidopsis thaliana]
Length=543

 Score = 172 bits (435),  Expect = 3e-54
 Identities = 88/194 (45%), Positives = 127/194 (65%), Gaps = 2/194 (1%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFA  62
            +E  + +++PT +G F    ++  + G EH+A+ KG EI     +LVR+HSECLTGD F 
Sbjct  333  VERASAARIPTMWGPFTAYCYRSILDGIEHIAMVKG-EIGDGQDILVRVHSECLTGDIFG  391

Query  63   SLKCDCGPQLQATQKLINDVGQGVILYLR-QEGRGIGLTNKIRAYALQDQGHDTVDANLL  121
            S +CDCG QL  + + I   G+GV++YLR  EGRGIGL +K+RAY LQD G DTV+AN  
Sbjct  392  SARCDCGNQLALSMQQIEATGRGVLVYLRGHEGRGIGLGHKLRAYNLQDAGRDTVEANEE  451

Query  122  LNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNE  181
            L LP D+R Y + + ++  L V+ +KL+TNNP K   L   G+ ++ RVPL       N+
Sbjct  452  LGLPVDSREYGIGAQIIRDLGVRTMKLMTNNPAKYVGLKGYGLAIVGRVPLLSLITKENK  511

Query  182  QYLKTKKERMAHLY  195
            +YL+TK+ +M H+Y
Sbjct  512  RYLETKRTKMGHMY  525


>P43525 GTP cyclohydrolase-2 [Azospirillum brasilense]
Length=385

 Score = 166 bits (419),  Expect = 3e-53
 Identities = 92/191 (48%), Positives = 119/191 (62%), Gaps = 2/191 (1%)

Query  6    VATSKLPTKFGD-FNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASL  64
            VA +++P    +  +I+ F+    G EH+A+  G  +A   PVL R+HSEC TGD  A L
Sbjct  196  VAEARVPLSGAENTSIAAFRPIDGGPEHLAIIVGNPVAGE-PVLARLHSECFTGDLLAGL  254

Query  65   KCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNL  124
            +CDCG QL+     I   G GV+LYL QEGRGIGL NK+RAY +QD+G DTVDAN +L  
Sbjct  255  RCDCGQQLRGAIAEIARHGSGVLLYLAQEGRGIGLVNKLRAYRIQDRGFDTVDANEILGF  314

Query  125  PADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQYL  184
             AD R Y   + ML  L    V+L+TNNP KL+ L   GI V++RVP     N  NE YL
Sbjct  315  EADERVYLPAAEMLRQLGFTAVRLMTNNPEKLRQLARCGIEVVERVPHIFPANGHNEGYL  374

Query  185  KTKKERMAHLY  195
            +TK ER  H++
Sbjct  375  RTKAERSGHMF  385


>O68248 GTP cyclohydrolase-2 [Sulfurospirillum multivorans]
Length=141

 Score = 152 bits (383),  Expect = 1e-50
 Identities = 75/143 (52%), Positives = 101/143 (71%), Gaps = 3/143 (2%)

Query  52   HSECLTGDAFASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQ  111
            HSECLTGDA  SLKCDCG QL+   + I+ +G G+I+YLRQEGR IGL NK+ AYALQDQ
Sbjct  1    HSECLTGDALGSLKCDCGEQLEFALQNISLLG-GMIIYLRQEGRNIGLFNKVNAYALQDQ  59

Query  112  GHDTVDANLLLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVP  171
            G DT++AN  L   +D R Y++   +L+H ++ +++L+TNNP K+  L +  I +I+R P
Sbjct  60   GFDTIEANHQLGFKSDERSYEVVETILEHFKIDKIRLLTNNPKKMSCLKN--IMIIERWP  117

Query  172  LTVGKNPFNEQYLKTKKERMAHL  194
            + +  N  N  YLKTKKE M HL
Sbjct  118  IIIPSNNHNVDYLKTKKEMMGHL  140


>O08315 GTP cyclohydrolase-2 [Helicobacter pylori (strain ATCC 
700392 / 26695)]
Length=192

 Score = 152 bits (384),  Expect = 3e-50
 Identities = 85/195 (44%), Positives = 122/195 (63%), Gaps = 10/195 (5%)

Query  3    IEFVATSKLPTKFGDFNISVFQDPVTG--EEH-VALSKGLEIAPTGPVLVRIHSECLTGD  59
            +E    +KLPT+FG+F I  F++  +   ++H V  +      P    LVR+HSECLTGD
Sbjct  4    LEVSNQAKLPTQFGEFYIQCFREKGSNGSKDHLVVFTPNFSQNP----LVRLHSECLTGD  59

Query  60   AFASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDAN  119
            A  S KCDCG  LQ   + I+  G G+++YLRQEGRGIGL NK+ AYALQD+G+DT+ AN
Sbjct  60   ALGSQKCDCGGALQMALERISKEG-GLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQAN  118

Query  120  LLLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPF  179
             ++    D R Y +   +L++ ++K+++L+TNNP K+ AL       + R  L V  N  
Sbjct  119  EMIGFKDDERDYSVAGEILEYYRIKKMRLLTNNPKKIAALEKYA--EVTRESLIVCANEH  176

Query  180  NEQYLKTKKERMAHL  194
            N+ YL+ KK +M HL
Sbjct  177  NQGYLEVKKLKMGHL  191


>P51618 GTP cyclohydrolase-2 [Photobacterium phosphoreum]
Length=200

 Score = 139 bits (351),  Expect = 4e-45
 Identities = 80/172 (47%), Positives = 104/172 (60%), Gaps = 3/172 (2%)

Query  28   TGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASLKCDCGPQLQATQKLINDVGQGVI  87
            +G+EH+AL          P LVR+HSECLTGD F S +CDCG QL  T +++ ++G G+I
Sbjct  30   SGKEHIALIFKDAYKAFVP-LVRMHSECLTGDGFHSTRCDCGEQLDETIEIMAELG-GII  87

Query  88   LYLRQEGR-GIGLTNKIRAYALQDQGHDTVDANLLLNLPADARRYDMCSIMLDHLQVKQV  146
            LYLRQEGR G+GL NKI AY LQ QG DT +AN  L    D R +   + ML  L +K +
Sbjct  88   LYLRQEGRWGLGLYNKIDAYKLQSQGMDTYEANNHLGFDDDLREFSEAAQMLTALGIKDI  147

Query  147  KLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQYLKTKKERMAHLYQKD  198
            +L+TNNP K+K L   GIN+++ V         NE YLK K     H +  D
Sbjct  148  RLVTNNPKKIKDLQQNGINIVEVVGTKAHLKEGNEGYLKAKASHGRHCFNFD  199


 Score = 18.5 bits (36),  Expect = 2.1
 Identities = 8/14 (57%), Positives = 10/14 (71%), Gaps = 0/14 (0%)

Query  164  INVIDRVPLTVGKN  177
            +NV +RV L VG N
Sbjct  2    VNVRERVSLKVGIN  15



Lambda      K        H        a         alpha
   0.323    0.140    0.412    0.792     4.96 

Gapped
Lambda      K        H        a         alpha    sigma
   0.267   0.0410    0.140     1.90     42.6     43.6 

Effective search space used: 785102


  Database: fde401b1a2eb7661ff3c4beeb3843928.SwissProt.fasta
    Posted date:  Jun 3, 2024  8:22 PM
  Number of letters in database: 5,958
  Number of sequences in database:  23



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40