BLASTP 2.12.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: 843b79d8f6d58fb443bcac3293ae3ab7.SwissProt.fasta
21 sequences; 15,753 total letters
Query= ACIAD3068
Length=769
Score E
Sequences producing significant alignments: (Bits) Value
P0AG23 GTP pyrophosphokinase [Shigella flexneri] 542 0.0
P0AG21 GTP pyrophosphokinase [Escherichia coli O6:H1 (strain CFT0... 542 0.0
P0AG22 GTP pyrophosphokinase [Escherichia coli O157:H7] 542 0.0
P0AG20 GTP pyrophosphokinase [Escherichia coli (strain K12)] 542 0.0
P55133 GTP pyrophosphokinase [Photobacterium angustum (strain S14... 519 2e-177
P44644 GTP pyrophosphokinase [Haemophilus influenzae (strain ATCC... 513 4e-175
O54408 GTP pyrophosphokinase [Bacillus subtilis (strain 168)] 464 2e-156
O52177 GTP pyrophosphokinase [Myxococcus xanthus] 460 2e-154
Q6GG70 GTP pyrophosphokinase [Staphylococcus aureus (strain MRSA2... 455 8e-153
P0A0E9 GTP pyrophosphokinase [Staphylococcus aureus (strain MW2)] 455 1e-152
Q6G8T5 GTP pyrophosphokinase [Staphylococcus aureus (strain MSSA4... 455 1e-152
Q99TL8 GTP pyrophosphokinase [Staphylococcus aureus (strain N315)] 455 1e-152
P0A0F0 GTP pyrophosphokinase [Staphylococcus aureus] 455 1e-152
Q8CS97 GTP pyrophosphokinase [Staphylococcus epidermidis (strain ... 454 2e-152
Q5HNR8 GTP pyrophosphokinase [Staphylococcus epidermidis (strain ... 454 2e-152
Q931Q4 GTP pyrophosphokinase [Staphylococcus aureus (strain Mu50 ... 453 6e-152
Q54089 GTP pyrophosphokinase / Guanosine-3',5'-bis(diphosphate) 3... 431 3e-143
O87331 GTP pyrophosphokinase [Corynebacterium glutamicum (strain ... 404 8e-133
O85709 GTP pyrophosphokinase [Streptomyces antibioticus] 392 2e-127
P52560 GTP pyrophosphokinase [Streptomyces coelicolor (strain ATC... 392 3e-127
P9WHG9 GTP pyrophosphokinase / Guanosine-3',5'-bis(diphosphate) 3... 383 6e-125
>P0AG23 GTP pyrophosphokinase [Shigella flexneri]
Length=744
Score = 542 bits (1397), Expect = 0.0
Identities = 282/714 (39%), Positives = 441/714 (62%), Gaps = 26/714 (4%)
Query 62 LETTVNHPSNTFTT--GIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQ 119
L+ T HP + G+ M +IL+ L +D DTL AA+L+ ++ + +R+ G+
Sbjct 43 LQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKS 102
Query 120 VHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAER 179
V +L+ G M + ++ H ++ E + + +ML+A+ +D R V+IKLAER
Sbjct 103 VVNLIHGVRDMAAIRQL------KATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAER 156
Query 180 TFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIAT 239
LRE+ + + + A+E IYAPLA+RLGI QLKWELED FRYL P YK IA
Sbjct 157 IAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAK 216
Query 240 LLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDI 299
LL+E+RL+RE YI+ + L+ E+ G+ AE+ GR KHIYSI+RKM+ KNL+FD+L+D+
Sbjct 217 LLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDV 276
Query 300 RALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAE-NKSLEV 358
RA+R++ + + +CY +LGIVH +RH+P +FDDY+ NPK NGY+S+HT V+ K++E+
Sbjct 277 RAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEI 336
Query 359 QIRTHEMHEEAELGVCSHFNYKEGSKTTDRSFNH--RLHSLRSVLEHYQERNETTVHKND 416
QIRT +MHE+AELGV +H+ YKEG+ H R+ LR ++ +E
Sbjct 337 QIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEM--------A 388
Query 417 DEAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRY 476
D E +E+++ +++YVF+ GD+ +LP GST LDFAYH+H++VG++C A++ R
Sbjct 389 DSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRI 448
Query 477 VPLTYTLKTGEQVEILTKKDREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIG 536
VP TY L+ G+Q+EI+T+K P+RDWL +LGY+ T+R R K+ WFR+QDR KN+ G
Sbjct 449 VPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAG 508
Query 537 KEILNKELSRLAIHPKSIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLIN----QINRQ 592
++IL+ EL L I K + +N D++L A+ GD+ L+ ++N Q N+
Sbjct 509 RQILDDELEHLGISLKEAE-KHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKP 567
Query 593 MHLDQDEPELVLKPTLNPRASHTLSAHG-ILIDGLDNVELHIAQCCQPVHGESIGGYITL 651
+QD L + + +G ++++G+ N+ HIA+CCQP+ G+ I G+IT
Sbjct 568 SAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQ 627
Query 652 NRGVSIHKVGCPDYQRMIKNEPERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVI 711
RG+S+H+ C + + PER V+A W + G S+ + + A DR GLL+D+T ++
Sbjct 628 GRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDRSGLLRDITTIL 687
Query 712 FSDQINIRQVNTISEA-DGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
++++N+ V + S+ +A + + IE+ L L R+L +L Q P +I ARRL
Sbjct 688 ANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRL 741
>P0AG21 GTP pyrophosphokinase [Escherichia coli O6:H1 (strain
CFT073 / ATCC 700928 / UPEC)]
Length=744
Score = 542 bits (1397), Expect = 0.0
Identities = 282/714 (39%), Positives = 441/714 (62%), Gaps = 26/714 (4%)
Query 62 LETTVNHPSNTFTT--GIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQ 119
L+ T HP + G+ M +IL+ L +D DTL AA+L+ ++ + +R+ G+
Sbjct 43 LQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKS 102
Query 120 VHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAER 179
V +L+ G M + ++ H ++ E + + +ML+A+ +D R V+IKLAER
Sbjct 103 VVNLIHGVRDMAAIRQL------KATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAER 156
Query 180 TFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIAT 239
LRE+ + + + A+E IYAPLA+RLGI QLKWELED FRYL P YK IA
Sbjct 157 IAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAK 216
Query 240 LLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDI 299
LL+E+RL+RE YI+ + L+ E+ G+ AE+ GR KHIYSI+RKM+ KNL+FD+L+D+
Sbjct 217 LLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDV 276
Query 300 RALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAE-NKSLEV 358
RA+R++ + + +CY +LGIVH +RH+P +FDDY+ NPK NGY+S+HT V+ K++E+
Sbjct 277 RAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEI 336
Query 359 QIRTHEMHEEAELGVCSHFNYKEGSKTTDRSFNH--RLHSLRSVLEHYQERNETTVHKND 416
QIRT +MHE+AELGV +H+ YKEG+ H R+ LR ++ +E
Sbjct 337 QIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEM--------A 388
Query 417 DEAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRY 476
D E +E+++ +++YVF+ GD+ +LP GST LDFAYH+H++VG++C A++ R
Sbjct 389 DSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRI 448
Query 477 VPLTYTLKTGEQVEILTKKDREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIG 536
VP TY L+ G+Q+EI+T+K P+RDWL +LGY+ T+R R K+ WFR+QDR KN+ G
Sbjct 449 VPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAG 508
Query 537 KEILNKELSRLAIHPKSIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLIN----QINRQ 592
++IL+ EL L I K + +N D++L A+ GD+ L+ ++N Q N+
Sbjct 509 RQILDDELEHLGISLKEAE-KHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKP 567
Query 593 MHLDQDEPELVLKPTLNPRASHTLSAHG-ILIDGLDNVELHIAQCCQPVHGESIGGYITL 651
+QD L + + +G ++++G+ N+ HIA+CCQP+ G+ I G+IT
Sbjct 568 SAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQ 627
Query 652 NRGVSIHKVGCPDYQRMIKNEPERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVI 711
RG+S+H+ C + + PER V+A W + G S+ + + A DR GLL+D+T ++
Sbjct 628 GRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDRSGLLRDITTIL 687
Query 712 FSDQINIRQVNTISEA-DGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
++++N+ V + S+ +A + + IE+ L L R+L +L Q P +I ARRL
Sbjct 688 ANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRL 741
>P0AG22 GTP pyrophosphokinase [Escherichia coli O157:H7]
Length=744
Score = 542 bits (1397), Expect = 0.0
Identities = 282/714 (39%), Positives = 441/714 (62%), Gaps = 26/714 (4%)
Query 62 LETTVNHPSNTFTT--GIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQ 119
L+ T HP + G+ M +IL+ L +D DTL AA+L+ ++ + +R+ G+
Sbjct 43 LQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKS 102
Query 120 VHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAER 179
V +L+ G M + ++ H ++ E + + +ML+A+ +D R V+IKLAER
Sbjct 103 VVNLIHGVRDMAAIRQL------KATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAER 156
Query 180 TFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIAT 239
LRE+ + + + A+E IYAPLA+RLGI QLKWELED FRYL P YK IA
Sbjct 157 IAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAK 216
Query 240 LLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDI 299
LL+E+RL+RE YI+ + L+ E+ G+ AE+ GR KHIYSI+RKM+ KNL+FD+L+D+
Sbjct 217 LLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDV 276
Query 300 RALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAE-NKSLEV 358
RA+R++ + + +CY +LGIVH +RH+P +FDDY+ NPK NGY+S+HT V+ K++E+
Sbjct 277 RAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEI 336
Query 359 QIRTHEMHEEAELGVCSHFNYKEGSKTTDRSFNH--RLHSLRSVLEHYQERNETTVHKND 416
QIRT +MHE+AELGV +H+ YKEG+ H R+ LR ++ +E
Sbjct 337 QIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEM--------A 388
Query 417 DEAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRY 476
D E +E+++ +++YVF+ GD+ +LP GST LDFAYH+H++VG++C A++ R
Sbjct 389 DSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRI 448
Query 477 VPLTYTLKTGEQVEILTKKDREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIG 536
VP TY L+ G+Q+EI+T+K P+RDWL +LGY+ T+R R K+ WFR+QDR KN+ G
Sbjct 449 VPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAG 508
Query 537 KEILNKELSRLAIHPKSIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLIN----QINRQ 592
++IL+ EL L I K + +N D++L A+ GD+ L+ ++N Q N+
Sbjct 509 RQILDDELEHLGISLKEAE-KHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKP 567
Query 593 MHLDQDEPELVLKPTLNPRASHTLSAHG-ILIDGLDNVELHIAQCCQPVHGESIGGYITL 651
+QD L + + +G ++++G+ N+ HIA+CCQP+ G+ I G+IT
Sbjct 568 SAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQ 627
Query 652 NRGVSIHKVGCPDYQRMIKNEPERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVI 711
RG+S+H+ C + + PER V+A W + G S+ + + A DR GLL+D+T ++
Sbjct 628 GRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDRSGLLRDITTIL 687
Query 712 FSDQINIRQVNTISEA-DGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
++++N+ V + S+ +A + + IE+ L L R+L +L Q P +I ARRL
Sbjct 688 ANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRL 741
>P0AG20 GTP pyrophosphokinase [Escherichia coli (strain K12)]
Length=744
Score = 542 bits (1397), Expect = 0.0
Identities = 282/714 (39%), Positives = 441/714 (62%), Gaps = 26/714 (4%)
Query 62 LETTVNHPSNTFTT--GIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQ 119
L+ T HP + G+ M +IL+ L +D DTL AA+L+ ++ + +R+ G+
Sbjct 43 LQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKS 102
Query 120 VHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAER 179
V +L+ G M + ++ H ++ E + + +ML+A+ +D R V+IKLAER
Sbjct 103 VVNLIHGVRDMAAIRQL------KATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAER 156
Query 180 TFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIAT 239
LRE+ + + + A+E IYAPLA+RLGI QLKWELED FRYL P YK IA
Sbjct 157 IAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAK 216
Query 240 LLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDI 299
LL+E+RL+RE YI+ + L+ E+ G+ AE+ GR KHIYSI+RKM+ KNL+FD+L+D+
Sbjct 217 LLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDV 276
Query 300 RALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAE-NKSLEV 358
RA+R++ + + +CY +LGIVH +RH+P +FDDY+ NPK NGY+S+HT V+ K++E+
Sbjct 277 RAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEI 336
Query 359 QIRTHEMHEEAELGVCSHFNYKEGSKTTDRSFNH--RLHSLRSVLEHYQERNETTVHKND 416
QIRT +MHE+AELGV +H+ YKEG+ H R+ LR ++ +E
Sbjct 337 QIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEM--------A 388
Query 417 DEAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRY 476
D E +E+++ +++YVF+ GD+ +LP GST LDFAYH+H++VG++C A++ R
Sbjct 389 DSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRI 448
Query 477 VPLTYTLKTGEQVEILTKKDREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIG 536
VP TY L+ G+Q+EI+T+K P+RDWL +LGY+ T+R R K+ WFR+QDR KN+ G
Sbjct 449 VPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAG 508
Query 537 KEILNKELSRLAIHPKSIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLIN----QINRQ 592
++IL+ EL L I K + +N D++L A+ GD+ L+ ++N Q N+
Sbjct 509 RQILDDELEHLGISLKEAE-KHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKP 567
Query 593 MHLDQDEPELVLKPTLNPRASHTLSAHG-ILIDGLDNVELHIAQCCQPVHGESIGGYITL 651
+QD L + + +G ++++G+ N+ HIA+CCQP+ G+ I G+IT
Sbjct 568 SAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQ 627
Query 652 NRGVSIHKVGCPDYQRMIKNEPERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVI 711
RG+S+H+ C + + PER V+A W + G S+ + + A DR GLL+D+T ++
Sbjct 628 GRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDRSGLLRDITTIL 687
Query 712 FSDQINIRQVNTISEA-DGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
++++N+ V + S+ +A + + IE+ L L R+L +L Q P +I ARRL
Sbjct 688 ANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRL 741
>P55133 GTP pyrophosphokinase [Photobacterium angustum (strain
S14 / CCUG 15956)]
Length=744
Score = 519 bits (1336), Expect = 2e-177
Identities = 279/752 (37%), Positives = 454/752 (60%), Gaps = 32/752 (4%)
Query 25 EKTQLDLASWFKRVSEILDGAELKQLEKVAQLTLKKVLETTVNHPSNTFTTGIGMADILA 84
E T +L SW + + + D ++E Q ++ E N P + G + +IL
Sbjct 11 ENTTFELVSWVESLRQ--DAKVSSRIEGTYQRCIELAAEQE-NGPLLLWR-GRELVEILV 66
Query 85 HLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEMIEKNKRLE 144
L +D DTL AA+LY V G + +++++ + LV G M +S++ +
Sbjct 67 TLSMDADTLIAALLYPLVEGGCYSTDALKEEYSGTILHLVQGVEQMCAISQLKSTAEETA 126
Query 145 DHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQERVAREILTI 204
Q + I +ML+++ +D R V+IKLAER LRE+ E + A+E I
Sbjct 127 ------QAAQVDNIRRMLLSMVDDFRCVVIKLAERICNLREVKDQPDEVRRAAAQECANI 180
Query 205 YAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVILKLKTELS 264
YAPLA+RLGI QLKWE+ED AFRY P+ YK+IA L+E+R++RE YI + L +
Sbjct 181 YAPLANRLGIGQLKWEIEDYAFRYQHPDTYKQIAKQLSERRIDREDYITHFVDDLSDAMK 240
Query 265 EYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSLGIVHQIWR 324
I AE+ GR KHIYSI+RKM+ K+L FD+L+D+RA+R++ + + +CY +LG+VH +R
Sbjct 241 ASNIRAEVQGRPKHIYSIWRKMQKKSLEFDELFDVRAVRIVAEELQDCYAALGVVHTKYR 300
Query 325 HIPHQFDDYITNPKANGYRSLHTAVIA-ENKSLEVQIRTHEMHEEAELGVCSHFNYKEGS 383
H+P +FDDY+ NPK NGY+S+HT V+ E K++E+QIRT +MHEE+ELGV +H+ YKEG+
Sbjct 301 HLPKEFDDYVANPKPNGYQSIHTVVLGPEGKTIEIQIRTKQMHEESELGVAAHWKYKEGT 360
Query 384 KT--TDRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEKIYVFSRDG 441
+ +++ +++ LR +L +E + D E +EL++ +++Y F+ G
Sbjct 361 ASGGAQSAYDEKINWLRKLLAWQEEMS--------DSGEMLDELRSQVFDDRVYAFTPKG 412
Query 442 DIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILTKKDREPNR 501
D+ +LP +T LDFAYH+H+EVG++C A+V R VP TY L+ G+QVEI+T+K+ P+R
Sbjct 413 DVVDLPSNATPLDFAYHIHSEVGHRCIGAKVEGRIVPFTYHLQMGDQVEIITQKEPNPSR 472
Query 502 DWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPKSIDLSDYCA 561
DWL +LG++ ++RAR K+ WFR+QDR KN+ GKEIL EL + IH D Y A
Sbjct 473 DWLNPNLGFVTSSRARAKVHAWFRKQDRDKNIIAGKEILEAEL--VKIHATLKDAQYYAA 530
Query 562 -HFNVKSGDDVLIALVSGDVSLHSLINQINRQMHL-DQDEPELVLKPTLNPRASHTLSAH 619
FNVKS +++ + SGD+ ++ +IN IN ++ +E + L L+ ++ ++H
Sbjct 531 KRFNVKSPEELYAGIGSGDLRINQVINHINALVNKPTAEEEDQQLLEKLSEASNKQATSH 590
Query 620 ------GILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCPDYQRMIKNEP 673
++++G+DN+ H+A+CCQP+ G+ I G++T RG+S+H++ C + + + P
Sbjct 591 KKPQRDAVVVEGVDNLMTHLARCCQPIPGDDIQGFVTQGRGISVHRMDCEQLEELRHHAP 650
Query 674 ERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQVNT-ISEADGIAN 732
ER ++ W ++ + + A +R GLLK+LT + ++++ + + + + ++
Sbjct 651 ERIIDTVWGGGFVGNYTITVRVTASERNGLLKELTNTLMNEKVKVAGMKSRVDYKKQMSI 710
Query 733 MKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
M +E+ L L R+L R+EQ + A+RL
Sbjct 711 MDFELELTDLEVLGRVLKRIEQVKDVAEAKRL 742
>P44644 GTP pyrophosphokinase [Haemophilus influenzae (strain
ATCC 51907 / DSM 11121 / KW20 / Rd)]
Length=743
Score = 513 bits (1321), Expect = 4e-175
Identities = 273/700 (39%), Positives = 441/700 (63%), Gaps = 27/700 (4%)
Query 75 TGIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLS 134
+G+ M +IL L++D +TL A+L+ V + E +++KFG ++ L+ G L M +
Sbjct 61 SGVEMVEILHELNMDAETLLTAMLFPIVANKLTDWESLKEKFGAKITKLLKGVLEMDNIR 120
Query 135 EMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQ 194
++ + +N +R ML+A+ +D R V+IKLAER LR+ E
Sbjct 121 QLNASHSANALQVDNVRR--------MLLAMVDDFRCVIIKLAERITFLRDAEHRCAEED 172
Query 195 ERVA-REILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQ 253
+ +A +E IYAPLA+RLGI QLKWELED FRYL PE+Y+ IA LL E+RL+RE YI
Sbjct 173 KVLAVKECSYIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRAIAKLLQERRLDREHYIA 232
Query 254 SVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECY 313
+ +L L E E+ GR KHIYSI+RKM+ K+L F LYD+RA+R++VQ + +CY
Sbjct 233 DFVSELSGYLRENIEQVEVYGRPKHIYSIWRKMQKKHLEFSGLYDVRAVRIIVQKLQDCY 292
Query 314 HSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAE-NKSLEVQIRTHEMHEEAELG 372
+LGIVH ++H+P +FDDY+ NPK NGY+S+HT V+ + K +EVQIRT +MH++AELG
Sbjct 293 TALGIVHTQFKHLPKEFDDYVANPKPNGYQSIHTVVLGKGGKPIEVQIRTQQMHDDAELG 352
Query 373 VCSHFNYKEGSKTTDRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFE 432
+ +H+ YKEG+ + ++ ++ LR +L + D E EL++ +
Sbjct 353 MAAHWKYKEGNTGSMSAYEEKIAWLRKLLAWQDDIT--------DSGEVLAELRSQVFDD 404
Query 433 KIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEIL 492
++YVF+ G++ +LP GST LDFAY +H+E+G++C A+V R VP TY L+ G+Q++I+
Sbjct 405 RVYVFTPKGEVVDLPTGSTPLDFAYAIHSEIGHRCIGAKVAGRIVPFTYQLQMGDQIDII 464
Query 493 TKKDREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
T+K+ P+RDWL +LG+ TA++R K++ WF++QDR KN+ GKE+L+ EL+ L + K
Sbjct 465 TQKNPNPSRDWLNPNLGFTHTAKSRAKIQAWFKKQDRDKNIPAGKELLDNELALLNLSIK 524
Query 553 SIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQINRQM---HLDQDEPELVL----K 605
++ +N+K+ DD+ + SGD+ L++LI+ + ++ ++ + E++ K
Sbjct 525 QVE-PYALPRYNLKNLDDLYAGIGSGDIRLNNLIHFLQSKLIKVTAEEADQEILRHVANK 583
Query 606 PTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCPDY 665
+N + + ++++G+DN+ HIA+CCQP+ G++I GYIT+ RG+SIH+ C +
Sbjct 584 SAVNSQQKSEKNNGCVIVEGVDNLMHHIARCCQPIPGDAIVGYITMGRGISIHRADCEQF 643
Query 666 QRMIKNEPERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQVNTIS 725
+ PER VE+ W G + I I A DR GLL+D+T V+ +++I++ V++ +
Sbjct 644 LDLQAAHPERVVESIWGENYASGFHINIRIVAGDRNGLLRDITTVLANEKISVLGVSSRA 703
Query 726 EA-DGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ +A + + IE+ + LS++LARL + +I A+RL
Sbjct 704 DTKKQLATIDMEIELHNVESLSKILARLAKLDDVIEAKRL 743
Score = 20.4 bits (41), Expect = 7.6
Identities = 14/43 (33%), Positives = 22/43 (51%), Gaps = 4/43 (9%)
Query 23 HAEKTQLDLASWFK---RVSEILDGAELKQLE-KVAQLTLKKV 61
H K++ + +WFK R I G EL E + L++K+V
Sbjct 484 HTAKSRAKIQAWFKKQDRDKNIPAGKELLDNELALLNLSIKQV 526
>O54408 GTP pyrophosphokinase [Bacillus subtilis (strain 168)]
Length=734
Score = 464 bits (1195), Expect = 2e-156
Identities = 258/706 (37%), Positives = 418/706 (59%), Gaps = 44/706 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL L +D T++ L+ V + + ++++++ F E+V LV G +GK+
Sbjct 55 IQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLVDGVTKLGKIKYK 114
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H KM +A+ +D+RV+LIKLA+R +R L +E+Q R
Sbjct 115 SQEEQQAENH------------RKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRR 162
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
++ E L I+APLAHRLGI+++KWELED A RYL P++Y I L+ +KR ERE Y+ V+
Sbjct 163 ISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVDEVV 222
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
++K + E I A+ +GR KHIYSIYRKM +N F+++YD+ A+R+LV +I +CY L
Sbjct 223 NEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIKDCYAVL 282
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIA-ENKSLEVQIRTHEMHEEAELGVCS 375
GI+H W+ +P +F DYI PK N Y+SLHT VI + LEVQIRT EMHE AE GV +
Sbjct 283 GIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHEIAEYGVAA 342
Query 376 HFNYKEGSKTTD-RSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDF-EK 433
H+ YKEG + +F +L R +LE +NE+T +AE F E + F +
Sbjct 343 HWAYKEGKAANEGATFEKKLSWFREILEF---QNEST------DAEEFMESLKIDLFSDM 393
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+YVF+ GD+ ELP GS +DF+Y +H+E+GNK A+VN + V L + L+TG+ VEILT
Sbjct 394 VYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVEILT 453
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P++DW + +T++A+ K+R +F++Q R +N+E G+E++ KE+ L K
Sbjct 454 SKHSYGPSQDW----VKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFELK 509
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI--NRQMHLDQDEPELVLKP 606
+ ++ FN + +D+ A+ ++ + N++ + DQ+E E +++
Sbjct 510 DVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKIVQE 569
Query 607 TL---NPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
P G+ + G+DN+ + +++CC PV G+ I G+IT RGVS+H+ CP
Sbjct 570 VTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVHREDCP 629
Query 664 DYQRMIKNEPERAVEADWE----MQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIR 719
+ + ER + +WE +Q + +V+I I YDRRGLL ++ Q + + NI
Sbjct 630 NVK--TNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNETKTNIS 687
Query 720 QVNTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRLI 765
V+ S+ + +A + + I ++ + L +++ R++Q I S RR++
Sbjct 688 SVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVM 733
>O52177 GTP pyrophosphokinase [Myxococcus xanthus]
Length=757
Score = 460 bits (1183), Expect = 2e-154
Identities = 254/740 (34%), Positives = 423/740 (57%), Gaps = 59/740 (8%)
Query 52 KVAQLTLKKVLETTVNHPSNTFTTGIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEE 111
KV Q L+K E + HP + +A IL L +DE ++ +L+ ++ + + EE
Sbjct 50 KVHQGQLRKSGEPYLVHP-------LEVAGILGELKLDEASIVTGLLHDTIEDTLATEEE 102
Query 112 VRDKFGEQVHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRV 171
+ + FG +V LV G + K S ++ + + KM+IA+ +D+RV
Sbjct 103 LTELFGSEVAHLVDGVTKLSKFSASASLSQ---------EEKQAENFRKMIIAMAQDIRV 153
Query 172 VLIKLAERTFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAP 231
+L+KLA+RT +R L S E+Q R+A+E L IYAPLA+RLGI+ +K ELEDL+FRY+ P
Sbjct 154 ILVKLADRTHNMRTLDHMSEEKQARIAQETLDIYAPLANRLGISWIKTELEDLSFRYVKP 213
Query 232 ERYKEIATLLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNL 291
+ + + LN+++ ERE+YI+ ++++L+E G+ E++GR KH+YSIY+K+KS+ +
Sbjct 214 QEFFALQAKLNKRKKEREKYIEDTCDLIRSKLAERGLKGEVSGRFKHVYSIYKKIKSQGI 273
Query 292 SFDQLYDIRALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIA 351
FDQ++DI A R++ P CY +LG+VH++W+ +P +F D+I PK N Y+SLHT +I
Sbjct 274 DFDQIHDIIAFRIIAPTAPSCYEALGLVHEMWKPVPGRFKDFIAIPKPNMYQSLHTTIIG 333
Query 352 E-NKSLEVQIRTHEMHEEAELGVCSHFNYKEGSKTTDRSFNHRLHSLRSVLEHYQERNET 410
++ +EVQIRT EMH+ AE G+ +H+ YKEG + + + LR ++E Q+
Sbjct 334 PLSERVEVQIRTSEMHKIAEEGIAAHWKYKEGKAVISKD-DEKFAWLRQLMEWQQDLK-- 390
Query 411 TVHKNDDEAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAA 470
D E E ++ ++++VF+ GD++ LPRG+T +DFAY +H++VGN+C A
Sbjct 391 ------DPKEFLETVKVDLFTDEVFVFTPKGDVRSLPRGATPVDFAYAIHSDVGNRCVGA 444
Query 471 RVNQRYVPLTYTLKTGEQVEILTKKDREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRS 530
+VN + VPL Y +K G+ VE+LT + P++DWL +++T+RA+ ++R + +QQ R
Sbjct 445 KVNGKIVPLRYKMKNGDTVEVLTSPQQHPSKDWLT----FVKTSRAQQRIRGFIKQQQRE 500
Query 531 KNLEIGKEILNKELSRLAIH----PKSIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLI 586
K+L++G+E+ ++EL R ++ KS ++ + DD+L+A+ G V+ L
Sbjct 501 KSLQLGRELADRELKRFQLNFNRLLKSGEMKKAAVDLGFRVEDDMLVAIGYGKVTPQQLS 560
Query 587 NQINRQMHLDQDE----------------------PELVLKPTLNPRASHTLSAHGILID 624
+++ Q L+ E P L L R + G+ I
Sbjct 561 HRLVPQEKLNAAEAGGRADANPAATTSGGAGNSVLPGLSRVTDLAKRLVGRSNRSGVQIG 620
Query 625 GLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCPDYQRMIKNEPERAVEADWEMQ 684
G+D+V + +CC PV G+ I G+IT RGV++H VGC ++ + +PER V+ W+++
Sbjct 621 GVDDVLVRFGRCCNPVPGDPIAGFITRGRGVTVHTVGC---EKALATDPERRVDVSWDVR 677
Query 685 PTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQVNTISEADGIANMKLLIEVKGLAQ 744
+ V + + DR GLL D+T +NI Q N + D A + + L Q
Sbjct 678 GDFKRPVTLRVLTADRPGLLADITNTFSKKGVNISQANCRATGDDRAVNTFEVIISDLKQ 737
Query 745 LSRLLARLEQQPGIISARRL 764
L+ L+ +E+ G+ S R+
Sbjct 738 LTDLMRTIERLQGVYSVERI 757
>Q6GG70 GTP pyrophosphokinase [Staphylococcus aureus (strain MRSA252)]
Length=736
Score = 455 bits (1171), Expect = 8e-153
Identities = 255/703 (36%), Positives = 412/703 (59%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V++ F E+V +V G + K+
Sbjct 62 IQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYR 121
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 122 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIR 169
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
++RE L IYAPLAHRLGI +KWELED A RY+ +Y I L+ +KR ERE YI++ I
Sbjct 170 ISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAI 229
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
+++TE+ I +I GR KHIYSIYRKM + FDQ++D+ A+RV+V +I +CY L
Sbjct 230 DRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAIL 289
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRT +MHE AE GV +
Sbjct 290 GLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAA 349
Query 376 HFNYKEGSKTT--DRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG K + D+++ ++L+ L+ + E H + D E E L+ +K
Sbjct 350 HWAYKEGKKVSEKDQTYQNKLNWLKELAE--------ADHTSSDAQEFMETLKYDLQSDK 401
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ VEI T
Sbjct 402 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRT 461
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E G+ ++ E+ +
Sbjct 462 SKHSYGPSRDW----LKIVKSSSAKGKIKSFFKKQDRSSNIEKGRMMVEAEIKEQGFRVE 517
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I ++ +N + DD+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 518 DILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDKQRALNEAQEV 577
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + ++ G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 578 TKSL--PIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 635
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE ER + +W T+ V + + AYDR GLL ++ Q + S N+ +V
Sbjct 636 N----IKNETERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKV 691
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 692 SGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGDVYTVTRV 734
>P0A0E9 GTP pyrophosphokinase [Staphylococcus aureus (strain MW2)]
Length=736
Score = 455 bits (1170), Expect = 1e-152
Identities = 255/703 (36%), Positives = 412/703 (59%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V++ F E+V +V G + K+
Sbjct 62 IQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYR 121
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 122 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIR 169
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
++RE L IYAPLAHRLGI +KWELED A RY+ +Y I L+ +KR ERE YI++ I
Sbjct 170 ISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAI 229
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
+++TE+ I +I GR KHIYSIYRKM + FDQ++D+ A+RV+V +I +CY L
Sbjct 230 DRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAIL 289
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRT +MHE AE GV +
Sbjct 290 GLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAA 349
Query 376 HFNYKEGSKTT--DRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG K + D+++ ++L+ L+ + E H + D E E L+ +K
Sbjct 350 HWAYKEGKKVSEKDQTYQNKLNWLKELAE--------ADHTSSDAQEFMETLKYDLQSDK 401
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ VEI T
Sbjct 402 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRT 461
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E G+ ++ E+ +
Sbjct 462 SKHSYGPSRDW----LKIVKSSSAKGKIKSFFKKQDRSSNIEKGRMMVEVEIKEQGFRVE 517
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I ++ +N + DD+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 518 DILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDKQRALNEAQEV 577
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + ++ G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 578 TKSL--PIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 635
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE ER + +W T+ V + + AYDR GLL ++ Q + S N+ +V
Sbjct 636 N----IKNETERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKV 691
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 692 SGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGDVYTVTRV 734
>Q6G8T5 GTP pyrophosphokinase [Staphylococcus aureus (strain MSSA476)]
Length=736
Score = 455 bits (1170), Expect = 1e-152
Identities = 255/703 (36%), Positives = 412/703 (59%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V++ F E+V +V G + K+
Sbjct 62 IQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYR 121
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 122 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIR 169
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
++RE L IYAPLAHRLGI +KWELED A RY+ +Y I L+ +KR ERE YI++ I
Sbjct 170 ISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAI 229
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
+++TE+ I +I GR KHIYSIYRKM + FDQ++D+ A+RV+V +I +CY L
Sbjct 230 DRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAIL 289
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRT +MHE AE GV +
Sbjct 290 GLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAA 349
Query 376 HFNYKEGSKTT--DRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG K + D+++ ++L+ L+ + E H + D E E L+ +K
Sbjct 350 HWAYKEGKKVSEKDQTYQNKLNWLKELAE--------ADHTSSDAQEFMETLKYDLQSDK 401
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ VEI T
Sbjct 402 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRT 461
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E G+ ++ E+ +
Sbjct 462 SKHSYGPSRDW----LKIVKSSSAKGKIKSFFKKQDRSSNIEKGRMMVEVEIKEQGFRVE 517
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I ++ +N + DD+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 518 DILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDKQRALNEAQEV 577
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + ++ G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 578 TKSL--PIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 635
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE ER + +W T+ V + + AYDR GLL ++ Q + S N+ +V
Sbjct 636 N----IKNETERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKV 691
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 692 SGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGDVYTVTRV 734
>Q99TL8 GTP pyrophosphokinase [Staphylococcus aureus (strain N315)]
Length=736
Score = 455 bits (1170), Expect = 1e-152
Identities = 255/703 (36%), Positives = 412/703 (59%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V++ F E+V +V G + K+
Sbjct 62 IQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYR 121
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 122 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIR 169
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
++RE L IYAPLAHRLGI +KWELED A RY+ +Y I L+ +KR ERE YI++ I
Sbjct 170 ISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAI 229
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
+++TE+ I +I GR KHIYSIYRKM + FDQ++D+ A+RV+V +I +CY L
Sbjct 230 DRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAIL 289
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRT +MHE AE GV +
Sbjct 290 GLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAA 349
Query 376 HFNYKEGSKTT--DRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG K + D+++ ++L+ L+ + E H + D E E L+ +K
Sbjct 350 HWAYKEGKKVSEKDQTYQNKLNWLKELAE--------ADHTSSDAQEFMETLKYDLQSDK 401
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ VEI T
Sbjct 402 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRT 461
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E G+ ++ E+ +
Sbjct 462 SKHSYGPSRDW----LKIVKSSSAKGKIKSFFKKQDRSSNIEKGRMMVEVEIKEQGFRVE 517
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I ++ +N + DD+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 518 DILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDKQRALNEAQEV 577
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + ++ G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 578 TKSL--PIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 635
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE ER + +W T+ V + + AYDR GLL ++ Q + S N+ +V
Sbjct 636 N----IKNETERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKV 691
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 692 SGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGDVYTVTRV 734
>P0A0F0 GTP pyrophosphokinase [Staphylococcus aureus]
Length=736
Score = 455 bits (1170), Expect = 1e-152
Identities = 255/703 (36%), Positives = 412/703 (59%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V++ F E+V +V G + K+
Sbjct 62 IQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYR 121
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 122 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIR 169
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
++RE L IYAPLAHRLGI +KWELED A RY+ +Y I L+ +KR ERE YI++ I
Sbjct 170 ISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAI 229
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
+++TE+ I +I GR KHIYSIYRKM + FDQ++D+ A+RV+V +I +CY L
Sbjct 230 DRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAIL 289
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRT +MHE AE GV +
Sbjct 290 GLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAA 349
Query 376 HFNYKEGSKTT--DRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG K + D+++ ++L+ L+ + E H + D E E L+ +K
Sbjct 350 HWAYKEGKKVSEKDQTYQNKLNWLKELAE--------ADHTSSDAQEFMETLKYDLQSDK 401
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ VEI T
Sbjct 402 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRT 461
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E G+ ++ E+ +
Sbjct 462 SKHSYGPSRDW----LKIVKSSSAKGKIKSFFKKQDRSSNIEKGRMMVEVEIKEQGFRVE 517
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I ++ +N + DD+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 518 DILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDKQRALNEAQEV 577
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + ++ G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 578 TKSL--PIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 635
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE ER + +W T+ V + + AYDR GLL ++ Q + S N+ +V
Sbjct 636 N----IKNETERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKV 691
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 692 SGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGDVYTVTRV 734
>Q8CS97 GTP pyrophosphokinase [Staphylococcus epidermidis (strain
ATCC 12228 / FDA PCI 1200)]
Length=729
Score = 454 bits (1168), Expect = 2e-152
Identities = 253/703 (36%), Positives = 411/703 (58%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V+D F E++ +V G + K+
Sbjct 55 IQVAGILTEMRLDGPTIVAGFLHDVIEDTSYTFEDVKDMFNEEIARIVDGVTKLKKVKYR 114
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 115 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQVR 162
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
+++E L IYAPLAHRLGI +KWELED A RY+ +Y I L+ +KR ERE YI + I
Sbjct 163 ISKETLEIYAPLAHRLGINTIKWELEDTALRYIDSVQYFRIVNLMKKKRSEREAYITNAI 222
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
K+K E+++ ++ EI GR KHIYSIYRKM + FDQ++D+ A+R++V +I +CY +L
Sbjct 223 NKIKNEMTKMNLSGEINGRPKHIYSIYRKMIKQKKQFDQIFDLLAIRIIVNSINDCYATL 282
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRTHEMHE AE GV +
Sbjct 283 GLVHTLWKPMPGRFKDYIAMPKQNMYQSLHTTVVGPNGDPLEIQIRTHEMHEIAEHGVAA 342
Query 376 HFNYKEGSKTTDRS--FNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG ++ F ++L+ L+ + E T H + D E E L+ +K
Sbjct 343 HWAYKEGKTVNQKTQDFQNKLNWLKELAE--------TDHTSADAQEFMESLKYDLQSDK 394
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ +EI T
Sbjct 395 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYVLQTGDIIEIRT 454
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E GK ++ E+ +
Sbjct 455 SKHSYGPSRDW----LKIVKSSSAKSKIKSFFKKQDRSSNIEKGKFMVEAEIKEQGFRVE 510
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I +L ++ + +D+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 511 DILTEKNLEVVNEKYHFANDEDLYAAVGFGGVTSIQIVNKLTERQRILDKQKALNEAQEV 570
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 571 TKSV--PIKKDITTDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 628
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE +R + +W T+ V + + AYDR GLL ++ Q + S ++ +V
Sbjct 629 N----IKNETDRLISVEWVKSKDSTQQYQVDLEVTAYDRNGLLNEVLQAVNSTAGSLIKV 684
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 685 SGRSDIDKNAVINISVMVKNVNDVYRVVEKIKQLGDVYTVSRV 727
>Q5HNR8 GTP pyrophosphokinase [Staphylococcus epidermidis (strain
ATCC 35984 / RP62A)]
Length=729
Score = 454 bits (1168), Expect = 2e-152
Identities = 253/703 (36%), Positives = 411/703 (58%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V+D F E++ +V G + K+
Sbjct 55 IQVAGILTEMRLDGPTIVAGFLHDVIEDTSYTFEDVKDMFNEEIARIVDGVTKLKKVKYR 114
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 115 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQVR 162
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
+++E L IYAPLAHRLGI +KWELED A RY+ +Y I L+ +KR ERE YI + I
Sbjct 163 ISKETLEIYAPLAHRLGINTIKWELEDTALRYIDSVQYFRIVNLMKKKRSEREAYITNAI 222
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
K+K E+++ ++ EI GR KHIYSIYRKM + FDQ++D+ A+R++V +I +CY +L
Sbjct 223 NKIKNEMTKMNLSGEINGRPKHIYSIYRKMIKQKKQFDQIFDLLAIRIIVNSINDCYATL 282
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRTHEMHE AE GV +
Sbjct 283 GLVHTLWKPMPGRFKDYIAMPKQNMYQSLHTTVVGPNGDPLEIQIRTHEMHEIAEHGVAA 342
Query 376 HFNYKEGSKTTDRS--FNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG ++ F ++L+ L+ + E T H + D E E L+ +K
Sbjct 343 HWAYKEGKTVNQKTQDFQNKLNWLKELAE--------TDHTSADAQEFMESLKYDLQSDK 394
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ +EI T
Sbjct 395 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYVLQTGDIIEIRT 454
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E GK ++ E+ +
Sbjct 455 SKHSYGPSRDW----LKIVKSSSAKSKIKSFFKKQDRSSNIEKGKFMVEAEIKEQGFRVE 510
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I +L ++ + +D+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 511 DILTEKNLEVVNEKYHFANDEDLYAAVGFGGVTSIQIVNKLTERQRILDKQKALNEAQEV 570
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 571 TKSV--PIKKDITTDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 628
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE +R + +W T+ V + + AYDR GLL ++ Q + S ++ +V
Sbjct 629 N----IKNETDRLISVEWVKSKDSTQQYQVDLEVTAYDRNGLLNEVLQAVNSTAGSLIKV 684
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 685 SGRSDIDKNAVINISVMVKNVNDVYRVVEKIKQLGDVYTVSRV 727
>Q931Q4 GTP pyrophosphokinase [Staphylococcus aureus (strain Mu50
/ ATCC 700699)]
Length=736
Score = 453 bits (1165), Expect = 6e-152
Identities = 254/703 (36%), Positives = 411/703 (58%), Gaps = 45/703 (6%)
Query 77 IGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEM 136
I +A IL + +D T+ A L+ + + E+V++ F E+V +V G + K+
Sbjct 62 IQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYR 121
Query 137 IEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQER 196
++ ++ E+H K+ IA+ +DVRV+L+KLA+R +R L RE+Q R
Sbjct 122 SKEEQQAENH------------RKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIR 169
Query 197 VAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVI 256
++RE L IYAPLAH LGI +KWELED A RY+ +Y I L+ +KR ERE YI++ I
Sbjct 170 ISRETLEIYAPLAHHLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAI 229
Query 257 LKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSL 316
+++TE+ I +I GR KHIYSIYRKM + FDQ++D+ A+RV+V +I +CY L
Sbjct 230 DRIRTEMDRMNIEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAIL 289
Query 317 GIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCS 375
G+VH +W+ +P +F DYI PK N Y+SLHT V+ N LE+QIRT +MHE AE GV +
Sbjct 290 GLVHTLWKPMPGRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAA 349
Query 376 HFNYKEGSKTT--DRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEK 433
H+ YKEG K + D+++ ++L+ L+ + E H + D E E L+ +K
Sbjct 350 HWAYKEGKKVSEKDQTYQNKLNWLKELAE--------ADHTSSDAQEFMETLKYDLQSDK 401
Query 434 IYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILT 493
+Y F+ D+ ELP G+ +DFAY +H+EVGNK A+VN + VP+ Y L+TG+ VEI T
Sbjct 402 VYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRT 461
Query 494 KK-DREPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPK 552
K P+RDW L ++++ A+ K++ +F++QDRS N+E G+ ++ E+ +
Sbjct 462 SKHSYGPSRDW----LKIVKSSSAKGKIKSFFKKQDRSSNIEKGRMMVEVEIKEQGFRVE 517
Query 553 SI----DLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQI-NRQMHLDQ----DEPELV 603
I ++ +N + DD+ A+ G V+ ++N++ RQ LD+ +E + V
Sbjct 518 DILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTERQRILDKQRALNEEQEV 577
Query 604 LKPTLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCP 663
K P + ++ G+ ++GL+NV + +++CC P+ G+ I GYIT G+ +H+ CP
Sbjct 578 TKSL--PIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCP 635
Query 664 DYQRMIKNEPERAVEADW--EMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQV 721
+ IKNE ER + +W T+ V + + AYDR GLL ++ Q + S N+ +V
Sbjct 636 N----IKNETERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKV 691
Query 722 NTISEADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+ S+ D A + + + VK + + R++ +++Q + + R+
Sbjct 692 SGRSDIDKNAIINISVMVKNVNDVYRVVEKIKQLGDVYTVTRV 734
>Q54089 GTP pyrophosphokinase / Guanosine-3',5'-bis(diphosphate)
3'-pyrophosphohydrolase [Streptococcus dysgalactiae subsp.
equisimilis]
Length=739
Score = 431 bits (1107), Expect = 3e-143
Identities = 249/724 (34%), Positives = 409/724 (56%), Gaps = 48/724 (7%)
Query 58 LKKVLETTVNHPSNTFTTGIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIEEVRDKFG 117
++K E + HP I +A ILA LH+D T++ L+ V + I ++ + FG
Sbjct 43 VRKSGEPYIVHP-------IQVAGILADLHLDAVTVACGFLHDVVEDTDITLDNIEFDFG 95
Query 118 EQVHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVRVVLIKLA 177
+ V +V G +GK+ + + E+H KML+A+++D+RV+L+KLA
Sbjct 96 KDVRDIVDGVTKLGKVEYKSHEEQLAENH------------RKMLMAMSKDIRVILVKLA 143
Query 178 ERTFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKWELEDLAFRYLAPERYKEI 237
+R +R L +++QER++RE + IYAPLAHRLGI+++KWELEDLAFRYL + +I
Sbjct 144 DRLHNMRTLKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKI 203
Query 238 ATLLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKNLSFDQLY 297
+ ++NEKR ERE + ++ K+K+ +E G+ ++ GR KHIYSIYRKM+ K FDQ++
Sbjct 204 SHMMNEKRREREALVDDIVTKIKSYTTEQGLFGDVYGRPKHIYSIYRKMRDKKKRFDQIF 263
Query 298 DIRALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVIAENKSLE 357
D+ A+R +++ + Y +G +H++WR +P +F DYI PKANGY+S+HT V +E
Sbjct 264 DLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKGPIE 323
Query 358 VQIRTHEMHEEAELGVCSHFNYKEGSKTTDRSFNHRLHSLRSVLEHYQERNETTVHKNDD 417
+QIRT EMH+ AE GV +H+ YK+G + ++ + +E E N D
Sbjct 324 IQIRTKEMHQVAEYGVAAHWAYKKGVRGKVNQAEQKVG-----MNWIKELVELQDASNGD 378
Query 418 EAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYV 477
+ + ++ E+IYVF+ G ++ELP+ S +DFAY +HT+VG K A+VN R V
Sbjct 379 AVDFVDSVKEDIFSERIYVFTPTGAVQELPKDSGPIDFAYAIHTQVGEKAIGAKVNGRMV 438
Query 478 PLTYTLKTGEQVEILTKKDR-EPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIG 536
PLT LKTG+ VEI+T + P+RDW + ++T +AR+K+R +F+ QD+ ++ G
Sbjct 439 PLTAKLKTGDVVEIVTNPNSFGPSRDW----IKLVKTNKARNKIRQFFKNQDKELSVNKG 494
Query 537 KEILNKELSRLA-IHPKSID---LSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQINRQ 592
+++L + K +D + +VKS + + A+ GD+S S+ N++ +
Sbjct 495 RDMLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPVSVFNKLTEK 554
Query 593 MHLDQDE-------PELVLKPTLNPRASHTL---SAHGILIDGLDNVELHIAQCCQPVHG 642
+++ ELV + L S +G++I G + + IA+CC PV G
Sbjct 555 ERREEERAKAKAEAEELVNGGEIKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPG 614
Query 643 ESIGGYITLNRGVSIHKVGCPDYQRMIKNEPERAVEADWEMQPTRGQSVQIVIDAY--DR 700
+ I GYIT RG++IH+ C + + ER +E +W++ + Q ID Y +R
Sbjct 615 DPIEGYITKGRGIAIHRADCNNIKSQ-DGYQERLIEVEWDLD-NSSKDYQAEIDIYGLNR 672
Query 701 RGLLKDLTQVIFSDQINIRQVNTISEAD-GIANMKLLIEVKGLAQLSRLLARLEQQPGII 759
RGLL D+ Q++ + +I VN D AN+ + + L L+ ++ +++ P +
Sbjct 673 RGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTTVVEKIKAVPDVY 732
Query 760 SARR 763
S +R
Sbjct 733 SVKR 736
>O87331 GTP pyrophosphokinase [Corynebacterium glutamicum (strain
ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730
/ NCIMB 10025)]
Length=760
Score = 404 bits (1038), Expect = 8e-133
Identities = 241/735 (33%), Positives = 410/735 (56%), Gaps = 56/735 (8%)
Query 51 EKVAQLTLKKVLETTVNHPSNTFTTGIGMADILAHLHVDEDTLSAAVLYRSVREGIIPIE 110
E++ ++K + + HP + +A I A + +D TL AA+L+ +V + ++
Sbjct 63 ERLHDGVIRKSGDPYITHP-------LAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLD 115
Query 111 EVRDKFGEQVHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIYKMLIAVTEDVR 170
++ FGE+V LV G + K++ I KM++A+++D R
Sbjct 116 DLTRDFGEEVARLVDGVTKLDKVAL--------------GAAAEAETIRKMIVAMSQDPR 161
Query 171 VVLIKLAERTFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKWELEDLAFRYLA 230
V++IK+A+R +R + E+Q + AR+ L + APLAHRLG+A +KWELEDL+F L
Sbjct 162 VLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILY 221
Query 231 PERYKEIATLLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHIYSIYRKMKSKN 290
P++Y+EI L+ ++ R++Y++ +I ++ L E I AE+ GR KH +SIY+KM +
Sbjct 222 PKKYEEIVRLVADRAPSRDRYLKEIIDQVTGGLRENNIAAEVLGRPKHYWSIYQKMIVRG 281
Query 291 LSFDQLYDIRALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKANGYRSLHTAVI 350
FD ++D+ +R+LV N+ CY ++G+VH ++ +P +F DYI+ P+ Y+SLHT V+
Sbjct 282 RDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGRFKDYISAPRFGVYQSLHTTVM 341
Query 351 AE-NKSLEVQIRTHEMHEEAELGVCSHFNYKE--GSKTTDRSFNHRLHSLRSVLEHYQER 407
K LEVQ RTH+MH AE G+ +H+ YKE GS + +++ ++ +R +L+ +E
Sbjct 342 GPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEA 401
Query 408 NETTVHKNDDEAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTVLDFAYHVHTEVGNKC 467
D E + L+ ++I+VF+ GD+ LP ST +DFAY VHTEVG++C
Sbjct 402 --------ADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRC 453
Query 468 YAARVNQRYVPLTYTLKTGEQVEILTKKDRE--PNRDWLVNSLGYIRTARARDKLRHWFR 525
A++N + V L LK+G++VE+ T KD+ P+R W ++ + RA+ K+R WF
Sbjct 454 IGAKINGKLVALETKLKSGDRVEVFTSKDQNAGPSRGW----QEFVVSPRAKAKIRQWFA 509
Query 526 QQDRSKNLEIGKEILNKELSR--LAIHP--KSIDLSDYCAHFNVKSGDDVLIALVSGDVS 581
++ R + LE G++ L + R L +H + + + D + A+ SG VS
Sbjct 510 KERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALYTAIGSGSVS 569
Query 582 LHSLINQINRQMHLDQDEPELVLKPT-----LNPRASHTLSAHGILIDGLDNVELHIAQC 636
++N++ ++D + ++ T +N RA+ T S+ GIL++G +V +A+C
Sbjct 570 AQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRAT-TESSTGILVEGSPDVMAKLAKC 628
Query 637 CQPVHGESIGGYITLNRGVSIHKVGCPDYQRMIKNEPERAVEADWEMQPTRGQ----SVQ 692
C PV G+ I G++T GVS+H+ C + ++ +K EPER V W + GQ S
Sbjct 629 CMPVPGDEIFGFVTRGGGVSVHRTDCTNVEK-LKEEPERIVSVSW---ASEGQGSVFSAT 684
Query 693 IVIDAYDRRGLLKDLTQVIFSDQINIRQVNTISEADGIANMKLLIEVKGLAQLSRLLARL 752
+ ++A DR GLL +LT+VI ++++ +N+ D +A ++ V QL L+ +L
Sbjct 685 LQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSEDRVATVRFTFAVSDTKQLGSLMTQL 744
Query 753 EQQPGIISARRLIQG 767
G+ R+ G
Sbjct 745 RNAEGVFDVYRVTSG 759
>O85709 GTP pyrophosphokinase [Streptomyces antibioticus]
Length=841
Score = 392 bits (1007), Expect = 2e-127
Identities = 245/761 (32%), Positives = 401/761 (53%), Gaps = 73/761 (10%)
Query 42 LDGAELKQLEKVAQLT-------LKKVLETTVNHPSNTFTTGIGMADILAHLHVDEDTLS 94
++ + L+Q+EK Q+ +K + + HP + + ILA L +D TL
Sbjct 116 IETSTLRQIEKAYQVAERWHRGQKRKSGDPYITHP-------LAVTTILAELGMDPATLM 168
Query 95 AAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREH 154
A +L+ S + ++++R FG+ V LV G + K+ +
Sbjct 169 AGLLHDSREDTEYGLDDLRRDFGDVVGLLVDGVTKLDKVKF--------------GEAAQ 214
Query 155 LSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQERVAREILTIYAPLAHRLGI 214
+ KM++A+ +D RV++IKLA+R +R + RE+QE+ ARE L IYAPLAHRLG+
Sbjct 215 AETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGM 274
Query 215 AQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVILKLKTELSEYGINAEITG 274
+KWELEDLAF L P+ Y EI L+ E+ +R++Y+ V +++++L I A +TG
Sbjct 275 NTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAIVTDEVQSDLRARRIKATVTG 334
Query 275 RVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYI 334
R KH YS+Y+K+ + F ++YD+ +RVLV + +CY +LG VH W +P +F DYI
Sbjct 335 RPKHYYSVYQKIIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYI 394
Query 335 TNPKANGYRSLHTAVIAEN-KSLEVQIRTHEMHEEAELGVCSHFNYKE------------ 381
PK N Y+SLHT VI N K +E+QIRT +MH AE G+ +H+ YK+
Sbjct 395 AMPKFNMYQSLHTTVIGPNGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVARASKVRTD 454
Query 382 ---GSKTTDRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEKIYVFS 438
+K D N + LR +L+ +E +D E E L+ +++VF+
Sbjct 455 VPKPAKGKDDHLND-MAWLRQLLDWQKE--------TEDPGEFLESLRFDLSRNEVFVFT 505
Query 439 RDGDIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILTKK--D 496
D+ LP G+T +DFAY VHTEVG++ ARVN R VPL TL G+ VE+ T K
Sbjct 506 PKSDVIALPAGATPVDFAYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAAG 565
Query 497 REPNRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEIL-------NKELSRLAI 549
P+RDW LG++++ RAR+K+R WF ++ R + +E GK+ + N + R+
Sbjct 566 AGPSRDW----LGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIARAMRKQNLPIQRILT 621
Query 550 HPKSIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQINRQMHLDQ---DEPELVLKP 606
+ L+ + ++ S D A+ G V +++ ++ + + ++ +E + +
Sbjct 622 GDSLVTLAHEMRYPDISSSD---AAIGEGHVGAQNVVQKLVQALGGEEAASEEIDEAVPS 678
Query 607 TLNPRASHTLSAHGILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCPDYQ 666
R + G+++ G+D+V + +A+CC PV GE I G++T VS+H+ C + +
Sbjct 679 RSRSRKRRSNQDPGVVVKGVDDVWVKLARCCTPVPGEPIIGFVTRGSAVSVHRSDCVNVE 738
Query 667 RMIKNEPERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQVNTISE 726
+ + EPER +E +W + V I ++A DR LL D+T+V+ +NI +
Sbjct 739 SLAR-EPERILEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTS 797
Query 727 ADGIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRLIQG 767
D +A + E+ L +L + G+ R+ G
Sbjct 798 RDRVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRVTPG 838
>P52560 GTP pyrophosphokinase [Streptomyces coelicolor (strain
ATCC BAA-471 / A3(2) / M145)]
Length=847
Score = 392 bits (1007), Expect = 3e-127
Identities = 242/756 (32%), Positives = 404/756 (53%), Gaps = 67/756 (9%)
Query 42 LDGAELKQLEKVAQLT-------LKKVLETTVNHPSNTFTTGIGMADILAHLHVDEDTLS 94
++ + L+Q+E+ Q+ +K + + HP + + ILA L +D TL
Sbjct 119 IETSTLRQIERAYQVAERWHRGQKRKSGDPYITHP-------LAVTTILAELGMDPATLM 171
Query 95 AAVLYRSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREH 154
A +L+ +V + +E++R FG+ V LV G + K+ +
Sbjct 172 AGLLHDTVEDTEYGLEDLRRDFGDVVTLLVDGVTKLDKVKF--------------GEAAQ 217
Query 155 LSGIYKMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQERVAREILTIYAPLAHRLGI 214
+ KM++A+ +D RV++IKLA+R +R + RE+QE+ ARE L IYAPLAHRLG+
Sbjct 218 AETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGM 277
Query 215 AQLKWELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVILKLKTELSEYGINAEITG 274
+KWELEDLAF L P+ Y EI L+ E+ +R++Y+ V +++ +L I A +TG
Sbjct 278 NTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAVVTDEVQQDLRAARIKATVTG 337
Query 275 RVKHIYSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYI 334
R KH YS+Y+KM + F ++YD+ +RVLV + +CY +LG VH W +P +F DYI
Sbjct 338 RPKHYYSVYQKMIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYI 397
Query 335 TNPKANGYRSLHTAVIAE-NKSLEVQIRTHEMHEEAELGVCSHFNYK------------E 381
PK N Y+SLHT VI K +E+QIRT +MH AE G+ +H+ YK +
Sbjct 398 AMPKFNMYQSLHTTVIGPGGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVAGASKVRTD 457
Query 382 GSKTTDRSFNHRLHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEKIYVFSRDG 441
K++ +S + L+ + + + + ET +D E E L+ +++VF+ G
Sbjct 458 APKSSGKSKDDHLNDMAWLRQLLDWQKET-----EDPGEFLESLRFDLSRNEVFVFTPKG 512
Query 442 DIKELPRGSTVLDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILTKK--DREP 499
D+ LP G+T +DFAY VHTEVG++ ARVN R VPL TL G+ VE+ T K P
Sbjct 513 DVIALPAGATPVDFAYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAAGAGP 572
Query 500 NRDWLVNSLGYIRTARARDKLRHWFRQQDRSKNLEIGKEIL-------NKELSRLAIHPK 552
+RDW LG++++ RAR+K+R WF ++ R + +E GK+ + N + R+
Sbjct 573 SRDW----LGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIVRAMRKQNLPIQRILTGDS 628
Query 553 SIDLSDYCAHFNVKSGDDVLIALVSGDVSLHSLINQINRQMHLDQ---DEPELVLKPTLN 609
+ L+ + ++ + + A+ G VS +++ ++ + + ++ +E + + P+
Sbjct 629 LVTLAHEMRYSDISA---LYAAIGEGHVSAPNIVQKLVQALGGEEAATEEIDESVPPSRG 685
Query 610 PRASHTLSAH-GILIDGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCPDYQRM 668
+A G+++ G+++V + +A+CC PV G+ I G++T GVS+H+ C +
Sbjct 686 RGRKRRANADPGVVVKGVEDVWVKLARCCTPVPGDPIIGFVTRGSGVSVHRSDCVNVD-S 744
Query 669 IKNEPERAVEADWEMQPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQVNTISEAD 728
+ EPER +E +W + V I ++A DR LL D+T+V+ +NI + D
Sbjct 745 LSREPERILEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTSRD 804
Query 729 GIANMKLLIEVKGLAQLSRLLARLEQQPGIISARRL 764
+A + E+ L +L + G+ R+
Sbjct 805 RVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRV 840
>P9WHG9 GTP pyrophosphokinase / Guanosine-3',5'-bis(diphosphate)
3'-pyrophosphohydrolase [Mycobacterium tuberculosis (strain
ATCC 25618 / H37Rv)]
Length=738
Score = 383 bits (983), Expect = 6e-125
Identities = 239/741 (32%), Positives = 384/741 (52%), Gaps = 43/741 (6%)
Query 40 EILDGAELKQLEKVAQLTLKKVLETTVNHPSNTFTTGIGMADILAHLHVDEDTLSAAVLY 99
EI A+L L++ ++ ++ T + +A+ILA L +D TL AA+L+
Sbjct 21 EIYPKADLSILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLH 80
Query 100 RSVREGIIPIEEVRDKFGEQVHSLVTGTLAMGKLSEMIEKNKRLEDHFNNNQREHLSGIY 159
+V + +E + ++FGE+V LV G + D I
Sbjct 81 DTVEDTGYTLEALTEEFGEEVGHLVDGVTKL--------------DRVVLGSAAEGETIR 126
Query 160 KMLIAVTEDVRVVLIKLAERTFTLRELAKSSRERQERVAREILTIYAPLAHRLGIAQLKW 219
KM+ A+ D RV++IK+A+R +R + E+Q R ARE L + APLAHRLG+A +KW
Sbjct 127 KMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKW 186
Query 220 ELEDLAFRYLAPERYKEIATLLNEKRLEREQYIQSVILKLKTELSEYGINAEITGRVKHI 279
ELEDL+F L P++Y+EI L+ + R+ Y+ V ++ L+ I A + GR KH
Sbjct 187 ELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHY 246
Query 280 YSIYRKMKSKNLSFDQLYDIRALRVLVQNIPECYHSLGIVHQIWRHIPHQFDDYITNPKA 339
+SIY+KM K FD ++D+ +R+L I +CY ++G+VH +W+ + +F DYI P+
Sbjct 247 WSIYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRY 306
Query 340 NGYRSLHTAVIA-ENKSLEVQIRTHEMHEEAELGVCSHFNYKEGSKTTDRSFNHR----- 393
Y+SLHT V+ E K LEVQIRT +MH AE G+ +H+ YKE H
Sbjct 307 GVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEID 366
Query 394 -LHSLRSVLEHYQERNETTVHKNDDEAENFEELQNFEDFEKIYVFSRDGDIKELPRGSTV 452
+ +R +L+ +E D E E L+ ++I+VF+ GD+ LP GST
Sbjct 367 DMAWMRQLLDWQREA--------ADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTP 418
Query 453 LDFAYHVHTEVGNKCYAARVNQRYVPLTYTLKTGEQVEILTKK--DREPNRDWLVNSLGY 510
+DFAY VHTEVG++C ARVN R V L L+ GE VE+ T K + P+RDW +
Sbjct 419 VDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDW----QQF 474
Query 511 IRTARARDKLRHWFRQQDRSKNLEIGKEILNKELSRLAIHPKSI----DLSDYCAHFNVK 566
+ + RA+ K+R WF ++ R + LE GK+ + +E+ R + + + ++ +
Sbjct 475 VVSPRAKTKIRQWFAKERREEALETGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYA 534
Query 567 SGDDVLIALVSGDVSLHSLINQINRQM-HLDQDEPELVLK--PTLNPRASHTLSAHGILI 623
+ A+ G VS ++ ++ ++ +DQ E EL + P PR + G+ +
Sbjct 535 DVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDDVGVSV 594
Query 624 DGLDNVELHIAQCCQPVHGESIGGYITLNRGVSIHKVGCPDYQRMIKNEPERAVEADWEM 683
G V +A+CC PV G+ I G++T GVS+H+ C + ++ + ER +E W
Sbjct 595 PGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTN-AASLQQQAERIIEVLWAP 653
Query 684 QPTRGQSVQIVIDAYDRRGLLKDLTQVIFSDQINIRQVNTISEADGIANMKLLIEVKGLA 743
P+ V I ++A DR LL D+T+ + +++NI + + D +A + E+
Sbjct 654 SPSSVFLVAIQVEALDRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPK 713
Query 744 QLSRLLARLEQQPGIISARRL 764
L LL + G+ R+
Sbjct 714 HLGHLLNAVRNVEGVYDVYRV 734
Lambda K H a alpha
0.319 0.135 0.385 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 10216857
Database: 843b79d8f6d58fb443bcac3293ae3ab7.SwissProt.fasta
Posted date: May 20, 2024 9:54 PM
Number of letters in database: 15,753
Number of sequences in database: 21
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40
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Data ...
